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| 1 | Influence of antibiotic-regimens on intensive-care unit-mortality and liver-cirrhosis as risk factor显示文摘AIM: To assess the rate of infection, appropriateness of antimicrobial-therapy and mortality on intensive care unit(ICU). Special focus was drawn on patients with liver cirrhosis.METHODS: The study was approved by the local ethical committee. All patients admitted to the Internal Medicine-ICU between April 1, 2007 and December 31, 2009 were included. Data were extracted retrospectively from all patients using patient charts and electronic documentations on infection, microbiological laboratory reports, diagnosis and therapy. Due to the large hepatology department and liver transplantation center, special interest was on the subgroup of patients with liver cirrhosis. The primary statistical-endpoint was the evaluation of the influence of appropriate versusinappropriate antimicrobial-therapy on in-hospitalmortality.RESULTS: Charts of 1979 patients were available. The overall infection-rate was 53%. Multiresistantbacteria were present in 23% of patients with infection and were associated with increased mortality(p < 0.000001). patients with infection had significantly increased in-hospital-mortality(34% vs 17%, p < 0.000001). Only 9% of patients with infection received inappropriate initial antimicrobial-therapy, no influence on mortality was observed. Independent risk-factors for in-hospital-mortality were the presence of septicshock, prior chemotherapy for malignoma and infection with pseudomonas spp. Infection and mortality-rate among 175 patients with liver-cirrhosis was significantly higher than in patients without liver-cirrhosis. Infection increased mortality 2.24-fold in patients with cirrhosis. patients with liver cirrhosis were at an increased risk to receive inappropriate initial antimicrobial therapy.CONCLUSION: The results of the present study report the successful implementation of early-goal-directed therapy. Liver cirrhosis patients are at increased risk of infection, mortality and to receive inappropriate therapy. Increasing burden are multiresistant-bacteria. | Mireen Friedrich-Rust Beate Wanger Florian Heupel Natalie Filmann Reinhard Brodt Volkhard AJ Kempf Johanna Kessel Thomas A Wichelhaus Eva Herrmann Stefan Zeuzem Joerg Bojunga | 2016 | World Journal of Gastroenterology2016，22，16： | 6 |
| 2 | Nosocomial outbreak caused by a multiresistant clone of Acinetobacter bau rnannii ; results of the ease control and molecular epidemiologic investigations显示文摘 | Scerpella E G Wanger A R Armitige L | 1995 | Infect Control Hosp Epidemiol1995，16，2： | 1 |
| 3 | Impronement of nitrc oxide-dependent vasadilation by HMG-COA reductase inhibitors through attenuation of endothelial superoxide anionformation显示文摘 | Wanger A H kohler J Buckschass U | 2000 | Arteriascl Thramb vase Bial2000，20，1： | 1 |
| 4 | Demonstration of renin mRNA,angiotension mRNA,and argiotensin converting enzyme mRNA expression in the human eye显示文摘 | Wanger J Danser A Perkx F | 1996 | Br J Ophthalmol1996，80，： | 1 |
| 5 | Toll-like receptor 2 participates in mediation of immune response in experimental pneumococcal meningitis显示文摘 | Koedel U Angele B Rupprecht T Wanger H Roggenkamp A Pfister HW | 2003 | J Immunol2003，170，1： | 1 |
| 6 | Nosocom ia lout break caused by a multi resistant colne of A cine tobacter baumannii: results of the case-control and molecular epidem iologic investigations 显示文摘 | Scerpella EG Wanger AR A rm itage L | 1995 | Infect Control Hosp Epidem iol1995，16，： | 1 |
| 7 | The micro- structure and theology of mixed cationic/anionic wormlike micelles 显示文摘 | Schubert B A Kaler E W Wanger N J | 2003 | Langmuir2003，19，： | 1 |
| 8 | Nosocomial outbreak caused by 9 multiresistance clone of Acinetobacter baumannii; results of the case control and molecular epide miologic investigations显示文摘 | Scerpella E G Wanger A R Armitige L | 1995 | Infect Control Hosp Epidemiol1995，16，2： | 1 |
| 9 | Gaussian decomposition and calibration of a novel small-footprint full-waveform digitising airborne laser scanner显示文摘 | Wanger W Ullrich A Ducic V | 2006 | Isprs Journal of Photogrammetry and Remote Sensing2006，60，2： | 1 |
| 10 | APACHE II:a Severity of Disease Classification System显示文摘 | Knaus W A Draper E A Wanger D P | 1985 | Crit Care Med1985，13，10： | 1 |
| 11 | A case of Penicillium marneffei in a US hospital显示文摘 | Nguyen K Taylor S Wanger A | 2006 | J Am Acad Dermato12006，54，4： | 1 |
| 12 | APACHEⅡ:a severity of disease classification System显示文摘 | KNAUS W A DRAPER F A WANGER D P | 1985 | Crit Care Med1985，13，： | 1 |
| 13 | ATS/ERS TASK FORCE: Standardisation of the measurement of lung volumes 显示文摘 | Wanger J Clausen J L Coates A | 2005 | Eur Respir J2005，26，： | 1 |
| 14 | Standardisation of the measurement of lung volumes显示文摘 | Wanger J Clausen JL Coates A | 2005 | Eur Respirat J2005，26，3： | 1 |
| 15 | Function and structure of he erodimeric amimo acid transporters显示文摘 | Wanger C A Lang F Broer S | 2001 | Am J Physiol Cell Physiol2001，281，： | 1 |
| 16 | A role for active oxygen species as second mes- sengers in the induction of alternative oxidase gene expression in Petunia hybrida cells显示文摘 | WANGER A M | 1995 | FEBS Lett1995，368，33： | 1 |
| 17 | Substitutes for mercury in alkaline zinc batteries显示文摘 | WANGER O HIMY A | 1976 | Power Sources Symposium1976，27，： | 1 |
| 18 | Clinical investigations in critical care:the APACHEⅢ prognostic system显示文摘 | Knaus W A Wanger D P Draper E A | 1991 | Chest1991，100，： | 1 |
| 19 | Daily prognostic estimates for critically ill adults in intensive care units:results from a prospective,multicenter,inception cohort analysis显示文摘 | Wanger D P Knaus W A Hrrell F E | 1994 | Crit Care Med1994，22，： | 1 |
| 20 | Mucilage protects roots meristems from aluminum injury 显示文摘 | HORST W J WANGER A MARSCHNER H | 1982 | Zeitschrift Far Pflanzen- physiologie1982，105，： | 1 |
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