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| 1 | Recombinant protein subunit vaccine booster following two-dose inactivated vaccines dramatically enhanced anti-RBD responses and neutralizing titers against SARS-CoV-2 and Variants of Concern显示文摘Dear Editor,As of October,2021,SARS-CoV-2 has infected more than 230 million people;promoting roll-out vaccinations could help build herd immunity for the pandemic.However,the waning of antibody in magnitude and decreased protective efficacy in multiple types of vaccines have been reported. | Jingwen Ai Haocheng Zhang Qiran Zhang Yi Zhang Ke Lin Zhangfan Fu Jieyu Song Yuanhan Zhao Mingxiang Fan Hongyu Wang Chao Qiu Yang Zhou Wenhong Zhang | 2022 | Cell Research2022，32，1： | 19 |
| 2 | Simultaneous quantification of several classes of antibiotics in water, sediments, and fish muscles by liquid chromatography-tandem mass spectrometry显示文摘为表面水,沉积,和鱼肌肉里的抗菌素,包括的磺胺, fluoroquinolones, macrolides,四圜素,和 trimethoprim 的不同的班的同时的决心的精确、敏感的方法被开发。在水样品,药被递给 1000 水的 mL 通过与稳固阶段的抽取(SPE ) 提取吸水脂性平衡(HLB ) SPE 子弹。沉积样品是提取溶剂的,由双人脚踏车 SPE (强壮的阴离子交换(萨克斯风管)+ HLB ) 列在后面大扫除。鱼肌肉被 acetonitrile 和柠檬性的缓冲区的混合物提取(80:20, v/v ) 答案,并且由 SPE 清洗了。有监视的多重反应(MRM ) 的液体层析双人脚踏车团 spectrometry (LC-MS/MS ) 察觉被采用确定所有混合物。为刺的水,沉积,和鱼样品里的抗菌素的恢复分别地是 60.2%95.8% , 48.1%105.3% ,和 59.8%103.4% 。方法被用于从达恩奇·莱克,拿的样品中国。它证明检测抗菌素的集中从 quantification (LOQ ) 的限制到 713.6 ng 獵瀭畬 ????? 猯'T ￣慮潮吗?? | Yimei WEI Yuan ZHANG Jian XU Changsheng GUO Lei LI Wenhong FAN | 2014 | Frontiers of Environmental Science & Engineering2014，8，3： | 10 |
| 3 | Application of enriched stable isotope technique to the study of copper bioavailability in Daphnia magna显示文摘The biokinetics of Cu in Daphnia magna, including dissolved uptake, assimilation and efflux, has been determined using a gamma 67 Cu radiotracer methodology. However, this gamma emitting radioisotope is not readily available due to its very short half-life. In the present study, we employed a stable isotope tracer ( 65 Cu) to determine the Cu biokinetics and compared our results to those determined using 67 Cu. The dissolved uptake rate constant of 65 Cu was 3.36 L/(g·day), which is higher than that of 67 Cu (1.32 L/(g·day)). With increasing food concentrations from 2×10 4 to 1×10 5 cells/mL, the Cu assimilation efficiency (AE) decreased from 46% to 11%, compared to a decrease from 27% to 16% when determined using 67 Cu. The efflux of Cu from Daphnia magna was quantified following both dissolved and dietary uptake. The efflux of waterborne Cu was comparable to that of dietborne Cu and the efflux rate constant (0.32-0.52 day 1 ) was higher than that determined by 67 Cu (0.19-0.20 day 1 ). By considering different water properties and handling procedure between the two experiments, we believe that these differences are reasonable. Overall, this study demonstrated that the enriched stable isotope tracer technique is a powerful tool to investigate metal bioavailability and maybe a good alternative to radioactive measurements. | Wenhong Fan Chenguang WU Chunmei Zhao Tao Yu Yuan Zhang | 2011 | Journal of Environmental Sciences2011，23，5： | 6 |
| 4 | Lacrimal sac diverticulum presenting as a lower eyelid mass with a secreting fistula显示文摘 | Zhang Chengyue Wu Qian Yu Jifeng Cui Yanhui Cao Wenhong Fan Yunwei Yu Gang | 2014 | Chinese Medical Journal2014，，18： | 4 |
| 5 | High-performance all-polymer solar cells enabled by a novel low bandgap non-fully conjugated polymer acceptor显示文摘The non-fully conjugated polymer as a new class of acceptor materials has shown some advantages over its small molecular counterpart when used in photoactive layers for all-polymer solar cells(all-PSCs),despite a low power conversion efficiency(PCE)caused by its narrow absorption spectra.Herein,a novel non-fully conjugated polymer acceptor PFY-2TS with a low bandgap of~1.40 eV was developed,via polymerizing a largeπ-fused small molecule acceptor(SMA)building block(namely YBO)with a non-conjugated thioalkyl linkage.Compared with its precursor YBO,PFY-2TS retains a similar low bandgap but a higher LUMO level.Moreover,compared with the structural analog of YBO-based fully conjugated polymer acceptor PFY-DTC,PFY-2TS shows a similar absorption spectrum and electron mobility,but significantly different molecular crystallinity and aggregation properties,which results in optimal blend morphology with a polymer donor PBDB-T and physical processes of the device in all-PSCs.As a result,PFY-2TS-based all-PSCs achieved a PCE of 12.31%with a small energy loss of 0.56 eV enabled by the reduced non-radiative energy loss(0.24 eV),which is better than that of 11.08%for the PFY-DTC-based ones.Our work clearly demonstrated that non-fully conjugated polymers as a new class of acceptor materials are very promising for the development of high-performance all-PSCs. | Qunping Fan Ruijie Ma Tao Liu Jianwei Yu Yiqun Xiao Wenyan Su Guilong Cai Yuxiang Li Wenhong Peng Tao Guo Zhenghui Luo Huiliang Sun Lintao Hou Weiguo Zhu Xinhui Lu Feng Gao Ellen Moons Donghong Yu He Yan Ergang Wang | 2021 | Science China Chemistry2021，64，8： | 3 |
| 6 | Adsorption of sulfonamides on lake sediments显示文摘 | Zhenxing ZHONG Jian XU Yuan ZHANG Lei LI ChangshengGUO Yan HE Wenhong FAN Beiping ZHANG | 2013 | Frontiers of Environmental Science & Engineering2013，7，4： | 2 |
| 7 | Sediment geochemical controls on Cd, Cr,and Zn assimilation by the clam ruditapes philippinarum 显示文摘 | FAN Wenhong WANG Wenxiong | 2001 | Environmental Toxicology and Chemistry2001，20，10： | 1 |
| 8 | Nano-TiO 2 enhances the toxicity of copper in natural water to Daphnia magna显示文摘 | Wenhong Fan Minming Cui Hong Liu Chuan Wang Zhiwei Shi Cheng Tan Xiuping Yang | 2010 | Environmental Pollution2010，，3： | 1 |
| 9 | The cloning and preliminarily functional analysis of the human neurotrimin gene显示文摘Proteins of the immunoglobulin superfamily (IgSF) are involved in a variety of spe- cific cell-cell interactions in the developing nervous system. To identify and characterize new members of this protein family in human nervous system, we screen the human fetal brain cDNA library and isolate a full-length cDNA clone which contains a 1032 bp open reading frame en- coding a protein of 344 amino acids. Sequence analysis reveals that it is a glycoprotein com- prised of three C2-1ike immunoglobulin domains and is anchored to the plasma membrane via a post-translationally attached glycosyl-phosphatidylinositol (GPI) moiety. The protein shows high sequence similarity to the rat Ntm (97%), so we term it human neurotrimin (NTM). Northern blot analysis reveals that (HUMAN)NTM has three different transcripts with the length of 3.2 kb, 4.0 kb and 9.0 kb respectively. It has a wider expression pattern than that of (RAT) Ntm. Notably, the expression of NTM in fetal brain is higher than that in mature brain and is stronger in nervous tumors than that in normal brain tissues. We insert an HA epitope tag between the third Ig-like domain of NTM and the site of GPI attachment, then construct it into the eukaryotic expression vector pcDNA3.1+/Zeocin. The pcDNA3.1-HA-NTM is transfected into the Chinese Hamster Ovary (CHO) cells. The results demonstrate that HA-NTM is expressed on the surface of CHO cells and could strengthen the aggregation of CHO-NTM cells. | LIU Jin, LI Guangtao, PENG Xiaozhong, LIU Bingyan, YIN Bin, TAN Xinyu, FAN Ming, FAN Wenhong, QIANG Boqin & YUAN Jiangang National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, National Human Genome North Center, Beijing 100005, China Department of Neuro- biology, Institute of Basic Medical Science, 27 Taiping Road, Beijing 100850, China | 2004 | Science China(Life Sciences)2004，47，2： | 1 |
| 10 | Role of titanium dioxide nanoparticles in the elevated uptake and retention of cadmium and zinc in Daphnia magna 显示文摘 | TAN Cheng FAN Wenhong WANG Wenxiong | 2011 | Environmental Science and Technology2011，46，1： | 1 |
| 11 | Cu, Ni, and Pb speciation in surface sediments from a contaminated bay of northern China显示文摘 | Wenhong Fan Wen-Xiong Wang Jingsheng Chen Xiangdong Li Yu-Fong Yen | 2002 | Marine Pollution Bulletin2002，，8： | 1 |
| 12 | Nano-TiO2 enhances the toxicity of copper in natural water to Daphnia magna 显示文摘 | FAN Wenhong CUI minming LIU Hong | 2011 | Environmental Pollution2011，159，3： | 1 |
| 13 | Cu, Ni, and Pb speciation in surface sediments from a contaminated bay of northern China显示文摘 | FAN Wenhong WANG Wenxiong CHEN Jingsheng | 2002 | Marine PollutionBulletin2002，44，8： | 1 |
| 14 | Bioavailability of sedimentary metals from a contaminated bay显示文摘 | WANG Wenxiong YAN Qilun FAN Wenhong | 2002 | Marine Ecology Progress Series2002，240，： | 1 |
| 15 | Dispersion and Stabilization of Photocatalytic TiO<sub> 2 </sub> Nanoparticles in Aqueous Suspension for Coatings Applications显示文摘 | Siti Hajar Othman Suraya Abdul Rashid Tinia Idaty Mohd Ghazi Norhafizah Abdullah Wenhong Fan | 2012 | Journal of Nanomaterials2012，，： | 1 |
| 16 | Gene Expression Profiling Identifies Genes Predictive of Oral Squamous Cell Carcinoma 显示文摘 | Chu Chen Eduardo Mendez John Houck Wenhong Fan | 2008 | Cancer Epidemiol Biomarkers2008，17，8： | 1 |
| 17 | Determination and partitioning behavior of perfluoroalkyl carboxylic acids and perfluorooctanesulfonate in water and sediment from Dianchi Lake, China显示文摘 | Yuan Zhang Wei Meng Changsheng Guo Jian Xu Tao Yu Wenhong Fan Lei Li | 2012 | Chemosphere2012，，11： | 1 |
| 18 | Outcomes of surgery for epiblepharon accompanied with lower eyelid retraction secondary to buphthalmos in children显示文摘Importance:In cases of epiblepharon with lower eyelid retraction secondary to glaucoma,correcting epiblepharon alone is ineffective.Combined surgery should be performed to obtain satisfactory outcomes.Objective:To investigate outcomes after surgery to correct epiblepharon with lower eyelid retraction secondary to buphthalmos in children.Methods:A retrospective analysis of six eyes in four patients was performed included lower lid retractor recession combined with marginal rotation with tarsal fixation.The margin reflex distance-2,lagophthalmus,resolution of clinical symptoms,and complications were assessed during 6 to 12 months of follow-up.Results:In all cases,epiblepharon and lagophthalmus were corrected,symptoms of photophobia and epiphora were relieved,and the corneal epithelium was repaired.The margin reflex distance-2 decreased and remained normal during the follow-up period,but slightly regressed within 6 months postoperatively.Interpretation:Epiblepharon caused by buphthalmos in children is often associated with lower eyelid retraction.Lower lid retractor recession combined with marginal rotation with tarsal fixation fundamentally solves the problems of high eyelid tension,lower eyelid retraction,and epiblepharon and reduces the recurrence rate. | Wenhong Cao Yuan Wang Li Li Yunwei Fan Wen Liu Cheng Li Tianwei Liang Junyan Zhang Qian Wu | 2021 | Pediatric Investigation2021，5，4： | 0 |
| 19 | Identification of human genomic DNA from suppressed metastatic phenotype cells of mouse lung adenocarcinoma显示文摘Objectives:To isolate tumor metastaticsuppressing genes or relating human DNA sequencesand to study the molecular biological regulatingmechanism of tumor metastasis. Methods: HumanDNA fragments were amplified by Inter Alu PCRtechnique from normal human genomic DNAtransfected mouse tumor cell clones of which themetastatic phenotype had been suppressed. Thehuman origin of the amplified DNA was furtherconfirmed by PCR in situ hybridization. One | Xueming Ge, Yinglin Lu, Shengfa Fu, Kun Chen, Wenhong Fan, Shuang LiuDepartment of Molecular Pathologv, Beijing Institute of Basic Medical Sciences, Beijing 100850 | 1997 | 中国实验血液学杂志1997，5，3： | 0 |
| 20 | Influence of humic acid on bioavailability of heavy metals in sediments显示文摘 | Wenhong FAN Jun CHEN | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 0 |
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