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| 1 | Neuroendocrine and squamous colonic composite carcinoma:Case report with molecular analysis显示文摘Composite colorectal carcinomas are rare. There are amodest number of cases in the medical literature,with even fewer cases describing composite carcinoma with neuroendocrine and squamous components. There areto our knowledge no reports of composite carcinomamolecular alterations. We present a case of composite carcinoma of the splenic flexure in a 33 year-old Cau-casian male to investigate the presence and prognos-tic significance of molecular alterations in rare coloniccarcinoma subtypes. Formalin-fixed paraffin-embedded(FFPE) tissue was hematoxylin and eosin- and mucicar-mine-stained according to protocol,and immuno-stained with cytokeratin(CK) 7,CK20,CDX2,AE1/AE3,chromo-granin-A and synaptophysin. DNA was extracted from FFPE tissues and molecular analyses were performed according to lab-developed methods,followed by capil-lary electrophoresis. Hematoxylin and eosin staining showed admixed neuroendocrine and keratinized squamous cells. Positive nuclear CDX2 expression confirme dintestinal derivation. CK7 and CK20 were negative.Neuroendocrine cells stained positively for synaptophysin and AE1/AE3 and negatively for chromogranin and mucicarmine. Hepatic metastases showed a similar immunohistochemical profile. Molecular analysis revealeda G13D KRAS mutation. BRAF mutational testing wasnegative and microsatellite instability was not detected.The patient had rapid disease progression on chemotherapy and died 60 d after presentation. Although theG13D KRAS mutation normally predicts an intermed iateoutcome,the aggressive tumor behavior suggests other modifying factors in rare types of colonic carcinomas. | Sabrina C Wentz Cindy Vnencak-Jones William V Chopp | 2011 | World Journal of Gastroenterology2011，17，42： | 3 |
| 2 | Lymph node ratio and preoperative CA 19-9 levels predict overall survival and recurrence-free survival in patients with resected pancreatic adenocarcinoma显示文摘AIM:Clinicopathologic factors predicting overall survival (OS) would help identify a subset to benefit from adjuvant therapy. METHODS: One hundred and sixty-nine patients patients from 1984 to 2009 with curative resections for pancreatic adenocarcinoma were included. Tumors were staged by American Joint Committee on Cancer 7th edition criteria. Univariate and multivariable analyses were performed using Kaplan-Meier methodology or Cox proportional hazard models. Log-rank tests were performed. Statistical inferences were assessed by two-sided 5% significance level. RESULTS: Median age was 67.1 (57.2-73.0) years with equal gender distribution. Tumors were in the head (89.3%) or body/tail (10.7%). On univariate analysis, adjuvant therapy, lymph node (LN) ratio, histologic grade, negative margin status, absence of peripancreatic extension, and T stage were associated with improved OS. Adjuvant therapy, LN ratio, histologic grade, number of nodes examined, negative LN status, and absence of peripancreatic extension were associated with improved recurrence-free survival (RFS). On multivariable analysis, LN ratio and carbohydrate antigen (CA) 19-9 levels were associated with OS. LN ratio was associated with RFS. CONCLUSION: The LN ratio and CA 19-9 levels are independent prognostic factors following curative resections of pancreatic cancer. | Sabrina C Wentz Zhi-Guo Zhao Yu Shyr Chan-Juan Shi Kay Washington Nipun B Merchant Fen Xia A Bapsi Chakravarthy | 2012 | World Journal of Gastrointestinal Oncology2012，4，10： | 3 |
| 3 | 母猪断奶—发情间隔天数对下一胎繁殖性能的影响显示文摘本文对巴西一个猪场的15600胎的断奶-发情间隔天数与繁殖成绩的关系进行了母猪统计分析。统计数据包括了母猪断奶-发情间隔天数在21d之内、哺乳天数在13~26d、1~8胎的所有成绩。统计发现,平均断奶-发情间隔天数为4.8d,有6.1%的母猪断奶-发情间隔天数为2d之内。不论初产母猪还是经产母猪,断奶-发情间隔天数在3~5d的母猪返情率最低。在断奶后第二天发情的初产母猪及断奶当天发情的经产母猪返情率最高,分娩率最低。所有母猪,凡断奶-发情间隔天数在0~2d,6~8d,9~12d,13~18d,下一胎的分娩率显著低于(P<0.05)断奶-发情间隔天数为3~5d的母猪。对初产母猪,断奶-发情间隔天数在6~8d,9~12d,下一胎的产仔数最低。对经产母猪,断奶-发情间隔天数由0~2d增加到3~5d,其下一胎的产仔数显著增加,当断奶-发情间隔天数增加到6~8d时,下一胎的产仔数明显降低,但断奶-发情间隔天数在9~21d时又增加。结论:断奶-发情间隔天数在0~2d和6~12d对下一胎繁殖成绩有不利影响。 | E.Poleze M.L.Bernardi W.S.Amaral Filha Ivo Wentz F.P.Bortolozzo 赵克斌 | 2007 | 今日养猪业2007，，1： | 2 |
| 4 | Autocatalytic cleavage within classical swine fever virus NS3 leads to a functional sep- aration of protease and helicase 显示文摘 | Lamp B1 Riedel C Wentz E | 2013 | J Virol2013，87，11： | 1 |
| 5 | The Human Library Sharing the Community with itself显示文摘 | Wentz E | 2012 | Public Libraries2012，51，3： | 1 |
| 6 | The use of clomiphene citrate显示文摘 | Garcia J Jones GS Wentz AC | 1997 | Fertil Steril1997，28，5： | 1 |
| 7 | Dimensions and relations of the dentogingivalJunction in humans显示文摘 | Gargiulo MF Wentz FM Orban B | 1961 | J Periodontol1961，32，3： | 1 |
| 8 | Measurement of oceanic wind vector using satellite microwave radiometers显示文摘 | WENTZ F J | 1992 | IEEE Transactions on Geoscience and Remote Sensing1992，30，5： | 1 |
| 9 | Measurement of Oceanic Wind Vector Using Sal-ellite Microwave Radiometers显示文摘 | Wentz F J | 1992 | IEEE Transactions on Geo-science and Remote Sensing1992，30，5： | 1 |
| 10 | Tomographic Three-dimensional Echocardiographic Determination of Chamber Size and Systolic Function in Patients With Left Ventricular Aneurysm: Comparison to Magnetic Resonance Imaging, Cineventriculography, and Two-dimensional Echocardiography显示文摘 | Thomas Buck Peter Hunold Klaus U. Wentz Wolfgang Tkalec H. Joachim Nesser Raimund Erbel | 1997 | Circulation1997，，12： | 1 |
| 11 | Thermoacoustic loads and fatigue of hypersonic vehicle skin panels显示文摘 | Blevins R D Holehouse I Wentz K R | | 0，，06： | 1 |
| 12 | Dimension and relations of the dentogingival junction in humans显示文摘 | Gargiulo AW Wentz FM Orban B | 1961 | J Periodontol1961，32，： | 1 |
| 13 | Construction of climate-quality atmospheric temperature records from the MSU and AMSU microwave sounders显示文摘 | Mears C A Wentz F J | | 0，，： | 1 |
| 14 | Middle cerebral artery stenoses;Assessment by magnetic resonance angiography and transcranial Doppler ultrasound显示文摘 | Rother J Schwartz A Wentz Ku | 1994 | Cerebrovasc Dis1994，4，4： | 1 |
| 15 | Tomographic three-dimensional echocardiographic with unrestricted selection of chamber size and systolic function in patients with left ventricular aneurysm:comparison to magnetic resonance imaging,cine ventriculography,and two-dimendional echocardiography显示文摘 | Buck T Hunold P Wentz KU | 1997 | Circulation1997，96，7： | 1 |
| 16 | Health-related quality of life of children with mild to moderate chronic kidney disease显示文摘 | Gerson AC Wentz A Abraham AG | | 0，，02： | 1 |
| 17 | Representation and spatial analysis in geographic information systems 显示文摘 | MILLER H J WENTZ E A | 2003 | Annals of the Association of American Geographers2003，93，3： | 1 |
| 18 | Performance and Social Life Perceived by Young Persons With ADHD and Autism: A Chat-Log Analysis显示文摘 | Britt Hedman Ahlstrom Elisabet Wentz | 2015 | Psychology Research2015，5，2： | 1 |
| 19 | Representation and Spatial Analysis in Geographic Information System显示文摘 | and Wentz E A | 2003 | Annals of the Association of American Geographers2003，93，3： | 1 |
| 20 | Biomechanics of larger femoral heads,what they do and don't do 显示文摘 | Crowninshield RD Maloney WJ Wentz DH | 2004 | Clin Orthop Relat Res2004，429，： | 1 |
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