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| 1 | Effects of Xinfeng capsule on pulmonary function based on treg-mediated notch pathway in a rat model of adjuvant arthritis显示文摘OBJECTIVE:To observe the impact of xinfeng xapsule(XFC) on pulmonary function in a rat model of adjuvant arthritis(AA) and to investigate the mechanism of action.METHODS:Forty rats were randomly divided into four groups of ten:normal control(NC);model control(MC);tripterygium glycosides tablet(TPT);and xinfeng capsule(XFC).Except for the NC group,AA was induced in all rats by intracutaneous injection of 0.1 mL Freund's complete adjuvant in the right paw on the 19th day.NC and MC groups were given(0.9%) physiological saline.The TPT and XFC groups were given TPT(10 mg/kg) and XFC(1.2 g/kg),respectively.Thirty days after administration,changes in paw edema(E),the arthritis index(AI),pulmonary function,levels of regulatory T-cells(Treg),ultrastructure of lung tissue,and expression of Notch receptors and ligands in lung tissue were observed.RESULTS:In the MC group,E and the AI were increased and pulmonary function significantly decreased;the structure of alveolar type-II cells was damaged;ratios of Treg in peripheral blood were reduced;and expression of Notch receptors such as Notch3 and Notch4 and ligands such as Delta1 in lung tissue were significantly increased whereas expression of Notch1,Jagged1 and Jagged2 were significantly decreased.After intervention with XFC,E and the AI were decreased;pulmonary function was enhanced;the structure of alveolar type-II cells was improved;and expression of Treg,Notch1,Jagged1,Jagged2 was elevated,whereas that of Notch3,Notch4 and Delta1 was reduced.CONCLUSION:XFC can not only inhibit E and the AI and improve joint symptoms,it can also improve pulmonary function and reduce inflammation in lung tissue.These actions could be carried out through increases in the expression of Treg,Notch receptors(Notch1) and ligands(Jagged1,Jagged2),and reductions in the expression of Notch3,Notch4 and Delta1.These phenomena would reduce the deposition of immune complexes and the inflammatory response in lung tissue,thereby improving joint symptoms and pulmonary function. | Lei Wan Jian Liu Chuanbing Huang Yuan Wang Xi Shen Wandong Zhang Guizheng Wang Haixia Fan Yao Ge Ruilian Chen Yunxiang Cao Ruikai Zong Li Lei | 2012 | Journal of Traditional Chinese Medicine2012，32，3： | 17 |
| 2 | Use of Xinfeng capsule to treat abarticular pathologic changes in patients with rheumatoid arthritis显示文摘OBJECTIVE: To observe the influence of Xinfengcapsule(XFC) on abarticular pathologic changes(APCs) and other indices of patients with rheumatoid arthritis(RA) and explore the mechanism of action of XFC in improving such changes.METHODS: Three-hundred RA patients were divided randomly into a treatment group(n=150) and control group(n=150). A normal control(NC)group(n=90) was also created. Changes in cardiac function, pulmonary function, anemia indices and platelet parameters of RA patients were measured.Curative effects of the two groups were compared,and comparison carried out with the NC group.RESULTS: In 300 RA patients, late diastolic peak flow velocity(A peak) was much higher(P<0.01)and early diastolic peak flow velocity(E peak), E/A,and left ventricular fraction shortening much lower(P<0.01) than those in the NC group. Vital capacity(VC), forced vital capacity in one second, forced vital capacity(FVC), maximal voluntary ventilation(MVV), maximal expiratory flow in 50% of VC(FEF50) and FEF75 were lowered remarkably(P<0.05 or P<0.01). Platelet count(PLT), plateletcrit(PCT) and mean platelet volume(MPV) increased markedly(P<0.05 or P<0.01), and hemoglobin(Hb)level decreased significantly(P<0.05). After XFC treatment, the A peak and PLT and PCT were much lower(P<0.05), and E/A and the number of red blood cells as well as Hb level were much higher(P<0.05), as were FVC, MVV and FEF50(P<0.05 or P<0.01), in the treatment group than those in the NC group. Total score of pain and swelling in joints,uric-acid level and high-sensitivity C-reactive protein level were much lower, and superoxide dismutase level as well as the number of CD4 +CD25+ regulation T cells(Treg) and CD4+CD25+CD127- Treg were much higher(P<0.05 or P<0.01)in the treatment group than those in the NC group.CONCLUSION: RA patients with pathologic changes in joints also suffer from lower cardiac and pulmonary functions and from parameters of anemia and platelet factors. XFC can improve the symptoms of RA patients, ameliorate their cardiac and pulmonary functions and reduce the parameters of anemia and platelet factors. XFC lowers the immune inflammatory reaction to improve APCs in RA patients. | Jian Liu Yunxiang Cao Chuanbing Huang Yuan Wang Xi Chen Wandong Zhang Guizhen Wang Haixia Fan Yao Ge Ruilian Chen Ruikai Zong Yajun Qi Yue Sun Yifei Liu Fang Wang | 2014 | Journal of Traditional Chinese Medicine2014，34，5： | 10 |
| 3 | Apolipoprotein E, amyloid-beta, and neuroinflammation in Alzheimer's disease显示文摘Alzheimer's disease(AD) is characterized by the accumulation and deposition of amyloid-beta(Aβ) peptides in the brain. Neuroinflammation occurs in the AD brain and plays a critical role in the neurodegenerative pathology. Particularly, Aβ evokes an inflammatory response that leads to synaptic dysfunction, neuronal death, and neurodegeneration. Apolipoprotein E(ApoE) proteins are involved in cholesterol transport, Aβ binding and clearance, and synaptic functions in the brain. The ApoE4 isoform is a key risk factor for AD, while the ApoE2 isoform has a neuroprotective effect. However, studies have reached different conclusions about the roles of the isoforms; some show that both ApoE3 and ApoE4 have anti-infl ammatory effects, while others show that ApoE4 causes a predisposition to inflammation or promotes an inflammatory response following lipopolysaccharide treatment. These discrepancies may result from the differences in models, cell types, experimental conditions, and inflammatory stimuli used. Further, little was known about the role of ApoE isoforms in the Aβ-induced inflammatory response and in the neuroinflammation of AD. Our recent work showed that ApoE isoforms differentially regulate and modify the Aβ-induced infl ammatory response in neural cells, with ApoE2 suppressing and ApoE4 promoting the response. In this article, we review the roles, mechanisms, and interrelations among Aβ, ApoE, and neuroinfl ammation in AD. | Evan Dorey Nina Chang Qing Yan Liu Ze Yang Wandong Zhang | 2014 | Neuroscience Bulletin2014，30，2： | 9 |
| 4 | Protectin D1 promotes resolution of inflammation in a murine model of lipopolysaccharide-induced acute lung injury via enhancing neutrophil apoptosis显示文摘 | Li Xingwang Li Chunlai Liang Wandong Bi Yuntian Chen Maohua Dong Sheng | 2014 | Chinese Medical Journal2014，，5： | 6 |
| 5 | Ab-Induced Insulin Resistance and the Effects of Insulin on the Cholesterol Synthesis Pathway and Ab Secretion in Neural Cells显示文摘Alzheimer's disease(AD) is characterized by amyloid-b(Ab) toxicity,tau pathology,insulin resistance,neuroinflammation,and dysregulation of cholesterol homeostasis,all of which play roles in neurodegeneration.Insulin has polytrophic effects on neurons and may be at the center of these pathophysiological changes.In this study,we investigated possible relationships among insulin signaling and cholesterol biosynthesis,along with the effects of Ab42 on these pathways in vitro.We found that neuroblastoma 2a(N2a) cells transfected with the human gene encoding amyloid-b protein precursor(Ab PP)(N2aAb PP) produced Ab and exhibited insulin resistance by reduced p-Akt and a suppressed cholesterol-synthesis pathway following insulin treatment,and by increased phosphorylation of insulin receptor subunit-1 at serine 612(p-IRS-S612) as compared to parental N2 a cells.Treatment of human neuroblastoma SH-SY5 Y cells with Ab42 also increased p-IRS-S612,suggesting that Ab42 is responsible for insulin resistance.The insulin resistance was alleviated when N2a-Ab PP cells were treated with higher insulin concentrations.Insulin increased Ab release from N2 aAb PP cells,by which it may promote Ab clearance.Insulin increased cholesterol-synthesis gene expression in SHSY5 Y and N2 a cells,including 24-dehydrocholesterol reductase(DHCR24) and 3-hydroxy-3-methyl-glutaryl-Co A reductase(HMGCR) through sterol-regulatory element-binding protein-2(SREBP2).While Ab42-treated SH-SY5 Y cells exhibited increased HMGCR expression and c-Jun phosphorylation as pro-inflammatory responses,they also showed down-regulation of neuro-protective/antiinflammatory DHCR24.These results suggest that Ab42 may cause insulin resistance,activate JNK for c-Jun phosphorylation,and lead to dysregulation of cholesterol homeostasis,and that enhancing insulin signaling may relieve the insulin-resistant phenotype and the dysregulated cholesterol-synthesis pathway to promote Ab release for clearance from neural cells. | Dema Najem Michelle Bamji-Mirza Ze Yang Wandong Zhang | 2016 | Neuroscience Bulletin2016，32，3： | 6 |
| 6 | Efficacy and safety of Xinfeng capsule in the treatment of osteoarthritis:a multicenter, randomized, double-blinded, controlled trial显示文摘OBJECTIVE: To evaluate the efficacy and safety of Xinfeng capsule(XFC) in patients with osteoarthritis(OA).METHODS: This was a multicenter, double-blinded,randomized, controlled, clinical trial. Patients with OA were assigned to the XFC group [treated with XFC and a glucosamine(GS) placebo, n = 129] or the GS group(treated with GS and an XFC placebo,n = 126). Both groups were treated for 4 weeks. The primary endpoint was the difference between the two groups in the Western Ontario and Mc Master Universities OA(WOMAC) index total score at 4 th week. The secondary endpoints were the visual analogue scale for pain, Lequesne index, function influence index rating, quality of life as assessed by the Short Form-36, erythrocyte sedimentation rate,and C-reactive protein concentration at baseline and at second week and 4 th week. Bone mineral density were checked by X ray absorptiometry at baseline and 4 th week.RESULTS: After 4 weeks of treatment, all patients in both groups showed similar significant improvements compared with baseline. There were no significant differences between groups regarding pain relief, bilateral femoral bone mineral density, and laboratory indices such as erythrocyte sedimentation rate and C-reactive protein concentration.Both groups had a significantly lower function influence index rating score and curative effect for each sign/symptom in week 4 than in week 0, and these changes did not significantly differ between groups. XFC was superior to GS in improving the WOMAC index total score, WOMAC scores for function and stiffness, integrated symptoms, physiological function, energy, emotional function, mental health, and health changes. Fourteen adverse reactions were reported, and the incidence of adverse reactions did not significantly differ between groups. The most common adverse reactions were hepatic impairment, kidney functional damage,gastrectasia, and facial skin allergy. The types of adverse reactions did not differ between groups.CONCLUSION: XFC is effective and safe in the treatment of OA. XFC was superior to GS in improving the WOMAC index total score, WOMAC scores for pain, stiffness, and function, visual analogue scale for pain, Lequesne index, and Short Form-36 quality of life. | Liu Jian Wang Yuan Sun Yue Huang Chuanbing Chen Xi Zhang Wandong He Liyun James Cheng-Chung Wei | 2020 | Journal of Traditional Chinese Medicine2020，40，2： | 5 |
| 7 | APOE and APOC1 gene polymorphisms are associated with cognitive impairment progression in Chinese patients with late-onset Alzheimer's disease显示文摘Current evidence shows that apolipoprotein E(APOE), apolipoprotein CI(APOC1) and low density lipoprotein receptor-related protein(LRP) variations are related to late-onset Alzheimer's disease. However, it remains unclear if genetic polymorphisms in these genes are associated with cognitive decline in late-onset Alzheimer's disease patients. We performed a 30-month longitudinal cohort study to investigate the relationship between Alzheimer's disease and APOE, APOC1, and LRP. In this study, 78 Chinese Han patients with late-onset Alzheimer's disease were recruited form Guangxi Zhuang Autonomous Region in China. APOE, APOC1, and LRP genotyping was performed using polymerase chain reaction-restriction fragment length polymorphisms. The Mini-Mental State Examination and Clinical Dementia Rating Scale were used to assess patients' cognitive function. After a 30-month follow-up period, we found a significant reduction in Mini-Mental State Examination total score, a higher proportion of patients fulfilling cognitive impairment progression criteria, and a higher proportion of APOC1 H2 carriers in APOE ε4 carriers compared with non-carriers. In addition, the APOE ε4 allele frequency was significantly higher in the cognitive impairment progression group compared with the non-cognitive impairment progression group. In conclusion, APOE ε4 plays an important role in augmenting cognitive decline, and APOC1 H2 may act synergistically with APOE ε4 in increasing the risk of cognitive decline in Chinese patients with late-onset Alzheimer's disease. | Qin Zhou Dantao Peng Xinrui Yuan Zeping Lv Shenghang Pang Wenyu Jiang Chuyu Yang Xiaohong Shi Guofang Pang Yige Yang Haiqun Xie Wandong Zhang Caiyou Hu Ze Yang | 2014 | Neural Regeneration Research2014，9，6： | 4 |
| 8 | Hypertransaminasemia in the course of infection with SARS-CoV-2:Incidence and pathogenetic hypothesis显示文摘In patients infected with severe acute respiratory syndrome coronavirus 2,the respiratory symptoms,such as fever,cough and dyspnea,are the most frequent clinical manifestations.These patients may also present with less well-defined symptoms like diarrhea,nausea,vomiting and/or abdominal discomfort both at the time of diagnosis and during the clinical course.In a few cases,these symptoms may also present before the appearance of respiratory symptoms.To penetrate the body,Severe acute respiratory syndrome coronavirus 2 uses ACE2 receptors,which are present not only in respiratory epithelium but also in gastrointestinal mucosa and liver cholangiocytes.In several cases,viral RNA is detectable in the stool of patients with coronavirus disease 2019(COVID-19).The liver damage seems to show a multifactorial origin.About 2%-11%of patients with COVID-19 have known underlying hepatic pathologies.In 14%-53%of COVID-19 cases,there is an alteration of the indices of liver cytolysis and is more frequently observed in severe forms of COVID-19,especially during hospitalization. | Maddalena Zippi Sirio Fiorino Giuseppe Occhigrossi Wandong Hong | 2020 | World Journal of Clinical Cases2020，8，8： | 4 |
| 9 | Mechanism studies of Xinfeng capsule on improving cardiovascular function though toll-like receptor 4/nuclear factor kappa B pathway in a rat model of adjuvant arthritis显示文摘OBJECTIVE: To observe the impact of Xinfeng capsule(XFC) on cardiovascular function in adjuvant arthritis(AA) model rats and investigate the mechanism though toll-like receptor 4(TLR4)/nuclear factor kappa B(NF-κB) signaling pathway.METHODS: Seventy rats were randomly divided into seven groups: normal control(NC), model control(MC), tripterygium glycosides tablet(TPT),methotrexate(MTX), high, moderate and low dose XFC group. The administration began from day 19 after modeling for 30 day. Paw swelling, arthritic in-dex(AI), cardiac function indexes and myocardial pathological pattern were detected. The expression of TLR4, myeloid differentiation factor(My D) 88, interleukin-1 receptor-associated kinase(IRAK) 1, tumor necrosis factor receptor associated factor(TRAF) 6, NF-κB, tumor necrosis factor-alpha(TNF-α) proteins in myocardial tissue were determined by western blot method.RESULTS: Paw swelling and AI in MC group increased in MC group(P < 0.01), and decreased in high and moderate dose XFC groups(P < 0.01 or P > 0.05). Left ventricular systolic pressure(LVSP),left ventricular end-diastolic pressure(LVEDP),heart rate(HR) were elevated in MC group(P <0.01), and ± dp/dtmax and CI were reduced(P <0.01); while LVSP, LVEDP and HR declined and ±dp/dtmax, CI improved in high dose XFC group(P <0.05 or P < 0.01). LVSP in high dose XFC group were reduced more than other treatment groups(P <0.05 or P < 0.01). The improvements on LVEDP, dp/dt-max were superior to MTX and low dose XFC group, and the improvement on CI was better than low dose XFC group(P < 0.05 or P < 0.01). Myocardial fibers arranged irregular in MC group with intracellular edema and mitochondria damage. The modifications on myocardial structural were shown in each treatment group, but more prominent in TPT, high and moderate dose XFC group. The proteins of TLR4, My D88, IRAK1, TRAF6, NF-κB, TNF-αwere highly expressed in MC group, and those proteins declined in high and moderate dose XFC group(P < 0.05 or P < 0.01). High dose XFC group was superior to MTX and low dose XFC group on reducing TLR4, NF-κB, TNF-α(P < 0.05).CONCLUSION: XFC can not only inhibit the excessive activation of TLR4/NF-κB signaling pathway and the increased inflammatory mediators, but also reduce the damage of myocardial tissue and cells. | Wang Yuan Liu Jian Huang Chuanbing Sun Yue Zhang Wandong Wan Lei Zong Ruikai Wang Yali | 2017 | Journal of Traditional Chinese Medicine2017，37，1： | 4 |
| 10 | Epidemic Spreading Model Based on Social Active Degree in Social Networks显示文摘In this paper,an improved Susceptible-Infected-Susceptible(SIS) epidemic spreading model is proposed in order to provide a theoretical method to analyze and predict the spreading of diseases.This model is based on the following ideas:in social networks,the contact probability between nodes is decided by their social distances and their active degrees.The contact probability of two indirectly connected nodes is decided by the shortest path between them.Theoretical analysis and simulation experiment were conducted to evaluate the performance of this improved model.Because the proposed model is independent of the network structure,simulation experiments were done in several kinds of networks,namely the ER network,the random regular network,the WS small world network,and the BA scale-free network,in order to study the influences of certain factors have on the epidemic spreading,such as the social contact active degree,the network structure,the average degree,etc.This improved model provides an idea for studying the spreading rule of computer virus,attitudes,fashion styles and public opinions in social networks. | WANG Yanben CAI Wandong | 2015 | China Communications2015，12，12： | 4 |
| 11 | Development of Human in vitro Brain-blood Barrier Model from Induced Pluripotent Stem Cell-derived Endothelial Cells to Predict the in vivo Permeability of Drugs显示文摘An in vitro blood-brain barrier(BBB) model is critical for enabling rapid screening of the BBB permeability of the drugs targeting on the central nervous system.Though many models have been developed, their reproducibility and renewability remain a challenge. Furthermore, drug transport data from many of the models do not correlate well with the data for in vivo BBB drug transport.Induced-pluripotent stem cell(i PSC) technology provides reproducible cell resources for in vitro BBB modeling.Here, we generated a human in vitro BBB model by differentiating the human i PSC(hi PSC) line GM25256 into brain endothelial-type cells. The model displayed BBB characteristics including tight junction proteins(ZO-1,claudin-5, and occludin) and endothelial markers(von Willebrand factor and Ulex), as well as high transendothelial electrical resistance(TEER)(1560 X.cm2±230 X.cm2) and c-GTPase activity. Co-culture with primary rat astrocytes significantly increased the TEER of the model(2970 X.cm2 to 4185 X.cm2). RNAseq analysis confirmed the expression of key BBB-related genes in the hi PSC-derived endothelial cells in comparison with primary human brain microvascular endothelial cells,including P-glycoprotein(Pgp) and breast cancer resistant protein(BCRP). Drug transport assays for nine CNS compounds showed that the permeability of non-Pgp/BCRP and Pgp/BCRP substrates across the model was strongly correlated with rodent in situ brain perfusion data for these compounds(R2= 0.982 and R2= 0.9973,respectively), demonstrating the functionality of the drug transporters in the model. Thus, this model may be used to rapidly screen CNS compounds, to predict the in vivo BBB permeability of these compounds and to study the biology of the BBB. | Yuan Li Xueying Sun Houfu Liu Liang Huang Guofeng Meng Yu Ding Wenji Su Jiaqi Lu Sophie Gong Georg C.Terstappen Ru Zhang Wandong Zhang | 2019 | Neuroscience Bulletin2019，35，6： | 3 |
| 12 | A Fast Multicast-based Approach to Inferring Loss Performance显示文摘 | Yongjun Li Wandong Cai | 2006 | 通讯和计算机(中英文版)2006，3，3： | 2 |
| 13 | ApoE基因、CYP46A1基因和RXRA基因与阿尔茨海默病的关联显示文摘目的探索ApoE基因(rs429358,T)、CYP46A1基因(rs4900442,T)和RXRA基因(rs3132299,G)的常见变异类型与阿尔茨海默病患病风险的关联研究,分析这些常见变异位点的基因型和等位基因的分布频率。方法运用病例对照研究设计,包括北京和呼和浩特146例确诊的阿尔茨海默病患者和140例健康对照,通过聚合酶链反应(PCR)和限制性片段长度多态性(RFLP)以及测序的方法,比较病例组和对照组ApoE基因(rs429358,T)、CYP46A1(rs4900442,T)基因和RXRA基因(rs3132299,G)的等位基因和基因型频率的差异。结果 ApoE基因(rs429358,T)的基因型和等位基因在病例组和对照组中的频率分布差异均有统计学意义(P=4.7×10-9,P=2.7×10-10)。ApoE基因(rs429358,T)和CYP46A1基因rs4900442,T)的TT+CT和CC基因型在病例组和对照组中的频率分布差异均有统计学意义(P=0.007,P=0.034)。RXRA基因(rs3132299,G)的基因型和等位基因在病例组和对照组中的频率分布差异均无统计学意义(P>0.05)。结论 ApoE基因与中国人阿尔茨海默病患病风险有关,CYP46A1(rs4900442,T)基因和RXRA基因(rs3132299,G)基因可能与阿尔茨海默病的患病风险无关。 | 王娜娜 惠娟 张毓洪 杨泽 Wandong Zhang | 2014 | 中国老年保健医学2014，12，2： | 2 |
| 14 | Comparative first-principles study of elastic constants of covalent and ionic materials with LDA,GGA,and meta-GGA functionals and the prediction of mechanical hardness显示文摘Accurate prediction of single-crystal elastic constants is critical for materials design and for understanding phase transition and elastic interactions in materials.In this work,the accuracy of elastic constants calculated with three density functional approximations has been compared,including the local density approximation(LDA),the generalized gradient approximation(GGA),and the recently developed strongly constrained and appropriately normed(SCAN)meta-GGA.The results show that SCAN and PBE describe elastic constants better than LDA.The strong correlation between the mechanical hardness and the stiffness of the softest eigenmode(SSE)has been given for above three density functionals.The correlation is capable of predicting accurately the hardness of covalent,ionic,and mixed covalent-ionic crystals,and providing us a convenient indicator for the discovery of hard or superhard materials. | XING WanDong MENG FanYan NING JinLiang SUN JianWei YU Rong | 2021 | Science China(Technological Sciences)2021，64，12： | 2 |
| 15 | Prognostic significance of MDR-1 P-glycoprotein expression in breast cancer显示文摘Objective: To investigate the expression of MDR-1 P-glycoprotein(MDR-1 Pgp) in breast cancer and analyze its correlation to the biological behavior and prognosis of the disease. Methods:The expression of MDR-1 Pgp was examined in 75 cases of breast cancer patients by using three different monoclonal antibodies(JSB1, C219 and C494) with S-P immunohistochemisty. These patients were followed up for 5 years, and the correlation between MDR-1 Pgp expression, survival rate and lymph metastasis was analyzed. Results: Positive detection of MDR-1 Pgp by JSB1, C219 and C494 in 75 cases of breast cancer was 86.7%, 48% and 85.3%, respectively. MDR-1 Pgp expression was not related to ages of patients (P > 0.05). JSB1-detected expression of MDR-1 Pgp was related to lymph node metastasis(P < 0.05); while C219 and C494 were not(P > 0.05). The patients with MDR-1 Pgp expression positively detected by either two of the three antibodies, had five-year survival rate that was significantly higher than those positively detected by all the three antibodies(P < 0.05). Conclusion:Three antibodies should be used simultaneously to detect MDR-1 Pgp expression in breast cancer. Positive MDR-1 Pgp expression in breast cancer detected by all the three antibodies may represent a poor prognosis; while positive MDR-1 Pgp detection by JSB1 and C494 is associated with lymph metastasis. | Huilin Zhang Wandong Zhang Fengshan Li | 2008 | Journal of Nanjing Medical University2008，22，3： | 2 |
| 16 | Paradoxical relationship between proton pump inhibitors and COVID-19: A systematic review and meta-analysis显示文摘BACKGROUND The proton pump inhibitors(PPIs),used to reduce gastric acid secretion,represent one of the most widely used pharmaceutical classes in the world.Their consumption as a risk factor for the evolution of severe forms of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has been investigated as well as the mortality of these patients.These risks also appear to be linked to the duration and the dosage.On the other hand,several studies have emerged with regard to the protective or therapeutic effects of these drugs.More and more evidence underlines the immunomodulatory and anti-fibrotic role of PPIs.In addition,their ability to alkalize the contents of endosomes and lysosomes serves as an obstacle to the entry of the virus into the host cells.AIM To identify studies on the relationship between the intake of PPIs and coronavirus disease 2019(COVID-19)in patients affected by SARS-CoV-2 infection,with the main objective of evaluating the outcomes related to severity and mortality.METHODS A literature review was performed in November 2020.The MEDLINE/PubMed,Cochrane Library,EMBASE and Google Scholar databases were searched for all relevant articles published in English on this topic.The search terms were identified by means of controlled vocabularies,such as the National Library of Medicine’s MESH(Medical Subject Headings)and keywords.The MESH terms and keywords used were as follows:“COVID-19”,“proton pump inhibitors”,“PPIs”,“SARS-CoV-2”,“outcomes”,“severity”and“mortality”.The inclusion criteria regarding the studies considered in our analysis were:meta-analysis,casecontrol,hospital-based case-control,population-based case-control,retrospective studies,online survey,as well as cohort-studies,while articles not published as full reports,such as conference abstracts,case reports and editorials were excluded.We tried to summarize and pool all the data if available.RESULTS A total of 9 studies were found that described the use of PPIs,of which only 5 clearly reported the severity and mortality data in SARS-CoV-2 patients.Our pooled incidence analysis of severe events did not differ between patients with and without PPIs(odds ratio 1.65,95%confidence interval:0.62-4.35)(P=0.314),or for mortality(odds ratio 1.77,95%confidence interval:0.62-5.03)(P=0.286).CONCLUSION Detailed and larger case studies are needed to accurately understand the role of PPIs in this viral infection. | Maddalena Zippi Sirio Fiorino Roberta Budriesi Matteo Micucci Ivan Corazza Roberta Pica Dario de Biase Claudio Giuseppe Gallo Wandong Hong | 2021 | World Journal of Clinical Cases2021，9，12： | 2 |
| 17 | 显示文摘 | ZhangZhenjiang(张振江) WanDong(万东) XingHaiping(邢海平) TangTao(唐涛) | 2011 | 应用化学2011，28，： | 1 |
| 18 | Cystic acoustic neuroma显示文摘 | Wandong S Meng L Xingang L | 2005 | J Clin Neurosci2005，12，3： | 1 |
| 19 | Using end-to-end data to infer sensor network topology显示文摘 | Zhao Tao Cai wandong Li Yongiun | 2007 | IEEE2007，，： | 1 |
| 20 | A Sequential Game-Theoretic Study of the Retweeting Behavior in Sina Weibo 显示文摘 | Wang Ru Cai Wandong | 2015 | Journal of Super- computing2015，71，9： | 1 |
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