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| 1 | Unity of Nature and Man: a new vision and conceptual framework for the Post-2020 Global Biodiversity Framework显示文摘People live in nature. However, substantial evidence confirms that, under the pressure of anthropogenic alteration,nature is being fragmented, imperiled and becoming less able to provide essential services [1]. Biodiversity loss is the most significant signal of this depletion,and could profoundly impact the future of human beings and the rest of life on Earth [2]. | Tianxiao Ma Yisi Hu Meng Wang Lijun Yu Fuwen Wei | 2021 | National Science Review2021，8，7： | 5 |
| 2 | Influence of Residual Stress on the Dimensional Instability of 7075 Aluminum Cone-Shaped Shells显示文摘This paper dealt with the influence of residual stress on the dimensional instability of 7075 aluminum cone-shaped shells. Finite element method was introduced to calculate residual stress distributions in 7075 aluminum cone-shaped shells during conventional heat treatment (CHT) and deep cryogenic treatment (DCT). An example was given to demonstrate effects of deep cryogenic treatment (DCT) and conventional heat treatment (CHT) on dimensional instability. It is concluded that initial residual stresses have detrimental influence on the dimensional instability of 7075 aluminum cone-shaped shells. | Wang Qiucheng Zhao Zude Wang Yisi Xing Hongyan Kang Feng | 2009 | 稀有金属材料与工程2009，38，A03： | 2 |
| 3 | Genetically-engineered“all-in-one”vaccine platform for cancer immunotherapy显示文摘An essential step for cancer vaccination is to break the immunosuppression and elicit a tumor-specific immunity.A major hurdle against cancer therapeutic vaccination is the insufficient immune stimulation of the cancer vaccines and lack of a safe and efficient adjuvant for human use.We discovered a novel cancer immunostimulant,trichosanthin(TCS),that is a clinically used protein drug in China,and developed a well-adaptable protein-engineering method for making recombinant protein vaccines by fusion of an antigenic peptide,TCS,and a cell-penetrating peptide(CPP),termed an'allin-one'vaccine,for transcutaneous cancer immunization.The TCS adjuvant effect on antigen presentation was investigated and the antitumor immunity of the vaccines was investigated using the different tumor models.The vaccines were prepared via a facile recombinant method.The vaccines induced the maturation of DCs that subsequently primed CD8^(+)T cells.The TCS-based immunostimulation was associated with the STING pathway.The general applicability of this genetic engineering strategy was demonstrated with various tumor antigens(i.e.,legumain and TRP2 antigenic peptides)and tumor models(i.e.,colon tumor and melanoma).These findings represent a useful protocol for developing cancer vaccines at low cost and time-saving,and demonstrates the adjuvant application of TCSdan old drug for a new application. | Aihua Wu Yingzhi Chen Hairui Wang Ya Chang Meng Zhang Pengfei Zhao Yisi Tang Qin Xu Zhuangzhi Zhu Yang Cao Yongzhuo Huang | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 1 |
| 4 | Potential benefits of precise corticosteroids therapy for severe 2019-nCoV pneumonia显示文摘Dear Editor,Since last December,the outbreak of 2019-nCoV in Wuhan has caused ever-increasing attention and public panic all over the world.Up to February 9,2020,40,171 patients had been diagnosed with 2019-nCoV infection,including 6484(16.14%)severe cases and 908 deaths(2.27%).Compared to SARS and MERS,2019-nCoV appears to be much more contagious but less lethal,as most patients have mild symptoms and good prognosis1,2.However,according to the Chinese government’s daily report,13.2–21.3%of patients with 2019-nCoV infection developed into severe or fatal illness(Fig.S1a),which is characterized by the rapid development to acute respiratory distress syndrome(ARDS)or septic shock.Along with an increasing number of confirmed cases,the cumulative total of severe patients with 2019-nCoV is growing(Fig.S1b).Treatment of these critically ill patients is becoming one of the major challenges we are facing. | Wei Zhou Yisi Liu Dongdong Tian Cheng Wang Sa Wang Jing Cheng Ming Hu Minghao Fang Yue Gao | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 5 | Landfill leachate treatment using the se- quencing batch biofilm reactor method inte- grated with the electro-fenton process 显示文摘 | Zhang Daobin Wu Xiaogang Wang Yisi | 2014 | Chemical Papers2014，68，6： | 1 |
| 6 | One-step,in situ formation of WN-W_(2)C heterojunctions implanted on N doped carbon nanorods as efficient oxygen reduction catalyst for metal-air battery显示文摘Transition metal nitrides and carbides have attracted intensive attentions in metal-air battery application due to their metallic electron transport behavior and high chemical stability toward the oxygen reduction reaction(ORR).Herein,the polyoxometalate@polyaniline composite derived WN-W_(2)C heterostructured composite(WN-W_(2)C@pDC)has been fabricated through an in situ nitriding-carbonization strategy,with WN-W_(2)C nanoparticles implanted on N doped carbon nanorods.Asfabricated WN-W_(2)C@pDC demonstrates prominent electrocatalytic performance towards ORR and excellent cycling stability in metal-air battery,which possesses positive half-wave potential and large diffusion limiting current density(0.81 V and 5.8 mA·cm^(-2)).Moreover,it demonstrates high peak power density of 157.4 mW·cm^(-2)as Al-air primary cathode and excellent stability at the discharge-charge test(>500 h)of Zn-air secondary battery.The excellent activity and durability of WNW_(2)C@pDC catalyst should be attributed to the combined effect of intimate WN-W_(2)C heterointerfaces,unique embedded nanoparticles structure,and excellent electrical media of N doped carbon,confirmed by a series of contrast experiments. | Yue Du Wenxue Chen Lina Zhou Rui Hu Shizhu Wang Xueqing Li Yunlong Xie Lun Yang Yisi Liu Zhenhui Liu | 2023 | Nano Research2023，16，7： | 0 |
| 7 | Hierarchical porous yolk-shell Co-N-C nanocatalysts encaged in graphene nanopockets for high-performance Zn-air battery显示文摘The rational design and preparation of promising cathode electrocatalysts with excellent activity and strong stability for metal-air batteries is a huge challenge.In this work,we innovate an approach of combining solvothermal with high-temperature pyrolysis utilizing zeolitic imidazolate framework(ZIF)-8 and ZIF-67 as the template to synthesize a novel hybrid material of hierarchical porous yolk-shell Co-N-C polyhedron nanocatalysts engaged in graphene nanopocket(yolk-shell Co-N-C@GNP).The obtained catalyst exhibits prominent bifunctional electrocatalytic performance for oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)in the alkaline condition,in which the half-wave potential is 0.86 V for ORR,and the over-potential for OER is 0.42 V at 10 mA·cm^(-2).The rechargeable aqueous Zn-air battery fabricated with yolk-shell Co-N-C@GNP cathode deliveries an open circuit voltage(OCV)of 1.60 V,a peak power density of 236.2 mW·cm^(-2),and excellent cycling stability over 94 h at 5 mA·cm^(-2).The quasi-solid-state Zn-air battery(ZAB)using yolk-shell Co-N-C@GNP displays a high OCV of 1.40 V and a small voltage gap of 0.88 V in continuous cycling tests at 2 mA·cm^(-2).This work provides a valuable thought to focus attention on the design of high-efficient bifunctional catalysts with hierarchical porous yolk-shell framework and high-density metal active sites for metal-air battery technologies. | Yisi Liu Zongxu Li Shizhu Wang Jinnan Xuan Dongbin Xiong Lina Zhou Jianqing Zhou Jun Wang Yahui Yang Yue Du | 2023 | Nano Research2023，16，7： | 0 |
| 8 | Structural Design Optimization Based on the Moving Baseline Strategy显示文摘Structural design optimization has always been a topic of concern in industry because good design can improve the safety and economic efficiency of structures during their service periods.Selecting the appropriate optimization algorithm is the key to solving structural optimal design problems.In this study,a new global optimization idea is proposed and named the moving baseline strategy.A baseline is initially set and will be repeatedly moving upward or downward to approach the optimal value.The proposed strategy is a simple but effective,general,and stable algorithm that can be used to solve constrained and unconstrained structural optimization problems.Different from traditional gradient-based,stochastic and heuristic algorithms,the developed algorithm provides a completely new idea to solve global or local optimization problems.Some unconstrained and constrained numerical benchmark examples are used to test the proposed methodology.In addition,structural optimal design problems of a ten-bar planar truss structure and a hypersonic wing structure(X-37B)are utilized to verify the effectiveness of the developed strategy in addressing structural design optimization problems in engineering. | Xiaojun Wang Qiang Ren Wenpin Chen Yisi Liu Lei Wang Xuyun Ding | 2020 | Acta Mechanica Solida Sinica2020，33，3： | 0 |
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