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| 1 | Management of borderline and locally advanced pancreatic cancer:Where do we stand?显示文摘Many patients with pancreas cancer present with locally advanced pancreatic cancer(LAPC).The principle tools used for diagnosis and staging of LAPC include endoscopic ultrasound,axial imaging with computed tomography and magnetic resonance imaging,and diagnostic laparoscopy.The definition of resectability has historically been vague,as there is considerable debate and controversy as to the definition of LAPC.For the patient with LAPC,there is some level of involvement of the surrounding vascular structures,which include the superior mesenteric artery,celiac axis,hepatic artery,superior mesenteric vein,or portal vein.When feasible,most surgeons would recommend possible surgical resection for patients with borderline LAPC,with the goal of an R0 resection.For initially unresectable LAPC,neoadjuvant should be strongly considered.Specifically,these patients should be offered neoadjuvant therapy,and the tumor should be assessed for possible response and eventual resection.The efficacy of neoadjuvant therapy with this approach as a bridge to potential curative resection is broad,ranging from 3%-79%.The different modalities of neoadjuvant therapy include sin-gle or multi-agent chemotherapy combined with radiation,chemotherapy alone,and chemotherapy followed by chemotherapy with radiation.This review focuses on patients with LAPC and addresses recent advances and controversies in the field. | Jin He Andrew J Page Matthew Weiss Christopher L Wolfgang Joseph M Herman Timothy M Pawlik | 2014 | World Journal of Gastroenterology2014，20，9： | 11 |
| 2 | 非诺贝特治疗与2型糖尿病患者长期心血管病风险的关系显示文摘2型糖尿病患者心血管病风险高,部分原因在于高三酰甘油和低高密度脂蛋白胆固醇血症。而在他汀类药物治疗基础上,加强降低三酰甘油治疗,能否降低这种风险尚不清楚。该研究的目的是在使用他汀类药物治疗的2型糖尿病患者中,确定非诺贝特能否降低心血管病风险。 | 刘莉 叶鹏 Elam MB Ginsberg HN Lovato LC Corson M Largay J Leiter LA Lopez C O'Connor PJ Sweeney ME Weiss D Friedewald WT Buse JB Gerstein HC Probstfield J Grimm R Ismail-Beigi F Goff DC Jr Fleg JL Rosenberg Y Byington RP ACCORDION study investigators | 2017 | 中华高血压杂志2017，25，6： | 7 |
| 3 | Adiponectin and its receptors in rodent models of fatty liver disease and liver cirrhosis显示文摘AIM: To determine circulating and hepatic adiponectin in rodents with fatty liver disease or liver cirrhosis and investigate expression of the adiponectin receptors AdipoR1 on the mRNA and protein level and AdipoR2 on the mRNA level. METHODS: Fat fed rats were used as a model for fatty liver disease and bile duct ligation in mice to investigate cirrhotic liver. Expression of AdipoR1 and AdipoR2 mRNA was determined by real time RT-PCR. AdipoR1 protein was analysed by immunoblot. Adiponectin was measured by ELISA. RESULTS: Systemic adiponectin is reduced in fat- fed rats but is elevated in mice after bile duct ligation (BDL). Hepatic adiponectin protein is lower in steatotic liver but not in the liver of BDL-mice when compared to controls. Adiponectin mRNA was not detected in human liver samples or primary human hepatocytes nor in rat liver but recombinant adiponectin is taken up by isolated hepatocytes in-vitro. AdipoR1 mRNA and AdipoR1 protein levels are similar in the liver tissue of control and fat fed animals whereas AdipoR2 mRNA is induced. AdipoR2 mRNA and AdipoR1 mRNA and protein is suppressed in the liver of BDL-mice. CONCLUSION: Our studies show reduced circulating adiponectin in a rat model of fatty liver disease whereas circulating adiponectin is elevated in a mouse model of cirrhosis and similar fi ndings have been described in humans. Diminished hepatic expression of adiponectinreceptors was only found in liver cirrhosis. | Markus Neumeier Claus Hellerbrand Erwin Gbele Roland Buettner Cornelius Bollheimer Johanna Weigert Andreas Schffler Thomas S Weiss Monika Lichtenauer Jürgen Schlmerich Christa Buechler | 2006 | World Journal of Gastroenterology2006，12，34： | 4 |
| 4 | 富含组织细胞型横纹肌母细胞肿瘤:一种组织学独特的横纹肌母细胞肿瘤显示文摘许多软组织肿瘤不能简单地划分为“良性”或“恶性”。WHO软组织和骨肿瘤分类将几种类型的软组织肿瘤(如脂肪细胞肿瘤中的非典型脂肪瘤性肿瘤和内皮细胞肿瘤中的血管内皮瘤)确定为中间型(交界型)。一些软组织肿瘤(如韧带样型纤维瘤病和含铁血黄素沉着性纤维脂肪瘤性肿瘤)被认为是中度恶性肿瘤,这可能是因为它们具有局部侵袭性生长的能力,也可能因为它们(如血管瘤样纤维组织细胞瘤和骨化性纤维黏液样肿瘤)具有较低但无法预测的远处转移风险。血管球肿瘤和PEComa等肿瘤的分类系统不仅可以预测临床良、恶性肿瘤具有合理的敏感性和特异性,而且还可以将这些肿瘤的少部分划分为恶性潜能不确定型。有选择的软组织肿瘤(如胃肠道间质肿瘤和孤立性纤维性肿瘤),应从风险评估的角度来看待,而非良、恶性。显示骨骼肌分化的肿瘤传统上一分为二为良性横纹肌瘤或完全恶性横纹肌肉瘤(RMS)。 | Martinez A P Fritchie K J Weiss S W 张仁亚 | 2019 | 临床与实验病理学杂志2019，35，11： | 3 |
| 5 | Maintaining clarity:Review of maintenance therapy in nonsmall cell lung cancer显示文摘The purpose of this article is to review the role of maintenance therapy in the treatment of advanced nonsmall cell lung cancer(NSCLC). A brief overview about induction chemotherapy and its primary function in NSCLC is provided to address the basis of maintenance therapies foundation. The development of how maintenance therapy is utilized in this population is discussed and current guidelines for maintenance therapy are reviewed. Benefits and potential pitfalls of maintenance therapy are addressed, allowing a comprehensive review of the achieved clinical benefit that maintenance therapy may or may not have on NSCLC patient population. A review of current literature was conducted and a table is provided comparing the results of various maintenance therapy clinical trials. The table includes geographical location of each study, the number of patients enrolled, progression free survival and overall survival statistics, post-treatment regimens and if molecular testing was conducted. The role of molecular testing in relation to therapeutic treatment options foradvanced NSCLC patients is discussed. A treatment algorithm clearly depicts first line and second line treatment for management of NSCLC and includes molecular testing, maintenance therapy and the role clinical trials have in treatment of NSCLC. This treatment algorithm has been specifically tailored and developed to assist clinicians in the management of advanced NSCLC. | Kristen R Dearing Ashish Sangal Glen J Weiss | 2014 | World Journal of Clinical Oncology2014，5，2： | 3 |
| 6 | 群体药物代谢动力学方法研究伏立康唑的变异度:以优化给药方案显示文摘伏立康唑为广谱抗真菌药物,主要经肝药代谢酶CYP2C19、或CYP3A4和CYP2C9代谢,其药动学特征呈非线性并变异程度大,且该药治疗窗窄,使临床应用复杂。本研究将4项健康受试者研究和2项患者临床研究的数据(包括240名受试者的3352个血药浓度数据)建立非线性混合效应模型分析(NONM EM ),以剂量模拟检验协变量影响效应和据CYP2C19表型分层的伏立康唑浓度(2~5 mg/L )达标情况。结果表明伏立康唑符合滞后时间的一级口服吸收和消除米氏方程的二房室模型。伏立康唑在健康受试者中的最大代谢速率(Vmax )比患者高111%。具有一个或多个CYP2C19功能缺失(LoF)等位基因的受试者的 Vmax较没有上述等位基因缺失的受试者偏低41.2%。合并使用苯妥英钠或利福平,圣约翰草提取物或糖皮质激素可显著增加伏立康唑的消除。口服或静脉注射伏立康唑200 mg ,每日2次,第7天的谷浓度<2 mg/L的概率对无CYP2C19 LoF等位基因的受试者分别为72%和63%;口服或静脉给药300 mg ,每日2次,该概率分别较低,为49%和35%。相反,对于具有CYP2C19 LoF等位基因的受试者,上述给药方案第7天的伏立康唑谷浓度>5 mg/L 的概率分别为29%、39%、57%和77%。因此,目前伏立康唑的给药方案在无CYP2C19 LoF等位基因的受试者中暴露量偏低,需增加给药剂量,但在CYP2C19活性降低的受试者中暴露量则偏高。尽管本研究中伏立康唑生物利用度较高(94%),但个体差异较大(36.7%),且不同研究的结果差异较大(63%~96%),改变给药途径时也需要进行药物浓度监测。本研究表明,为保证伏立康唑的有效性和安全性,需进行治疗药物浓度监测。 | Dolton M J Mikus G Weiss J 赵苗 | 2015 | 中国感染与化疗杂志2015，15，5： | 2 |
| 7 | Evidence for Substantial Variations of Atmospheric Hydroxyl Radicals in the Past Two Decades 显示文摘 | Prinn R G Huang J Weiss R F | 2001 | SCIENCE2001，292，5523： | 2 |
| 8 | Direction finding in the presence of mutual coupling显示文摘 | B Friendlander Anthony J Weiss | 1991 | IEEE Trans on AP1991，39，3： | 2 |
| 9 | Stability and instability of fluid models for reentrant lines显示文摘 | Dai J G Weiss G | 1996 | Mathematics of Operations Research1996，，21： | 2 |
| 10 | Lipid-induced up-regulation of human acyl-CoA synthetase 5 promotes hepatocellular apoptosis显示文摘 | Andrea Reinartz Josef Ehling Andrea Leue Christian Liedtke Ursula Schneider Jürgen Kopitz Thomas Weiss Claus Hellerbrand Ralf Weiskirchen Ruth Knüchel Nikolaus Gassler | 2010 | BBA - Molecular and Cell Biology of Lipids2010，，9： | 2 |
| 11 | Chlorofluoromethans in South Atlantic antarctic intermediate water显示文摘 | WARNER M J WEISS R F | 1992 | Deep-Sea Res1992，39，： | 2 |
| 12 | Experimental Separation of Rashba and Dresselhaus Spin - Splittings in Semiconductor Quantum Wells 显示文摘 | Ganichev S D Bel'kov V V GoRlub L E Ivchenko E L Schneider P Giglberger S Eroms J DeBoeck J Borghs G Wegscheider W Weiss D Prettl W | | cond0，，： | 1 |
| 13 | Electromagnetic induction in a fully 3-D anisotropic earth 显示文摘 | WEISS C J NEWMAN G A | 2002 | Geophysics2002，67，4： | 1 |
| 14 | The coexistence of multiple distribution systems for financial services: The case of property-liability insurance显示文摘 | Berger Allen N Cummins J David Weiss Mary A | 1997 | Journal of Business1997，10，： | 1 |
| 15 | Moral Hazard In Home Equity Conversion显示文摘 | Robert J shiller and Allan N Weiss | 2000 | Real Estate Economics2000，，1： | 1 |
| 16 | Assessing Residual Stress Development and Stress Relaxation in Restrained Concrete Ring Specimens显示文摘 | Hossain A B Weiss J | 2004 | Cement & Concrete Composite2004，26，： | 1 |
| 17 | A history of chemically and radioactively important gases in air deduced from ALE/GAGE/AGAGE显示文摘 | Prinn R R Weiss R F Fraser P J | 2000 | Journal of Geophysical Research2000，105，17： | 1 |
| 18 | Pathophysiologic features of a pneumoperitoneum at laparoseopy:a swine model显示文摘 | Volz J Koster S Weiss M | 1996 | Am J Obstet Gynecol1996，174，11： | 1 |
| 19 | Zn and Cu isotopic variability in the Alexan- drinka volcanic-hosted massive sulphide (VHMS) ore deposit,Urals,Russia显示文摘 | MASON T F D WEISS D J CHAPMAN J B | 2005 | Chemical Geology2005，221，34： | 1 |
| 20 | Laboratory study of heavy metal phytoremediation by three wetland macrophytes 显示文摘 | Weiss J Hondzo M Biesboer D | 2006 | International Journal of Phytoremediation2006，8，3： | 1 |
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