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您的检索式：作者名="WanHong Xu"
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| 1 | Lnc-RP5 Regulates the mi R-129-5p/Notch1/PFV Internal Promoter Axis to Promote the Expression of the Prototype Foamy Virus Transactivator Tas显示文摘Prototype foamy virus(PFV)is a unique retrovirus that infects animals and humans and does not cause clinical symptoms.Long noncoding RNAs(lncRNAs)are believed to exert multiple regulatory functions during viral infections.Previously,we utilized RNA sequencing(RNA-seq)to characterize and identify the lncRNA lnc-RP5-1086 D14.3.1-1:1(lnc-RP5),which is markedly decreased in PFV-infected cells.However,little is known about the function of lnc-RP5 during PFV infection.In this study,we identified lnc-RP5 as a regulator of the PFV transcriptional transactivator(Tas).Lnc-RP5 enhanced the activity of the PFV internal promoter(IP).The expression of PFV Tas was found to be promoted by lnc-RP5.Moreover,mi R-129-5 p was found to be involved in the lnc-RP5-mediated promotion of PFV IP activity,while the Notch1 protein suppressed the activity of PFV IP and the expression of Tas.Our results demonstrate that lnc-RP5 promotes the expression of PFV Tas through the miR-129-5 p/Notch1/PFV IP axis.This work provides evidence that host lnc RNAs can manipulate PFV replication by employing mi RNAs and proteins during an early viral infection. | Shanshan Xu Liujun Chen Yinglian Tang Peipei Yuan Jun Yan Yingcheng Zheng Li Huang Zhi Li Yan Sun Song Han Jun Yin Qin Pan Biwen Peng Xiaohua He Wanhong Liu | 2020 | Virologica Sinica2020，35，1： | 1 |
| 2 | Type -Specific Identification of Human Adenovirus 3,7, and 21 by a Multiplex PCR Assay显示文摘 | WanHong Xu Dean D E | 2001 | Journal of Medical Virology2001，64，： | 1 |
| 3 | Construction and Expression of Serratia Marcescens ECU1010 Lipase (lipA) in Pichia Pastoris显示文摘 | Faxiang Ye Liqiang Fan Jianhe Xu Jian Zhao Wanhong He Minjun Ni | 2010 | Journal of Life Sciences2010，4，3： | 1 |
| 4 | Type - Specific Identifica- tion of Human Adenovirus 3,7 ,and 21 by a Multiplex PCR Assay显示文摘 | WanHong Xu Dean D Erdman | 2001 | J Med Virol2001，64，4： | 1 |
| 5 | Quantitative Proteomic Analyses of Influenza Virus-Infected Cultured Human Lung Cells显示文摘 | KEVIN M COOMBS ALICIA BERARD WANHONG XU | 2010 | Journal of Virology2010，84，10： | 1 |
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