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| 1 | Inflammation, oxidative stress and renin angiotensin system in atherosclerosis显示文摘Atherosclerosis is a chronic inflammatory disease associated with cardiovascular dysfunction including myocardial infarction, unstable angina, sudden cardiac death, stroke and peripheral thromboses. It has been predicted that atherosclerosis will be the primary cause of death in the world by 2020. Atherogenesis is initiated by endothelial injury due to oxidative stress associated with cardiovascular risk factors including diabetes mellitus, hypertension, cigarette smoking, dyslipidemia, obesity, and metabolic syndrome. The impairment of the endothelium associated with cardiovascular risk factors creates an imbalance between vasodilating and vasoconstricting factors, in particular, an increase in angiotensin Ⅱ(Ang Ⅱ) and a decrease in nitric oxide. The renin-angiotensin system(RAS), and its primary mediator Ang Ⅱ, also have a direct influence on the progression of the atherosclerotic process via effects on endothelial function, inflammation, fibrinolytic balance, and plaque stability. Anti-inflammatory agents [statins, secretory phospholipase A2 inhibitor, lipoprotein-associated phospholipase A2 inhibitor, 5-lipoxygenase activating protein, chemokine motif ligand-2, C-C chemokine motif receptor 2 pathway inhibitors, methotrexate, IL-1 pathway inhibitor and RAS inhibitors(angiotensin-converting enzyme inhibitors)], Ang Ⅱ receptor blockers and ranin inhibitors may slow inflammatory processes and disease progression. Several studies in human using anti-inflammatory agents and RAS inhibitors revealed vascular benefits and reduced progression of coronary atherosclerosis in patients with stable angina pectoris; decreased vascular inflammatory markers, improved common carotid intima-media thickness and plaque volume in patients with diagnosed atherosclerosis. Recent preclinical studies have demonstrated therapeutic efficacy of vitamin D analogs paricalcitol in Apo E-deficient atherosclerotic mice. | Kazim Husain Wilfredo Hernandez Rais A Ansari Leon Ferder | 2015 | World Journal of Biological Chemistry2015，6，3： | 84 |
| 2 | Accumulation of Pb and Zn in Bidens triplinervia and Senecio sp. spontaneous species from mine spoils in Peru and their potential use in phytoremediation显示文摘 | Jaume Bech Paola Duran Núria Roca Wilfredo Poma Isidoro Sánchez Luis Roca-Pérez Rafael Boluda Juan Barceló Charlotte Poschenrieder | 2012 | Journal of Geochemical Exploration2012，，： | 2 |
| 3 | 显示文摘 | Lara Wilfredo C Schweitzer Jeremy | 1998 | Journal of Long-Term Effects of Medical Implants1998，8，1： | 1 |
| 4 | Effect of Al Additions and AlN Inter layers on the Stabilization of c-BN Sputtered Thin Films显示文摘 | O R Wilfredo R Messier L J Pilione | 2004 | Diamond Relat Mater2004，13，9： | 1 |
| 5 | 显示文摘 | Lara Wilfredo C Jeremy S Lewis Rodney P | 1998 | Journal of Long-Term Effects of Medical Implants1998，8，1： | 1 |
| 6 | Neurotrophins elevate cAMP to reach a threshold required to overcome inhibition by MAG through extracellular signal-regulated kinase-dependent inhibition of phosphodiesterase 显示文摘 | Ying G Elena N Wilfredo M | 2003 | J Neurosci2003，23，11： | 1 |
| 7 | Propylene/1-hexene copolymer as a tailor-made poly(propylene) for membrane preparation via the thermally induced phase separation (TIPS) process 显示文摘 | Yave Wilfredo Lloyd Douglas R | 2006 | Macromolecular Mater Eng2006，291，2： | 1 |
| 8 | Gas permeability and free volume in poly(amide-b-ethylene oxide)/polyethylene glycol blend membranes显示文摘 | Wilfredo Yave Anja Car Klaus-Viktor Peinemann Muhammed Q. Shaikh Klaus R?tzke Franz Faupel | 2009 | Journal of Membrane Science2009，，1： | 1 |
| 9 | Pebax ? /polyethylene glycol blend thin film composite membranes for CO 2 separation: Performance with mixed gases显示文摘 | Anja Car Chrtomir Stropnik Wilfredo Yave Klaus-Viktor Peinemann | 2008 | Separation and Purification Technology2008，，1： | 1 |
| 10 | Data analysis using regression models with missing observations and long -memory: an application study 显示文摘 | Pilar Iglesias Hector Jorquera Wilfredo Palma | 2006 | Computational Statistics & Data Analysis2006，，50： | 1 |
| 11 | The interleukin-6 (?174) G/C promoter polymorphism is associated with type-2 diabetes mellitus in Native Americans and Caucasians显示文摘 | Barbora Vozarova José-Manuel Fernández-Real William C. Knowler Lluis Gallart Robert L. Hanson Jonathan D. Gruber Wilfredo Ricart Joan Vendrell Cristóbal Richart P. Antonio Tataranni Johanna K. Wolford | 2003 | Human Genetics2003，，4： | 1 |
| 12 | Hypoglycemic activity of leaf organic extracts from Smallanthus sonchifolius : Constituents of the most active fractions显示文摘 | Susana B. Genta Wilfredo M. Cabrera María I. Mercado Alfredo Grau César A. Catalán Sara S. Sánchez | 2010 | Chemico-Biological Interactions2010，，2： | 1 |
| 13 | Analysis, manufacture and characterization of Ni/Cu functionally graded structures显示文摘 | Wilfredo Montealegre Rubio Glaucio H. Paulino Emilio Carlos Nelli Silva | 2012 | Materials and Design2012，，： | 1 |
| 14 | J Phys Chem B显示文摘 | Wilfredo Ortiz Krueger Brent P Kleiman Valeria D Krause Jeffrey L and Roitberg Adrian E | 2005 | 1092005，，11： | 1 |
| 15 | Enolase as a plasminogen binding protein in Leishmania mexicana显示文摘 | Gilmer Vanegas Wilfredo Qui?ones Cesar Carrasco-López Juan Luis Concepción Fernando Albericio Luisana Avilán | 2007 | Parasitology Research2007，，6： | 1 |
| 16 | Performance and Analysis of Perfluoropolyalkyl Ether Grease Used on Space Shuttle Actuators—A Case Study显示文摘 | Wilfredo Morales KennethW. Street ErwinV. Zaretsky | 2012 | Tribology Transactions2012，，1： | 1 |
| 17 | A Comment on: Ronlands & Carson 'Where Would Formal, Academic Mathematics Stand in a Curriculum Informed by Ethnomathematics? A Critical Review of Ethnomathematics' 显示文摘 | Shehenaz Adam Wilfredo Alangui Bill Barton | 2003 | Educational Studies in Mathematics2003，，52： | 1 |
| 18 | Analysis, manu facture and characterization of Ni/Cu functionally graded structures 显示文摘 | Wilfredo M R Glaueio H P Emilio S | 2012 | Materials & Design2012，41，： | 1 |
| 19 | High molecular weight tau:preferential localization in the peripheral nervous system显示文摘 | Ronald KHL Wilfredo M | 1991 | Journal of Cell Science1991，100，： | 1 |
| 20 | Effect of A1 additions and AIN interlayers on the stabilization of cBN sputtered thin films显示文摘 | Otaoo-Rivera Wilfredo Messier Russell Pilione J Lawrence | 2004 | Diamond & Related Materials2004，13，9： | 1 |
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