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| 1 | The modulation of co-stimulatory molecules by circulating exosomes in primary biliary cirrhosis显示文摘Exosomes 是 endocytic 起源的 nanoparticles,由由他们调制 cell-to-cell 通讯的能力的优点正在吸引增加的注意的无数房间人口藏匿了。他们也在许多免疫学的问题正在吸引注意,包括 autoimmunity 和,特别地调整 cytokine 和 chemokine 激活的他们的能力。主要胆汁的肝硬化(PBC ) 被认为一个模型自体免疫疾病,它对胆汁的上皮的房间有高度集中的细胞毒素的回答。我们与 PBC 和 30 健康控制(HC ) 从 29 个病人从血浆孤立 exosomes,并且用一个前 vivo 系统在 mononuclear 房间人口在 co-stimulatory 分子表示和 cytokine 生产上学习了这些 exosomes 的效果。我们也与 HC exosomes 相比在 PBC 识别了 microRNA (miRNA ) 人口。我们此处报导尽管 exosomes 不改变 cytokine 生产,他们显著地确实在介绍抗原的人口上改变 co-stimulatory 分子表示。进一步,我们在 CD14 + 单核白血球上表明了那 CD86 起来调整的表情,而在 CD11c + 上起来调整的 CD40 由从有 PBC 的病人的 exosomes 的树枝状的房间。另外,有在有 PBC 的病人的传播 exosomes 的 miRNA 表示的差别。这些数据基于 co-stimulatory 分子玩的观察有重要重要性在 T 房间激活的规定的一个微分角色。我们的观察显示从 PBC 的异常 exosomes 有选择地在介绍抗原的房间的不同子集导致 co-stimulatory 分子的表示。这些改变可以在自体免疫的肝疾病的致病包含。 | Takashi Tomiyama Guo-Xiang Yang Ming Zhao Weici Zhang Hajime Tanaka Jing Wang Patrick SC Leung Kazuiclli Okazaki Xiao-Song He Qianjin Lu Ross L Coppel Christopher L Bowlus M Eric Gershwin | 2017 | Cellular & Molecular Immunology2017，14，3： | 18 |
| 2 | Nursing Care of the Laryngeal Mask Airway in Pediatric Cataract Surgery显示文摘Purpose:.To investigate the important experience of nursing care of the laryngeal mask airway(LMA) in children undergoing cataract surgery.Methods: Fifty-five children undergoing cataract surgery were anesthetized by inhaling sevoflurane through a LMA and received perioperative nursing care. The safety of perioperative nursing for these children was also evaluated.Results: Through perioperative nursing care and psychological counseling for children with LMA,.all patients were anesthetized without complications and underwent successful surgeries..No severe postoperative complications were observed.Conclusion: Nursing care specific for LMA is a vital part of the success of anesthesia and pediatric cataract surgery. | Aihuan Chen Ronghua Ye Yanchan Liu Weici Liu Jingyi Lin | 2014 | Eye Science2014，29，2： | 6 |
| 3 | The Main Ecological Issues of Water-Level -Fluctuating Zone and The strategies in Three Gorges Reservoir Area显示文摘 | Weici Su Jinping Liu Hua Yang Junyi Zhang | 2010 | Journal of Environmental Science and Engineering2010，4，1： | 4 |
| 4 | Liver-resident NK cells suppress autoimmune cholangitis and limit the proliferation of CD4^(+) T cells显示文摘Liver-resident NK cells are distinct from conventional NK cells and play an important role in the maintenance of liver homeostasis.How liver-resident NK cells participate in autoimmune cholangitis remains unclear.Here,we extensively investigated the impact of NK cells in the pathogenesis of autoimmune cholangitis utilizing the well-established dnTGFβRII cholangitis model,NK cell-deficient(Nfil3−/−)mice,adoptive transfer and in vivo antibody-mediated NK cell depletion.Our data demonstrated that disease progression was associated with a significantly reduced frequency of hepatic NK cells.Depletion of NK cells resulted in exacerbated autoimmune cholangitis in dnTGFβRII mice.We further confirmed that the DX5−CD11c^(hi) liver-resident NK cell subset colocalized with CD4^(+) T cells and inhibited CD4^(+) T cell proliferation.Gene expression microarray analysis demonstrated that liver-resident NK cells had a distinct gene expression pattern consisting of the increased expression of genes involved in negative regulatory functions in the context of the inflammatory microenvironment. | Zhi-Bin Zhao Fang-Ting Lu Hong-Di Ma Yin-Hu Wang Wei Yang Jie Long Qi Miao Weici Zhang Zhigang Tian William M.Ridgway Jie Cao M.Eric Gershwin Zhe-Xiong Lian | 2020 | Cellular & Molecular Immunology2020，17，2： | 4 |
| 5 | History,progress and future challenges of artificial blood vessels:a narrative review显示文摘Cardiovascular disease serves as the leading cause of death worldwide,with stenosis,occlusion,or severe dysfunction of blood vessels being its pathophysiological mechanism.Vascular replacement is the preferred surgical option for treating obstructed vascular structures.Due to the limited availability of healthy autologous vessels as well as the incidence of postoperative complications,there is an increasing demand for artificial blood vessels.From synthetic to natural,or a mixture of these components,numerous materials have been used to prepare artificial vascular grafts.Although synthetic grafts are more appropriate for use in medium to large-diameter vessels,they fail when replacing small-diameter vessels.Tissue-engineered vascular grafts are very likely to be an ideal alternative to autologous grafts in small-diameter vessels and are worthy of further investigation.However,a multitude of problems remain that must be resolved before they can be used in biomedical applications.Accordingly,this review attempts to describe these problems and provide a discussion of the generation of artificial blood vessels.In addition,we deliberate on current state-of-the-art technologies for creating artificial blood vessels,including advances in materials,fabrication techniques,various methods of surface modification,as well as preclinical and clinical applications.Furthermore,the evaluation of grafts both in vivo and in vitro,mechanical properties,challenges,and directions for further research are also discussed. | Ke Hu Yuxuan Li Zunxiang Ke Hongjun Yang Chanjun Lu Yiqing Li Yi Guo Weici Wang | 2022 | Biomaterials Translational2022，3，1： | 3 |
| 6 | TLR3 Ligand-Induced Accumulation of Activated Splenic Natural Killer Cells into Liver显示文摘It has been revealed that poly Ⅰ:C is a potent stimulator for NK cells, which can induce NK cell rapid activation and preferential accumulation into liver. However, the process mediating the influx of NK cells remains obscure. In this study, we found that poly Ⅰ:C administration increased the portion and absolute number of NK cells in liver,but largely decreased those in spleen. There were no obvious changes of these lymphocytes in other immune organs.The results from splenic adoptive transfer and splenectomy showed that the recruited spleen NK cells contributed to the accumulation of NK cells in liver, and this process was regulated by the production of chemokines and the presence of T cells. This investigation will help to understand the enhanced immune cell recruitment in liver upon viral infection. | Jing Wang~1 Jiawei Xu~1 Weici Zhang~1 Haiming Wei~1 Zhigang Tian~(1,2) ~1Institute of Immunology,School of Life Sciences,University of Science and Technology of China,Hefei,Anhui,China ~2Institute of Immunology,School of Life Sciences,University of Science and Technology of China,443 Huangshan Road,Hefei 230027,Anhui,China. | 2005 | Cellular & Molecular Immunology2005，2，6： | 3 |
| 7 | Adaptive immunity in the liver显示文摘 | Zongwen Shuai Miranda WY Leung Xiaosong He Weici Zhang Guoxiang Yang Patrick SC Leung M Eric Gershwin | 2016 | Cellular & Molecular Immunology2016，13，3： | 3 |
| 8 | Long noncoding RNA lncKdm2b: A critical player in the maintenance of group 3 innate lymphoid cells显示文摘Innate lymphoid cells(ILCs)represent a heterogeneous population,including both effectors and regulators of innate immunity,inflammation and tissue modeling.1 ILCs are categorized into three subgroups,ILC1s,ILC2s and ILC3s,based on similarities in phenotypic,ontogenetic and functional characteristics.2 ILC3s intrinsically require the transcription factor retinoic acid receptor-related orphan receptorγt(RORγt)for their development and function.3 In response to specific stimuli,ILC3s produce IL-17 and IL-22 and play a critical role in intestinal mucosal protection,inflammation and innate responses 4 accompanied by a series of pathophysiological changes involving large-scale genetic upregulation and downregulation.5,6 However,a key challenge remains in understanding the molecular mechanisms underlying the development and maintenance of ILC3s. | Can-Jie Guo Weici Zhang M Eric Gershwin | 2018 | Cellular & Molecular Immunology2018，15，1： | 3 |
| 9 | Proteomic analysis reveals distinctive protein profiles involved in CD8^(+) T cell-mediated murine autoimmune cholangitis显示文摘Autoimmune cholangitis arises from abnormal innate and adaptive immune responses in the liver,and T cells are critical drivers in this process.However,little is known about the regulation of their functional behavior during disease development.We previously reported that mice with T cell-restricted expression of a dominant negative form of transforming growth factor beta receptor type Ⅱ(dnTGFβ RII)spontaneously develop an autoimmune cholangitis that resembles human primary biliary cholangitis(PBC).Adoptive transfer of CD8^(+) but not CD4^(+) T cells into Rag1^(−/−)mice reproduced the disease,demonstrating a critical role for CD8^(+) T cells in PBC pathogenesis.Herein,we used SOMAscan technology to perform proteomic analysis of serum samples from dnTGFβRII and B6 control mice at different ages.In addition,we analyzed CD8 protein profiles after adoptive transfer of splenic CD8^(+) cells into Rag1^(−/−)recipients.The use of the unique SOMAscan aptamer technology revealed critical and distinct profiles of CD8 cells,which are key to biliary mediation.In total,254 proteins were significantly increased while 216 proteins were significantly decreased in recipient hepatic CD8^(+) cells compared to donor splenic CD8^(+) cells.In contrast to donor splenic CD8^(+) cells,recipient hepatic CD8^(+) cells expressed distinct profiles for proteins involved in chemokine signaling,focal adhesion,T cell receptor and natural killer cell-mediated cytotoxicity pathways. | Weici Zhang Ren Zhang Jun Zhang Ying Sun Patrick SC Leung Guo-Xiang Yang Zongwen Shuai William M Ridgway M Eric Gershwin | 2018 | Cellular & Molecular Immunology2018，15，8： | 3 |
| 10 | Exosomal microRNA in autoimmunity显示文摘Exosomes are small extracellular vesicles that contain a potpourri of nucleic acids,including microRNAs(miRNAs).Importantly,exosomes and these miRNAs are actively secreted from multiple cell populations and play a critical role in intercellular communication.The exosomal miRNA profile reflects the cellular pathophysiological status and modulates multiple biological processes.Accumulating evidence indicates that exosomes and miRNAs are biomarkers for disease diagnosis and may have therapeutic targets.Research studies on exosomal miRNAs have brought new insights into understanding autoimmune diseases.This article summarizes the detection methodologies and updates the potential applications of exosomal miRNAs in autoimmune diseases. | Weijia Duan Weici Zhang Jidong Jia Qianjin Lu M.Eric Gershwin | 2019 | Cellular & Molecular Immunology2019，16，12： | 2 |
| 11 | Eco-economic control mode and benefit analysis of rock desertification region in Huajiang Karst Valley of Guizhou Province显示文摘It is difficult to afforest in rock desertification region and is the key area for eco-environment treatment. To speed up the comprehensive treatment of rock desertification, several anti-rock desertification modes implemented in Dingtan region, located on the right bank of Huajiang Grand Valley in Beipanjiang Town, are introduced as examples. This paper first analyzes the natural and environmental conditions, the development of rock desertification in the Dingtan region, then the detail of the treatment modes, such as “Chinese wingleaf pricklyash – pig breeding – marsh gas” (Mode One), “amomum villosum – pig breeding – marsh gas” mode (Mode Two), “traditional grain and economic crop (corn, peanut) – amomum villosum or Chinese wingleaf pricklyash” (Mode Three), etc. The eco-economic effects, potential and shortcomings of the above mentioned modes are analyzed and compared. It is proved that Mode One and Mode Two are of good economic effect, but Mode Three of better ecological effect. Solutions to the shortcomings of the modes are also put forward. | Su Weici He Tairong Teng Jianzhen | 2006 | Ecological Economy2006，2，3： | 2 |
| 12 | Efficient search of compositional space for hybrid organic-inorganic perovskites via Bayesian optimization显示文摘Accelerated searches,made possible by machine learning techniques,are of growing interest in materials discovery.A suitable case involves the solution processing of components that ultimately form thin films of solar cell materials known as hybrid organic–inorganic perovskites(HOIPs).The number of molecular species that combine in solution to form these films constitutes an overwhelmingly large“compositional”space(at times,exceeding 500,000 possible combinations).Selecting a HOIP with desirable characteristics involves choosing different cations,halides,and solvent blends from a diverse palette of options.An unguided search by experimental investigations or molecular simulations is prohibitively expensive.In this work,we propose a Bayesian optimization method that uses an application-specific kernel to overcome challenges where data is scarce,and in which the search space is given by binary variables indicating whether a constituent is present or not.We demonstrate that the proposed approach identifies HOIPs with the targeted maximum intermolecular binding energy between HOIP salt and solvent at considerably lower cost than previous state-of-the-art Bayesian optimization methodology and at a fraction of the time(less than 10%)needed to complete an exhaustive search.We find an optimal composition within 15±10 iterations in a HOIP compositional space containing 72 combinations,and within 31±9 iterations when considering mixed halides(240 combinations).Exhaustive quantum mechanical simulations of all possible combinations were used to validate the optimal prediction from a Bayesian optimization approach.This paper demonstrates the potential of the Bayesian optimization methodology reported here for new materials discovery. | Henry C.Herbol Weici Hu Peter Frazier Paulette Clancy Matthias Poloczek | 2018 | npj Computational Materials2018，，1： | 2 |
| 13 | Analysisoftargettrackingbasedonrangedi//erencemeasurementwithmultistaticradarsystem显示文摘 | WeiCY XuSJ WangDJ | 2000 | JournalofChinaUniversityofScienceandTechnology2000，30，1： | 1 |
| 14 | Modeling and dynamic assessment of urban economy-resource-environment system with a coupled system dynamics - geographic information system model 显示文摘 | Guana Dongjie Gao Weijun Su Weici | 2011 | Ecological Indicators2011，11，5： | 1 |
| 15 | The main ecological issues of water-level -fluctuating zone and the strategies in Three Gorges reservoir area 显示文摘 | Su Weici Liu Jinping Zhang Junyi | 2011 | Remote Sensing Envi- ronment and Transportation Engineering2011，1，： | 1 |
| 16 | A preliminarystudy on land exploitation and utilization models of water- level- fluctuating zone (WLFZ) in the Three Gorges Res- ervoir area of Chongqing 显示文摘 | Su Weici Liu Junping Yang Hua | 2010 | Advanced Management Science2010，3，： | 1 |
| 17 | Sawtooth activity during lower hybrid current drive experiment in HT-7 superconducting tokamak 显示文摘 | Shen Weici Kuang Guangli Liu Yuexiu | 2000 | Plssma Science & Technology2000，2，2： | 1 |
| 18 | Treatment with a JAK1/2 inhibitor ameliorates murine autoimmune cholangitis induced by IFN overexpression显示文摘The interferon(IFN)signaling pathways are major immunological checkpoints with clinical significance in the pathogenesis of autoimmunity.We have generated a unique murine model named ARE-Del,with chronic overexpression of IFNγ,by altering IFNγmetabolism.Importantly,these mice develop an immunologic and clinical profile similar to patients with primary biliary cholangitis,including high titers of autoantibodies and portal inflammation.We hypothesized that the downregulation of IFN signaling pathways with a JAK1/2 inhibitor would inhibit the development and progression of cholangitis.To study this hypothesis,ARE-Del^(+/−)mice were treated with the JAK1/2 inhibitor ruxolitinib and serially studied.JAK inhibition resulted in a significant reduction in portal inflammation and bile duct damage,associated with a significant reduction in splenic and hepatic CD4^(+)T cells and CD8^(+)T cells.Functionally,ruxolitinib inhibited the secretion of the proinflammatory cytokines IFNγand TNF from splenic CD4^(+)T cells.Additionally,ruxolitinib treatment also decreased the frequencies of germinal center B(GC B)cells and T follicular helper(Tfh)cells and led to lower serological AMA levels.Of note,liver and peritoneal macrophages were sharply decreased and polarized from M1 to M2 with a higher level of IRF4 expression after ruxolitinib treatment.Mechanistically,ruxolitinib inhibited the secretion of IL-6,TNF and MCP1 and the expression of STAT1 but promoted the expression of STAT6 in macrophages in vitro,indicating that M1 macrophage polarization to M2 occurred through activation of the STAT6-IRF4 pathway.Our data highlight the significance,both immunologically and clinically,of the JAK/STAT signaling pathway in autoimmune cholangitis. | Tihong Shao Patrick S.C.Leung Weici Zhang Koichi Tsuneyama William M.Ridgway Howard A.Young Zongwen Shuai Aftab A.Ansari M.Eric Gershwi | 2022 | Cellular & Molecular Immunology2022，19，10： | 1 |
| 19 | ChungMutagenicity studies of kojic acid显示文摘 | WeiCI HuangTS FernandoSY | | 0，，1： | 1 |
| 20 | AsurveyofstudyofchemicalcomponentsofPanaxquinquefoliumL显示文摘 | WeiCY MouJM | 1997 | 特产研究1997，4，： | 1 |
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