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| 1 | Anemia and long-term outcome in adjuvant and neoadjuvant radiochemotherapy of stage Ⅱ and Ⅲ rectal adenocarcinoma:The Freiburg experience(1989-2002)显示文摘AIM:To evaluate the long-term outcome of standard5-FU based adjuvant or neoadjuvant radiochemotherapyand to identify the predictive factors,especially anemiabefore and after radiotherapy as well as hemoglobinincrease or decrease during radiotherapy.METHODS:Two hundred and eighty-six patientswith Union International Contre Cancer(UICC)stageⅡ and Ⅲ rectal adenocarcinomas,who underwentresection by conventional surgical techniques(lowanterior or abdominoperineal resection),receivedeither postoperative(n=233)or preoperative(n=53)radiochemotherapy from January 1989 until July 2002.Overall survival(OAS),cancer-specific survival(CSS),disease-free survival(DFS),local-relapse-free(LRS)and distant-relapse-free survival(DRS)were evaluatedusing Kaplan-Meier,Log-rank test and Cox's proportionalhazards as statistical methods.Multivariate analysis wasused to identify prognostic factors.Median follow-uptime was 8 years.RESULTS:Anemia before radiochemotherapy was anindependent prognostic factor for improved DFS(riskratio 0.76,P=0.04)as well as stage,grading,R status(free radial margins),type of surgery,carcinoembryonicantigen(CEA)levels,and gender.The univariate analysisrevealed that anemia was associated with impaired LRS (better local control)but with improved DFS.In contrast,hemoglobin decrease during radiotherapy was anindependent risk factor for DFS(risk ratio 1.97,P=0.04).During radiotherapy,only 30.8% of RO-resected patientssuffered from hemoglobin decrease compared to 55.6%if R1/2 resection was performed(P=0.04).The 5-yearOAS,CSS,DFS,LRS and DRS were 47.0%,60.0%,41.4%,67.2%,and 84.3%,respectively.Significantdifferences between preoperative and postoperativeradiochemotherapy were not found.CONCLUSION:Anemia before radiochemotherapyand hemoglobin decrease during radiotherapy have nopredictive value for the outcome of rectal cancer.Stage,grading,R status(free radial margins),type of surgery,CEA levels,and gender have predictive value for theoutcome of rectal cancer. | Christian Weissenberger Geissler Michael Otto Florian Barke Annette Henne Karl von Plehn Georg Rein Alex Müller Christine Bartelt Susanne Henke Michael | 2006 | World Journal of Gastroenterology2006，12，12： | 4 |
| 2 | Dietary curcu- min attenuates glioma growth in a syngeneic mouse model by inhibi- tion of the JAK1,2/STAT3 signaling pathway 显示文摘 | Weissenberger J Priester M Bemreuther C | 2010 | Clin Cancer Res2010，16，23： | 1 |
| 3 | Isocratic non-aqueous revesed-phase high-performance liquid chromatographic separation of capsanthin and capsarubin in red peppers, paprika and oleoresin显示文摘 | Weissenberg M Schaeffler I Menagem E | 1997 | Journal of Chromatography A1997，757，1： | 1 |
| 4 | Aggression and psychiatric comorbidity in children with hypothalanie hamanomas and their unaffected siblings显示文摘 | Weissenberger A A Dell M L Liow K | | 0，，： | 1 |
| 5 | Mesoporous silica from lyotropic liquid crystal polymer templates显示文摘 | Goltner C G Henke S Weissenberger M C | 1998 | Angew Chem Int Ed1998，37，5： | 1 |
| 6 | Isolation of solasodine and other steroidal alka- loids and sapogenins by direct hydrolysis-extraction of Solanum plants or glycosides therefrom 显示文摘 | Weissenberg M | 2001 | Phytochemistry2001，58，3： | 1 |
| 7 | Isolation of solasodine and other steroidal alkaloids and sapogenins by direct hydrolysis-extraction of Solanurn plants or glycosides therefrom 显示文摘 | Weissenberg M | 2001 | Phytoehemis- try2001，58，3： | 1 |
| 8 | Interactions between the glycoalkaloids solasonine and solamargine in relation to inhibition of fungal growth显示文摘 | FEWELL A M RODDICK J G WEISSENBERG M | 1994 | Phytochemistry1994，37，4： | 1 |
| 9 | Dietary curcumin attenuates glioma growth in a syngeneic mouse model by inhibition of the JAK1,2/STAT3 signaling pathway显示文摘 | Weissenberger J Priester M Bernreuther C | 2010 | Clin Cancer Res2010，16，23： | 1 |
| 10 | Isolation of solasodine and other steroidal alkaloids and sapogenins by direct hydrolysis-extraction of Solanum plants or glycosides therefrom显示文摘 | WEISSENBERG M | 2001 | Phytochemistry2001，58，3： | 1 |
| 11 | Meso- porous silica from lyotropic polymer templates显示文摘 | GOLTNER C G HENKE S WEISSENBERGER M C | 1998 | Angewandte Chemie International Edition1998，37，5： | 1 |
| 12 | Multibodysimulation of machine tools as mechatronie systems for optimization of motion dynamics in the design process 显示文摘 | Reinhart G Weissenberger M | 1999 | Proceedings of the IEEE/ASME International Conference on Advanced Intelligent Mechatronics1999，，： | 1 |
| 13 | Isocratic non-aqueous reversed-phase high-performance liquid chromatographic separation of capsanthin and capsorubin in red peppers, paprika and oleoresin 显示文摘 | WEISSENBERG M SCHAEFFLER I MENAGEM E | 1997 | Journal of Chromatography1997，757，1： | 1 |
| 14 | Dietary curcumin attenuates glioma growth in a syngeneic mouse model by inhibition of the JAK1,2/STAT3 signaling pathway 显示文摘 | Weissenberger J Priester M Bemreuther C | 2010 | Clin Cancer Res2010，16，23： | 1 |
| 15 | Identification and characterization of the Bel 3 protein of human foamy virus显示文摘 | Weissenberger J Flugel R M | 1994 | AIDS Res Hum Retroviruses1994，10，5： | 1 |
| 16 | Membrane disruption and enzyme inhibition by naturally-occurring and modified chacotriose-containing Solanum steroidal glycoalkaloids 显示文摘 | James G Roddick Weissenberg M | 2001 | Phytochemistry2001，56，： | 1 |
| 17 | Dietary curcumin attenuates glioma growth in a syngeneic mouse model by inhibition of the JAK1, 2/STAT3 signaling pathway 显示文摘 | Weissenberger J Priester M Bernreuther C | 2010 | Clin Cancer Res2010，16，23： | 1 |
| 18 | Nursing care for the elderly with hip fracture in an acute care hospital显示文摘 | Weissenberger - Leduc M Zmaritz M | 2013 | Wien Med Wochenschr2013，163，1920： | 1 |
| 19 | Dietary curcumin attenuates glioma growth in a syngeneie mouse model by inhibition of the JAK1,2/STAT3 signaling pathway显示文摘 | Weissenberger J Priester M Bernreuther C | 2010 | Clin Cancer Res2010，16，23： | 1 |
| 20 | Isolation of solasodine and other steroidal alkaloids and sapogenins by direct hydrolysis-extraction of Solanum plants or glycosides therefrom显示文摘 | Weissenberg M | 2001 | Phytochemistry2001，58，3： | 1 |
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