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| 1 | Genotyping-by-sequencing of pear (Pyrus spp.) accessions unravels novel patterns of genetic diversity and selection footprints显示文摘Understanding of genetic diversity and marker-trait relationships in pears(Pyrus spp.)forms an important part of gene conservation and cultivar breeding.Accessions of Asian and European pear species,and interspecific hybrids were planted in a common garden experiment.Genotyping-by-sequencing(GBS)was used to genotype 214 accessions,which were also phenotyped for fruit quality traits.A combination of selection scans and association analyses were used to identify signatures of selection.Patterns of genetic diversity,population structure and introgression were also investigated.About 15000 high-quality SNP markers were identified from the GBS data,of which 25%and 11%harboured private alleles for European and Asian species,respectively.Bayesian clustering analysis suggested negligible gene flow,resulting in highly significant population differentiation(Fst=0.45)between Asian and European pears.Interspecific hybrids displayed an average of 55%and 45%introgression from their Asian and European ancestors,respectively.Phenotypic(firmness,acidity,shape and so on)variation between accessions was significantly associated with genetic differentiation.Allele frequencies at large-effect SNP loci were significantly different between genetic groups,suggesting footprints of directional selection.Selection scan analyses identified over 20 outlier SNP loci with substantial statistical support,likely to be subject to directional selection or closely linked to loci under selection. | Satish Kumar Chris Kirk Cecilia Deng Claudia Wiedow Mareike Knaebel Lester Brewer | 2017 | Horticulture Research2017，4，1： | 8 |
| 2 | Human leukocyte elastase induces keratinocyte proliferation by epidermal growth factor receptor activation 显示文摘 | Meyer-Hoffert U Wingertszahn J Wiedow O | 2004 | J Invest Dermatol2004，123，2： | 1 |
| 3 | Genome mapping of an apple scab, a powdery mildew and a woolly apple aphid resistance gene from open-pollinated Mildew Immune Selection显示文摘 | Vincent G. M. Bus Heather C. M. Bassett Deepa Bowatte David Chagné Chandra A. Ranatunga Dulantha Ulluwishewa Claudia Wiedow Susan E. Gardiner | 2010 | Tree Genetics & Genomes2010，，3： | 1 |
| 4 | The trappin gene family:proteins defined by an N-terminal transglutaminase substrate domain and a C-terminal four-disulphide core显示文摘 | Schalkwijk J Wiedow O Hirose S | 1999 | Biochem J1999，340，3： | 1 |
| 5 | Human leukocyte elastase induces keratinoeyte proliferation by epidermal growth factor receptor activation显示文摘 | Meyer-Hoffert U Wingertszahn J Wiedow O | 2004 | J Invest Dermatol2004，123，2： | 1 |
| 6 | Lesional elastase ac- tivity in psoriasis, contact dermatitis, and atopic dermatitis 显示文摘 | Wiedow O Wiese F Streit V | 1992 | J Invest Dermatol1992，99，3： | 1 |
| 7 | The train gene family:proteins defined by an N-terminal transglutaminase substrate domain and a Cterminal four-disulphide core显示文摘 | Schalkwijk J Wiedow O Hirose S | 1999 | Biochem J1999，340，3： | 1 |
| 8 | Induction of Acute Myeloid Leukemia with Idarubicin,Cytarabine and Cladribine显示文摘 | Wiedower E Jamy O Martin MG | 2015 | Anticancer Res2015，35，11： | 1 |
| 9 | Human leukocyte elastase induces keratinocyte proliferation by epidermal growth factor receptor activation显示文摘 | Meyer-Hoffert U Wingertszahn J Wiedow O | 2004 | J Invest Dermatol2004，123，2： | 1 |
| 10 | The trappin gene family:proteins defined by an N-terminal transglutaminase substrate domain and a C-terminal four-disulphide core 显示文摘 | Schalkwijk J Wiedow O Hirose S | 1999 | Biochem J1999，340，3： | 1 |
| 11 | Lesional elastase activity in psoriasis, contact dermatitis, and atopic dermatiris显示文摘 | Wiedow O Wiese F Streit V | 1992 | J Invest Dermatol1992，99，3： | 1 |
| 12 | The trappin gense family:proteins defined by an n terminal transglutaminase substrate domain and a c-Terminal four-disulphide core显示文摘 | Schalkwijk J Wiedow O Hirose S | 1999 | Biolchem J1999，34，3： | 1 |
| 13 | Fine-mapping and validation of the genomic region underpinning pear red skin colour显示文摘Red skin colour is an important target trait in various pear breeding programmes.In this study,the genetic control of red skin colour was investigated in an interspecific population derived using the descendants of the red sport European pear cultivar‘Max Red Bartlett’(MRB)and the red-blushed Chinese pear cultivar‘Huobali’.Approximately 550 seedlings from nine families were phenotyped for red skin over-colour coverage(Ocolcov)and the intensity of red over-colour(Ocolint)on a 0–9 scale,and genotyped using genotyping-by-sequencing.Genome-wide association analyses were conducted using 7500 high-quality single nucleotide polymorphisms(SNPs).Genomic regions on linkage groups(LG)4 and 5 were found to be associated,and the best SNP(S578_25116)on LG4 accounted for~15%of phenotypic variation in Ocolcov and Ocolint.The association of S578_25116 with Ocolcov and Ocolint was successfully validated in a sample of~200 European and Asian pear accessions.The association with red skin at locus S578_25116 was not present in Asian pear accessions,suggesting its close proximity to the MRB’s Cardinal gene.Several putative candidate genes,including MYB transcription factors(PCP027962 and PCP027967),were identified in the quantitative trait locus region on LG4 and await functional validation. | Satish Kumar Chris Kirk Cecilia Hong Deng Claudia Wiedow Mengfan Qin Richard Espley Jun Wu Lester Brewer | 2019 | Horticulture Research2019，6，1： | 1 |
| 14 | Human leukocyte elastase induces keratinocyte proliferation by epidermal growth factor receptor activation 显示文摘 | Meyer-Hoffert U Wingertszahn J Wiedow O | 2004 | J Invest Dermatol2004，123，2： | 1 |
| 15 | The trappin gene family:proteins defined by an N-terminal transglutaminase substrate domain and a C-terminal four-disulphide core显示文摘 | SCHALKWIJK J WIEDOW O HIROSE S | 1999 | Biochem J1999，340，3： | 1 |
| 16 | Neutrophil serine proteases:potential key regulators offcell signalling during inflammation 显示文摘 | Wiedow O Meyer-Hoffert U | 2005 | J Intern Meal2005，257，4： | 1 |
| 17 | Human leukocyte elastase induces keralinocyte proliferation by epidermal growth factor receptor activation 显示文摘 | MHOFFERT U WINGERTSZAHN J WIEDOW O | 2004 | J Invest Dermatol2004，123，2： | 1 |
| 18 | The trappin gene family: proteins defined by an N - terminal transglutaminase substrate domain and a C - terminal four -disulphide core显示文摘 | Schalkwijk J Wiedow O Hirose S | 1999 | Biochem J1999，340，3： | 1 |
| 19 | The trappin gene family: pro- teins defined by an N-terminal transglutaminase substrate domain and a C-terminal four-disulphide core 显示文摘 | Schalkwijk J Wiedow O Hirose S | 1999 | Biochem J1999，340，3： | 1 |
| 20 | The trappin gene family: proteins defined by an N-terminal transglutaminase substrate domain and a C-terminal four-disulphide core 显示文摘 | Schalkwijk J Wiedow O Hirose S | 1999 | Biochem J1999，3403，： | 1 |
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