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215篇 您的检索式：作者名="Wilhelm P"

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	题名	作者	年代	出处	被引量
1	Disparities of conjugating protective enzyme activities in the colon of patients with adenomas and carcinomas显示文摘AIM:To investigate the metabolic enzymatic capacity of the colon mucosa to detoxify noxious carcinogenic compounds.METHODS:We investigated the activity of 2 conjugating enzymes-the microsomal uridine glucuronosyltransferase(UGT)and the cytosomal glutathione S-transferase(GST)in the uninvolved mucosa of the colon transversum and sigmoideum in patients with adenomatous polyps and colorectal cancer.Biopsies were taken from the mucosa during colonoscopies which were done for clinical(diagnostic)reasons.After storage,the biopsy material was homogenized and after differential centrifugation the enzyme assays were performed with 4-nitrophenol(UGT)and 1-chloro 2,4-dinitrobenzene(GST)as substrates.RESULTS:About 48 patients were included of which28 had adenomas and 20 had colorectal carcinomas confirmed by histopathology.Enzyme activities were expressed as nmol/mg per minute protein for the GST and as pmol/mg per minute protein for the UGT.Analysis of variance(F-test)indicated that both enzymes were more widely distributed in adenoma than in cancer patients.The means±SD were smaller for cancer patients:GST for adenomas 268±152 vs 241±69 for carcinomas and UGT for adenomas 197±200 vs 150±86 for carcinomas.CONCLUSION:Compared to patients with adenomatous colon polyps those with colorectal carcinoma exhibited a lower capacity of detoxifying enzyme metabolism and their activities clustered over a smaller range.	Harald P Hoensch Hennie MJ Roelofs Lutz Edler Wilhelm Kirch Wilbert HM Peters	2013	World Journal of Gastroenterology2013，19，36：	3
2	The Role of Organic Matter During Metal Enrichment in Permian Kupferschiefer of the Rudna Mine,Southwest Poland显示文摘The bulk composition of organic matter and saturated and aromatic hydrocarbons extracted from 16 samples collected from two Kupferschiefer profiles in the Rudna mine, Southwest Poland has been analyzed to study the role of organic matter during base metal enrichment in the Kupferschiefer shale. The results indicated that the extract yields and saturated hydrocarbon yields decreased with increasing base metal contents. GC and GC/MS analyses indicated that n-alkanes and alkylated aromatic compounds were depleted and may have served as hydrogen donators for thermochemical sulfate reduction. The enrichment of base metals is closely connected with the destruction of hydrocarbons.	孙玉壮 WILHELM PüTTMANN	2003	Chinese Journal Of Geochemistry2003，22，1：	2
3	Duration of opioid antagonism by nalmefene and nalox one in the dog tAn integrated pharmacokinetic/pharma- codynamic comparison 显示文摘	Veng-Pedersen P Wilhelm J A Zakszewski T B	1995	Journal of Pharmaceutical Sciences1995，84，：	1
4	The relation- ship between interpersonal sensitivity, anxiety disorders and major depression 显示文摘	WILHELM K BOYCE P BROWNHILL S	2004	Journal of Affective Disorders2004，79，13：	1
5	Emulsification by ultrasound: drop size distribution and stability 显示文摘	ABISMAIL B CANSELIER J P WILHELM A M	1999	Ultrasonics Sonochem1999，，6：	1
6	Lossy image compression for digital medical imaging systems显示文摘	Wilhelm P Haynor D R Kim Y	1991	Opt Eng1991，30，10：	1
7	Sox genes and cancer显示文摘	Dong C Wilhelm D Koopman P	2004	Cy- togenet Genome Res2004，105，24：	1
8	Preclinical overview of sorafenib,a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling显示文摘	Wilhelm SM Adnane L Newell P		0，，10：	1
9	Endopolyploidization of mesoeotyls in Nebraska maize populations selected for cold tolerance 显示文摘	Wilhelm E d Biradar D P Bullock D G	1995	Crop Science1995，35，：	1
10	Cellular and humoral immune reconstitution after autologous peripheral blood stem cell transplantation (PBSCT) 显示文摘	Reimer P Kunzmann V Wilhelm M	2003	Ann Hematol2003，82，5：	1
11	Standard- ized flexible ureteroseopie technique to improve stone- free rates显示文摘	Miernik A Wilhelm K Ardelt P U	2012	Urology2012，80，6：	1
12	Duration of opioid antagonism by nalmefene and naloxone in the dog:an integrated pharmacokinetic/pharmacodynamic comparison显示文摘	Veng-Pedersen P Wilhelm JA Zakszewski TB	1995	Pharm Sci1995，84，：	1
13	Anorectal manovolumetry in the diagnosis of fecal incontinence显示文摘	Anders Holmberg M.D. Dr. Wilhelm Graf M.D. Ph.D. Asbj?rn ?sterberg M.D. Lars P?hlman M.D. Ph.D	1995	Diseases of the Colon & Rectum1995，，5：	1
14	Ultrasound in organic electrosynthesis显示文摘	WILHELM A M DELMAS H	2000	Ultrasonics Sonochemistry2000，7，4：	1
15	Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling 显示文摘	Wilhelm SM Adnane L Newell P	2008	Mol Cancer Ther2008，7，：	1
16	Preclinical overview of sorafenib,a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling显示文摘	Wilhelm SM Adnane L Newell P	2008	Mol Cancer Ther2008，7，10：	1
17	Circuit card assembly on tandem turret-type placement machines显示文摘	Wilhelm W E I Tarmy P K	2003	IIE Transactions2003，35，7：	1
18	Extracellular enzymes affect biofilm formation of mucoid Pseudomonas aeruginosa 显示文摘	TIELEN P ROSENAU F WILHELM S	2010	Mi- crobiology2010，156，：	1
19	Platelet-activating prota- mine-heparin-antibodies lead to higher prommine demand in patients undergoing cardiac surgery显示文摘	Grieshaber P Bakchoul T Wilhelm J	2015	J Thorac Cardiovasc Surg2015，150，4：	1
20	The influence of layered compounds on the properties of starch/layered compound composites 显示文摘	Helena - M Wilhelm Maria - R Sierakowski Gabriel P Souza	2003	Polymer International2003，52，：	1

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