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| 1 | Role of Hox genes in stem cell differentiation显示文摘Hox genes are an evolutionary highly conserved gene family. They determine the anterior-posterior body axis in bilateral organisms and influence the developmental fate of cells. Embryonic stem cells are usually devoidof any Hox gene expression, but these transcription factors are activated in varying spatial and temporal patterns defining the development of various body regions. In the adult body, Hox genes are among others responsible for driving the differentiation of tissue stem cells towards their respective lineages in order to repair and maintain the correct function of tissues and organs. Due to their involvement in the embryonic and adult body, they have been suggested to be useable for improving stem cell differentiations in vitro and in vivo. In many studies Hox genes have been found as driving factors in stem cell differentiation towards adipogenesis, in lineages involved in bone and joint formation, mainly chondrogenesis and osteogenesis, in cardiovascular lineages including endothelial and smooth muscle cell differentiations, and in neurogenesis. As life expectancy is rising, the demand for tissue reconstruction continues to increase. Stem cells have become an increasingly popular choice for creating therapies in regenerative medicine due to their self-renewal and differentiation potential. Especially mesenchymal stem cells are used more and more frequently due to their easy handling and accessibility, combined with a low tumorgenicity and little ethical concerns. This review therefore intends to summarize to date known correlations between natural Hox gene expression patterns in body tissues and during the differentiation of various stem cells towards their respective lineages with a major focus on mesenchymal stem cell differentiations. This overview shall help to understand the complex interactions of Hox genes and differentiation processes all over the body as well as in vitro for further improvement of stem cell treatments in future regenerative medicine approaches. | Anne Seifert David F Werheid Silvana M Knapp Edda Tobiasch | 2015 | World Journal of Stem Cells2015，7，3： | 10 |
| 2 | The influence of self-efficacy, pre-stroke depression and perceived social support on selfreported depressive symptoms during stroke rehabilitation 显示文摘 | Lewin A Iobges M Werheid K | 2013 | Neuropsychol Rehabil2013，23，4： | 1 |
| 3 | Syn- tactic structural parallelisms influence processing of positive stimuli : Evidence from cross-modal ERP priming 显示文摘 | Czerwon B Hohlfeld A Wiese H Werheid K | 2012 | Interna- tional Journal of Psychophysiology2012，，11： | 1 |
| 4 | Priming emotional facial ex-pressions as evidenced by event-related brain potentials显示文摘 | Werheid K AlPay G Jentzsch I | 2005 | Int J Psy-chophysiol2005，55，2： | 1 |
| 5 | Rule learning in a serial reaction time task:an fMRI study on patients with early Parkinson's disease显示文摘 | Werheid K Zysset S Mailer A | 2003 | Brain Res Cogn Brain Res2003，16，2： | 1 |
| 6 | Syntactic comprehension in Parkinson' s disease: investigating early automatic and late integrational processes using event-related brain potentials显示文摘 | Friederici AD Kotz SA Werheid K | 2003 | Neuropsychology2003，17，1： | 1 |
| 7 | The influence of self-efficacy,pre-stroke depression and perceived social support on self-reported depressive symptoms during stroke rehabilitation显示文摘 | Lewin A Jobges M Werheid K | 2013 | Neuropsychol Rehabil2013，23，4： | 1 |
| 8 | Facial attractiveness modulates early and late event related brain potentials显示文摘 | Werheid K Schachta A Sommera W | 2007 | Biological Psychology2007，76，12： | 1 |
| 9 | Facial Attractiveness Modulates Early and Late Event-related Brain Potentials显示文摘 | Werheid K Schacht A Sommer W | 2007 | Biological Psychology2007，76，2： | 1 |
| 10 | Prefrontal cognitive deficits in patients with schizophrenia treated with atypical or conventional antipsychotics 显示文摘 | Muller U Werheid K Hammerstein E | 2005 | eur Psychlatr2005，20，： | 1 |
| 11 | The influence of self-efficacy,pre-stroke depression and perceived social support on self-reported depressive symptoms during stroke rehabilitation显示文摘 | Lewin A Jobges M Werheid K | 2013 | Neuropsychol Rehabil2013，23，4： | 1 |
| 12 | The influence of self - efficacy, prestroke depression and perceived social support on self - reported depressive symptoms during stroke rehabilitation 显示文摘 | Lewin A Jcbges M Werheid K | 2013 | Neuropsychol Rehabil2013，23，4： | 1 |
| 13 | Syntactic structural parallelisms influence processing of positive stimuli: Evidence from cross-modal ERP priming显示文摘 | Beate Czerwon Annette Hohlfeld Heike Wiese Katja Werheid | 2012 | International Journal of Psychophysiology2012，，： | 1 |
| 14 | The influence of self-efficacy, pre-stroke depression and pereeived social support on self-re- ported depressive symptoms during stroke rehabilitation 显示文摘 | Lewin A Jobges M Werheid K | 2013 | Neuropsyehol Rehabil2013，23，4： | 1 |
| 15 | The influence of self-efficacy, pre-stroke depression and perceived social support on self-reported depressive symptoms during stroke rehabilitation显示文摘 | A. Lewin M. J?bges K. Werheid | 2013 | Neuropsychological Rehabilitation2013，，4： | 1 |
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