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| 1 | Recognition and implication of eclogite in the western Altun Mountains, Xinjiang显示文摘SINCE high-pressure metapelitic rocks have been discovered in the Beiketan area of eastern Al-tun Mountains,a set of eclogite has been recognized in south of Jianggesayi,western Altun.The eclogite,associated with quartz-garnet-clinopyroxenite and metamorphosed retrogradelyto garnet-amphibolite partially,is exposed in the Proterozoic meso- to hypometamorphic rocksand can be traced eastward to northwest of Mangya asbestos deposit,for about 200 | Liu, L Che, ZC Luo, JH Wang, Y Gao, ZJ | 1997 | Chinese Science Bulletin1997，42，11： | 33 |
| 2 | Cloning and expression of MXR7 gene in human HCC tissue显示文摘AIM To clone and identify the whole cDNA ofMXR7 gene and to find out its expression inhuman HCC,and normal tissues.METHODS The DNA primers were designed andsynthesized according to the whole cDNAsequence of MXR? gene.The cDNA of humanHCC was taken as the template while the cDNA ofMXR7 gene was synthesized by polymerasechain reaction(PCR).Recombinant DNAconforming to reading frame was constructed byconnecting purified PCR product of the cDNA ofMXR? gene with expression vector pGEX-5X-1 offusion protein.The plasmid MXRT/pGEX-5X-1was identified by sequencing.Using 32p labeledMXR? cDNA as probe,MXR7 mRNA expressionwas detected by Northern blot analysis in 12different human normal tissues,7 preoperativelyuntreated non-liver tumor tissues,30preoperatively untreated HCC,theparacancerous liver tissues and 12 normal livertissues samples.RESULTS Restriction enzyme and sequenceanalysis confirmed that the insertion sequence invector pGEX-5X-1 was the same as the cDNAsequence of MXR7 gene.Northern blot analysisshowed no expression of MXR? mRNA in 12 kindsof normal human tissues including liver,7 tumortissues in other sites and 12 normal livertissues,the frequencies of MXR7 mRNA expression in HCC and paracancerous livertissues were 76.6% and 13.3%,respectively.The frequency of MXR7 mRNA expression in HCCwithout elevation of serum AFP and in HCC<5cm was 90%(9/10)and 83.3%(5/6),respectively.CONCLUSION MXR7 mRNA is highly expressedin human HCC,which is specific and occurs at anearly stage of HCC,suggesting MXR7 mRNA canbe a tumor biomarker for HCC.The detection ofMXR7 mRNA expression in the biopsied livertissue is helpful in discovering early subclinicalliver cancer in those with negative serum AFP. | Zhou XP Wang HY Yang GS Chen ZJ Li BA Wu MC | 2000 | World Journal of Gastroenterology2000，6，1： | 23 |
| 3 | 地震岩石物理学基本准则显示文摘引言
过去的50年间,在研究与地震勘探学和天然地震学有关的岩石和矿物的物理特性方面取得了巨大的进步.在此期间,发展了很多的理论,同时进行了很多实验.许多这样的理论与实验结果已经在推进地球科学和勘探技术方面起到了重要准则的作用.本论文试图对这些结果做出一定的总结. | Wang,ZJ 王炳章 | 2001 | 石油物探译丛2001，，4： | 15 |
| 4 | Effects of HBV gene variations on disease development and antiviral therapy for patients with chronic hepatitis B显示文摘Viral variation may change pathogenicity, escape immunity, lead to persistence infection, and cause drug resistance against antiviral therapy. This study was undertaken to investigate the effects of HBV gene variation on the progression of disease and on the efficacy of antiviral therapy for patients with chronic hepatitis B(CHB). METHODS:Hepatitis B virus (HBV) gene mutational sites were detected using gene chip in selected hepatitis B patients. RESULTS:In the patients HBeAg did not show serologic conversion or HBeAg(-)/anti-HBe(+), but their HBV DNA remained positive 24 weeks after α-interferon therapy, which was associated with mutations of nt1896, nt1814, nt1762 and nt1764. In the patients, that HBV DNA levels decreased or were undetectable, but rebounded later after antiviral therapy by lamivudine was associated with mutations of aa528 and(or) aa552(i.e.YMDD mutation), which resulted in lamivudine-resistance. YMDD mutation was prone to occur 52 weeks after lamivudine therapy in some chronic hepatitis B patients (26.4%). Nt1896 mutation was common in most chronic hepatitis B patients (68.5%). Chronic severe hepatitis, cirrhosis, and primary liver carcinoma were related to the mutations of nt1896, nt1762 and nt1764. CONCLUSIONS:HBV gene mutations could aggravate patient’s condition and affect the efficacy of antiviral therapy. The regular detection of HBV gene mutation is helpful for identification of disease prognosis and adjustment of therapeutic strategy. | Shenzhen Eastlake Hospital, Shenzhen 518020, China (Chen JY) and National Key Laboratory of Virology (Wuhan University) Department of Infectious Diseases, Renmin Hospital, Wuhan University, Wuhan 430060, China(Wang LW, Sun XM and Gong ZJ) | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 8 |
| 5 | NEOLIGNAN GLUCOSIDES FROM PEDICULARIS TORTA显示文摘NEOLIGNANGLUCOSIDESFROMPEDICULARISTORTA￥ChangZengWANGandZhongJianJIA(InstituteofOrganicChemistryandStateKeyLaboratoryofApplie... | Wang, CZ Jia, ZJ | 1996 | Chinese Chemical Letters1996，7，2： | 2 |
| 6 | Chronic obstructive parotitis:Report of 92 cases 显示文摘 | Wang SL Zhu JR | 1992 | Oral Surg Oral Med Oral Pathol1992，73，4： | 1 |
| 7 | Phenylpropanoid and iridoid glycosides from Pedicularis spicata显示文摘 | Jia ZJ Liu ZM Wang CZ | 1991 | Phytochemistry1991，30，11： | 1 |
| 8 | Randomized clinical trial of conventional versus cylindrical abdominoperineal resection for locally advanced lower rectal cancer 显示文摘 | Han JG Wang ZJ Wei GH | 2012 | Am J Surg2012，204，3： | 1 |
| 9 | Germline mutations of the LKB1 (STKll) gene in Peutz-Jeghers patients 显示文摘 | Wang ZJ Churchman M Avizienyte E | 1999 | J Med Genet1999，36，5： | 1 |
| 10 | Langerhans cell histiocytosis of bone in children:a clinicopathologic study of 108 cases显示文摘 | Wang J Wu X Xi ZJ | | 0，，03： | 1 |
| 11 | Prognostic significance of heart rate turbulence parameters in patients with chronic heart failure显示文摘 | Yin DC Wang ZJ Guo S | 2014 | BMC Cardiovasc Disord2014，14，7： | 1 |
| 12 | STIs and HIV among men having sex with men in china:a ticking time bomb显示文摘 | Wong FY Huang ZJ Wang W | 2009 | AIDS Educ Pre2009，21，： | 1 |
| 13 | Evaluation of pulmonary em- bolism in pediatric patients with nephrotic syndrome with dual en- ergy CT pulmonary angiography 显示文摘 | Zhang LJ Wang ZJ Zhou CS | 2012 | Acad Radiol2012，19，3： | 1 |
| 14 | Oral health knowledge, attitudes, and practices of Chinese adults显示文摘 | Lin HC Wong MC Wang ZJ | 2001 | J Dent Res2001，80，5： | 1 |
| 15 | Malignant pleural mesothelioma:evaluation with CT,MR imaging,and PET显示文摘 | Reddy GP Gotway MB | 2004 | Raiographics2004，24，： | 1 |
| 16 | Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz-Jeghers' syndrome provides evidence for a hamartoma-(adenoma)-carcinoma sequence显示文摘 | Ellis I Zauber P | 1999 | J Pathol1999，188，1： | 1 |
| 17 | Intraganglionic laminar endings in the rat esophagus contain purinergic P2X2 and P2X3 receptor immunoreactivity显示文摘 | Wang ZJ Neuhuber WL | 2003 | Anat Embryol2003，207，34： | 1 |
| 18 | Blood oxygen level - dependent (BOLD) Mill of diabetic nephropathy: Preliminary experience 显示文摘 | Wang ZJ Kumar R Banerjee S | 2011 | J Magn Reson Imaging2011，33，3： | 1 |
| 19 | Decreased expression of serotonin 1A receptor in the dentate gyrus in association with chronic mild stress:a rat model of post-stroke depression显示文摘 | Wang SH Zhang ZJ Guo YJ | | 0，，： | 1 |
| 20 | Computer-aided diagnosis expert system for cerebrovascular diseases显示文摘 | Chen X Wang ZJ Sy C | 2014 | Neurol Res2014，36，5： | 1 |
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