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| 1 | 澳大利亚临床共识指南:儿童卒中的诊断和急性期处理显示文摘卒中是导致儿童死亡的十大原因之一,幸存的致残患儿将面临几十年的残疾生活,给患儿及其家庭带来了巨大负担。由于安全性和有效性的证据有限,以及诊断的延误,目前卒中患儿无法接受再灌注治疗。儿童卒中诊断和急性期处理的澳大利亚临床共识指南,旨在最大限度地减少临床诊疗中的不确定性,并记录与成人卒中不同的危险因素、病因和假性卒中情况的最佳证据。临床问题的阐述来自于对2007年至2017年数据库的系统检索,但仅限于英语和儿科研究。该指南应用SIGN方法和国家健康与医学研究委员会系统对证据进行筛选和分类,通过推荐、评估、发展和评价系统(GRADE系统)对推荐进行强弱分级。该指南提供了60多项基于证据的推荐,以帮助参与院前和急症处理的临床医师快速识别儿童卒中,选择最合适的初步检查方案来确定诊断、明确病因,并选择最恰当的干预措施以挽救脑组织、预防复发。同时,指南也提供了颅内压和先天性心脏病管理方面的推荐。该指南的实施需要将院前和急诊系统重组,包括建立区域性卒中网络,建立儿科卒中疾病编码,快速MRI,以及对能够提供再灌注治疗的初级儿科卒中中心进行认证。该指南能够审核治疗的基准时间线,获得急性期的干预措施及预后判断。它还将促进澳大利亚儿童卒中登记的发展,并与国际登记处建立数据联系,以便准确收集卒中发病率、治疗和结果相关的数据。 | Medley TL Miteff C Andrews I Ware T Cheung M Monagle P Mandelstam S Wray A Pridmore C Troedson C Dale RC Fahey M Sinclair A Walsh P Stojanovski S Macka MT 徐佳丽(译) 吴川杰(译) 肖潇(译) 吕俊萱(译) 张博维(译) 吉训明(译) | 2019 | 中国脑血管病杂志2019，16，4： | 9 |
| 2 | The complete reference genome for grapevine (Vitis vinifera L.) genetics and breeding显示文摘Grapevine is one of the most economically important crops worldwide.However,the previous versions of the grapevine reference genome tipically consist of thousands of fragments with missing centromeres and telomeres,limiting the accessibility of the repetitive sequences,the centromeric and telomeric regions,and the study of inheritance of important agronomic traits in these regions.Here,we assembled a telomere-to-telomere(T2T)gap-free reference genome for the cultivar PN40024 using PacBio HiFi long reads.The T2T reference genome(PN_T2T)is 69 Mb longer with 9018 more genes identified than the 12X.v0 version.We annotated 67%repetitive sequences,19 centromeres and 36 telomeres,and incorporated gene annotations of previous versions into the PN_T2T assembly.We detected a total of 377 gene clusters,which showed associations with complex traits,such as aroma and disease resistance.Even though PN40024 derives from nine generations of selfing,we still found nine genomic hotspots of heterozygous sites associated with biological processes,such as the oxidation–reduction process and protein phosphorylation.The fully annotated complete reference genome therefore constitutes an important resource for grapevine genetic studies and breeding programs. | Xiaoya Shi Shuo Cao Xu Wang Siyang Huang Yue Wang Zhongjie Liu Wenwen Liu Xiangpeng Leng Yanling Peng Nan Wang Yiwen Wang Zhiyao Ma Xiaodong Xu Fan Zhang Hui Xue Haixia Zhong Yi Wang Kekun Zhang Amandine Velt Komlan Avia Daniela Holtgräwe Jérôme Grimplet JoséTomás Matus Doreen Ware Xinyu Wu Haibo Wang Chonghuai Liu Yuling Fang Camille Rustenholz Zongming Cheng Hua Xiao Yongfeng Zhou | 2023 | Horticulture Research2023，10，5： | 3 |
| 3 | Orientation and dynamics of an antimicrobial peptide in the lipid bilayer by solid-state NMR spectroscopy 显示文摘 | Yamaguchi S I-Iuster D Waring A | 2001 | Biophysical Jour- nal2001，81，4： | 1 |
| 4 | Evaluating translations of health status questionnaires显示文摘 | Ware J E Keller S D Gandek B | 1995 | Int J Technol Assess in Health Care1995，11，3： | 1 |
| 5 | Mild cognitive impairment: clinical characterization and out come显示文摘 | Petersen RC Smith G Waring S | 1999 | Arch Neurol1999，56，： | 1 |
| 6 | Differential effects of protein kinase Con human vascular smooth muscle cell proliferation and migration显示文摘 | Itoh H Yamamura S Ware JA | 2001 | Am J Physiol Heart Circ Physiol2001，281，： | 1 |
| 7 | Anesthesia in female white-tailed deer using Telazol and xylazine显示文摘 | Murray S Monfort S L Ware L | 2000 | J Wild Dis2000，36，： | 1 |
| 8 | A new group B ad-enovirus receptor is expressed at high levels on hu-man stem and tumor cells 显示文摘 | Tuve S? Wang HJ Ware C | 2006 | Journal of Virology2006，80，12： | 1 |
| 9 | A ContingentApproach to the Organization and Management ofPublic-Private Partnerships:An Empirical Studyof English Health Care显示文摘 | Waring G Currie G Bishop S | 2013 | Public Administration Review2013，，2： | 1 |
| 10 | Thyroid function and prevalent and incident metabolic syndrome in old adults: the health, ageing and body composition study显示文摘 | WARING AC RODONDI N HARRISON S | 2012 | Clin Endocrinol2012，76，6： | 1 |
| 11 | Distinctive patterns of gene expression in premalignant gastric cancer显示文摘 | Boussioutas A Li H Liu J Waring P Lade S HoUoway A J | 2003 | Cancer research2003，63，10： | 1 |
| 12 | Factors associated with relief from chest pain following emergency care 显示文摘 | Linn LS Ware JE Greenfield S | 1980 | Med Care1980，18，6： | 1 |
| 13 | A 12-item short-form health survey: Construction of scales and preliminary tests of reliability and validity显示文摘 | Ware J Jr Kosinski M Keller S D | 1996 | Med Care1996，34，3： | 1 |
| 14 | Gas Chromatographic Deteminationon of Deoxynivalenol in Wheat with E1ectron Capture Detection显示文摘 | Octave Jfrancis Allen S German | 1986 | AOAC int1986，69，5： | 1 |
| 15 | Carcinoma of the Duodenum:Comparison of Surgery,radiotherapy and chemotherapy显示文摘 | Ware CC | 1993 | Br J Surg1993，60，： | 1 |
| 16 | Usefulness of the SF-8 Health for Comparing the Impact of Mingraine and Other Conditions显示文摘 | Turner-Bowker D M Bayliss M S Ware J E | 2003 | Quality Life Resarch2003，12，8： | 1 |
| 17 | Differential effects of protein kinase C on human vascular smooth muscle cell proliferation and migration显示文摘 | Iton H Yamamura S Ware JA | 2001 | Am J Physiol Heart Circ Physiol2001，281，： | 1 |
| 18 | Explaining adherence suc- cess in sub-Saharan Africa: an ethnographic study显示文摘 | Ware NC Idoko J Kaaya S | 2009 | PLoS Med2009，6，1： | 1 |
| 19 | Purification, characterization,and immunogenicity of a disulfide cross2linked Plasmodi um vivax vaccine candidate antigen, merozoite surface protein 1, expressedin Escherichia coli显示文摘 | Dutta S Ware LA Barbosa A | 2001 | Infect Immune2001，69，9： | 1 |
| 20 | Finding competitive intelligence on Inter- net start-up companies: A study of secondary resource use and information-seeking processes显示文摘 | Erdelez S Ware N | 2001 | Information Research2001，7，1： | 1 |
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