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| 1 | Epigenetics in the pathogenesis of diabetic nephropathy显示文摘Diabetic nephropathy(DN),which is a common microvascular complication with a high incidence in diabetic patients,greatly increases the mortality of patients.With further study on DN,it is found that epigenetics plays a crucial role in the pathophysiological process of DN.Epigenetics has an important impact on the development of DN through a variety of mechanisms,and promotes the generation and maintenance of metabolic memory,thus ultimately leading to a poor prognosis.In this review we discuss the methylation of DNA,modification of histone,and regulation of non-coding RNA involved in the progress of cell dysfunction,inflammation and fibrosis in the kidney,which ultimately lead to the deterioration of DN. | Xue Li Lihong Lu Wenting Hou Ting Huang Xiangyuan Chen Jie Qi Yanjun Zhao Minmin Zhu | 2022 | Acta Biochimica et Biophysica Sinica2022，54，2： | 6 |
| 2 | A New Congestion-driven Placement Algorithm Based on Cell Inflation显示文摘 | Hou Wenting Yu Hong Hong Xianlong | 2001 | Chinese Journal of Semiconductors2001，22，3： | 1 |
| 3 | FAME: A fast detailed placement algorithm for standard cell layout based on mixed mincut and enumeration 显示文摘 | Yao Bo Hou Wenting Hong Xianlong | 2000 | Chinese Journal of Semiconductors2000，21，8： | 1 |
| 4 | A dual-use probe for nano-metric photoelectric characterization using a confined light field generated by photonic crystals in the cantilever显示文摘We propose a plasmonic atomic force microscopy (AFM) probe, which takes a part of the laser beam for monitoring cantilever deflection as the excitation light source. Photonic crystal cavities are integrated near the cantilever’s free end where the laser spot locates. The transmitted light excites surface plasmon polaritons on the metal-coated tip and induces a confined hot-spot at the tip apex. Numerical simulations demonstrate that the plasmonic probe can couple a tilted, linearly polarized beam efficiently and yield a remarkable local electromagnetic enhancement with the intensity being around 21 times stronger than that of the original probe. For demonstration, we employ the plasmonic probe in electrostatic force microscopy and scanning Kelvin probe microscopy to study the impact of local light field on the photoelectric characteristics of SiO_(2) and Au nanoparticles. Compared with the original probe, obvious differences are observed in the electrostatic force gradients on SiO_(2) nanoparticles and in the surface potentials of Au nanoparticles. The plasmonic probe can enable AFM as a powerful tool for simultaneous optical, mechanical and electrical characterizations. | Yaoping Hou Chengfu Ma Wenting Wang Yuhang Chen | 2021 | Nano Research2021，14，11： | 1 |
| 5 | Split graphs whose half-strong endomorphisms form a monoid显示文摘In this paper,the half-strong,the locally strong and the quasi-strong endomorphisms of a split graph are investigated.Let X be a split graph and let End(X),hEnd(X),lEnd(X) and qEnd(X) be the endomorphism monoid,the set of all half-strong endomorphisms,the set of all locally strong endomorphisms and the set of all quasi-strong endomorphisms of X,respectively.The conditions under which hEnd(X) forms a submonoid of End(X) are given.It is shown that lEnd(X) = qEnd(X) for any split graph X.The conditions under which lEnd(X)(resp.qEnd(X)) forms a submonoid of End(X) are also given.In particular,if hEnd(X) forms a monoid,then lEnd(X)(resp.qEnd(X)) forms a monoid too. | LUO YanFeng ZHANG WenTing QIN YingYing HOU HaiLonga | 2012 | Science China Mathematics2012，55，6： | 1 |
| 6 | GmNMHC5 may promote nodulation via interaction with GmGAI in soybean显示文摘Soybean(Glycine max[L.]Merr.)is a food and oil crop whose growth and yield are influenced by root and nodule development.In the present study,Gm NMHC5 was found to promote the formation of nodules in overexpressing mutants.In contrast,the number of nodules in Gmnmhc5 edited with CRISPR/Cas9 decreased sharply.In 35 S:Gm NMHC5 mutants,expression levels of genes involved in nodulation were significantly up-regulated.Both in vitro and in vivo biochemical analyses showed that Gm NMHC5 directly interacted with Gm GAI(a DELLA protein),and the content of gibberellin 3(GA_(3))in overexpressing mutants was lower than that in the wild type.These results revealed that Gm NMHC5 participates in the classical GA signaling pathway,and may regulate the content of GA_3 to match the optimal concentration required for nodule formation,thereby promoting nodulation by directly interacting with Gm GAI.A model illustrating the mechanism by which Gm NMHC5 promotes soybean nodulation is presented. | Wenting Wang Zhili Wang Wensheng Hou Li Chen Bingjun Jiang Wenya Ma Lijuan Bai Wenwen Song Cailong Xu Tianfu Han Yongjun Feng Cunxiang Wu | 2022 | The Crop Journal2022，10，1： | 0 |
| 7 | Deletion of the first glycosylation site promotes Lassa virus glycoprotein-mediated membrane fusion显示文摘The Lassa virus(LASV)is endemic in West Africa and causes severe hemorrhagic Lassa fever in humans.The glycoprotein complex(GPC)of LASV is highly glycosylation-modified,with 11 N-glycosylation sites.All 11 N-linked glycan chains play critical roles in GPC cleavage,folding,receptor binding,membrane fusion,and immune evasion.In this study,we focused on the first glycosylation site because its deletion mutant(N79Q)results in an unexpected enhanced membrane fusion,whereas it exerts little effect on GPC expression,cleavage,and receptor binding.Meanwhile,the pseudotype virus bearing GPC_(N79Q)was more sensitive to the neutralizing antibody 37.7H and was attenuated in virulence.Exploring the biological functions of the key glycosylation site on LASV GPC will help elucidate the mechanism of LASV infection and provide strategies for the development of attenuated vaccines against LASV infection. | Siqi Dong Wenting Mao Yang Liu Xiaoying Jia Yueli Zhang Minmin Zhou Yuxia Hou Gengfu Xiao Wei Wang | 2023 | Virologica Sinica2023，38，3： | 0 |
| 8 | Investigation on the short-term outcome and prognostic impact of predisposition,and precipitants in inpatients with chronic liver disease from Chinese AcuTe on CHronic LIver FailurE(CATCH-LIFE)cohorts显示文摘Aim:The study aimed to investigate the short-term outcomes of hospitalized patients with chronic liver disease(CLDs)and assess the prognostic impact of predisposition and precipitants,which currently remains unclear.Methods:The study included 3970 hospitalized patients with CLDs from two prospective longitudinal multicenter studies(NCT02457637 and NCT03641872)conducted in highly endemic hepatitis B virus(HBV)areas.Competing risk analysis was used to evaluate the effect of predispositions,including the etiology and severity of CLDs and precipitants;on sequential 28,90,and 365-day liver transplantation(LT)-free mortality.Results:Among all enrolled patients,76.8%of adverse outcomes(including death and LT)within one year occurred within 90 days.Compared with alcoholic etiology,the association of HBV etiology with poorer outcomes was remarkably on the 28th day(hazard ratio[HR],1.81;95%confidence interval[CI],1.07-3.06;p=0.026);however,and dimin-ished or became insignificant at 90 days and 365 days.Cirrhosis increased the adjusted risk for 365-day(HR,1.50;CI,1.13-1.99;p=0.004)LT-free mortality when compared with noncirrhosis.In patients with cirrhosis,prior decompensation(PD)independently increased the adjusted risk of 365-day LT-free mortality by 1.25-fold(p=0.021);however,it did not increase the risk for 90-day mortality.Neither the category nor the number of precipitants influenced the adjusted risk of 28 or 90-day LT-free mortality.Conclusions:The 90-day outcome should be considered a significant endpoint for evaluating the short-term prognosis of hospitalized patients with CLD.Predisposing factors,other than etiology,mainly affected the delayed(365-day)outcome.Timely effective therapy for CLD etiology,especially antiviral treatments for HBV,and post-discharge long-term surveillance monitoring in cirrhotic patients undergoing PD are suggested to enhance disease management and reduce mortality. | Yan Zhang Wenting Tan Xiaobo Wang Xin Zheng Yan Huang Beiling Li Zhongji Meng Yanhang Gao Zhiping Qian Feng Liu Xiaobo Lu Jia Shang Yubao Zheng Weituo Zhang Shan Yin Wenyi Gu Tongyu Wang Jianyi Wei Zixuan Shen Guohong Deng Yi Zhou Yixin Hou Qun Zhang Shue Xiong Jing Liu Liyuan Long Ruochan Chen Jinjun Chen Xiuhua Jiang Sen Luo Yuanyuan Chen Chang Jiang Jinming Zhao Liujuan Ji Xue Mei Jing Li Tao Li Rongjiong Zheng Xinyi Zhou Haotang Ren Yu Shi Hai Li for the CATCH‐LIFE Study Investigators of Chinese(Acute‐on)Chronic Liver Failure(CLIF)Consortium(Ch‐CLIFC) | 2023 | Portal Hypertension & Cirrhosis2023，2，3： | 0 |
| 9 | Propofol protects against high glucose-mediated endothelial injury via inhibition of COX2 and iNOS expressions显示文摘Perioperative hyperglycemia is a common metabolic disorder in the clinic.Hyperglycemia,via upregulation of E74-like ETS transcription factor 3(ELF3),induces cyclooxygenase 2(COX2)and inducible nitric oxide synthase(iNOS)expressions,thus leading to endothelial apoptosis and vascular endothelial injury.Propofol is a widely used anesthetic.In the present study,we explored whether and how propofol protects against high glucose-induced COX2 and iNOS expressions in human umbilical vein endothelial cells(HUVECs).We found that high glucose level decreases cell viability and increases COX2 and iNOS expressions in HUVECs.Our data also indicated that ELF3 overexpression participates in high glucose-mediated cell viability reduction and high glucose-induced COX2 and iNOS expressions.Moreover,propofol treatment improves high glucose-mediated reduction in cell viability and decreases COX2 and iNOS expressions via inhibition of ELF3 expressions.Furthermore,specificity protein 1(SP1)was found to regulate ELF3 expression,thus mediating endothelial injury.Propofol inhibits high glucose-induced SP1 expression.High glucose increases the abundance of SP1 bound to the ELF3 promoter,which can be reversed by propofol treatment.The protective effect of propofol is reversed by SP1 overexpression.In conclusion,propofol downregulates high glucose-induced SP1 expression,thus attenuating high glucose-induced ELF3 expression,inhibiting high glucose-induced COX2 and iNOS expressions,and improving high glucose-mediated cell viability reduction in HUVECs. | Jiayun Shao Juan Ding Lihong Lu Wenting Hou Fei Wang Zhirong Sun Hui Jiang Yanjun Zhao | 2022 | Acta Biochimica et Biophysica Sinica2022，54，4： | 0 |
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