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| 1 | In vitro activity of moxifloxacin and piperacillin/sulbactam against pathogens of acute cholangitis显示文摘AIM: To analyze the in vitro activity of moxifloxacin and piperacillin/sulbactam against pathogens isolated from patients with acute cholangitis. METHODS: In this prospective study a total of 65 patients with acute cholangitis due to biliary stone obstruction (n = 7), benign biliary stricture (n = 16), and malignant biliary stricture (n = 42) were investigated with regard to spectrum of bacterial infection and antibiotic resistance. Pathogens were isolated from bile cultures in all study patients. In 22 febrile patients, blood cultures were also obtained. In vitro activity of moxifloxacin and piperacillin/ sulbactam was determined by agar diffusion. RESULTS: Thirty-one out of 65 patients had positive bile and/or blood cultures. In 31 patients, 63 isolates with 17 different species were identified. The predominant strains were Enterococcus species (26/63), E.coli (13/63) and Klebsiella species (8/63). A comparable in vitro activity of moxifloxacin and piperacillin/sulbactam was observed for E.coli and Klebsiella species. In contrast, Enterococcus species had higher resistances towards moxifloxacin. Overall bacteria showed antibiotic resistances in vitro of 34.9% for piperacillin/sulbactam and 36.5% for moxifloxacin.CONCLUSION: Enterococcus species , E.coli and Klebsiella species were the most common bacteria isolated from bile and/or blood from patients with acute cholangitis. Overall, a mixed infection with several species was observed, and bacteria showed a comparable in vitro activity for piperacillin/sulbactam and moxifloxacin. | Andreas Weber Wolfgang Huber Klaus Kamereck Philipp Winkle Petra Voland Hans Weidenbach Roland M Schmid Christian Prinz | 2008 | World Journal of Gastroenterology2008，14，20： | 18 |
| 2 | Endoscopic transpapillary brush cytology and forceps biopsy in patients with hilar cholangiocarcinoma显示文摘AIM: To evaluate the sensitivity of brush cytology and forceps biopsy in a homogeneous patient group with hilar cholangiocarcinoma.METHODS: Brush cytology and forceps biopsy were routinely performed in patients with suspected malignant biliary strictures. Fifty-eight consecutive patients undergoing endoscopic retrograde cholangio-pancreatography (ERCP) including forceps biopsy and brush cytology in patients with hilar cholangiocarcinoma between 1995-2005.RESULTS: Positive results for malignancy were obtained in 24/58 patients (41.4%) by brush cytology and in 31/58 patients (53.4%) by forceps biopsy. The combination of both techniques brush cytology and forceps biopsy resulted only in a minor increase in diagnostic sensitivity to 60.3% (35/58 patients). In 20/58 patients (34.5%), diagnosis were obtained by both positive cytology and positive histology, in 11/58 (19%) by positive histology (negative cytology) and only 4/58 patients (6.9%) were confirmed by positive cytology (negative histology).CONCLUSION: Brush cytology and forceps biopsy have only limited sensitivity for the diagnosis of malignant hilar tumors. In our eyes, additional diagnostic techniques should be evaluated and should become routine in patients with negative cytological and histological findings. | Andreas Weber Claus von Weyhern Falko Fend Jochen Schneider Bruno Neu Alexander Meining Hans Weidenbach Roland M Schmid Christian Prinz | 2008 | World Journal of Gastroenterology2008，14，7： | 17 |
| 3 | Polarized Defense Against Fungal Pathogens Is Mediated by the Jacalin-Related Lectin Domain of Modular Poaceae-Specific Proteins显示文摘模块化的蛋白质是一个进化答案优化身体上为功能与对方一起交往的蛋白质的性能。用基因、生物化学的实验的联合,我们描绘了米饭蛋白质 OsJAC1,它由领域预言了绑包含甘露糖的 oligosaccharides,和可能在 monolignols 联合的 stereoselective 工作的一个 dirigent 领域的 jacalin 相关的 lectin (JRL ) 组成。在米饭的 OsJAC1 的转基因的 overexpression 包括细菌, oomycetes,和真菌对不同病原体导致了量的用途广泛的抵抗。在大麦的这基因或它的小麦 ortholog TAJA1 的 Overexpression 对粉的霉真菌提高了抵抗。OsJAC1 的两个蛋白质领域被要求建立由单个领域的单个或联合的短暂表示显示了的抵抗。表示人工地分开了,标注荧光的蛋白质领域证明 JRL 领域为指向粉的霉穿入地点是足够的。不过, lectinand 的合作本地化 dirigent 领域发生了。种系发生的分析专门在 Poaceae 植物家庭以内揭示了 OsJAC1 的 orthologs。Dicots 由对比,仅仅与 JRL 或 dirigent 领域包含蛋白质。总的来说,我们的结果从植物作为抵抗 proteinderived 的一种新奇类型的一个代表识别 OsJAC1 为在本地病原体防卫的更好的功能的系特定的基因熔化事件。 | Denise Weidenbach Lara Esch Claudia Moller Goetz Hensel Jochen Kumlehn Caroline Hofle Ralph Huckelhoven Ulrich Schaffrath | 2016 | Molecular Plant2016，9，4： | 4 |
| 4 | NF-kappaB/Rel activication in cerulean pancreatitis显示文摘 | Steinle AU Weidenbach H Wagner M | 1999 | Gastroenterology1999，116，2： | 1 |
| 5 | Cytologic and DNA-cytometric early diagnosis of oral cancer显示文摘 | Torsten W Remmerbach Horst Weidenbach | 2001 | Analytical Cellular Pathology2001，22，4： | 1 |
| 6 | Cytologic and DNA - cytometfic early diagnosis of oral cancer 显示文摘 | Remmerbach TW Weidenbach H Pomjanski N | 2001 | Anal Cell Pathol2001，22，4： | 1 |
| 7 | NF - κB/Rel activation in cerulein pancreatitis 显示文摘 | Steiule AU Weidenbach H Wagner M | 1999 | Gastroenterology1999，116，： | 1 |
| 8 | Effect of kinin inhibition in experimental acute pancreatitis显示文摘 | Lerch MM Weidenbach H Gress TM | 1995 | Am J Physiol1995，269，41： | 1 |
| 9 | Cy- tologic and DNA-cytometric early diagnosis of oral cancer 显示文摘 | Remmerbach TW Weidenbach H Pomjanski N | 2001 | Anal Cell Pathol2001，22，4： | 1 |
| 10 | Stimulation of pancreatic secretory process in the rat by low-molecular weight proteinase inhibitor显示文摘 | U. Rausch H. Weidenbach G. Adler H. F. Kern | 1987 | Cell and Tissue Research1987，，： | 1 |
| 11 | Sechs neue Kafer aus der Umgegend yon Augsburg显示文摘 | von Weidenbach C | | Bericht des Naturhistorischen Vereins in Augsburg0，12，： | 1 |
| 12 | Cytologic and DNA- cytometric early diagnosis of oral cancer 显示文摘 | Remmerbach T Weidenbach H Pomjanski N | 2001 | Anal Cell Pathol2001，22，4： | 1 |
| 13 | NF-κB/Rel activation in caerulein pancreatitis显示文摘 | Steinle AU Weidenbach H Wagner M | | 0，，： | 1 |
| 14 | NF-Kb/Rel activation in cerulein pancreatitis显示文摘 | STEINLE A U WEIDENBACH H WAGNER M | 1999 | Gastroenterology1999，116，3： | 1 |
| 15 | Cytologicand DNA-cytometric early diagnosis of oral cancer显示文摘 | Remmerbach TW Weidenbach H Pomjanski N | 2001 | Anal Cell Pathol2001，22，4： | 1 |
| 16 | Long-term outcome of endoscopic and/or percutaneous transhepatic therapy in patients with biliary stricture after orthotopic liver transplantation显示文摘 | Andreas Weber Christian Prinz Carlos Gerngro? Leopold Ludwig Wolfgang Huber Bruno Neu Matthias P. Ebert Alexander Meining Hans Weidenbach Roland M. Schmid Ewert Schulte-Frohlinde | 2009 | Journal of Gastroenterology2009，，12： | 1 |
| 17 | Cytologic and DNA-cytometric early diagnosis of oral cancer显示文摘 | Remmerbach TW Weidenbach H Pomjanski N | 2001 | Anal Cell Pathol2001，22，4： | 1 |
| 18 | Cytologic and DNA-cytometric early diagnosis of oral cancer显示文摘 | Remmerbach T Weidenbach H Pomjanski N | 2001 | Anal Cell Pathol2001，22，4： | 1 |
| 19 | NF-rB/Rel activa- tion in cacrulein pancretitis显示文摘 | Steinle AU Weidenbach H Wagner M | 1999 | Gastroenterology1999，116，： | 1 |
| 20 | National surveillance of emergency department visits for outpatient adverse drug events显示文摘 | Budnitz DS Pollock DA Weidenbach KN | 2006 | JAMA2006，296，15： | 1 |
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