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| 1 | Effects of Cr interlayer on mechanical and tribological properties of Cr-Al-Si-N nanocomposite coating显示文摘Cr-Al-Si-N coatings were deposited on SUS 304 substrate by a hybrid coating system. A Cr interlayer was introduced between Cr-Al-Si-N coating and SUS 304 substrate to improve the coating adherence. The effects of Cr interlayer on the microhardness, adhesion, and tribological behavior of Cr-Al-Si-N coatings were systematically investigated. The results indicate that the microhardness of the Cr-Al-Si-N coatings gradually deceases with increasing thickness of Cr interlayers. The adhesion between Cr-Al-Si-N and SUS 304 substrate is improved by addition of the Cr interlayers. A peak critical load of ~50 N is observed for the coating containing Cr interlayer of 60 nm as compared ~ 20 N for the coating without Cr interlayer. The thicker Cr interlayers result in reduced critical load values. Moreover, the wear resistance of the Cr-Al-Si-N coatings is greatly enhanced by introducing the Cr interlayer with thickness of 60 nm in spite of the decreased microhardness. The friction coefficient of the coating system is also moderately reduced. | Young Su HONG Se Hun KWON Tiegang WANG Doo-In KIM Jihwan CHOI Kwang Ho KIM | 2011 | Transactions of Nonferrous Metals Society of China2011，21，A01： | 6 |
| 2 | Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels显示文摘Brachydactyly 打 A1 (BDA1 ) ,第一在人记录了孟德尔的正染色体的主导的混乱,被弄短或中间的指骨的缺席描绘。在印度刺猬(IHH ) 基因的异质接合的错误感觉变化作为 BDA1 的一个原因被识别了;然而,这些变化的生物化学的后果是不清楚的。在这份报纸,我们在印度刺猬(IhhN ) 的 N 终端碎片分析了三个 BDA1 变化(E95K, D100E,和 E131K ) 。结构的分析证明 E95K 变化在一条钙绑定沟把一个否定地控告的区域改变到一个断然控告的区域,并且 D100E 变化改变本地第三级的结构。而且,我们证明 E95K 和 D100E 变化导致了一温度敏感并且 IhhN 的钙依赖者不稳定性,它可能经由 lysosome 贡献变异的蛋白质的提高的细胞内部的降级。尤其是,所有三个变化影响了对受体 Patched1 (PTC1 ) 有约束力的 Hh,减少它的能力导致细胞的区别。我们建议这些是引起 BDA1 的变化的普通特征,影响 Hh 第三级的结构,细胞内部的命运,到受体 / 搭挡的绑定,和到细胞外的部件的绑定。这些特征的联合改变发信号的能力和范围,但是影响是可能的是变量和变化依赖者。在发信号的范围的潜在的变化被和 heparan 硫酸盐的一个提高的相互作用与 E95K 变化,然而并非 E131K 变化为 IHH 描绘。一起拿,我们的结果建议这些 IHH 变化影响在多重层次,引起的反常骨头发展和反常的位形成发信号的 Hh。 | Gang Ma Jiang Yu Yue Xiao Danny Chan Bo Gao Jianxin Hu Yongxing He Shengzhen Guo Jian Zhou Lingling Zhang Linghan Gao Wenjuan Zhang Yan Kang Kathryn SE Cheah Guoyin Feng Xizhi Guo Yujiong Wang Cong-zhao Zhou Lin He | 2011 | Cell Research2011，21，9： | 6 |
| 3 | Possible negative influences of increasing content of cerium on activity and hydrothermal stability of Rh/ceria-zirconia three-way catalysts显示文摘The activity and hydrothermal stability of the Rh/Ce_(x)Zr_(1-x)O_(2)(x=0,0.05,0.3,0.5) model three-way catalysts for gasoline vehicle emissions control were investigated in this work.Among the Rh/Ce_(x)Zr_(1-x)O_(2) samples with different Ce/Zr ratios,the Rh/ZrO_(2) sample exhibits a significantly better activity and hydrothermal stability than the rest of the samples.The impacts of having more Ce components in the Rh/Ce_(x)Zr_(1-x)O_(2) catalysts are associated with the strong Rh-O-Ce interaction that tends to over stabilize the rhodium species.A significant amount of such rhodium atoms can be found in the bulk of the support oxides after a hydrothermal aging at 1050℃ with 10% H_(2)O in air for 12 h.Differently,the sintering of rhodium on the surface of Rh/ZrO_(2) catalysts is the main reason for the catalyst deactivation during the hydrothermal aging.These findings provide an example where high dispersion of supported metal induced by strong metal-support interactions does not necessarily lead to high catalytic activity. | Tianming Huang Meiqing Shen Guanghao Cheng Yunhao Wang Jianqiang Wang Wei Li Se HOh Gongshin Qi Ming Yang Jun Wang | 2021 | Journal of Rare Earths2021，39，7： | 3 |
| 4 | Cerebral amyloid angiopathy pathology and cognitive domains in older persons显示文摘 | Arvanitakis Z Leurgans SE Wang Z | 2011 | Ann Neurol2011，69，2： | 1 |
| 5 | Cytoskeletal remodeling 显示文摘 | Wang X Li F Campbell SE et ak Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: Ⅱ | 1999 | J Mol Cell Cardiol1999，31，： | 1 |
| 6 | Osthole stimulates osteoblast differentiation and bone formation by activation of beta-catenin-BMP signaling显示文摘 | Tang DZ Hou W Zhou Q Zhang M Holz J Sheu TJ Li TF Cheng SD Shi Q Harris SE Chen D Wang YJ | 2010 | J Bone Miner Res2010，25，6： | 1 |
| 7 | Tissue plasminogen activator(tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice显示文摘 | Wang YE Tsirka SE Strickland S | 1998 | Nat Med1998，4，： | 1 |
| 8 | Apoptotic signaling induced by H2O2-mediated oxidative stress in differentiated C2C 12 myotubes显示文摘 | Siu PM Wang Y Alway SE | 2009 | Life Sci2009，84，1314： | 1 |
| 9 | Antileukemic activity of Flt3 ligand in murine leukemia显示文摘 | Wang A Braun SE Sonpavde G | 2000 | Cancer Res2000，60，7： | 1 |
| 10 | Neuroprotection by inhibition of matrix metallo- proteinases in a mouse model of intracerebral hemorrhage 显示文摘 | Wang J Tsirka SE | 2005 | Brain2005，127，： | 1 |
| 11 | Risk factors for post-pancreaticoduodenectomy bleeding and finding an innovative approach to treatment显示文摘 | Wei HK Wang SE Shyr YM | 2009 | Dig Surg2009，26，4： | 1 |
| 12 | Sustained morphine exposure induces a spinal dynorphin-dependent enhancement of excitatory transmitter release from primary afferent fibers显示文摘 | Gardell LR Wang R Burgess SE | 2002 | J Neurosci2002，22，15： | 1 |
| 13 | Acquired resistance to EGFR tyro- sine kinase inhibitors in cancer cells is mediated by loss of IGF-bind- ing proteins 显示文摘 | Guix M Faber AC Wang SE | 2008 | J Clin Invest2008，118，： | 1 |
| 14 | Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins显示文摘 | Guix M Faber AC Wang SE | 2008 | J Clin Invest2008，118，7： | 1 |
| 15 | Abnormal polarization and axon outgrowth in retinal ganglion cells lacking the POU domain transcription factor Brn-3b 显示文摘 | Wang SW Gan L Martin SE | 2000 | Mol Cell Neurosci2000，16，： | 1 |
| 16 | Tissue plasminogen activator (t-PA) increases neuronal damage after focal cerebral ischemia in wild-type and t-PA-deficient mice显示文摘 | Tsieka SE Strickland S | 1998 | Nature Med1998，4，： | 1 |
| 17 | Apoptotie signaling induced by H2O2-mediated oxidative stress in differentiated C2C12 myotubes 显示文摘 | Siu PM Wang Y Alway SE | 2009 | Life Sci2009，84，： | 1 |
| 18 | Mutation of MEF2Ain an inherited disorder with features of coronary artery disease显示文摘 | Wang Q Fan C Topol SE | 2003 | Science2003，302，5650： | 1 |
| 19 | Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins显示文摘 | Guix M Faber AC Wang SE | | 0，，07： | 1 |
| 20 | Mutation of MEF2A in an inherited disorder with the features of coronary artery disease显示文摘 | Wang L Fan C Topoi SE | 2003 | Science2003，302，5650： | 1 |
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