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| 1 | 基于IMRT时代的第八版AJCC/UICC鼻咽癌临床分期建议显示文摘目的准确的分期系统对癌症的治疗至关重要。随着癌症分期和治疗方法的演变,需要不断评价分期的适用性和改进性。方法基于第7版AJCC/UICC分期回顾性分析香港和中国大陆2个肿瘤中心收治的1609例接受调强放射治疗的首诊无转移鼻咽癌患者临床资料,所有患者治疗前均行核磁共振分期评估。结果无其他T3、T4期解剖结构受侵患者中,伴有咀嚼肌间隙(翼内肌和/或翼外肌)侵犯、椎前肌侵犯及咽旁间隙侵犯的三组患者之间0s相近。伴广泛软组织(上述侵犯结构以外的软组织)受侵患者OS与伴有颅内侵犯或颅神经侵犯相似。仅2%患者锁骨上窝以上淋巴结转移者直径〉6cm,其0s率与下颈淋巴结转移者类似。用下颈(环状软骨尾侧缘水平以下)代替锁骨上窝并不影响N分期之间的风险差异性。采用推荐的T、N分期,T。N。、T。N,期0s相近。结论经AJCC/UICC分期筹备委员会审阅后,建议第8版分期应将翼内肌/翼外肌从T。降到T:期,增加椎前肌为L期,用下颈取代锁骨上窝,将淋巴结最大直径〉6cm合并归为N,期,将T。、N,期统一归为Ⅳ。期。这些改变不仅使得相邻分期间风险差异性更好,而且使得临床实践性与全球适用性之间达到最佳平衡。 | 潘建基 Wai Tong Ng 宗井凤 Lucy L.K.Chan Brian O' Sullivan 林少俊 Henry C.K.Sze 陈韵彬 Horace C.W.Choi 郭巧娟 Wai Kuen Kan 肖友平 Xu Wei Quynh Thu Le Christine M.Glastonbury A.Dimtrios Colevas Randal S.Weber Jatin P.Shah Anne W.M.Lee | 2016 | 中华放射肿瘤学杂志2016，25，3： | 65 |
| 2 | 尿钠排泄、血压、心血管病与死亡率的关系:社区前瞻性流行病学队列研究显示文摘WHO建议人群钠摄人<2 g/d作为预防心血管病的措施之一,但这一目标在任何国家都没有实现。该建议主要基于短期血压试验的个体水平数据,没有来自随机试验或观察性研究的关于低钠摄入与降低心血管事件的数据。前瞻性城市农村流行病学研究目前正在21个国家进行。该文对其中18个国家的数据进行分析,其中包含了临床结果数据。 | Mente A O'Donnell M Rangarajan S McQueen M Dagenais G Wielgosz A Lear S Ah STL Wei L Diaz R Avezum A Lopez-Jaramillo P Lanas F Mony P Szuba A Iqbal R Yusuf R Mohammadifard N Khatib R Yusoff K Ismail N Gulec S Rosengren A Yusufali A Kruger L Tsolekile LP Chifamba J Dans A Alhabib KF Yeates K Teo K Yusuf S 刘莉 叶鹏 | 2018 | 中华高血压杂志2018，26，12： | 29 |
| 3 | Grenvillian orogeny in the Southern Cathaysia Block:Constraints from U-Pb ages and Lu-Hf isotopes in zircon from metamorphic basement显示文摘Metamorphic basement rocks in the Cathaysia Block are composed mainly of meta-sediments with different ages. New zircon U-Pb geochronological results from the meta-sedimentary rocks exposed in the Zengcheng and Hezi areas, southern Cathaysia Block, show that they consist dominantly of early Neoproterozoic (1.0―0.9 Ga) materials with minor Paleo- to Mesoproterozoic and late Neoproterozoic (0.8―0.6 Ga) components, suggesting that the detritus mostly come from a Grenvillian orogen. The youngest detrital zircon ages place a constraint on the deposition time of these sediments in Late Neoproterozoic. Zircon Hf isotopic compositions indicate that the Grenvillian zircons were derived from the reworking of Mesoproterozoic arc magmatic rocks and Paleoproterozoic continental crust, implying an arc-continent collisional setting. Single-peak age spectra and the presence of abundant euhedral Grenvillian zircons suggest that the sedimentary provenance is not far away from the sample location. Thus, the Grenvillian orogen probably preexisted along the southern margin of the Cathaysia Block, or very close to the south. Similarity in the ages of Grenvillian orogeny and the influence of the assembly of Gondwana in South China with India and East Antarctic are discussed, with suggestion that South China was more likely linked with the India-East Antarctica continents in Early Neoproterozoic rather than between western Laurentia and eastern Australia. | WANG LiJuan YU JinHai S.Y. O'REILLY W.L. GRIFFIN SUN Tao WEI ZhenYang JIANG ShaoYong SHU LiangShu | 2008 | Chinese Science Bulletin2008，53，19： | 21 |
| 4 | Characterization of the Nanoscale Microstructure of an Immersion Silver on Sputtered Copper显示文摘Silver has grown its attraction of the scientists in microelectronic field recently. Electrochemical deposition of silver onto copper substrates by immersion method has been one of the keen topics. In this study, ethanol was used as the plating solution in which some chemicals were added. The silver deposits were characterized by a field emission scanning electron microscopy (FESEM), an atom force microscope (AFM), a transmission electron microscope (TEM) and a selected area electron diffraction (SAED). It was found that silver immersion using ethanol-based bath has good coverage feature. The highlands of the copper substrate are coated by silver particles whose sizes are around 12 nm, but those sizes at low-lying lands are a little smaller. | TANG Dian WEI Zhe-Liang SHAO Yan-Qun YOU Shao-Xin O'KEEFE Mathew O' KEEFE Thomas | 2005 | Chinese Journal of Structural Chemistry2005，24，8： | 6 |
| 5 | NANO-STRUCTURED SILVER COATING ON COPPER PREPARED IN AN ETHANOL-BASED SOLUTION显示文摘Recently, silver as an electrochemical deposit on copper substrate has been attracting much attention in the microelectronics field. To deposit nano-scale silver particles on copper, immersion plating using cyanide-based baths is commonly used. In this study, non-toxic ethanol was used as the plating solution. Sputtered copper samples were terized by a field emission scanning electron microscope (FE-SEM), an energy dispersive X-ray spectroscope (EDS),and an atomic force microscope (AFM). It was found that the deposited particles are metallic silver. After 3 s immersion,fine particles whose diameters were around 6 nm had covered about 40% of the surface of the copper substrate. After10 s immersion, the copper surface was completely covered by silver particles, the diameters of which have increased to about 10-15 nm. After the whole surface was covered, a dense and smooth silver coating was obtained. | Zheliang Wei Dian Tang Thomas O'Keefe | 2005 | China Particuology2005，3，5： | 6 |
| 6 | Aurora-A modulates MMP-2 expression via AKT/NF-κB pathway in esophageal squamous cell carcinoma cells显示文摘食道的有鳞的房间癌(ESCC ) 是最普通的恶意之一。识别预言肿瘤前进和治疗学的分子的目标的新 markersfor 是必要的。它被报导了 Aurora-Aand 矩阵 metalloproteinases 的那 overexpressions (MMP-2 ) 2 可以支持肿瘤的恶意的发展。然而,关系 betweenAurora -- 在肿瘤病人的 A 和 MMP-2 表示没被调查。另外, Aurora-Aregulates MMP-2 表示不充分仍然是的内在的机制阐明了。在这研究,我们表明了那曙光 A, MMP-2 与配对的正常邻近的纸巾相比是 overexpressedin ESCC 纸巾(P ? | Xiaoxia Wang Xiaozhong Li Chaohui Li Chun He Benhong Ren Oing Deng Wei Gao Binquan Wang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，6： | 6 |
| 7 | Roles of P-glycoprotein and multidrug resistance protein in transporting para-aminosalicylic acid and its N-acetylated metabolite in mice brain显示文摘目的: Para-aminosalicylic 酸(舞步) 在导致 manganism 的 neurotoxicity (manganism ) 的处理是有效的。在这研究,我们在通过血大脑障碍搬运舞步和它的 N-acetylated 代谢物 AcPAS 调查了 P-glycoprotein (MDR1a ) 和 multidrug 抵抗蛋白质(MRP ) 的角色。 | Lan HONG Cong XU Stefanie O'NEAL Hui-chang BI Min HUANG Wei ZHENG Su ZENG | 2014 | Acta Pharmacologica Sinica2014，35，12： | 4 |
| 8 | The amazing potential of fungi:50 ways we can exploit fungi industrially显示文摘Fungi are an understudied,biotechnologically valuable group of organisms.Due to the immense range of habitats that fungi inhabit,and the consequent need to compete against a diverse array of other fungi,bacteria,and animals,fungi have developed numerous survival mechanisms.The unique attributes of fungi thus herald great promise for their application in biotechnology and industry.Moreover,fungi can be grown with relative ease,making production at scale viable.The search for fungal biodiversity,and the construction of a living fungi collection,both have incredible economic potential in locating organisms with novel industrial uses that will lead to novel products.This manuscript reviews fifty ways in which fungi can potentially be utilized as biotechnology.We provide notes and examples for each potential exploitation and give examples from our own work and the work of other notable researchers.We also provide a flow chart that can be used to convince funding bodies of the importance of fungi for biotechnological research and as potential products.Fungi have provided the world with penicillin,lovastatin,and other globally significant medicines,and they remain an untapped resource with enormous industrial potential. | Kevin D.Hyde Jianchu Xu Sylvie Rapior Rajesh Jeewon Saisamorn Lumyong Allen Grace T.Niego Pranami D.Abeywickrama Janith V.S.Aluthmuhandiram Rashika S.Brahamanage Siraprapa Brooks Amornrat Chaiyasen K.W.Thilini Chethana Putarak Chomnunti Clara Chepkirui Boontiya Chuankid Nimali I.de Silva Mingkwan Doilom Craig Faulds Eleni Gentekaki Venkat Gopalan Pattana Kakumyan Dulanjalee Harishchandra Hridya Hemachandran Sinang Hongsanan Anuruddha Karunarathna Samantha C.Karunarathna Sehroon Khan Jaturong Kumla Ruvishika S.Jayawardena Jian-Kui Liu Ningguo Liu Thatsanee Luangharn Allan Patrick G.Macabeo Diana S.Marasinghe Dan Meeks Peter E.Mortimer Peter Mueller Sadia Nadir Karaba N.Nataraja Sureeporn Nontachaiyapoom Meghan O’Brien Watsana Penkhrue Chayanard Phukhamsakda Uma Shaanker Ramanan Achala R.Rathnayaka Resurreccion B.Sadaba Birthe Sandargo Binu C.Samarakoon Danushka S.Tennakoon Ramamoorthy Siva Wasan Sriprom T.S.Suryanarayanan Kanaporn Sujarit Nakarin Suwannarach Thitipone Suwunwong Benjarong Thongbai Naritsada Thongklang Deping Wei S.Nuwanthika Wijesinghe Jake Winiski Jiye Yan Erandi Yasanthika Marc Stadler | 2019 | Fungal Diversity2019，，4： | 3 |
| 9 | Safety of endovascular therapy for symptomatic intracranial artery stenosis:a national prospective registry显示文摘Introduction The safety outcomes of endovascular therapy for intracranial artery stenosis in a real-world stetting are largely unknown.The Clinical Registration Trial of Intracranial Stenting for Patients with Symptomatic Intracranial Artery Stenosis(CRTICAS)was a prospective,multicentre,real-world registry designed to assess these outcomes and the impact of centre experience.Methods 1140 severe,symptomatic intracranial arterial stenosis(ICAS)patients treated with endovascular therapy were included from 26 centres,further divided into three groups according to the annual centre volume of intracranial angioplasty and stent placement procedures over 2 years:(1)high volume for≥25 cases/year;(2)moderate volume for 10–25 cases/year and(3)low volume for<10 cases/year.Results The rate of 30-day stroke,transient ischaemic attack or death was 9.7%(111),with 5.4%,21.1%and 9.7%in high-volume,moderate-volume and low-volume centres,respectively(p<0.05).Multivariable logistic regression confirmed high-volume centres had a significantly lower primary endpoint compared with moderate-volume centres(OR=0.187,95%CI:0.056 to 0.627;p≤0.0001),while moderate-volume and low-volume centres showed no significant difference(p=0.8456).Conclusion Compared with the preceding randomised controlled trials,this real-world,prospective,multicentre registry shows a lower complication rate of endovascular treatment for symptomatic ICAS.Non-uniform utilisation in endovascular technology,institutional experience and patient selection in different volumes of centres may have an impact on overall safety of this treatment. | Yabing Wang Tao Wang Adam Andrew Dmytriw Kun Yang Liqun Jiao Huaizhang Shi Jie Lu Tianxiao Li Yujie Huang Zhenwei Zhao Wei Wu Jieqing Wan Qinjian Sun Bo Hong Yongli Li Liyong Zhang Jianfeng Chu Qiong Cheng Yiling Cai Pengfei Wang Qi Luo Hua Yang Baijing Dong Yang Zhang Jun Zhao Zuoquan Chen Wei Li Xiaoxin Bai Weiwen He Xueli Cai Maimai Ti Osama O Zaidat | 2022 | Stroke & Vascular Neurology2022，7，2： | 3 |
| 10 | Inhaled nanoparticles: a current review显示文摘 | YANG Wei PETERS J I WILLIAMS R O | 2008 | International Journal of pharmaceutics2008，356，2： | 1 |
| 11 | Methylation of Naphthalene on MTW-Type Zeolites: Influence of Template Origin and Substitution of Al by Ga 显示文摘 | Wu Wei Wu Weiguo Kikhtyanin O V | 2010 | Appl Catal A2010，375，2： | 1 |
| 12 | Transient variations in the serum concentrations of cell adhesion molecules following retrop- eritoneal laparoscopic and open radical nephrectomy for lo- caliz-ed renal-cell carcinoma显示文摘 | Yang L Fan T Wei O | 2012 | J Endourol2012，26，10： | 1 |
| 13 | Subspaee pursuit for compressive sensing signal reconstruction显示文摘 | Dai Wei Milenkovic O | 2009 | IEEE Transactions of In- formation Theory2009，55，5： | 1 |
| 14 | An order-disorder transition in Sr2IrD5: Evidence for square pyramidal IrD5 units from powder neutron diffraction data 显示文摘 | ZHUANG J HASTINGS J M CORLISS L M BAU R WEI C Y MOYER R O J | 1981 | J Solid State Chem1981，40，： | 1 |
| 15 | Safety and effi- cacy of sertraline for depression in patients with heart failure: re- suits of the SADHART-CHF (Sertraline Against Depression and Heart Disease in Chronic Heart Failure) trial显示文摘 | O'connor CM Jiang Wei Kuchibhatla M | 2010 | J Am Coil Cardi- ol2010，56，9： | 1 |
| 16 | A platoon dispersion model based on a truncated normal distribution of speed 显示文摘 | WEI M JIN W Z SHEN L O | 2012 | Journal of Applied Mathematics2012，，2012： | 1 |
| 17 | Tan Aptamer-assisted cell targeting and its application in cell-based immunotherapy of cancer 显示文摘 | Xiang ling Xiong Meghan O'Donoghue Wei hong | 2012 | FASEBJ2012，26，： | 1 |
| 18 | Ad- vances in the study of hydrogen transfer to model com- pounds for coal liquefaction 显示文摘 | Wei Xianyong Eisuke O Zong Zhimin | 2000 | Fuel Processing Tech- nology2000，62，： | 1 |
| 19 | IL-10 Suppresses chemokines,inflammation,and fibrosis in a model of chronic renal disease 显示文摘 | Wei M Xiaosen O Anupam A | 2005 | J Am Soc Nephrol2005，16，12： | 1 |
| 20 | 5-ALA-mediated photodynamic therapy in multidrug resistant leukemia cells显示文摘 | Wei L Wenjie Z Kazunori O | 2001 | J Photochem Photobiol (B: Biology)2001，60，： | 1 |
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