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| 1 | AMF siRNA treatment of keloid through inhibition signaling pathway of RhoA/ROCK1显示文摘A keloid(KD)is a benign dermal fibrotic tumor.Treatment of KDs is challenging and the recurrence rate is high;thus,there is an unmet need to explore new target sites and new treatment methods.As a tumor-associated cytokine,autocrine motility factor(AMF)can effectively stimulate the random and directional movement of cells.We first found that AMF was overexpressed in keloid fibroblasts(KFs)and the proliferation and migration of KFs were promoted by AMF stimulation.After treatment with Y-27632,RhoA kinase inhibitor,the proliferation and migration capacity of KFs declined significantly,and type I collagen protein,active RhoA and ROCK1 also were downregulated.In addition,a KD transplantation model was established under the skin of nude mice,with KD intramural injection AMF siRNA,we found that the weight of the KD was smaller than in the control group(P<0.05),KD tissue sections stained by HE and Masson showed that fibers became loose and the blood vessels were visibly reduced.In conclusion,AMF siRNA is expected to be a novel strategy to treat KD by inhibiting signaling pathway of RhoA/ROCK1. | Yi Tian Lan Jin Wenhong Zhang Zumeng Ya Yuan Cheng Hongyun Zhao | 2019 | Genes & Diseases2019，6，2： | 4 |
| 2 | Non-suicidal self-injury in Shanghai inner bound middle school students显示文摘Background Non-suicidal self-injury (NSSI) behaviour is very common among adolescents. Its prevalence and behavioural characteristics may vary according to regional and cultural differences. Investigation of NSSI locations and diagnosis of adolescents with NSSI are relatively lacking in China. Aims The study objective was to determine the prevalence and features of NSSI among middle school students in Shanghai. Methods The participants were from grade 6 to 8 selected from three junior schools in Jing’an District. Consenting students completed the Ottawa Self-Injury Inventory to determine the prevalence and characteristics of NSSI. Those who indicated NSSI within the past month were administered the Mini-International Neuropsychiatric Interview for Children and Adolescents to assess for emotional disorders. Result The result shows 510 participants (21.7%;mean age 13.51 (0.97) years old;56.7% female) reported at least one instance of NSSI during the previous 12 months. NSSI was significantly more common in girls than boys (24.9% vs 18.5%;χ^2=14.03, p=0.00). Commonly reported reasons for NSSI were for internal and external emotion regulation (87.9%, 82.3%) and social influence (57.8%). Anxiety disorders were the most common (28.9%) disorder associated with NSSI. Conclusion The rate of NSSI of middle school students in Shanghai inner bound is similar to those reported in North American and European youth. It is essential that school mental health professionals are aware of how to manage NSSI within the school setting. | Fang Zhang Paula F Cloutier Hongmei Yang Wenjing Liu Wenhong Cheng Zeping Xiao | 2019 | General Psychiatry2019，32，4： | 3 |
| 3 | Development of a psychological first-aid model in inpatients with COVID-19 in Wuhan,China显示文摘Background Facing the social panic and substantial shortage of medical resources during the coronavirus disease 2019(COVID-19)outbreak,providing psychological first-aid to inpatients is essential for their rehabilitation and the orderly operating of medical systems.However,the closed-ward environment and extreme shortage of onsite mental health workers have limited the use of traditional face-to-face diagnosis and psychological interventions.Aim To develop a mental health intervention model for inpatients that can be applied during a widespread epidemic,such as COVID-19.Methods In a medical team stationed in Leishenshan Hospital,Wuhan,China,we integrated onsite and online psychological support resources to implement a graded psychological intervention system.The onsite psychiatrist established trust with the patients and classified them into categories according to their symptom severity.While face-to-face evaluation and intervention are critical for effective online support,the online team effectively extended the scope of the'first-aid'to all patients.Conclusion This integrated onsite and online approach was effective and eficient in providing psychological interventions for inpatients during the crisis.Our model provides a realistic scheme for healthcare systems in or after the COVID-19 epidemic and also could be adopted in areas of the world with insufficient mental healthcare resources. | Wenhong Cheng Fang Zhang Yingqi Hua Zhi Yang Jun Liu | 2020 | General Psychiatry2020，33，3： | 3 |
| 4 | Nano-TiO 2 enhances the toxicity of copper in natural water to Daphnia magna显示文摘 | Wenhong Fan Minming Cui Hong Liu Chuan Wang Zhiwei Shi Cheng Tan Xiuping Yang | 2010 | Environmental Pollution2010，，3： | 1 |
| 5 | Role of titanium dioxide nanoparticles in the elevated uptake and retention of cadmium and zinc in Daphnia magna 显示文摘 | TAN Cheng FAN Wenhong WANG Wenxiong | 2011 | Environmental Science and Technology2011，46，1： | 1 |
| 6 | Adolescent anxiety disorders and the developing brain: comparing neuroimaging findings in adolescents and adults显示文摘Adolescence is the peak period for the incidence of anxiety disorders.Recent findings have revealed the immaturity of neural networks underlying emotional regulation in this population.Brain vulnerability to anxiety in adolescence is related to the unsynchronised development of anxiety-relevant brain functional systems.However,our current knowledge on brain deficits in adolescent anxiety is mainly borrowed from studies on adults.Understanding adolescent-specific brain deficits is essential for developing biomarkers and brain-based therapies targeting adolescent anxiety.This article reviews and compares recent neuroimaging literature on anxiety-related brain structural and functional deficits between adolescent and adult populations,and proposes a model highlighting the differences between adolescence and adulthood in anxiety-related brain networks.This model emphasises that in adolescence the emotional control system tends to be hypoactivated,the fear conditioning system is immature,and the reward and stress response systems are hypersensitive.Furthermore,the striatum’s functional links to the amygdala and the prefrontal cortex are strengthened,while the link between the prefrontal cortex and the amygdala is weakened in adolescence.This model helps to explain why adolescents are vulnerable to anxiety disorders and provides insights into potential brain-based approaches to intervene in adolescent anxiety disorders. | Shuqi Xie Xiaochen Zhang Wenhong Cheng Zhi Yang | 2021 | General Psychiatry2021，34，4： | 1 |
| 7 | SARS-CoV-2 helicase NSP13 hijacks the host protein EWSR1 to promote viral replication by enhancing RNA unwinding activity显示文摘Background:Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)emerged in December 2019 and has led to a global coronavirus disease 2019(COVID-19)pandemic.Currently,incomplete understanding of how SARS-CoV-2 arrogates the host cell to establish its life cycle has led to slow progress in the development of effective drugs.Results:In this study,we found that SARS-CoV-2 hijacks the host protein EWSR1(Ewing Sarcoma breakpoint region 1/EWS RNA binding protein 1)to promote the activity of its helicase NSP13 to facilitate viral propagation.NSP13 is highly conserved among coronaviruses and is crucial for virus replication,providing chemical energy to unwind viral RNA replication intermediates.Treatment with different SARS-CoV-2 NSP13 inhibitors in multi-ple cell lines infected with SARS-CoV-2 effectively suppressed SARS-CoV-2 infection.Using affinity-purification mass spectrometry,the RNA binding protein EWSR1 was then identified as a potent host factor that physically associated with NSP13.Furthermore,silencing EWSR1 dramatically reduced virus replication at both viral RNA and protein levels.Mechanistically,EWSR1 was found to bind to the NTPase domain of NSP13 and potentially enhance its dsRNA unwinding ability.Conclusions:Our results pinpoint EWSR1 as a novel host factor for NSP13 that could potentially be used for drug repurposing as a therapeutic target for COVID-19. | Hongxiang Zeng Xiang Gao Gang Xu Shengyuan Zhang Lin Cheng Tongyang Xiao Wenhong Zu Zheng Zhang | 2022 | Infectious Medicine2022，1，1： | 0 |
| 8 | Diagnosis and Treatment Guidelines for Mesenchymal Stem Cell Therapy for Coronavirus Disease 2019(Beijing,2021)显示文摘The coronavirus disease 2019(COVID-19)can be caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,and has led to millions of deaths among more than 100 million infected people around the world according to the declaration from World Health Organization.Dysregulated immune response of both the innate and adaptive immune systems is subsistent on COVID-19 patients,of which the degree are associated with disease severity,lung damage and long term functional disability.Current treatment options have included antiretroviral drugs,anti-inflammatory factors,antibodies,immune checkpoint inhibitors,and convalescent plasma therapy.More recently,mesenchymal stem cell(MSC)therapy has been explored for the management and control of COVID-19,particularly with the aim of preventing or at least mitigating respiratory co-morbidities.Though the safety and efficacy of stem cell therapy have been validated in multiple phase I–III clinical trials,to date,no standardized stem cell preparation,administration dosage or interval,product QA/QC testing,storage,transportation,or disposal protocols have been established.The present paper proposes a systematic methodology that addresses all the foregoing process steps and evaluation criteria for the efficacious and safe administration of MSCs in the treatment of patients infected with COVID-19. | Ruonan Xu Lei Shi Wei-Fen Xie Zhe Xu Fan-Ping Meng Jun-Liang Fu Xin Yuan Lei Huang Ming Shi Yonggang Li Yuanyuan Li Chen Yao Yu Zhang Zhongmin Liu Chenyan Gao Zhaohui Wu Shufang Meng Weidong Han Charlie Xiang Gui-Qiang Wang Taisheng Li Xiaoying Wang Yunxia Sun Zunyou Wu Wenhong Zhang Chunhua Zhao Yu Hu Tao Cheng Yuquan Wei Qi Zhou Fu-Sheng Wang | 2021 | Infectious Diseases & Immunity2021，1，2： | 0 |
| 9 | Outcomes of surgery for epiblepharon accompanied with lower eyelid retraction secondary to buphthalmos in children显示文摘Importance:In cases of epiblepharon with lower eyelid retraction secondary to glaucoma,correcting epiblepharon alone is ineffective.Combined surgery should be performed to obtain satisfactory outcomes.Objective:To investigate outcomes after surgery to correct epiblepharon with lower eyelid retraction secondary to buphthalmos in children.Methods:A retrospective analysis of six eyes in four patients was performed included lower lid retractor recession combined with marginal rotation with tarsal fixation.The margin reflex distance-2,lagophthalmus,resolution of clinical symptoms,and complications were assessed during 6 to 12 months of follow-up.Results:In all cases,epiblepharon and lagophthalmus were corrected,symptoms of photophobia and epiphora were relieved,and the corneal epithelium was repaired.The margin reflex distance-2 decreased and remained normal during the follow-up period,but slightly regressed within 6 months postoperatively.Interpretation:Epiblepharon caused by buphthalmos in children is often associated with lower eyelid retraction.Lower lid retractor recession combined with marginal rotation with tarsal fixation fundamentally solves the problems of high eyelid tension,lower eyelid retraction,and epiblepharon and reduces the recurrence rate. | Wenhong Cao Yuan Wang Li Li Yunwei Fan Wen Liu Cheng Li Tianwei Liang Junyan Zhang Qian Wu | 2021 | Pediatric Investigation2021，5，4： | 0 |
| 10 | Comments on the development of blockchain technology from the perspective of patent analysis显示文摘Blockchain is a new application mode of distributed data storage with point-to-point transmission,consensus mechanism,encryption algorithm and other computer technologies.In particular,blockchain is a kind of chained data structure that combines data blocks in sequence in accordance with time and an unchangeable and unforgeable distributed ledger that is ensured by cryptography.It utilizes distributed node consensus to generate and update data and cryptography to secure data transmission and access(Yang,2017).The characteristics of blockchain include decentralization,openness,independence,security,and anonymity.Blockchain is widely used in trading securities,e-commerce,Internet of Things,social media,file storage,authentication,stock crowdfunding,and many other fields because of its core technologies. | Wenhong LI Chunxiao FU Deli CHENG | 2020 | Frontiers of Engineering Management2020，7，4： | 0 |
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