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| 1 | Ever-increasing diversity of drug-induced pancreatitis显示文摘With over 100000 hospital admissions per annum,acute pancreatitis remains the leading gastrointestinal cause of hospitalization in the United States and has farreaching impact well beyond.It has become increasingly recognized that druginduced pancreatitis(DIP),despite accounting for less than 3%of all cases,represents an important and growing though often inconspicuous cause of acute pancreatitis.Nevertheless,knowledge of DIP is often curtailed by the limited availability of evidence needed to implicate given agents,especially for nonprescription medications.Indeed,the majority of available data is derived from case reports,case series,or case control studies.Furthermore,the mechanism of injury and causality for many of these drugs remain elusive as a definitive correlation is generally not established(<10%of cases).Several classification systems have been proposed,but no single system has been widely adopted,and periodic updates are required in light of ongoing pharmacologic expansion.Moreover,infrequently prescribed medications or those available over-thecounter(including herbal and other alternative remedies)are often overlooked as a potential culprit of acute pancreatitis.Herein,we review the ever-increasing diversity of DIP and the potential mechanisms of injury with the goal of raising awareness regarding the nature and magnitude of this entity.We believe this manuscript will aid in increasing both primary and secondary prevention of DIP,thus ultimately facilitating more expedient diagnosis and a decrease in DIPrelated morbidity. | Simcha Weissman Muhammad Aziz Ryan B Perumpail Tej I Mehta Rutwik Patel James H Tabibian | 2020 | World Journal of Gastroenterology2020，26，22： | 8 |
| 2 | Elevated basal intestinal mucosal cytokine levels in asymptomatic first-degree relatives of patients with Crohn's disease显示文摘AIM To determine levels of cytokines incolonic mucosa of asymptomatic first degreerelatives of Crohn’s disease patients.METHODS Cytokines(Interleukin(IL)1-Beta,IL-2,IL-5 and IL-8)were measured using ELISAin biopsy samples of normal looking colonicmucosa of first degree relatives of Crohn’sdisease patients(n = 9)and from normalcontrols(n = 10)with no family history ofCrohn’s disease.RESULTS Asymptomatic first degree relativesof patients with Crohn’s disease had significantlyhigher levels of basal intestinal mucosalcytokines(IL-2,IL-5 and IL-8)than normalcontrols.Whether these increased cytokinelevels serve as phenotypic markers for a geneticpredisposition to developing Crohns diseaselater on,or whether they indicate early(pre-clinical)damage has yet to be further defined.CONCLUSION Asymptomatic first degreerelatives of Crohn’s disease patients have higherlevels of cytokines in their normal-lookingintestinal mucosa compared to normal controls,This supports the hypothesis that increasedcytokines may be a cause or an early event inthe inflammatory cascade of Crohns disease andare not merely a result of the inflammatoryprocess. | Indaram AVK Nandi S Weissman S Lam S Bailey B Blumstein M Greenberg R Bank S | 2000 | World Journal of Gastroenterology2000，6，1： | 8 |
| 3 | Ovarian stimulation and in vitro fertilization in women with mature cystic teratomas显示文摘 | CASPI B WEISSMAN A ZALEL Y | 1998 | Obstet Gynecol1998，92，6： | 1 |
| 4 | Oxidative protein folding in eukaryotes:mechanisms and consequences显示文摘 | Tu B P Weissman J S | 2004 | J Cell Biol2004，164，： | 1 |
| 5 | Solar energy conversion with microalgal sewage treatment ponds显示文摘 | BENEMANN J R KOOPMAN B L WEISSMAN J C | 1977 | Proceedings of Annual Meeting of the American Section of the International Solar Energy Society1977，，： | 1 |
| 6 | Marital dis- putes and treatment outcome in depressed women显示文摘 | Rounsaville B J Weissman MM Prusoff BA | 1979 | Compre- hensive Psychiatry1979，20，： | 1 |
| 7 | The high copper tolerance of Candida albicans is madiated by a P-type ATPase显示文摘 | WEISSMAN Z BERDICEVSKY I CAVARI B Z | 2000 | Proceedings of the National Academy of Sciences2000，97，5： | 1 |
| 8 | Working on a chain:E3s ganging up for ubiquitylation显示文摘 | Metzger M B Weissman A M | 2010 | Nat Cell Biol2010，12，12： | 1 |
| 9 | Molecular identification of candida albicans显示文摘 | Weissman Z Berdicevsky I Cavari B | 1995 | J Med Vet Mycol1995，33，： | 1 |
| 10 | Molecular characterization of QM, a novel gene with properties consistent with tumor suppressor function显示文摘 | Weissman B Stanbridge E Farmer A | 1994 | Cold Spring Harb Symp Quant Biol1994，59，： | 1 |
| 11 | Pigmented vitlonodular synovitis 显示文摘 | Bravo S M Winalski C S Weissman B N | 1996 | Radiol Clin North Am1996，34，2： | 1 |
| 12 | Thermally switchable periodici ties and diffraction from mesoscopically ordered materials 显示文摘 | Weissman J M Sunkara H B Tse A S | 1996 | Science1996，274，： | 1 |
| 13 | Introduction of a normal human chromosome 11 into a Wilms' tumor cell line controls its tumorigenic expression显示文摘 | Weissman B E Saxon P J Pasquale S R | 1987 | Science1987，236，： | 1 |
| 14 | Isolation of a crystalline disaecharide, hyalobiuronic acid from hyaluronic acid显示文摘 | Rapport MM Weissman B LinkerA | 1951 | Nature1951，168，： | 1 |
| 15 | Molecular chaperones and protein quality control显示文摘 | Bukau B Weissman J Horwich A | 2006 | Cell2006，125，3： | 1 |
| 16 | HECT and RING finger families of E3 ubiquitin ligases at a glance显示文摘 | Metzger M B Hristova V A Weissman A M | 2012 | J Cell Sci2012，125，3： | 1 |
| 17 | Hijacking the chromatin remodeling machinery:impact of SWI/SNF perturbations in cancer显示文摘 | Weissman B Knudsen KE | 2009 | Cancer Res2009，69，82： | 1 |
| 18 | Thermally switchable periodicities and diffraction from mesoscopically ordered materials 显示文摘 | Weissman J M Sunkara H B Tse A S | 1996 | Science1996，274，： | 1 |
| 19 | Oxidative protein folding in eukaryotes: mechanisms and consequences 显示文摘 | Tu B P Weissman J S | 2004 | J Cell Biol2004，164，3： | 1 |
| 20 | NG-Nitro- 1 -arginine enhances neuronal death following transient forebrain ischemia in gerbils 显示文摘 | Weissman B A Kadar T Brandeis R | 1992 | Neurosci Lett1992，146，2： | 1 |
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