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| 1 | Nanog and transcriptional networks in embryonic stem cell pluripotency显示文摘象 LIF, BMP 和 Wnt 那样的几个外来的信号能支持胚胎的茎(ES ) 的 theself 更新和 pluripotency 通过调整的房间“ pluripotentgenes。“一个唯一的 homeobox 抄写因素, Nanog,是这些信号的关键下游的受动器之一。Nanog 的提高的水平能维持老鼠 ES 细胞自强独立人士 ofLIF 并且没有喂入器饲料分送器细胞,启用人的 ES 细胞生长。除了外部信号,小径,象 FoxD3 那样的内在的抄写因素, P53 和 Oct4 也涉及调整 Nanog 的表示。机能上地, Nanog 和象 Oct4 和 Sox2 那样的另外的关键 pluripotentfactors 工作控制在 EScell pluripotency 有重要函数的一套目标基因。这些关键因素形成一个规章的网络支持或限制对方“ sexpression 铺平房间,它维持 ES 的性质。 | Guangjin Pan James A Thomson | 2007 | Cell Research2007，17，1： | 51 |
| 2 | A Phytophthora capsici RXLR Effector Targets and Inhibits a Plant,PPlase to Suppress Endoplasmic Reticulum-Mediated Immunity显示文摘 | Guangjin Fan Yang Yang Tingting Li Wenqin Lu Yu DU Xiaoyu Qiang Qujiang Wen Weixing Shan | 2018 | Molecular Plant2018，11，8： | 18 |
| 3 | Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription显示文摘为 histone crotonylation 的酶和读者蛋白质上的最近的研究在抄写支持 histone crotonylation 的功能。然而,为 histone decrotonylation (HDCR ) 负责的酶仍然保持糟糕定义。而且,如果 histone crotonylation 从生理地重要、机能上地不同或对 histone acetylation 冗余,它尚待坚定。这里我们一级 histone deacetylases (HDAC ) 而非 sirtuin 家庭 deacetylases (SIRT ) 是主要 histone decrotonylases 的现在的证据,和那 histone crotonylation 象在哺乳动物的房间的 histone acetylation 一样动态。尤其是,我们与损害 HDAC 产生了新奇 HDAC1 和 HDAC3 异种但是未经触动的 HDCR 活动。用这些异种,我们证明在哺乳动物的房间的选择 HDCR 与宽广 transcriptional 压抑和 crotonylation 然而并非 acetylation 读者蛋白质的减少的倡导者协会相关。而且,我们证明那 histone crotonylation 被充实在并且为老鼠的自强要求了胚胎的干细胞。 | Wei Wei Xiaoguang Liu Jiwei Chen Shennan Gao Lu Lu Huifang Zhang Guangjin Ding Zhiqiang Wang Zhongzhou Chen Tieliu Shi Jiwen Li Jianjun Yu Jiemin Wong | 2017 | Cell Research2017，27，7： | 18 |
| 4 | Study on the recovery of hydrogen from refinery (hydrogen+methane) gas mixtures using hydrate technology显示文摘A novel technique for separating hydrogen from (H2 + CH4) gas mixtures through hydrate formation/dissociation was proposed. In this work, a systematic experimental study was performed on the separation of hydrogen from (H2 + CH4) feed mixtures with various hydrogen contents (mole fraction x = 40%-90%). The experimental results showed that the hydrogen content could be enriched to as high as ~94% for various feed mixtures using the proposed hydrate technology under a temperature slightly above 0℃ and a pressure below 5.0 MPa. With the addition of a small amount of suitable additives, the rate of hydrate formation could be increased significantly. Anti-agglomeration was used to disperse hydrate particles into the condensate phase. Instead of preventing hydrate growth (as in the kinetic inhibitor tests), hydrates were allowed to form, but only as small dispersed particles. Anti-agglomeration could keep hydrate particles suspended in a range of condensate types at 1℃ and 5 MPa in the water-in-oil emulsion. | WANG XiuLin CHEN GuangJin YANG LanYing ZHANG LinWei | 2008 | Science China Chemistry2008，51，2： | 17 |
| 5 | Rare SNP Identified a TCP Transcription Factor Essential for Tendril Development in Cucumber显示文摘稀罕基因变体充满染色体,但是少些在染色体宽的协会学习易控制。这里,我们利用稀罕变化印射在黄瓜(Cucumis sativus L.) 为卷须开发发现基因必需品的策略。在里面许多 > 3000 根线,我们发现形成的一根唯一的卷须更少线分叉而不是卷须并且因此,失去它的爬的能力。我们假设了那这不平常的显型被一个稀罕变化引起并且随后识别了原因的单个核苷酸多型性。影响基因十编码一个 TCP 抄写因素在葫芦以内保存了并且在卷须明确地被表示,代表新机关身份基因。变化在对葫芦唯一的一个蛋白质主题以内发生并且作为 transcriptional 使活跃之物损害它的功能。从 near-isogenic 线的 transcriptomes 的分析识别了要求让卷须的能力察觉到并且爬支持的下游的基因。这研究提供一个例子在植物染色体探索稀罕功能的变体。 | Shenhao Wang Xueyong Yang Mengnan Xu Xingzhong Lin Tao Lin Jianjian Qi Guangjin Shao Nana Tian QingYang Zhonghua Zhang Sanwen Huang | 2015 | Molecular Plant2015，8，12： | 12 |
| 6 | Fundamental mechanisms and phenomena of clathrate hydrate nucleation显示文摘Insights into the mechanism of hydrate nucleation are of great significance for the development of hydrate-based technologies,hydrate relevant flow assurance,and the exploration of in situ natural gas hydrates.Compared with the thermodynamics of hydrate formation,understanding the nucleation mechanism is challenging and has drawn substantial attention in recent decades.In this paper,we attempt to give a comprehensive review of the recent progress of studies of clathrate hydrate nucleation.First,the existing hypotheses on the hydrate nucleation mechanism are introduced and discussed.Then,we summarize recent experimental studies on induction time,a key parameter evaluating the velocity of the nucleation process.Subsequently,the memory effect is particularly discussed,followed by the suggestion of several promising research perspectives. | Jinlong Cui Zhenfeng Sun Xiaohui Wang Bin Yu Shudong Leng Guangjin Chen Changyu Sun | 2019 | Chinese Journal of Chemical Engineering2019，27，9： | 11 |
| 7 | CT image fusion in the evaluation of radiation treatment planning for non-small cell lung cancer显示文摘Objective: We studied the application of CT image fusion in the evaluation of radiation treatment planning for non-small cell lung cancer (NSCLC). Methods: Eleven patients with NSCLC, who were treated with three-dimensional con-formal radiation therapy, were studied. Each patient underwent twice sequential planning CT scan, i.e., at pre-treatment, and at mid-treatment for field reduction planning. Three treatment plans were established in each patient: treatment plan A was based on the pre-treatment planning CT scans for the first course of treatment, plan B on the mid-treatment planning CT scans for the second course of treatment, and treatment plan F on the fused images for the whole treatment. The irradiation doses received by organs at risk in the whole treatment with treatment A and B plans were estimated by the plus of the parameters in treatment plan A and B, assuming that the parameters involve the different tissues (i.e. V20=AV20+BV20), or the same tissues within an organ (i.e. Dmax=ADmax+BDmax). The assessment parameters in the treatment plan F were calculated on the basis of the DVH of the whole treatment. Then the above assessment results were compared. Results: There were marked differ-ences between the assessment results derived from the plus of assessment parameters in treatment plan A and B, and the ones derived from treatment plan F. Conclusion: When a treatment plan is altered during the course of radiation treatment, image fusion technique should be performed in the establishment of a new one. The estimation of the assessment parameters for the whole treatment with treatment plan A and B by simple plus, is inaccurate. | WeiGe Guangjin Yuan Changhu Li Yaogui Wu Yanyan Zhang Ximing Xu | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，6： | 10 |
| 8 | Influence of 3A molecular sieve on tetrahydrofuran (THF) hydrate formation显示文摘Visual observation of the THF hydrate formation process in the presence of a 3A molecular sieve has been made at normal atmosphere and below a temperature of zero by microscopy. The results indicate that a 3A molecular sieve can induce the nucleation of the THF hydrate and promote the THF hydrate growth. With the existence of a 3A molecular sieve, the growth rate of THF hydrate is between 0.01 and 0.05 μm/s. In comparison with the system without any 3A molecular sieve, the growth rate increases about 4 nm/s. After the THF hydrate grows into megacryst, the crystals will recombine and partially change under the same condition. | ZANG XiaoYa FAN ShuanShi LIANG DeQing LI DongLiang CHEN GuangJin | 2008 | Science China Chemistry2008，51，9： | 6 |
| 9 | A continuous and high-efficiency process to separate coal bed methane with porous ZIF-8 slurry:Experimental study and mathematical modelling显示文摘Coal bed methane has been considered as an important energy resource.One major difficulty of purifying coal bed methane comes from the similar physical properties of CH_4 and N_2.The ZIF-8/water-glycol slurry was used as a medium to separate coal bed methane by fluidifying the solid adsorbent material.The sorption equilibrium experiment of binary mixture(CH_4/N_2)and slurry was conducted.The selectivity of CH_4 to N_2 is within the range of 2-6,which proved the feasibility of the slurry separation method.The modified Langmuir equation was used to describe the gas-slurry phase equilibrium behavior,and the calculated results were in good agreement with the experimental data.A continuous absorption-adsorption and desorption process on the separation of CH_4/N_2 in slurry is proposed and its mathematical model is also developed.Sensitivity analysis is conducted to determine the operation conditions and the energy performance of the proposed process was also evaluated.Feed gas contains 30 mol%of methane and the methane concentration in product gas is 95.46 mol%with the methane recovery ratio of 90.74%.The total energy consumption for per unit volume of product gas is determined as 1.846 kWh Nm^(-3).Experimental results and process simulation provide basic data for the design and operation of pilot and industrial plant. | Wan Chen Xiaonan Guo Enbao Zou Mengling Luo Mengzijing Chen Mingke Yang Hai Li Chongzhi Jia Chun Deng Changyu Sun Bei Liu Lanying Yang Guangjin Chen | 2020 | Green Energy & Environment2020，5，3： | 5 |
| 10 | A comparative study of hydrothermal aging effect on cerium and lanthanum doped Cu/SSZ-13 catalysts for NH_(3)-SCR显示文摘Ce-or La-doped Cu/SSZ-13 catalysts were prepared by a hydrothermal method and Cu,Ce or La ions were incorporated through stepwise ion exchange,The catalyst activity was measured for the ammonia selective catalytic reduction reaction.The structure and composition of catalyst were characterized by using X-ray diffraction,scanning electron microscopy,inductively coupled plasma mass spectrometry solid-state NMR,NH_(3)-TPD techniques,and the active components were examined by XPS and XANES.The results indicate that the Ce and La doping can both completely preserve the SCR activity of Cu/SSZ-13 above 300℃,but there is also a decrease of activity below 200℃.On the other hand,Ce doping is beneficial to the formation of framework aluminum,stabilizes molecular sieve framework and Cu active sites of Cu/SSZ-13,thereby improves the catalyst hydrothermal stability.But La doping will decrease the amount of framework aluminum and Cu active sites of Cu/SSZ-13 after hydrothermally aging,even destroy zeolite CHA structure.This is quite harmful to the catalyst hydrothermal stability. | Di Deng Shujun Deng Dandan He Zhiheng Wang Zhipeng Chen Yi Ji Guoping Yan Guangjin Hou Licheng Liu Hong He | 2021 | Journal of Rare Earths2021，39，8： | 5 |
| 11 | Rambutan-like hollow carbon spheres decorated with vacancy-rich nickel oxide for energy conversion and storage显示文摘Transition metal oxides hold great promise for lithium-ion batteries(LIBs)and electrocatalytic water splitting because of their high abundance and high energy density.However,designing and fabrication of efficient,stable,high power density electrode materials are challenging.Herein,we report rambutan-like hollow carbon spheres formed by carbon nanosheet decorated with nickel oxide(NiO)rich inmetal vacancies(denoted as h-NiO/C)as a bifunctional electrode material for LIBs and electrocatalytic oxygen evolution reaction(OER).When being used as the anode of LIBs,the h-NiO/C electrode shows a large initial capacity of 885mAh g−1,a robust stability with a high capacity of 817mAh g−1 after 400 cycles,and great rate capability with a high reversible capacity of 523mAh g−1 at 10Ag−1 after 600 cycles.Moreover,working as an OER electrocatalyst,the h-NiO/C electrode shows a small overpotential of 260mV at 10mAcm−2,a Tafel slope of 37.6mVdec−1 along with good stability.Our work offers a cost-effective method for the fabrication of efficient electrode for LIBs and OER. | Zixu Sun Xinghui Wang Hu Zhao See W.Koh Junyu Ge Yunxing Zhao Pingqi Gao Guangjin Wang Hong Li | 2020 | Carbon Energy2020，2，1： | 4 |
| 12 | Generation of tooth-like structures from integration-free human urine induced pluripotent stem cells显示文摘Background:Tooth is vital not only for a good smile,but also good health.Yet,we lose tooth regularly due to accidents or diseases.An ideal solution to this problem is to regenerate tooth with patients’own cells.Here we describe the generation of tooth-like structures from integration-free human urine induced pluripotent stem cells(ifhU-iPSCs).Results:We first differentiated ifhU-iPSCs to epithelial sheets,which were then recombined with E14.5 mouse dental mesenchymes.Tooth-like structures were recovered from these recombinants in 3 weeks with success rate up to 30%for 8 different iPSC lines,comparable to H1 hESC.We further detected that ifhU-iPSC derived epithelial sheets differentiated into enamel-secreting ameloblasts in the tooth-like structures,possessing physical properties such as elastic modulus and hardness found in the regular human tooth.Conclusion:Our results demonstrate that ifhU-iPSCs can be used to regenerate patient specific dental tissues or even tooth for further drug screening or regenerative therapies. | Jinglei Cai Yanmei Zhang Pengfei Liu Shubin Chen Xuan Wu Yuhua Sun Ang Li Ke Huang Rongping Luo Lihui Wang Ying Liu Ting Zhou Shicheng Wei Guangjin Pan Duanqing Pei | 2013 | Cell Regeneration2013，2，1： | 4 |
| 13 | Vapor-hydrate phases equilibrium of (CH_4+C_2H_6) and (CH_4+C_2H_4) systems显示文摘Separation of the(C1+C2)hydrocarbon system is of importance in natural gas processing and ethylene production.However it is the bottleneck because of its high refrigeration energy consumption, and needs to be urgently addressed.The technology of separating gas mixtures by forming hydrate could be used to separate(C 1 +C 2 )gas mixtures at around 0°C and has attracted increasing attention worldwide.In this paper,investigation of vapor-hydrate two-phase equilibrium was carried out for(C 1 +C 2 )systems with and without tetrahydrofuran(THF).The compositions of vapor and hydrate phases under phase equilibrium were studied with model algorithm when structure I and structure II hydrates coexisted for the(methane+ethane)system.The average deviation between the modeled and actual mole fractions of ethane in hydrate and vapor phases was 0.55%,and that of ethylene was 5.7%when THF was not added.The average deviation of the mole fraction of ethane in vapor phase was 11.46%and ethylene was 7.38%when THF was added.The test results showed that the proposed algorithm is practicable. | Ma Qinglan Chen Guangjin Zhang Lingwei | 2008 | Petroleum Science2008，5，4： | 4 |
| 14 | Synthesis and methane storage of binder-free porous graphene monoliths显示文摘Nanomesh graphene(NMG) obtained by template chemical vapor deposition was used to synthesize the binder-free graphene monoliths by simple tablet pressing.The stacking manner of the NMG sheets was crucial to the cohesion interaction between the graphene sheets,only the NMG materials with a loosely stacking manner could be pressed into binder-free monoliths.At the tableting pressure of 2-8 MPa,both the bulk densities and the specific surface areas of the monoliths keep nearly constant as the tableting pressure increases,indicating that the NMG monoliths have obvious elasticity and a porous structure due to the large corrugations and the mesh structures of the graphene sheets.As a result,an extraordinary methane storage capacity of 236(v/v) at 9 MPa was obtained in the graphene monolith prepared by tableting at 4 MPa. | Guoqing Ning Hao Wang Xiaoxin Zhang Chenggen Xu Guangjin Chen Jinsen Gao | 2013 | Particuology2013，11，4： | 4 |
| 15 | Strain-controlled graphdiyne membrane for CO2/CH4 separation:First-principle and molecular dynamic simulation显示文摘Tensile strain of porous membrane materials can broaden their capacity in gas separation.In this work,using van der Waals corrected density functional theory(DFT)and molecular dynamics(MD)simulations,the performance and mechanism of CO2/CH4 separation through strain-oriented graphdiyne(GDY)monolayer were studied by applying lateral strain.It is demonstrated that the CO2 permeance peaks at 1.29×10^6 gas permeation units(GPU)accompanied with CO2/CH4 selectivity of 5.27×10^3 under ultimate strain,both of which are far beyond the Robeson’s limit.Furthermore,the GDY membrane exhibited a decreasing gas diffusion energy barrier and increasing permeance with the increase of applied tensile strain.CO2 molecule tends to reoriented itself vertically to permeate the membrane.Finally,the CO2 permeability decreases with the increase of the temperature from300 K to 500 K due to conserving of rotational freedom,suggesting an abnormal permeance of CO2 in relation to temperature.Our theoretical results suggest that the stretchable GDY monolayer holds great promise to be an excellent candidate for CO2/CH4 separation,owing to its extremely high selectivity and permeability of CO2. | Xin Zheng Shuai Ban Bei Liu Guangjin Chen | 2020 | Chinese Journal of Chemical Engineering2020，28，7： | 3 |
| 16 | 中国淮安地区2009年至2011年恶性肿瘤的发病率及死亡率分析(英文)显示文摘Objective: The aim of the study was to investigate the cancer incidence and mortality in Huai'an area, China, from 2009 to 2011. Methods: The data about cancer incidence and mortality were provided by Huai'an Cancer Registry, China. In- cidence and mortality rates, and standardized rates were calculated by age, gender, areas (urban and rural areas of Huai'an) and cancer sites. Results: The crude incidence rate for all cancer sites was 205.60/10 5 and the standardized incidence rate was 166.22/10 5 . Both the crude and standardized rates were higher in urban area than in rural area for both sexes. The inci- dence rates increased in people aged 40 and over, and the peak ages of incidence were between 70-75 in both males and females. The crude mortality rate for all cancer sites was 153.88/10 5 and the standardized mortality rate was 122.14/10 5 . Both the crude and standardized rates were similar in urban and rural areas for both men and women. The mortality rates were at low level under the age 50 in both sexes, but increased after the age 50, reaching the peak at the ages of 80-85 in both males and females. The top 10 most common cancer sites in rank were esophagus, stomach, lung, liver, colon-rectum, breast, pancreas, cervix uteri, brain and central nervous system, and leukemia, accounting for 87.56% of all cancers. The top 10 most leading causes of cancer death in order were cancers of esophagus, lung, liver, stomach, colon-rectum, pancreas, brain and central nervous system, leukemia, breast and lymphoma, accounting for 90.53% of all cancer deaths. Conclusion: Cancer is one kind of major diseases threatening people's health in Huai'an area, China. Cancer prevention and control should be enhanced, especially for esophageal cancer. | Guangjin Yuan Qianwen Li Yunxiang Du Shunlin Shan Zhimin Wang Enchun Pan Yuan He Ting Wang | 2012 | The Chinese-German Journal of Clinical Oncology2012，11，9： | 3 |
| 17 | Neural progenitor cells from human induced pluripotent stem cells generated less autogenous immune response显示文摘The breakthrough development of induced pluripotent stem cells(iPSCs)raises the prospect of patient-specific treatment for many diseases through the replacement of affected cells.However,whether iPSC-derived functional cell lineages generate a deleterious immune response upon auto-transplantation remains unclear.In this study,we differentiated five human iPSC lines from skin fibroblasts and urine cells into neural progenitor cells(NPCs)and analyzed their immunogenicity.Through co-culture with autogenous peripheral blood mononuclear cells(PBMCs),we showed that both somatic cells and iPSC-derived NPCs do not stimulate significant autogenous PBMC proliferation.However,a significant immune reaction was detected when these cells were co-cultured with allogenous PBMCs.Furthermore,no significant expression of perforin or granzyme B was detected following stimulation of autogenous immune effector cells(CD3+CD8 T cells,CD3+CD8+T cells or CD3 CD56+NK cells)by NPCs in both PBMC and T cell co-culture systems.These results suggest that human iPSC-derived NPCs may not initiate an immune response in autogenous transplants,and thus set a base for further preclinical evaluation of human iPSCs. | HUANG Ke LIU PengFei LI Xiang CHEN ShuBin WANG LiHui QIN Li SU ZhengHui HUANG WenHao LIU JuLi JIA Bei LIU Jie CAI JingLei PEI DuanQing PAN GuangJin | 2014 | Science China(Life Sciences)2014，57，2： | 3 |
| 18 | Experimental investigation of methane hydrate decomposition by depressurizing in porous media with 3-Dimension device显示文摘In order to simulate the behavior of gas hydrate formation and decomposition,a 3-Dimension experimental device was built,consisting of a high-pressure reactor with an inner diameter of 300 mm,effective height of 100 mm,and operation pressure of 16 MPa.Eight thermal resistances were mounted in the porous media at different depthes and radiuses to detect the temperature distribution during the hydrate formation/decomposition.To collect the pressure,temperature,and flux of gas production data,the Monitor and Control Generated System(MCGS) was used.Using this device,the formation and decomposition behavior of methane hydrate in the 20 ~ 40 mesh natural sand with salinity of 3.35 wt% was examined.It was found that the front of formation or decomposition of hydrate can be judged by the temperature distribution.The amount of hydrate formation can also be evaluated by the temperature change.During the hydrate decomposition process,the temperature curves indicated that the hydrate in the top and bottom of reactor dissociated earlier than in the inner.The hydrate decomposition front gradually moved from porous media surface to inner and kept a shape of column form,with different moving speed at different surface position.The proper decomposition pressure was also determined. | Kehua Su Changyu Sun Xin Yang Guangjin Chen Shuanshi Fan | 2010 | Journal of Natural Gas Chemistry2010，19，3： | 3 |
| 19 | SC-IrO_2 NR-carbon hybrid:A catalyst with high electrochemical stability for oxygen reduction显示文摘The enhanced electrochemical stability of the synthesized hybrid catalyst has been demonstrated by the introduction of the synergistic effect between carbon powder additive and the prepared catalyst.Single crystal IrO 2 nanorod (SC-IrO 2 NR) catalyst was prepared by a sol-gel method.The structure and performance of the catalyst sample were characterized by X-ray diffraction spectroscopy (XRD),scanning electron microscope (SEM),transmission electron microscope (TEM),rotating disk electrode (RDE) and cyclic voltammetry (CV) measurements.XRD patterns and TEM images indicate that the catalyst sample has a rutile IrO 2 single crystal nanorod structure.The onset potential for oxygen reduction reaction (ORR) of the SC-IrO 2 NR-carbon hybrid catalyst specimen is 0.75 V (vs.RHE) in RDE measurement.CV and RDE test results show that the SC-IrO 2 NR-carbon hybrid catalyst has a better electrochemical stability in comparison with the commercial Pt/C catalyst,with attenuation ratios of 17.67% and 44.60% for the SC-IrO 2 NR-carbon hybrid catalyst and the commercial Pt/C catalyst after 1500 cycles,respectively.Therefore,in terms of stability,the SC-IrO 2 NR-carbon hybrid catalyst has a promising potential in the application of the proton exchange membrane fuel cell. | WANG GuangJin CHENG Feng YU Yi LIANG Cong XU Tian PAN Mu | 2013 | Science China Chemistry2013，56，1： | 3 |
| 20 | Nuclear UHRF1 is a gate-keeper of cellular AMPK activity and function显示文摘The AMP-activated protein kinase(AMPK)is a central regulator of energy homeostasis.Although much has been learned on how low energy status and glucose starvation activate AMPK,how AMPK activity is properly controlled in vivo is still poorly understood.Here we report that UHRF1,an epigenetic regulator highly expressed in proliferating and cancer cells,interacts with AMPK and serves to suppress AMPK activity under both basal and stressed conditions.As a nuclear protein,UHRF1 promotes AMPK nuclear retention and strongly suppresses nuclear AMPK activity toward substrates H2B and EZH2.Importantly,we demonstrate that UHRF1 also robustly inhibits AMPK activity in the cytoplasm compartment,most likely as a consequence of AMPK nucleocytoplasmic shuttling.Mechanistically,we found that UHRF1 has no obvious effect on AMPK activation by upstream kinases LKB1 and CAMKK2 but inhibits AMPK activity by acting as a bridging factor targeting phosphatase PP2A to dephosphorylate AMPK.Hepatic overexpression of UHRF1 showed profound effects on glucose and lipid metabolism in wild-type mice but not in those with the liver-specific knockout of AMPKα1/α2,whereas knockdown of UHRF1 in adipose tissue led to AMPK activation and reduced sizes of adipocytes and lipogenic activity,highlighting the physiological significance of this regulation in glucose and lipid metabolism.Thus,our study identifies UHRF1 as a novel AMPK gate-keeper with critical roles in cellular metabolism. | Xiang Xu Guangjin Ding Caizhi Liu Yuhan Ding Xiaoxin Chen Xiaoli Huang Chen-Song Zhang Shanxin Lu Yunpeng Zhang Yuanyong Huang Zhaosu Chen Wei Wei Lujian Liao Shu-Hai Lin Jingya Li Wei Liu Jiwen Li Sheng-Cai Lin Xinran Ma Jiemin Wong | 2022 | Cell Research2022，32，1： | 3 |
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