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| 1 | Perfluorooctane sulfonate(PFOS) and related fluorochemicals in chicken egg in China显示文摘The ubiquitous occurrence of perfluorinated compounds(PFCs) in environmental samples has drawn much attention.Recent human exposure studies found relatively high perfluorooctane sulfonate(PFOS) concentrations in blood samples from several cities in China when compared with other countries.The objectives of the present study were:(1) to measure PFC concentrations and compositions in chicken egg samples from local markets in China;and(2) to conduct a preliminary human health risk assessment of egg consumption.Eight pooled egg samples from eight locations were analyzed for 11 PFCs.The results showed that close to 100% of the PFOS in the egg was distributed in egg yolk and PFOS was not detected in egg white(<0.08 ng/g wet weight,w/w).Of the perfluoroalkylsulfonates,only PFOS was detected in all egg samples,while of the perfluoroalkylcarboxylates,perfluoroundecanoic acid(PFUnDA) was detected in all samples,followed by perfluorooctanoate(PFOA)(75% occurrence) and perfluorodecanoic acid(PFDA)(50% occurrence).PFOS concentrations in egg ranged from 45.0 to 86.9 ng/g w/w.The results suggested that current concentrations of PFOS in domestic chicken eggs are unlikely to cause immediate harm to Chinese populations. | WANG Yuan YEUNG Leo Wai Yin YAMASHITA Nobuyoshi TANIYASU Sachi SO Man Ka Margaret B. MURPHY LAM Paul Kwan Sing | 2008 | Chinese Science Bulletin2008，53，4： | 13 |
| 2 | Lycium barbarum polysaccharides promotes in vivo proliferation of adult rat retinal progenitor cells显示文摘Lycium barbarum is a widely used Chinese herbal medicine prescription for protection of optic nerve.However,it remains unclear regarding the effects of Lycium barbarum polysaccharides,the main component of Lycium barbarum,on in vivo proliferation of adult ciliary body cells.In this study,adult rats were intragastrically administered low-and high-dose Lycium barbarum polysaccharides(1 and 10 mg/kg)for 35 days and those intragastrically administered phosphate buffered saline served as controls.The number of Ki-67-positive cells in rat ciliary body in the Lycium barbarum polysaccharides groups,in particular low-dose Lycium barbarum polysaccharides group,was significantly greater than that in the phosphate buffered saline group.Ki-67-positive rat ciliary body cells expressed nestin but they did not express glial fibrillary acidic protein.These findings suggest that Lycium barbarum polysaccharides can promote the proliferation of adult rat retinal progenitor cells and the proliferated cells present with neuronal phenotype. | Hua Wang Benson Wui-Man Lau Ning-li Wang Si-ying Wang Qing-jun Lu Raymond Chuen-Chung Chang Kwok-fai So | 2015 | Neural Regeneration Research2015，10，12： | 7 |
| 3 | Garlic-derived compound S-allylmercaptocysteine inhibits hepatocarcinogenesis through targeting LRP6/Wnt pathway显示文摘Whether and how garlic-derived S-allylmercaptocysteine(SAMC) inhibits hepatocellular carcinoma(HCC) is largely unknown. In the current study, the role of low-density lipoprotein receptor(LDLR)-related protein 6(LRP6) in HCC progression and the anti-HCC mechanism of SAMC was examined in clinical sample, cell model and xenograft/orthotopic mouse models. We demonstrated that SAMC inhibited cell proliferation and tumorigenesis, while induced apoptosis of human HCC cells without influencing normal hepatocytes. SAMC directly interacted with Wnt-pathway co-receptor LRP6 on the cell membrane. LRP6 was frequently over-expressed in the tumor tissue of human HCC patients(66.7% of 48 patients) and its overexpression only correlated with the over-expression of β-catenin, but not with age, gender, tumor size, stage and metastasis. Deficiency or over-expression of LRP6 in hepatoma cells could partly mimic or counteract the anti-tumor properties of SAMC, respectively. In vivo administration of SAMC significantly suppressed the growth of Huh-7 xenograft/orthotopic HCC tumor without causing undesirable side effects. In addition, stable down-regulation of LRP6 in Huh-7 facilitated the anti-HCC effects of SAMC. In conclusion, LRP6 can be a potential therapeutic target of HCC. SAMC is a promising specific anti-tumor agent for treating HCC subtypes with Wnt activation at the hepatoma cell surface. | Jia Xiao Feiyue Xing Yingxia Liu Yi Lv Xiaogang Wang Ming-Tat Ling Hao Gao Songying Ouyang Min Yang Jiang Zhu Yu Xia Kwok-Fai So George L.Tipoe | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 6 |
| 4 | Oligomeric proanthocyanidin protects retinal ganglion cells against oxidative stress-induced apoptosis显示文摘The death of retinal ganglion cells is a hallmark of many optic neurodegenerative diseases such as glaucoma and retinopathy.Oxidative stress is one of the major reasons to cause the cell death Oligomeric proanthocyanidin has many health beneficial effects including antioxidative and neuroprotective actions.Here we tested whether oligomeric proanthocyanidin may protect retina ganglion cells against oxidative stress induced-apoptosis in vitro.Retinal ganglion cells were treated with hydrogen peroxide with or without oligomeric proanthocyanidin3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assay showed that treating retinal ganglion cell line RGC-5 cells with 20μmol/L oligomeric proanthocyanidin significantly decreased the hydrogen peroxide(H2O2)induced death.Results of flow cytometry and Hoechst staining demonstrated that the death of RGC-5 cells was mainly caused by cell apoptosis.We further found that expression of pro-apoptotic Bax and caspase-3 were significantly decreased while anti-apoptotic Bcl-2 was greatly increased in H2O2damaged RGC-5 cells with oligomeric proanthocyanidin by western blot assay.Furthermore,in retinal explant culture,the number of surviving retinal ganglion cells in H2O2-damaged retinal ganglion cells with oligomeric proanthocyanidin was significantly increased.Our studies thus demonstrate that oligomeric proanthocyanidin can protect oxidative stress-injured retinal ganglion cells by inhibiting apoptotic process. | Hui Wang Chanjuan Zhang Dan Lu Xiaoming Shu Lihong Zhu Renbing Qi Kwok-Fai So Daxiang Lu Ying Xu | 2013 | Neural Regeneration Research2013，8，25： | 5 |
| 5 | Perfluorinated compounds in the Pearl River and Yangtze River of China显示文摘 | M.K. So Y. Miyake W.Y. Yeung Y.M. Ho S. Taniyasu P. Rostkowski N. Yamashita B.S. Zhou X.J. Shi J.X. Wang J.P. Giesy H. Yu P.K.S. Lam | 2007 | Chemosphere2007，，11： | 2 |
| 6 | Medical training fails to prepare providers to care for patients with chronic hepatitis B infection显示文摘AIM: To investigate physicians' knowledge including chronic hepatitis B(CHB) diagnosis, screening, and management in various stages of their training.METHODS: A voluntary 20-question survey was administered in Santa Clara County, CA where Asian and Pacific Islanders(API) account for a third of the population. Among the 219 physician participants,there were 63 interns, 60 second-year residents, 26 chief residents and 70 attending physicians. The survey asked questions regarding respondents' demographics,general hepatitis B virus knowledge questions(i.e.,transmission, prevalence, diagnostic testing, prevention,and treatment options), as well as, self-reported practice behavior and confidence in knowledge.RESULTS: Knowledge about screening and managing patients with CHB was poor: only 24% identified the correct tests to screen for CHB, 13% knew the next steps for patients testing positive for CHB, 18% knew the high prevalence rate among API, and 31% knew how to screen for liver cancer. Wald chi-square analysis determined the effect of training level on knowledge; in all cases except for knowledge of liver cancer screening(p = 0.0032), knowledge did not significantly increase with length in residency training or completion of residency.CONCLUSION: Even in a high-risk region, both medical school and residency training have not adequatelyprepared physicians in the screening and management of CHB. | Stephanie D Chao Bing-Mei Wang Ellen T Chang Li Ma Samuel K So | 2015 | World Journal of Gastroenterology2015，21，22： | 2 |
| 7 | Melatonin alleviates alcoholic liver disease via EGFR-BRG1-TERT axis regulation显示文摘Chronic alcohol consumption causes liver steatosis,cell death,and inflammation.Melatonin(MLT)is reported to alleviate alcoholic liver disease(ALD)-induced injury.However,its direct regulating targets in hepatocytes are not fully understood.In the current study,a cell-based screening model and a chronic ethanol-fed mice ALD model were used to test the protective mechanisms of MLT.MLT ameliorated ethanol-induced hepatocyte injury in both cell and animal models(optimal doses of 10μmol/L and 5 mg/kg,respectively),including lowered liver steatosis,cell death,and inflammation.RNA-seq analysis and loss-of-function studies in AML-12 cells revealed that telomerase reverse transcriptase(TERT)was a key downstream effector of MLT.Biophysical assay found that epidermal growth factor receptor(EGFR)on the hepatocyte surface was a direct binding and regulating target of MLT.Liver specific knock-down of Tert or Egfr in the ALD mice model impaired MLT-mediated liver protection,partly through the regulation of nuclear brahma-related gene-1(BRG1).Long-term administration(90 days)of MLT in healthy mice did not cause evident adverse effect.In conclusion,MLT is an efficacious and safe agent for ALD alleviation.Its direct regulating target in hepatocytes is EGFR and downstream BRG1-TERT axis.MLT might be used as a complimentary agent for alcoholics. | Zhaodi Che Yali Song Chengfang Xu Wei Li Zhiyong Dong Cunchuan Wang Yixing Ren Kwok-Fai So George L.Tipoe Fei Wang Jia Xiao | 2023 | Acta Pharmaceutica Sinica B2023，13，1： | 2 |
| 8 | Roles of paroxetine and corticosterone on adult mammalian ciliary body cell proliferation显示文摘背景在成年哺乳动物的视网膜的神经发生通常被废除,并且这显示再生 capacity.Despite 的视网膜缺乏这,有在保留学习在调查二药,皮质脂酮和 paroxetine 的效果瞄准了的在场的神经原的 potential.The 的睫的上皮的nestin积极的房间的一张小人口,在老鼠是的睫的 body.Methods 成年人 Sprague-Dawley 的房间增长上给车辆,皮质脂酮, paroxetine ,或两个 | WANG Hua LAU Benson WM YAU Suk-yu LI Suk-yee LEUNG Nelson WANG Ning-li TANG Siu-wa LEE Tatia MC SO Kwok-fai | 2010 | Chinese Medical Journal2010，，10： | 2 |
| 9 | Phenotypic heterogeneity and associations of two aldose reductase gene polymorphismas with nephropathy retinopathy in type 2 diabetes显示文摘 | Wang Y Lee SC So WY | | 0，，08： | 1 |
| 10 | Immediate expression of Cdh2 is essential for efficient neural differentiation of mouse induced pluripotent stem cells显示文摘 | Huanxing Su Lihui Wang Wenhao Huang Dajiang Qin Jinglei Cai Xiaoli Yao Chengqian Feng Zhiyuan Li Yitao Wang Kwok-Fai So Guangjin Pan Wutian Wu Duanqing Pei | 2013 | Stem Cell Research2013，，： | 1 |
| 11 | Association between tumour necrosis factor-a G-308A polymorphism and risk of nephropathy in obese Chinese type 2 diabetic patients 显示文摘 | Wang Y Ng MC So WY | 2005 | Nephrol Dial Transplant2005，20，12： | 1 |
| 12 | Laparoscopicmana- gent of gastrointestsinal stromal tumors显示文摘 | Nguyen SO Divino CM Wang JL | 2006 | Surg Endose2006，20，5： | 1 |
| 13 | Lysophosphatidic acid enhances epithelial ovarian carcinoma invasion through the increased expression of interleukin-8显示文摘 | John So Jason Navari Feng-Qiang Wang David A. Fishman | 2004 | Gynecologic Oncology2004，，2： | 1 |
| 14 | BCR/ABL translocation in aclult acute lymphoblastic leukemia:a comparison of conventional and interphase cytogenetic studies显示文摘 | So CC Wang KF Chung J | 1999 | Cancer Genet Cytogenet1999，110，： | 1 |
| 15 | DNA hypermethylation is a mechanism for loss of expression of the HLA class I genes in human esophageal squamous cell carcinomas显示文摘 | Yan Nie Guang-yu Yang Yunlong Song Xin Zhao Chi So Jie Liao Li-Dong Wang | 2001 | Carcinogenesis2001，，： | 1 |
| 16 | Lysophosphatidic acid enhances epithelial ovarian carcinoma invasion through the increased expression of interleukin-8显示文摘 | SO J NAVARI J WANG F Q | 2004 | Gynecol Oncol2004，95，2： | 1 |
| 17 | Discovery of (2,3-difluoro-6- methoxyphenyl)methanone (R547), a potent and selective cyclin-dependent kinase inhibitor with significant in vivo antitumor activity显示文摘 | Chu XJ DePinto W Bartkovitz D So SS Vu BT Packman K Lukacs C Ding Q Jiang N Wang K Goelzer P Yin X Smith MA Higgins BX Chen Y Xiang Q Moliterni J Kaplan G Graves B Lovey A Fotouhi N | 2006 | J Med Chem2006，49，22： | 1 |
| 18 | Optimization Model in Manufacturing Scheduling for the Garment Industry显示文摘The garment industry in Vietnam is one of the country’s strongest industries in the world.However,the production process still encounters problems regarding scheduling that does not equate to an optimal process.The paper introduces a production scheduling solution that resolves the potential delays and lateness that hinders the production process using integer programming and order allocation with a make-to-order manufacturing viewpoint.A number of constraints were considered in the model and is applied to a real case study of a factory in order to viewhowthe tardiness and latenesswould be affected which resulted in optimizing the scheduling time better.Specifically,the constraints considered were order assignments,production time,and tardiness with an objective function which is to minimize the total cost of delay.The results of the study precisely the overall cost of delay of the orders given to the plant and successfully propose a suitable production schedule that utilizes the most of the plant given.The study has shown promising results that would assist plant and production managers in determining an algorithm that they can apply for their production process. | Chia-Nan Wang Yu-Chen Wei Po-Yuk So Viet Tinh Nguyen Phan Nguyen Ky Phuc | 2022 | Computers, Materials & Continua2022，，6： | 1 |
| 19 | The Prophylactic Effect of Tropisetron on Epidural Morphine-Related Nausea and Vomiting: A Comparison of Dexamethasone with Saline显示文摘 | Jhi-Joung Wang Jann-Inn Tzeng Shung-Tai Ho Jen-Yin Chen Chin-Chen Chu Edmund C. So | 2002 | Anesthesia & Analgesia2002，，3： | 1 |
| 20 | Experimental investigation of the mean and fluctuating forces of wavy (varicose) cylinders in a cross-flow显示文摘 | Lam K Wang F H Li J Y So R M C | 2004 | Journal of Fluids and Structures2004，19，3： | 1 |
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