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| 1 | Effect of minor Sc addition on microstructure and stress corrosion cracking behavior of medium strength Al–Zn–Mg alloy显示文摘Influence of Sc content on microstructure and stress corrosion cracking behavior of medium strength Al–Zn–Mg alloy have been investigated by optical microscopy, scanning electron microscopy, electron backscatter diffraction, transmission electron microscopy and slow strain rate test. The results indicate that the addition of Sc results in the formation of the quaternary coherent Al_3(Sc, Zr, Ti) dispersoids during homogenization treatment, which will inhibit the dynamic recrystallization behavior. The number density of Al_3(Sc, Zr, Ti) particles increases with the increase of Sc content, and thus the recrystallization fraction of hot-extruded alloy is reduced and the peak strength in two-stage artificial aging sample is enhanced. At the same time, the wide of precipitation free zone is reduced, and the content of Zn and Mg in grain boundary particles and precipitation free zone is increased with the increase of Sc content. In peak-aged state, the 0.06 wt% Sc added alloy shows the better stress corrosion cracking resistance than the Sc-free alloy because of the reduction of recrystallization fraction and the interrupted distribution of grain boundary precipitates along grain boundary. However, the further addition of Sc to 0.11 wt% will result in the deterioration of stress corrosion cracking resistance due to the increase of electrochemical activity of grain boundary particles and precipitation free zone as well as hydrogen embrittlement. | Zhaoming Li Haichang Jiang Yunli Wang Duo Zhang Desheng Yan Lijian Rong | 2018 | Journal of Materials Science & Technology2018，34，7： | 14 |
| 2 | Angiotensin Ⅱ promotes NO production, inhibits apoptosis and enhances adhesion potential of bone marrow-derived endothelial progenitor cells显示文摘Endothelial 祖先房间(EPC ) 响应织物局部缺血和 endothelial 损害参予出生后的 neovascularization 和 re-endothelialization 的过程。在场的 EPC 的水平被发现了直接与心血管的疾病的结果被联系,并且能被 stimulatory 或禁止的因素调整。给在血管收缩素 II (AngII ) 和心血管的系统之间的靠近的关系,我们在导出的骨头髓(BM ) 的活动调查了 AngII 的效果 EPC。房间被密度坡度 centrifugation 从老鼠的 BM 孤立。AngII 的管理显著地支持了氮的氧化物(没有) 版本,禁止的 EPC apoptosis 和提高的 EPC 粘附潜力。所有被预告的处理与 valsartan 或 L 名字 EPC 上的这些调停 AngII 的效果稀释。而且, LY294002 和 wortmannin 废除了 AngII 的 anti-apoptotic 效果。西方的污点分析显示了没有 synthase (eNOS ) 蛋白质和 phosphorylated Akt 在 EPC 与 AngII 的处理增加了的那 endothelial。因此, AngII 通过 AngII 类型 1 受体(AT1R ) 改进了 EPC 的几项活动,它可以代表与 angiogenesis 连接 AngII 和 AT1R 的可能的机制。另外,导致 AngII 通过在 EPC 的 eNOS 的合成都不调整 apoptosis 和粘附,并且 PI3-kinase/Akt 小径在导致 AngII 的 antiapoptosis 发信号有一个必要角色。 | Tao Yin Xinliang Ma Li Zhao Kang Cheng Haichang Wang | 2008 | Cell Research2008，18，7： | 12 |
| 3 | Nine-month angiographic and two-year clinical follow-up of polymer-free sirolimus-eluting stent versus durable-polymer sirolimus-eluting stent for coronary artery disease: the Nano randomized trial显示文摘 | Zhang Yaojun Chen Fang Takashi Muramatsu Xu Bo Li Zhanquan Ge Junbo He Qing Yang Zhijian Li Shumei Wang Lefeng Wang Haichang He Ben Li Kang Qi Guoxian Li Tianchang Zeng Hesong Peng Jianjun Jiang Tieming Zeng Qiutang Zhu Jianhua Fu Guosheng Christos V. Bourantas Patrick W. Serruys Huo Yong | 2014 | Chinese Medical Journal2014，，11： | 8 |
| 4 | Role ofδ-ferrite in fatigue crack growth of AISI 316 austenitic stainless steel显示文摘FF sample(nearly free ofδ-ferrite)and CF sample(containing∼4%δ-ferrite)were prepared from the AISI 316 austenitic stainless steel plate to elucidate the role ofδ-ferrite in the fatigue crack growth under the solution treated and accelerated aged conditions.It is found that the fatigue crack growth resistance of the CF sample is higher than the FF sample under the solution treated condition.However,a significant deterioration of the fatigue crack growth resistance is observed in the CF sample while little variation is found in the FF sample after accelerated aging treatment at 750°C for 10 h.In the solution treated condition,deflected crack growth path is present when the main crack encounters theδ-ferrite in the CF sample due to the differences in the fatigue responses between austenite andδ-ferrite.The measured growth rate of the deflected crack is significantly slower than that of the flat crack of the same length.After the accelerated aging treatment,microcracks are produced at the M_(23)C_(6)/δinterface due to the strain incompatibility between M_(23)C_(6) and retainedδ-ferrite when the decomposedδ-ferrite is subject to plastic deformation in the crack tip plastic zone.The preexisting microcracks in the front of crack tip provide a viable path for crack propagation,resulting in the relatively flat crack path. | Qiyu Wang Shenghu Chen Xinliang Lv Haichang Jiang Lijian Rong | 2022 | Journal of Materials Science & Technology2022，，19： | 3 |
| 5 | Soil aggregation and aggregate-associated organic carbon under typical natural halophyte communities in arid saline areas of Northwest China显示文摘Information on the effects of halophyte communities on soil organic carbon(SOC)is useful for sequestrating C in arid regions.In this study,we identified four typical natural halophyte communities in the Manasi River Basin in Xinjiang Province,Northeast China,namely,Karelinia caspia(Pall.)Less.,Bassia dasyphylla(Fisch.et C.A.Mey.)Kuntze,Haloxylon ammodendron(C.A.Mey.)Bunge,and Tamarix ramosissima Lour.We compared soil aggregation and aggregated-associated SOC under these communities.The aggregate fraction of 0.053–0.25 mm accounted for 47%–75%of the total soil mass,significantly more than the>0.25 and<0.053 mm fractions,under all the halophyte communities.Significant differences in soil aggregate size distribution were observed among the plant communities,with the H.ammodendron and B.dasyphylla communities showing the highest proportions of>0.25 mm aggregates(13.3%–43.8%)and T.ramosissima community having more<0.053 mm aggregates(14.1%–27.2%).Aggregate-associated SOC concentrations were generally the highest in the>0.25 mm fraction,followed by the<0.053 mm fraction,and were the lowest in the 0.053–0.25 mm fraction;however,because of their large mass,0.25–0.053 mm aggregates contributed significantly more to the total SOC.Total SOC concentrations(0–60 cm depth)decreased in the order of H.ammodendron(5.7 g kg^-1)>T.ramosissima(4.9 g kg^-1)>K.caspia(4.2 g kg^-1)>B.dasyphylla(3.4 g kg^-1).The H.ammodendron community had the highest total SOC and aggregate-associated SOC,which was primarily because aggregate-associated SOC content at the 0–10 and 10–20 cm depths under this community were higher than those under other plant communities.The H.ammodendron community could be beneficial for increasing SOC in saline soils in the arid region. | Zhibo CHENG Jingya WANG William JGALE Haichang YANG Fenghua ZHANG | 2020 | Pedosphere2020，30，2： | 1 |
| 6 | Insulin inhibits leukocyte–endothelium adherence via an Akt-NO-dependent mechanism in myocardial ischemia/reperfusion显示文摘 | Jia Li Feng Wu Haifeng Zhang Feng Fu Lele Ji Ling Dong Qiuxia Li Wenchong Liu Yuan Zhang Anlin Lv Haichang Wang Jun Ren Feng Gao | 2009 | Journal of Molecular and Cellular Cardiology2009，，4： | 1 |
| 7 | Insulin inhibits tumor necrosis factor-α induction in myocardial ischemia/reperfusion: Role of Akt and endothelial nitric oxide synthase phosphorylation显示文摘 | Jia Li Haifeng Zhang Feng Wu Ying Nan Heng Ma Wenyi Guo Haichang Wang Jun Ren Undurti N. Das Feng Gao | 2008 | Critical Care Medicine2008，，5： | 1 |
| 8 | P-glycoprotein associates with Anxa2 and promotes invasion in multidrug resistant breast cancer cells显示文摘 | Fei Zhang Haichang Zhang Zhiyong Wang Man Yu Ran Tian Wei Ji Yi Yang Ruifang Niu | 2013 | Biochemical Pharmacology2013，，： | 1 |
| 9 | Comparative Study of Culture in Vitro and Differentiate of EPCs from Bone Marrow Source of Minipig显示文摘 | Kang Cheng Guoliang Jia Haichang Wang Ronghua Luan Xiang Zhou Xiaojuan Zong | 2006 | Journal of US-China Medical Science2006，3，2： | 0 |
| 10 | Natural anti-oxLDL IgM monoclonal antibody in the pathogenesis of atherosclerosis显示文摘Objective To explore the role and the possible molecular mechanisms of natural anti-oxLDL IgM monoclonal antibody played and involved in pathogenesis of atherosclerosis. Methods Natural anti-oxLDL IgM monoclonal antibody 3A6 was generated by using standard hybridoma production techniques. Influence of 3A6 on formation of foam cells was observed by Oil Red O staining and affinity of Na125I-conjugated oxLDL on the naive and LPS-activated macrophages. After LPS stimulation on macrophages, anti-TLR4 neutralizing mAb, p38MAPK specific inhibitor SB203580, NF-kB specific inhibitor PDTC or RNAi targeting Fcα/μ receptor (Fcamr) were applied, respectively. Results Natural anti-oxLDL IgM monoclonal antibody 3 A6 were found specifically inhibit the binding of CuoxLDL to naive macrophages but not the binding of CuoxLDL to LPS-activated macrophages. It also promoted the formation of CuoxLDL-mediated foam macrophages. 3A6 F(ab')2 or pre-incubation with un-related IgM inhibited the binding of 3A6/CuoxLDL complex to LPS-activated macrophages. LPS up-regulated the expression of Fcamr in macrophages in a dose- and time-dependent manner, which was attenuated by treatment with anti-TLR4. LPS induced the phosphorylation of p38MAPK and translocation of NF-kB p65, contributing to the up-regulated expression of Fcα/μ receptor in macrophages. Conclusions Natural anti-oxLDL IgM monoclonal antibody 3A6 specifically inhibited the binding of CuoxLDL to naive macrophages in vitro. However, LPS, through the Toll-like receptor (TLR)4 receptor, activated the p38MAPK and NF-kB pathways and up-regulated the expression of Fcα/μ receptor in macrophages, which promoted the binding of 3A6/CuoxLDL complex to macrophages through binding with Fc fragments and the formation of foam macrophages. Therefore, our findings provide a new explanation why bacterial infection deteriorates the pathogenesis of atherosclerosis. | Xuyang Feng Ruifen Xu Yan Gao Haokao Gao Zheng He Haichang Wang | 2009 | Journal of Geriatric Cardiology2009，6，1： | 0 |
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