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| 1 | Clinical use of bone-targeting radiopharmaceuticals with focus on alpha-emitters显示文摘Various single or multi-modality therapeutic options are available to treat pain of bone metastasis in patients with prostate cancer.Different radionuclides that emitβ-rays such as 153Samarium and 89Strontium and achieve palliation are commercially available.In contrast toβ-emitters,223Radium as a a-emitter has a short path-length.The advantage of the a-emitter is thus a highly localized biological effect that is caused by radiation induced DNA double-strand breaks and subsequent cell killing and/or limited effectiveness of cellular repair mechanisms.Due to the limited range of the a-particles the bone surface to red bone marrow dose ratio is also lower for 223Radium which is expressed in a lower myelotoxicity.The a emitter 223Radium dichloride is the first radiopharmaceutical that significantly prolongslife in castrate resistant prostate cancer patients with wide-spread bone metastatic disease.In a phaseⅢ,randomized,double-blind,placebo-controlled study 921patients with castration-resistant prostate cancer and bone metastases were randomly assigned.The analysis confirmed the 223Radium survival benefit compared to the placebo(median,14.9 mo vs 11.3 mo;P<0.001).In addition,the treatment results in pain palliation and thus,improved quality of life and a delay of skeletal related events.At the same time the toxicity profile of223Radium was favourable.Since May 2013,223Radium dichloride(Xofigo?)is approved by the US Food and Drug Administration. | Hinrich A Wieder Michael Lassmann Martin S Allen-Auerbach Johannes Czernin Ken Herrmann | 2014 | World Journal of Radiology2014，6，7： | 4 |
| 2 | Paclitaxel-induced apoptosis in BJAB cells proceeds via a death receptor-independent,caspases-3 /-8-driven mitochondrial amplification loop显示文摘 | von Haefen C Wieder T Essmann F | 2003 | Oncogene2003，22，15： | 1 |
| 3 | Overexpression of caspase-3 restores sensitivity for drug-induced apoptosis in breast cancer cell lines with acquired drug resistance显示文摘 | Friedrich K Wieder T Von HC | | 0，，22： | 1 |
| 4 | photo-electronic properties of InAsSb films显示文摘 | WIEDER H H CLAWSON A R | 1973 | Thin Solid Films1973，15，： | 1 |
| 5 | Positron emission tomography as a tool for translational research in oncology显示文摘 | Stahl A Wieder H Piert M | 2004 | Mol Imaging Biol2004，6，4： | 1 |
| 6 | Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3显示文摘 | Wieder T Essmann F Prokop A | 2001 | Blood2001，97，5： | 1 |
| 7 | Relapse in childhood acute lymphoblastic leukemia is associated with a decrease of the Bax/Bcl-2 ratio and loss of spontaneous caspase-3 processing in vivo显示文摘 | Prokop A Wieder T Sturm I | 2000 | Leukemia2000，14，9： | 1 |
| 8 | GDP dissociation inhibitor D4-GDI(Rho-GDI2), but not the homologous Rho-GDII, is cleaved by caspase-3 during drug-induced apoptosis显示文摘 | Essmann F Wieder T Otto A | 2000 | Biochem J2000，346，3： | 1 |
| 9 | Anesthetic block of the dorsal penile nerve inhibits vibratory-induced ejaculation in men with spinal cord injuries显示文摘 | Brackett NL Lynne CM | 2000 | Urology2000，55，6： | 1 |
| 10 | The kiss of death:promises and failures of death receptors and ligands in cancer therapy显示文摘 | Daniel PT Wieder T Sturm I | 2001 | Leukemia2001，15，7： | 1 |
| 11 | Time course of tumor metabolic activity during chemoradiotherapy of esophageal squamous cell carcinoma and response to treatment 显示文摘 | Wieder H Brucher BL Zimmerman F | 2004 | J Clin Oncol2004，22，5： | 1 |
| 12 | Activated innate immune system in irritable bowel syndrome 显示文摘 | LANGHORST J WIEDER A MICHALSEN A | 2007 | Gut2007，56，9： | 1 |
| 13 | Recent developments of silicon thin film solar cells on glass substrates显示文摘 | Beneking C Rech B Wieder S | 1999 | Thin Solid Films1999，351，： | 1 |
| 14 | The kiss of death : Promise and failures of death receptors and ligands in cancer therapy显示文摘 | Daniel PT Wieder T Sturrn I | 2001 | Leukemia2001，15，7： | 1 |
| 15 | Piceatannol, a hy- droxylated analog of the chemopreventive agent resveratrol, is a potent inducer of apoptosis in the lymphoma cell line B JAB and in primary, leukemic lymphoblasts 显示文摘 | WIEDER T PROKOP A BAGCI B | 2001 | Leukemia2001，15，11： | 1 |
| 16 | Loss of Tlymphocyte clonal dominance in patients with myelodysplastic syndrome responsive to immunosupprcssion显示文摘 | KOCHENDERFER J N KOBAYASHI S WIEDER E D | 2002 | Blood2002，100，10： | 1 |
| 17 | Some properties of polyethylene glycol: phenylalanine ammonia lyase adducts 显示文摘 | Wieder K J Palczuk N C Davis F | 1979 | J Biol Chem1979，254，12： | 1 |
| 18 | Dual FGF-2 and Intergrin α5β1 Signaling Mediate GRAF-Induced RhoA Inactivation in a Model of Breast Cancer Dormancy显示文摘 | Judith Barrios Robert Wieder | 2009 | Cancer Microenvironment2009，，： | 1 |
| 19 | On the strain-free lattice constants in residual stressevaluation by diffxaction显示文摘 | WIEDER T | 2000 | Journal of Structural Geology2000，22，： | 1 |
| 20 | Time course of tumor metabolic activityduring chemoradiotherapy of esophageal squamouscell carcinoma and response to treatment显示文摘 | Wieder HA Brucher BL Zimmermann F | | 0，，05： | 1 |
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