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| 1 | Immunohistochemical analysis of the Wnt/β-catenin signaling pathway in pancreatic neuroendocrine neoplasms显示文摘AIM: To investigate the role of the Wnt/β-catenin pathway in pancreatic neuroendocrine neoplasms(PanN ENs). METHODS: Tissue microarrays containing 88 PanN ENs were immunohistochemically labeled with antibodies to β-catenin, E-cadherin, adenomatous polyposis coli(APC), chromogranin and synaptophysin. One case had only metastatic tumors resected, whereas others(n = 87) received pancreatectomy with or without partial hepatectomy. Pathology slides, demographic, clinicopathologic, and follow up data were reviewed. Patients' demographics, clinicopathologic features, and immunohistochemical results from 87 primary tumors were compared between patients with low stage(stage Ⅰ/Ⅱ) and high stage(stage Ⅲ/Ⅳ) tumors. In addition, correlation of immunohistochemical results from primary tumors with disease-specific survival(DSS) was evaluated. RESULTS: Strong membranous β-catenin staining in the primary tumor was observed in all 13 stage Ⅲ/Ⅳ Pan NENs as compared to 47%(35/74) of stage Ⅰ/Ⅱtumors(P < 0.01). However, the strong membranous β-catenin staining was unassociated with tumor grade or DSS. Decreased membranous β-catenin staining was associated with decreased membranous E-cadherin labeling. Nuclear β-catenin staining was seen in 15%(2/13) of stage Ⅲ/Ⅳ Pan NENs as compared to 0%(0/74) of stage Ⅰ/Ⅱ tumors(P = 0.02). The case with metastasectomy only also showed nuclear β-catenin staining. Two of the three cases with nuclear β-catenin staining were familial adenomatous polyposis(FAP) patients. Lack of APC expression was seen in 70%(57/81) of the cases, including the 3 cases with nuclear β-catenin staining. Expression of E-cadherin and APC in primary tumor was not correlated with tumor grade, tumor stage, or disease specific survival. CONCLUSION: The Wnt/β-catenin pathway was altered in some PanN ENs, but did not Impact DSS. PanN ENs in FAP patients demonstrated nuclear β-catenin accumulation and loss of APC. | Vivian Weiss Julie Dueber Jesse P Wright Justin Cates Frank Revetta Alexander A Parikh Nipun B Merchant Chanjuan Shi | 2016 | World Journal of Gastrointestinal Oncology2016，8，8： | 3 |
| 2 | Assessing Residual Stress Development and Stress Relaxation in Restrained Concrete Ring Specimens显示文摘 | Hossain A B Weiss J | 2004 | Cement & Concrete Composite2004，26，： | 1 |
| 3 | Preparation of conductive polypyrrole/polyurethane compositefoams by in situ polymerization of pyrrole显示文摘 | Wang Y B sotzing G A Weiss R A | 2008 | Chem Mater2008，20，7： | 1 |
| 4 | Preparation and mechanical properties of ultrafine grained metals显示文摘 | Gunther B Baal man A Weiss H | 1990 | Journal of materials research1990，5，： | 1 |
| 5 | Direction finding using spatial smoothing with interpolated arrays 显示文摘 | FRIEDLANDER B WEISS A J | 1993 | IEEE Transaction on Signal Processing1993，41，4： | 1 |
| 6 | Eigenstructure methods for direction finding with sensor gain and phase uncertainties 显示文摘 | Weiss A J Friedlander B | 1990 | Circutis Systems Signal Process1990，9，3： | 1 |
| 7 | Ursodeoxycholate stabilizes phospholipid- rich membranes and mimics the effect of cholesterol: investigations on large unilamellar vesicles 显示文摘 | Deisinger B Weiss A | 1997 | Biochim Biophys Acta1997，1326，2： | 1 |
| 8 | Eigenstructure methods for direction finding with sensor gain and phase uncertainties显示文摘 | WEISS A J FRIEDLANDER B | 1990 | Circuits Syst Signal Processing1990，9，2： | 1 |
| 9 | Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system显示文摘 | Reynolds B A Weiss S | 1992 | Science1992，27，5052： | 1 |
| 10 | Reduction of postharvest decay in organic citrus fruits by a short hot water brushing treatment显示文摘 | PORAT R DAUS A WEISS B | 2000 | Postharvest Biol Technol2000，18，： | 1 |
| 11 | Eigenstructure methods for direc- tion finding with sensor gain and phase uncertainties显示文摘 | Weiss A J Friedlander B | 1993 | Cir- cuits Syst Signal Processing1993，12，1： | 1 |
| 12 | An empirical investigation of market structure, efficiency, and performance in property-liability insurance显示文摘 | Choi B P M A Weiss | 2005 | Journal of Risk and Insurance2005，72，4： | 1 |
| 13 | Direction finding in the presence of mutual coupling显示文摘 | Friedlander B Weiss A J | 1991 | IEEE Trans on AP1991，39，3： | 1 |
| 14 | Cooperation and competition in an R & D market with spillovers 显示文摘 | SILIPO D B WEISS A | 2005 | Research in Economics2005，59，1： | 1 |
| 15 | Effects of modeling errors on the resolution threshold of the MUSIC algorithm 显示文摘 | WEISS A J Friedlander B | 1994 | IEEE Transactions on Signal Processing1994，42，6： | 1 |
| 16 | Nitrous oxide solubility in water and seawater显示文摘 | WEISS R F PRICE B A | 1980 | Marine Chemistry1980，8，： | 1 |
| 17 | Direction Finding Using Spatial Smoothing with Interpolated Array显示文摘 | Friedlander B Weiss A J | 1992 | IEEE Transactions on Aerospace and Electronic Systems1992，28，2： | 1 |
| 18 | A multipotent EGF-responsire striatal embryonic progenitor cell produces neurons and astrocytes显示文摘 | Reynolds B A Tetzlaff W Weiss S | 1992 | J Neurosci1992，12，： | 1 |
| 19 | The resolution threshold of a direction-uding algorithm for diversely polarized arrays 显示文摘 | FRIENDLANDER B WEISS A J | 1994 | Signal Processing IEEE Transactions on1994，42，7： | 1 |
| 20 | Targeting survivin in cancer:novel drug development approaches显示文摘 | Groner B Weiss A | 2014 | BioDrugs2014，28，1： | 1 |
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