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| 1 | The microbiota is dispensable for the early stages of peripheral regulatory T cell induction within mesenteric lymph nodes显示文摘Intestinal Foxp3+regulatory T cell(Treg)subsets are crucial players in tolerance to microbiota-derived and food-borne antigens,and compelling evidence suggests that the intestinal microbiota modulates their generation,functional specialization,and maintenance.Selected bacterial species and microbiota-derived metabolites,such as short-chain fatty acids(SCFAs),have been reported to promote Treg homeostasis in the intestinal lamina propria.Furthermore,gut-draining mesenteric lymph nodes(mLNs)are particularly efficient sites for the generation of peripherally induced Tregs(pTregs).Despite this knowledge,the direct role of the microbiota and their metabolites in the early stages of pTreg induction within mLNs is not fully elucidated.Here,using an adoptive transfer-based pTreg induction system,we demonstrate that neither transfer of a dysbiotic microbiota nor dietary SCFA supplementation modulated the pTreg induction capacity of mLNs.Even mice housed under germ-free(GF)conditions displayed equivalent pTreg induction within mLNs.Further molecular characterization of these de novo induced pTregs from mLNs by dissection of their transcriptomes and accessible chromatin regions revealed that the microbiota indeed has a limited impact and does not contribute to the initialization of the Treg-specific epigenetic landscape.Overall,our data suggest that the microbiota is dispensable for the early stages of pTreg induction within mLNs. | Carolin Wiechers Mangge Zou Eric Galvez Michael Beckstette Maria Ebel Till Strowig Jochen Huehn Joern Pezoldt | 2021 | Cellular & Molecular Immunology2021，18，5： | 2 |
| 2 | New concepts of the reinnervated motor unit revealed by vaccine-associated poliomyelitis显示文摘 | Wiechers DO | 1988 | Muscle Nerve1988，11，： | 1 |
| 3 | Hacking Commercial Quantum Cryptography Systems by Tailored Bright Illumination显示文摘 | LYDERSEN L WIECHERS C WITTMANN C | 2010 | Nature Photonics2010，4，： | 1 |
| 4 | A new mechanism of action for skin whitening agents: Binding to the peroxisome pro liferator-activated receptor显示文摘 | Wiechers JW Rawlings AV Garcia C et a l | 2005 | Int J Cosmet Sci2005，27，2： | 1 |
| 5 | Early feeding of fortified breast milk and in-hospital-growth in very pre mature infants: a retrospective cohort analysis显示文摘 | Maas C Wiechers C Bernhard W | 2013 | BMC Pediatr2013，13，1： | 1 |
| 6 | Impact of location of CaCO3 precipitation on the development of intact anaerobic sludge显示文摘 | Van Langerak E.P.A Ramaekers H Wiechers J | | 0，，2： | 1 |
| 7 | New concepts of the reinnervated unit revealed by vaccine-associated poliomyelitis显示文摘 | Wiechers DO | 1988 | Muscle Nerve1988，11，： | 1 |
| 8 | Initial decay of woody fragments in soil is influenced by size, vertical position, nitrogen availability and soil origin显示文摘 | Annemieke Wal Wietse Boer Wiecher Smant Johannes A. Veen | 2007 | Plant and Soil (-)2007，，1： | 1 |
| 9 | Copolymerization of2-Acrylamido-2-methl-1-propanesulfonic acid and 1-Vinylimdazole in inverse miniemulsion显示文摘 | Susann Wiechers Gudrun Schmidt-Naake | 2008 | Macromolecular Reaction Engineering2008，2，2： | 1 |
| 10 | Impact of location of CaCO3 precipitation on the development of intact anaerobic sludge 显示文摘 | Van L Ramaekers H Wiechers J | 2002 | Water Research2002，34，2： | 1 |
| 11 | Single fiber EMG evaluation in denervation and reinnervation显示文摘 | Wiechers D | 1990 | Muscle Nerve1990，13，9： | 1 |
| 12 | An improved syntheses of 4,4-ethylenedio-xycyclohexanone显示文摘 | Forbes C P Wiechers A Woudenberg M | 1978 | South African Tydskr Chem1978，31，3： | 1 |
| 13 | Witnessing Effec rive Entanglement over a 2km Fiber Channel显示文摘 | Wittmann C Furst J Wiechers C | 2010 | Optics Ex press2010，18，5： | 1 |
| 14 | Impact of location of CaCO3 precipitation on the development of intact anaerobic sludge显示文摘 | Van Langerak E P A Ramaekers H Wiechers J | 2000 | Wat Res2000，34，2： | 1 |
| 15 | PrPc capping in T cells promotes its association with the lipid raft proteins reggie-1 and reggie-2 and leads to signal transduetion显示文摘 | Stuermer C A Langhorst M F Wiechers M F | 2004 | FASEB J2004，18，14： | 1 |
| 16 | Water distribution and related morphology in human stratum comeum at different hydration levels 显示文摘 | Bouwstra J A De Graaff A Gooris G S Nijsse J Wiechers J W Van Aelst A C | 2003 | J Invest Dermato2003，，120： | 1 |
| 17 | Efficacy studies using octadecenedioic acid, a new nature - derived ingredient to even Asian skin tone 显示文摘 | Wiechers J W Groenhof F J Wortel V A L Hindle N A Miller R M | 2002 | SOFW2002，128，9： | 1 |
| 18 | Octadecenedioic Acid for a more even skin tone 显示文摘 | Wiechers J W Groenhof F J Wortel V A L Miller M Hindle N A Drewitt- Barlow A | 2002 | Cosmetics & Toiletries2002，117，7： | 1 |
| 19 | Calcium Carbonate Crystallization Kinetics 显示文摘 | H N S Wiechers P Sturrock | 1975 | Water Research1975，9，： | 1 |
| 20 | Hac- king Commercial Quantum Cryptography Systems by Tai- lored Bright Illumination 显示文摘 | LYDERSEN L WIECHERS C WITrMANN C | 2010 | Nature Photonics2010，，4： | 1 |
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