|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Obesity-induced hypertension develops in young rats independently of the rennin-angiotensin-aldosterone system显示文摘 | Smith AD Brands MW Wang MH | 2006 | Exp Biol Med2006，231，： | 1 |
| 3 | Chinese ischemic stroke subclassification显示文摘 | Gao S Wang YJ Xu AD | 2011 | Front Neurol2011，2，： | 1 |
| 4 | Circulating levels of IL- l beta,a prothrombotic cytokine,are elevated in unstable angina versus stable angina显示文摘 | Simon AD Yazdani S Wang W | 2000 | J Thromb Thrombolysis2000，9，3： | 1 |
| 5 | Connexin43 with a cytoplasmic loop deletion inhibits the function of several connexins显示文摘 | Wang M Martínez AD Berthoud VM | 2005 | Biochem Biophys Res Commun2005，333，： | 1 |
| 6 | Angiotensin II in- creases urokinase-type plasminogen activator expression and in- duces aneurysm in the abdominal aorta of apolipoprotein E- deficient mice显示文摘 | Wang YX Martin- MeNulty B Freay AD | 2001 | Am J Pathol2001，159，4： | 1 |
| 7 | Polylactic acid mesh recon- struction of the anterior iliac crest after bone harvesting reduces ear- ly postoperative pain after anterior cervical fusion surgery显示文摘 | Wang MY Levi AD Shah S | 2002 | Neu- rosurgery2002，51，2： | 1 |
| 8 | Assessment of arterial stiffness, a translational medicine biomarker system for evaluation of vascular risk显示文摘 | Wang X Keith JC Struthers AD | 2008 | Cardiovasc Ther2008，26，3： | 1 |
| 9 | Bilineal Disease and Trans-Heterozygotes in Autosomal Dominant Polycystic Kidney Disease显示文摘 | Pei Y Paterson AD Wang KR | 2001 | Am J Hum Genet2001，68，： | 1 |
| 10 | A pooled analysis of gemcitabine plus docetaxel versus capecitabine plus docetaxel in metastatic breast cancer显示文摘 | Seidman AD Chan S Wang J | 2014 | Oncologist2014，19，5： | 1 |
| 11 | The overexpression of RHAMM, a hyaluronan-binding protein that regulates ras signaling, correlates with overexpression of mitogen-activated protein kinase and is a significant parameter in breast cancer progression显示文摘 | Wang C Thor AD Moore DH | 1998 | Clin Cancer Res1998，4，3： | 1 |
| 12 | Chinese ischemic stroke subclassification显示文摘 | Gao S Wang Y J Xu AD | 2011 | Front Neurol2011，2，： | 1 |
| 13 | Chinese ischemic stroke subclas-sification显示文摘 | Gao S Wang YJ Xu AD | 2011 | Front Neurol2011，2，6： | 1 |
| 14 | Chinese ischemic stroke subclassification 显示文摘 | Gao S Wang YJ Xu AD | 2011 | Front Neuro12011，2，： | 1 |
| 15 | Chinese ischemic stroke subclassification显示文摘 | Gao S Wang YJ Xu AD | 2011 | Front Neurol2011，15，： | 1 |
| 16 | Evolution of radiation-induced brain injury: MR imaging-based study 显示文摘 | Wang YX King AD Zhou H | 2010 | Radiology2010，254，1： | 1 |
| 17 | Assessment of arterial stiffness, a translational medicine biomarker system for evaluation of vascular risk显示文摘 | Wang X Keith JC Jr Struthers AD | 2008 | Cardiovase Ther2008，26，3： | 1 |
| 18 | Nitric oxide modulates fracture healing显示文摘 | Diwan AD Wang MX Jang D | 2000 | J Bone Miner Res2000，15，2： | 1 |
| 19 | Chinese ischemic stroke subclassification 显示文摘 | GAO S WANG YJ XU AD | 2011 | Front Neurol2011，15，2： | 1 |
| 20 | Cavitation clouds created by shock scattering from bubbles during histotripsy显示文摘 | Maxwell AD Wang TY Cain CA | 2011 | J Acoust Soc Am2011，130，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员