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11篇 您的检索式:作者名="Wani AI"
    题名 作者 年代 出处 被引量
1Malignant solid pseudopapillary tumor of pancreas causing sinistral portal hypertension 显示文摘Wani NA Lone TK Shah AI 2011Indian J Pathol Microbiol2011,54,1:1
2Malignant solid pseudo- papillary tumor of pancreas causing sinistral portal hyperten- sion显示文摘Wani NA Lone TK Shah AI 2011Indian J Pathol Microbiol2011,54,1:1
3Management of Mirizzi syndrome: a new surgical approach显示文摘Shahao J Dar Ma Wani Ma et ai 2001ANZJ Stag2001,7,7:1
4Malignant solid pseudopapillary tumor of pancreas causing sinistral portal hypertension显示文摘Wani NA Lone TK Shah AI 2011Indian J Pathol Microbiol2011,54,:1
5Pregancy in premature ovarian failur:a possible role of estrogen plus progesterone treatment显示文摘Zaggar AH Salahuddln M Wani AI 2000J Asssoe physicians India2000,48,2:1
6Interleukin - 1 receptor - associ-ated kinase 2 is critical for lipopolysaccharide - mediated post - tran-scriptional control 显示文摘WanY Xiao H Affolter J et ai 2009J Biol Chem2009,284,10:1
7Causes of Mortality in Dia- betes Mellitus: Data from a Tertiary Teaching Hospital in India 显示文摘Zargar AH Wani AI Masoodi SR 2009Postgrad Med J2009,85,:1
8Malignant solid pseudopapillary tumor of pancreas causing sinistral portal hypertension显示文摘Wani NA Lone TK Shah AI 2011Indian J Pathol Microbiol2011,54,1:1
9Interleukin - 1 receptor - associ-ated kinase 2 is critical for lipopolysaccharide - mediated post - tran-scriptional control 显示文摘WanY Xiao H Affolter J et ai 2009J Biol Chem2009,284,10:1
10Pregnancy in premature o- varian failure: a possible role of estrogen plus progesterone treat- ment显示文摘Zargar AH Salahuddin M Wani AI 2000J Assoc Physicians India2000,48,2:1
11Sulfation modification of dopamine in brain regulates aggregative behavior of animals显示文摘Behavioral plasticity and the underlying neuronal plasticity represent a fundamental capacity of animals to cope with environmental stimuli.Behavioral plasticity is controlled by complex molecular networks that act under different layers of regulation.While various molecules have been found to be involved in the regulation of plastic behaviors across species,less is known about how organisms orchestrate the activity of these molecules as part of a coherent behavioral response to varying environments.Here we discover a me chanism for the regulation of animal behavioral plasticity involving molecular sulfation in the brain,a modification of substrate molecules by sulfo transferase(ST)-catalyzed addition of a sulfonate group(SO_(3))from an obligate donor,3'-phosphoadenosine 5'-phosphosulfate(PAPS)to the substrates.We investigated aggregation behaviors of migratory locusts,which are well-known for extreme phase change plasticity triggered by population density.The processes of PAPS biosynthesis acted efficiently on induction of locust behavioral transition:Inhibition of PAPS synthesis solicited a behavioral shift from gregarious to solitarious states;external PAPS dosage,by contrast,promoted aggregation in solitarious locusts.Genetic or pharmacological intervention in the sulfation catalyzation resulted into pronounced solitarizing effects.Analysis of substrate-specific STs suggests a widespread involvement of sulfated neurotransmitters in the behavioral response.D opamine in the brain was finally identified to be actively sulfate conjugate d,and the sulfate conjugation enhanced the free DA-mediated behavioral aggregation.Similar results in Caenorhabditis elegans and mice indicate that sulfation may be involved more broadly in the modulation of animal aggregation.These findings reveal a general me chanism that effectively regulates animal social-like behavioral plasticity,possibly through sulfation-mediated modification of neural networks.Bing Chen Xiwen Tong Xia Zhang Wanying Gui Guoming Ai Lihua Huang Ding Ding Jiangxu Zhang Le Kang 2022National Science Review2022,9,4:0
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