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| 1 | Update on pathogenesis and predictors of response of therapeutic strategies used in inflammatory bowel disease显示文摘The search for biomarkers that characterize specific aspects of inflammatory bowel disease(IBD), has received substantial interest in the past years and is moving forward rapidly with the help of modern technologies. Nevertheless, there is a direct demand to identify adequate biomarkers for predicting and evaluating therapeutic response to different therapies. In this subset, pharmacogenetics deserves more attention as part of the endeavor to provide personalized medicine. The ultimate goal in this area is the adjustment of medication for a patient's specific genetic background and thereby to improve drug efficacy and safety rates. The aim of the following review is to utilize the latest knowledge on immunopathogenesis of IBD and update the findings on the field of Immunology and Genetics, to evaluate the response to the different therapies. In the present article, more than 400 publications were reviewed but finally 287 included based on design, reproducibility(or expectancy to be reproducible and translationable into humans) or already measured in humans. A few testshave shown clinical applicability. Other, i.e., genetic associations for the different therapies in IBD have not yet shown consistent or robust results. In the close future it is anticipated that this, cellular and genetic material, as well as the determination of biomarkers will be implemented in an integrated molecular diagnostic and prognostic approach to manage IBD patients. | Emilio G Quetglas Zlatan Mujagic Simone Wigge Daniel Keszthelyi Sebastian Wachten Ad Masclee Walter Reinisch | 2015 | World Journal of Gastroenterology2015，21，44： | 3 |
| 2 | Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing显示文摘The impact of the microenvironment on innate lymphoid cell(ILC)-mediated immunity in humans remains largely unknown.Here we used full-length Smart-seq2 single-cell RNA-sequencing to unravel tissue-specific transcriptional profiles and heterogeneity of CD127+ILCs across four human tissues.Correlation analysis identified gene modules characterizing the migratory properties of tonsil and blood ILCs,and signatures of tissue-residency,activation and modified metabolism in colon and lung ILCs.Trajectory analysis revealed potential differentiation pathways from circulating and tissue-resident naïve ILCs to a spectrum of mature ILC subsets.In the lung we identified both CRTH2+and CRTH2−ILC2 with lung-specific signatures,which could be recapitulated by alarmin-exposure of circulating ILC2.Finally,we describe unique TCR-V(D)J-rearrangement patterns of blood ILC1-like cells,revealing a subset of potentially immature ILCs with TCR-δ rearrangement.Our study provides a useful resource for in-depth understanding of ILC-mediated immunity in humans,with implications for disease. | Luca Mazzurana Paulo Czarnewski Viktor Jonsson Leif Wigge Markus Ringnér Teresa CWilliams Avinash Ravindran Åsa KBjörklund Jesper Säfholm Gunnar Nilsson Sven-Erik Dahlén Ann-Charlotte Orre Mamdoh Al-Ameri Charlotte Höög Charlotte Hedin Sylwester Szczegielniak Sven Almer Jenny Mjösberg | 2021 | Cell Research2021，31，5： | 2 |
| 3 | Attention-deficit hyperactivity disorder and the adrenergic receptors alpha 1C and alpha 2C显示文摘 | Barr CL Wigg K Zai G | 2001 | Mol Psychiatry2001，6，3： | 1 |
| 4 | Desert dune dynamics and evaluation ofshear velocity: an integrated approach显示文摘 | Wiggs G F S | 1993 | GeologicalSociety1993，72，1： | 1 |
| 5 | The role of streamline curvature in sand dune dynamics:Evidence from field and wind tunnel measurements显示文摘 | Wiggs G F S Livingstone I Warren A | 1996 | Geomorphology1996，17，： | 1 |
| 6 | Desert dune processes and dynamics显示文摘 | Wiggs G F S | 2001 | Progressin Physical Geography2001，25，1： | 1 |
| 7 | Using gravestones to assess changing rates of weathering in the United Kingdom显示文摘 | COOKE R U INKPEN R J WIGGS G F S | 1995 | Earth Surface Processes and Landforms1995，20，6： | 1 |
| 8 | Using gravestones to assess changing rates of weathering in the United Kingdom显示文摘 | Cooke R U Inkpen R J Wiggs G F S | 1995 | Earth Surface Processes and Landforms1995，20，6： | 1 |
| 9 | Sleep Patterns and Sleep Disorders in Children with Autistic Spectrum Disorders: Insights U- sing Parent Report and Cctigraphy 显示文摘 | WIGGS L STORES G | 2004 | Developmental Medicine : Child Neurology2004，46，6： | 1 |
| 10 | The dynamic effects of moisture on the entrainment and transport of sand by wind 显示文摘 | Wiggs G F S Bullard J E Atherton R J | 2004 | Geomorphology2004，59，14： | 1 |
| 11 | The role of streamline curvature in sand dune dynamics:evidence from field and wind tunnel measurements显示文摘 | Wiggs G F S Livingstone I Warren A | 1996 | Geomorphology1996，17，： | 1 |
| 12 | Numerical modelling of airflow over an idealised transverse dune 显示文摘 | PARSONS D R WIGGS G F S | 2004 | Envi- ronmental Modelling & Software2004，19，： | 1 |
| 13 | Experimental study of wind directional variability in the vicinity of a model valley显示文摘 | Bullard J E Wiggs G Nash D J | 2000 | Geo- morphology2000，35，1： | 1 |
| 14 | Dune mobility and vegetation cover in the southwest Kalahari Desert显示文摘 | Wiggs G F S Thomas D S J Bullard J E | 1995 | Earth Surface Processes and Landforms1995，20，6： | 1 |
| 15 | Sleep disorders and their relationship to psychological disturbances in children with epilepsy 显示文摘 | Wiggs L Campling G | 1998 | Child Care Health Dev1998，24，1： | 1 |
| 16 | Support for EKN1 as the susceptibility locus for dyslexia on 15q21 显示文摘 | WIGG K G COUTO J M FENG Y | 2004 | Mol Psychiatr2004，9，： | 1 |
| 17 | Dune mobility and vegetation cover in the southwest Kalahari Desert 显示文摘 | Wiggs G F S Thomas D S J Bullard J E | 1995 | Earth Surface Processes and Landforms1995，20，6： | 1 |
| 18 | Air flow and roughness characteristics over partially vegetated linear dunes in the southwest Karahari Desert显示文摘 | Wiggs G F S Livinstone L G Thomas D S | 1996 | Earth Surface Processes and Landforms1996，21，1： | 1 |
| 19 | Geomorphology of desert sand dunes:a review of recent progress显示文摘 | LIVINGSTONE I WIGGS G F S WEAVER C M | 2007 | Earth-Science Reviews2007，80，34： | 1 |
| 20 | The psychosocial problerms of chil-dren with narcolepsy and those with excessive daytimes sleepiness ofuncertain origin显示文摘 | Store G Montgomery P Wiggs L | 2006 | Pediatrics2006，118，4： | 1 |
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