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| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | Comprehensive numerical modeling of vertical cavity surfaceemitting lasers显示文摘 | HADLEY G R LEAR K L WARREN M E | 1996 | IEEE J Quant Electron1996，32，4： | 1 |
| 3 | Recent Advexnces in the Diagnosis and Treatment of Renal Arteriovenous Malformatins and fistula显示文摘 | Crotty K L Orihuela E Warren M M | 1993 | J Urol1993，150，51： | 1 |
| 4 | Solar Water Splitting Cells显示文摘 | Walter M G Warren E L McKone J R | 2010 | Chemical Reviews2010，110，11： | 1 |
| 5 | Mechanisms for subcritical penetration into a sandy bottom: Experimental and modelling results显示文摘 | Maguer A Fox Warren L J Schmidt H Pouliquen E Bovio E | 2000 | JASA2000，107，3： | 1 |
| 6 | Effects of concentric and eccentric training on muscle strength, cross-sectional area, and neural activation 显示文摘 | Higbie E J Cureton K J Warren G L III | 1996 | J Appl Physiol1996，81，5： | 1 |
| 7 | Distribution and chemistry ofdiagenetic minerals at Yucca mountain,Nye county,Nevada显示文摘 | Broxton D E Btsh D L Warren R G | 1987 | Clays and Clay Minerals1987，35，2： | 1 |
| 8 | Microbial geo- engineers显示文摘 | WARREN L A KAUFFMAN M E | 2003 | Science2003，299，： | 1 |
| 9 | Biogeochemical controls on metal behaviour in freshwater environments显示文摘 | Warren L A Haack E A | 2001 | Earth-Sci Rev2001，54，4： | 1 |
| 10 | Recent advances in the diagnosis and treatment of renal arteriovenous malformations and fistulas显示文摘 | Crotty K L Orihuela E Warren M M | 1993 | J Urol1993，150，51： | 1 |
| 11 | Projecting monthly natural gas sales for space heating using a monthly updated model and degree-days from monthly outlooks显示文摘 | Lehman R L Warren H E | 1994 | Jour- nal of Applied Meteorology1994，33，1： | 1 |
| 12 | The sfr6 mutation in Arabidopsis suppresses low-temperature induction of genes dependent on the CRT/ DRE sequence motif显示文摘 | Knight H Veale E L Warren G J | 1999 | Plant Cell1999，11，： | 1 |
| 13 | A test for linkage and association in general pedigrees:the pedigree disequilibrium test显示文摘 | Martin E R Monks S A Warren L L | 2000 | Am J Hum Genet2000，67，： | 1 |
| 14 | Microbial geoengineers显示文摘 | Warren L A Kauffman M E | 2003 | Science2003，299，： | 1 |
| 15 | Solar water splitting cells 显示文摘 | WALTER M G WARREN E L MCKONE J R etal | 2010 | Chemical Reviews2010，110，11： | 1 |
| 16 | Observations on asthma mortality显示文摘 | McFADDEN E R Jr WARREN E L | 1997 | Ann Intern Med1997，127，2： | 1 |
| 17 | The effect of an education program on the incidence of central venous catheter-associated blood stream infection in a medical ICU 显示文摘 | Warren D K Zack J E Mayfield J L | 2004 | Chest2004，126，5： | 1 |
| 18 | Photoelectrochemical hydrogen evolution using Si microwire arrays显示文摘 | Boettcher S W Warren E L Putnam M C | 2011 | Journal of the American Chemical Society2011，133，5： | 1 |
| 19 | The effect of an education program on the incidence of central venous catheter-associated bloodstream infection in a medical ICU 显示文摘 | Warren K Zack J E Mayfield J L | 2004 | Chest2004，126，： | 1 |
| 20 | Hydrogen-evolution characteristics of Ni-Mo-coated, radial junction, np-silicon microwire array photocathodes 显示文摘 | Warren E L McKone J R Atwater H A | 2012 | Energy & Environmental Science2012，5，11： | 1 |
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