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| 1 | Highlights of the 2nd International Symposium on Tribbles and Diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer显示文摘The Tribbles(TRIB) family of pseudokinase proteins has been shown to play key roles in cell cycle, metabolic diseases, chronic inflammatory disease, and cancer development. A better understanding of the mechanisms of TRIB pseudokinases could provide new insights for disease development and help promote TRIB proteins as novel therapeutic targets for drug discovery. At the 2 nd International Symposium on Tribbles and Diseases held on May 7–9, 2018 in Beijing, China, a group of leading Tribbles scientists reported their findings and ongoing studies about the effects of the different TRIB proteins in the areas of immunity, metabolism, fundamental cell biology and cancer. Here, we summarize important and insightful overviews from 4 keynote lectures, 13 plenary lectures and 8 short talks that took place during this meeting. These findings may offer new insights for the understanding of the roles of TRIB pseudokinases in the development of various diseases. | Bing Cui Patrick A. Eyers Leonard L. Dobens Nguan Soon Tan Peter D. Mace Wolfgang A. Link Endre Kiss-Toth Karen Keeshan Takuro Nakamura Warren S. Pear Yodit Feseha Jessica Johnston Arkatiz Carracedo Marcel Scheideler Zabran llyas Robert C. Bauer Jorge D. Erusalimsky Dominika Grzesik Juan Salamanca-Viloria Xiaoxi Lv Yishi Jin Ke Li Guillermo Velasco Shuang Shang Jose M. Lizcano Xiaowei Zhang Jichao Zhou Jiaojiao Yu Fang Hua Feng Wang Shanshan Liu Jinmei Yu Zhuowei Hu | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 2 |
| 2 | Proton magnetic resonance spectroscopic imaging in children with recurrent primary brain tumors 显示文摘 | Warren KE Frank JA Black JL | 2000 | J Clin Oncol2000，18，5： | 1 |
| 3 | Diffuse intrinsic pontine glioma:poised for progress显示文摘 | Warren KE | | 0，，： | 1 |
| 4 | Unmet needs as indicator of improving chronic care delivery system in China显示文摘In 2009, China strengthened its public health service system. Since then, the country has made remarkable achievements in community-based chronic disease prevention and control;however, certain groups still have unmet needs. During 2019 to 2029, China will consolidate the top-level design of its medical health system. During this period, the coordination of department policies, improvement of service delivery mechanisms, building an integrated health service system, and other issues will be highlighted. This study will provide a basis for designing China’s chronic disease prevention and control system during the next stage of development. We will consider the unmet needs of patients with chronic diseases as an indicator for remodeling the prediction system in combination with the elements and structural theories of complex health systems. In this article, we first introduce the definition and measurement methods of unmet needs. Second, we identify the existing unmet needs found among patients with chronic diseases with reference to the chronic disease prevention and control policies of China as well as current service items. Finally, we propose the design of community chronic disease service package for the next development stage based on unmet needs of patients with chronic diseases. We also provide suggestions for how to improve China’s chronic care delivery system. | Xia-Tong Ke Chun-Lu Wang Jack Warren Salmon Wen-Xi Tang | 2021 | Chronic Diseases and Translational Medicine2021，7，1： | 1 |
| 5 | Soft drink consumption and caries risk in children and adolescents显示文摘 | SHENKIN JD HELLER KE WARREN JJ | 2003 | Gen Dent2003，51，1： | 1 |
| 6 | Does axial limb rotation affect the alignment measurements in deformed limbs显示文摘 | Swanson KE Stocks GW Warren PD | 2000 | Clin Orhop2000，371，： | 1 |
| 7 | NMR spectroscopy and pediatric brain tumors显示文摘 | Warren KE | 2004 | Oncologist2004，9，3： | 1 |
| 8 | The mouse metallothionein-1 gene is transcriptionally regulated by cadmium following transfection into human or mouse cells显示文摘 | Mayo KE Warren R Palmiter RD | 1982 | Cell1982，29，： | 1 |
| 9 | Proton Magnetic Resonance Spectroscopic Imaging in Children with Recurrent Primary Brain Tumors显示文摘 | Warren KE Frank JA Black JL | 2000 | J Clin Oncol2000，18，5： | 1 |
| 10 | Real-time image-guided direct convective perfusion of intrinsic brainstem lesions显示文摘 | Lonser RR Warren KE Butman JA | 2007 | J Neurosurg2007，107，1： | 1 |
| 11 | Does axial limb rotation affect the alignment measurements in deformed limbs显示文摘 | Swanson KE Stocks GW Warren PD | 2000 | Clin Orthop Rel Res2000，371，： | 1 |
| 12 | Does axial limb rotation affect the alignment measurements in deformed limbs 显示文摘 | Swanson KE Stocks GW Warren PD | 2000 | Clin Orthop Relat Res2000，317，： | 1 |
| 13 | Pharmacokinetics oftemozolomide administered in combination with 06 -benzylguaninein children and adolescents with refractory solid tumors 显示文摘 | MEANY HJ WARREN KE FOX E | 2009 | Cancer Chemother Pharm2009，65，1： | 1 |
| 14 | Prevalence and outcomes of antimicrobial treatment for Staphylococcus aureus bacteremia in outpatients with ESRD 显示文摘 | Chan KE Warren HS Thadhani RI | 2012 | J Am Soc Nephrol2012，23，： | 1 |
| 15 | The mouse metallothionein -1gene is transcriptionally regulated by cadmium following transfection into human or mouse cells显示文摘 | Mayo KE Warren R Palmiter RD | 1982 | Cell1982，29，1： | 1 |
| 16 | Antibody, complement and accommodation in ABO incompatible trans plants显示文摘 | King KE Warren DS Samaniego-Picota M | 2004 | Curr Opin Immunol2004，16，5： | 1 |
| 17 | NMR spectroscopy and pediatric brain tumors 显示文摘 | Warren KE | 2004 | On- cologist2004，9，3： | 1 |
| 18 | Urban ecological systems:scientific foundations and a decade of progress显示文摘 | Pickett STA Band LE Belt KE Boone CG Cadenasso ML Groffman PM Grove JM Nilon CH Irwin E Kaushal S Marshall V McGrath BP Pouyat RV Szlavecz K Troy A Warren PS | | 0，，： | 1 |
| 19 | NMR spectroscopy and pediatric brain tumors 显示文摘 | Warren KE | 2004 | Oncologist2004，9，3： | 1 |
| 20 | Current approaches to CNS tumors in infants and very young children显示文摘 | Warren KE Packer RJ | | 0，，04： | 1 |
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