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| 1 | Optimizing hepatitis C virus treatment through pharmacist interventions: Identification and management of drug-drug interactions显示文摘AIM To quantify drug-drug-interactions(DDIs) encountered in patients prescribed hepatitis C virus(HCV) treatment, the interventions made, and the time spent in this process.METHODS As standard of care, a clinical pharmacist screened for DDIs in patients prescribed direct acting antiviral(DAA) HCV treatment between November 2013 and July 2015 at the University of Colorado Hepatology Clinic. HCV regimens prescribed included ledipasvir/sofosbuvir(LDV/SOF), paritaprevir/ritonavir/ombitasvir/dasabuvir(OBV/PTV/r + DSV), simeprevir/sofosbuvir (SIM/SOF), and sofosbuvir/ribavirin (SOF/RBV). This retrospective analysis reviewed the work completed by the clinical pharmacist in order to measure the aims identified for the study. The number and type of DDIs identified were summarized with descriptive statistics.RESULTS Six hundred and sixty four patients(83.4% Caucasian, 57% male, average 56.7 years old) were identified; 369 for LDV/SOF, 48 for OBV/PTV/r + DSV, 114 for SIM/SOF, and 133 for SOF/RBV. Fifty-one point five per cent of patients were cirrhotic. Overall, 5217 medications were reviewed (7.86 medications per patient) and 781 interactions identified (1.18 interactions per patient). The number of interactions were fewest for SOF/RBV (0.17 interactions per patient) and highest for OBV/PTV/r + DSV (2.48 interactions per patient). LDV/SOF and SIM/SOF had similar number of interactions (1.28 and 1.48 interactions per patient, respectively). Gastric acid modifiers and vitamin/herbal supplements commonly caused interactions with LDV/SOF. Hypertensive agents, analgesics, and psychiatric medications frequently caused interactions with OBV/PTV/r + DSV and SIM/SOF. To manage these interactions, the pharmacists most often recommended discontinuing the medication (28.9%), increasing monitoring for toxicities (24.1%), or separating administration times (18.2%). The pharmacist chart review for each patient usually took approximately 30 min, with additional time for more complex patients. CONCLUSION DDIs are common with HCV medications and management can require medication adjustments and increased monitoring. An interdisciplinary team including a clinical pharmacist can optimize patient care. | Jacob A Langness Matthew Nguyen Amanda Wieland Gregory T Everson Jennifer J Kiser | 2017 | World Journal of Gastroenterology2017，23，9： | 5 |
| 2 | Pathogenesis of hepatitis B virus infection显示文摘 | F.V. Chisari M. Isogawa S.F. Wieland | 2009 | Pathologie Biologie2009，，4： | 4 |
| 3 | 土耳其德里内尔拱坝在最大可信地震下的动力稳定性分析显示文摘本文讨论了位于土耳其东北部克鲁赫河上正在建设中的高250m德里内尔拱坝。该拱坝建基面开挖施工已于2005年完成,大坝混凝土已经开始浇筑,预计将于2010年完成大坝混凝土浇筑。建成后,该坝混凝土总方量为330万m3,将是土耳其最高的拱坝,也是世界上最高的拱坝之一。本文详细讨论了大坝的抗震设计。重现期为10000年的安全评估地震的峰值加速度为0.35g。在该地震作用下,坝体中上部将出现沿水平施工缝的裂缝,带有键槽的灌浆横缝也将张开。于是,大坝顶部由于开裂而形成的混凝土坝块可能向水库方向发生位移,本文研究了该混凝土坝块可能出现的最大位移和转动位移。 | Martin Wieland Sujan Malla Roland Ruoss | 2006 | 水利学报2006，37，12： | 2 |
| 4 | Radioembolization of Symptomatic, Unresectable Neuroendocrine Hepatic Metastases Using Yttrium-90 Microspheres显示文摘 | Philipp M. Paprottka Ralf-T. Hoffmann Alexander Haug Wieland H. Sommer Franziska Rae?ler Christoph G. Trumm Gerwin P. Schmidt Nima Ashoori Maximilian F. Reiser Tobias F. Jakobs | 2012 | CardioVascular and Interventional Radiology2012，，2： | 2 |
| 5 | Thermoelectric properties of silicon and recycled silicon sawing waste显示文摘Large-scale-applicable thermoelectric materials should be both self-sustaining,in order to survive longterm duty cycles,and nonpolluting.Among all classes of known thermoelectric materials,these criteria reduce the available candidate pool,leaving silicon as one of the remaining options.Here we first review the thermoelectric properties of various silicon-related materials with respect to their morphologies and microstructures.We then report the thermoelectric properties of silicon sawing wastes recycled from silicon wafer manufacturing.We obtain a high power factor of~32 mWcm1 K2 at 1273 K with 6%phosphorus substitution in the Si crystal,a value comparable to that of phosphorus-doped silicongermanium alloys.Our work suggests the large-scale thermoelectric applicability of recycled silicon that would otherwise contribute to the millions of tons of industrial waste produced by the semiconductor industry. | Ran He Wieland Heyn Felix Thiel Nicolas Perez Christine Damm Darius Pohl Bernd Rellinghaus Christian Reimann Maximilian Beier Jochen Friedrich Hangtian Zhu Zhifeng Ren Kornelius Nielsch Gabi Schierning | 2019 | Journal of Materiomics2019，5，1： | 2 |
| 6 | 混凝土及土石坝工程寿命与大坝安全工程经济效益(英文)显示文摘大坝安全与大坝结构的物理状态密切相关,而大坝的物理状态取决于维护及加固工程。在一定程度上,维修维护工程控制了大坝结构的使用年限。大坝安全措施带来的效益很大程度上取决于维护、监测及管理工程的投资。第一部分讨论了诸如老化、维护、缺陷的影响,以及可能使用年限内对混凝土和土石坝及其基础的设计要求;第二部分评价了有关大坝安全设计与安全措施的投资效益,如维护、监测及管理。结果表明,投资效益不直接源于货币收入,而是体现在良好的安全运行、原建筑物的投资保护、避免溃坝带来的经济损失等方面,同时提高了公众意识,降低了下游地区的风险。 | Martin Wieland R.Peter Brenner | 2008 | 岩土工程学报2008，30，11： | 2 |
| 7 | Neutal Carrier Based Ion-Selective Electrode for the Determination of Total Calcium in Blood Serum显示文摘 | Anker P Wieland E Ammann D | 1981 | J anal Chem1981，53，13： | 2 |
| 8 | High-resolution ex vivo analysis of the degradation and osseointegration of Mg-xGd implant screws in 3D显示文摘Biodegradable magnesium(Mg)alloys can revolutionize osteosynthesis,because they have mechanical properties similar to those of the bone,and degrade over time,avoiding the need of removal surgery.However,they are not yet routinely applied because their degradation behavior is not fully understood.In this study we have investigated and quantified the degradation and osseointegration behavior of two biodegradable Mg alloys based on gadolinium(Gd)at high resolution.Mg-5Gd and Mg-10Gd screws were inserted in rat tibia for 4,8 and 12 weeks.Afterward,the degradation rate and degradation homogeneity,as well as bone-to-implant interface,were studied with synchrotron radiation micro computed tomography and histology.Titanium(Ti)and polyether ether ketone(PEEK)were used as controls material to evaluate osseointegration.Our results showed that Mg-5Gd degraded faster and less homogeneously than Mg-10Gd.Both alloys gradually form a stable degradation layer at the interface and were surrounded by new bone tissue.The results were correlated to in vitro data obtained from the same material and shape.The average bone-to-implant contact of the Mg-xGd implants was comparable to that of Ti and higher than for PEEK.The results suggest that both Mg-xGd alloys are suitable as materials for bone implants. | Diana Krüger Silvia Galli Berit Zeller-Plumhoff D.C.Florian Wieland Niccolo Peruzzi Bjorn Wiese Philipp Heuser Julian Moosmann Ann Wennerberg Regine Willumeit-Romer | 2022 | Bioactive Materials2022，7，7： | 2 |
| 9 | CD8(+) T Cells Mediate Viral Clearance and Disease Pathogenesis during Acute Hepatitis B Virus Infection显示文摘 | Thimme R Wieland S Steiger C | 2003 | J Virol2003，77，1： | 2 |
| 10 | Weighing the options in the pharmacotherapy of obesity 显示文摘 | Wieland H A Hamilton B S | 2001 | Int J Clin Pharmacol Therapeut2001，39，9： | 2 |
| 11 | Safety Aspects of Sustainable Storage Dams and Earthquake Safety of Existing Dams显示文摘近年来,风险分析技术日渐成为大坝安全管理的有效工具。本文系统总结了由国际大坝委员会大坝分析和设计计算专家委员会主办的基准研讨会中与大坝风险分析主题相关的三方面研究成果。2011年,基准研讨会讨论了估算重力坝滑动破坏模式下的溃坝概率等问题;2013年,会议讨论了大坝风险分析中后果评估在计算方面所面临的挑战;2015年,会议对土石坝滑动和漫顶破坏的概率进行了分析。从这三次会议关于大坝风险分析数值计算的研究进展可以发现,对于大坝系统的风险分析,包括下游后果评价以及结构模型的不确定性,风险分析方法都是非常有用的工具。 | Martin Wieland | 2016 | Engineering2016，2，3： | 2 |
| 12 | Direct and indirect effects of microstructured titanium substrates on the induction of mesenchymal stem cell differentiation towards the osteoblast lineage显示文摘 | Rene Olivares-Navarrete Sharon L. Hyzy Daphne L. Hutton Christopher P. Erdman Marco Wieland Barbara D. Boyan Zvi Schwartz | 2010 | Biomaterials2010，，10： | 2 |
| 13 | Infrequent genetic alterations of the tumor suppressor gene PTEN/MMAC1 in squamous cell carcinoma of the oral cavity显示文摘 | Mavros A Hahn M Wieland I | 2002 | J Oral Pathol Med2002，31，5： | 1 |
| 14 | Non-viral vector delivery from PEG-hyaluronic acid hydrogels 显示文摘 | Wieland J A Houchin-Ray T L Shea L D | 2007 | J Control Release2007，120，3： | 1 |
| 15 | Interleukin-18 inhibits hepatitis B virus replication in the livers of transgenic mice显示文摘 | Kimura K Kakimi K Wieland S | 2002 | J Virol2002，76，10： | 1 |
| 16 | Adrenomedullin me-diates vasodilation via CGRP receptors显示文摘 | Doods HN Wieland HA | 1994 | Life Sci1994，56，1： | 1 |
| 17 | Expression profile and function of triggering receptor expressed on myeloid cells-1 during melioidosis显示文摘 | Wiersinga WJ Veer CT Wieland CW | 2007 | J Infect Dis2007，196，11： | 1 |
| 18 | Plasmacytoid dendriticcells sense hepatitis C virus-infected cells,produce interferon,andinhibit infection显示文摘 | Takahashi K Asabe S Wieland S | 2010 | Proc Natl Acad Sci USA2010，107，16： | 1 |
| 19 | Anxiolytic and anticonvulsant activity of a synthetic neuroactive steroid Co-3-0593 显示文摘 | Wieland S | 1997 | Psychopharmacology1997，134，1： | 1 |
| 20 | Cell cycle-dependent coupling of the vasopressin V1a receptor to different G proteins显示文摘 | Abel A Wittau N Wieland T | 2000 | Biol Chem2000，275，2： | 1 |
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