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| 1 | Combined hepatocellular and cholangiocellular carcinoma presenting with radiological characteristics of focal nodular hyperplasia显示文摘Combined hepatocellular and cholangiocellular carcinoma (cHCC-CC) is a rare tumor type containing unequivocal elements of both hepatocellular carcinoma and cholangiocarcinoma that are intimately mixed. Although these tumors are usually considered to be more related to hepatocellular carcinoma than to cholangiocarcinoma, they sometimes, in contrast to hepatocellular carcinoma, contain a significant amount of fibrous stroma. This might in some cases explain atypical radiological features. We report a case of a cHCC-CC in a 47-year-old female that resembled focal nodular hyperplasia on Magnetic Resonance Imaging. Correlation of imaging and serum levels of α-fetoprotein and CA19.9 can help to make the correct diagnosis preoperatively. | Inneke Willekens Anne Hoorens Caroline Geers Bart Op de Beeck Frederik Vandenbroucke Johan de Mey | 2009 | World Journal of Gastroenterology2009，15，31： | 4 |
| 2 | Coeliac disease in Dutch patients with Hashimoto’s thyroiditis and vice versa显示文摘AIM: To define the association between Hashimoto’s thyroiditis and coeliac disease in Dutch patients. METHODS: A total of 104 consecutive patients with Hashimoto’s thyroiditis underwent coeliac serological tests (antigliadins, transglutaminase and endomysium antibodies) and HLA-DQ typing. Small intestinal biopsy was performed when any of coeliac serological tests was positive. On the other hand, 184 patients with coeliac disease were subjected to thyroid biochemical (thyroid stimulating hormone and free thyroxine) and thyroid serological tests (thyroglobulin and thyroid peroxidase antibodies). RESULTS: Of 104 patients with Hashimoto’s thyroiditis, sixteen (15%) were positive for coeliac serology and five patients with documented villous atrophy were diagnosed with coeliac disease (4.8%; 95% CI 0.7-8.9). HLA-DQ2 (and/or -DQ8) was present in all the five and 53 patients with Hashimoto’s thyroiditis (50%; 95% CI 43-62). Of 184 patients with coeliac disease, 39 (21%) were positive for thyroid serology. Based on thyroid biochemistry, the 39 patients were subclassified into euthyroidism in ten (5%; 95% CI 2-9), subclinicalhypothyroidism in seven (3.8%; 95% CI 1.8-7.6), and overt hypothyroidism (Hashimoto’s thyroiditis) in 22 (12%; 95% CI 8-16). Moreover, four patients with coeliac disease had Graves’ disease (2%; 95% CI 0.8-5) and one patient had post-partum thyroiditis. CONCLUSION: The data from a Dutch population confirm the association between Hashimoto’s thyroiditis and coeliac disease. Screening patients with Hashimoto’s thyroiditis for coeliac disease and vice versa is recom- mended. | Muhammed Hadithi Hans de Boer Jos WR Meijer Frans Willekens Jo A Kerckhaert Roel Heijmans Amado Salvador Pea Coen DA Stehouwer Chris JJ Mulder | 2007 | World Journal of Gastroenterology2007，13，11： | 4 |
| 3 | Moving averages with random coefficients and random coefficient autoregressive models显示文摘 | Resnick S I Willekens E | 1991 | Comm Statist Stochastic Models1991，7，4： | 1 |
| 4 | ()zone, sulfur dioxide, and ultraviolet have similar effects on mRNA ac cumulation of antioxidant genes in Nicotiana plumbagimfolia L显示文摘 | Willekens H Van Camp W Van Montagu M | 1994 | Plant Physiology1994，，106： | 1 |
| 5 | Clinically relevant anterograde amnesia and its relationship with blood levels of benzodiazepines in suicide attempters who took an overdose显示文摘 | Bas Verwey Alex Muntendam Kees Ensing Guus Essink Pieternel C.M. Pasker-de Jong Frans L.A. Willekens Frans G. Zitman | 2004 | Progress in Neuropsychopharmacology & Biological Psychiatry2004，，1： | 1 |
| 6 | Morphology of the aging human lens显示文摘 | VRENSEN G KAPPDHOF J WILLEKENS B | 1990 | Lens Eye Toxic Res1990，7，1： | 1 |
| 7 | Duodenal metastasis of alveolar soft part sarcoma 显示文摘 | Willekens I Paradisi C Sarfia L | 2011 | JBR-BTR2011，94，5： | 1 |
| 8 | Moving averages with random coeificients and random autoregressive models 显示文摘 | Resnick S I Willekens E | 1991 | Comm Statist Stochastic Models1991，7，4： | 1 |
| 9 | Defense activation and enhanced pathogen tolerance induced by H2O2 in transgenic plants显示文摘 | CHAMNONGPOL S WILLEKENS H MOEDER W | 1998 | Proc Natl Acad Sci USA1998，95，： | 1 |
| 10 | Different responses of tobacco antioxidant enzymes to light and chilling stress显示文摘 | Gechev T Willekens H Montagu M V | 2003 | Journal of Plant Physiology2003，160，： | 1 |
| 11 | Catalase is a sink for H2O2 and is indispensable for stress defence in C3 plants显示文摘 | Willekens H Chamnongpol S Davey M | 1997 | The EMBO Journal1997，16，： | 1 |
| 12 | Elevated levels of superoxide dismutase protect transgenic plants against Ozone damage显示文摘 | Van Camp W Willekens H | 1994 | Biotechnology1994，12，： | 1 |
| 13 | Ozone, sulfur dioxide, and ultravi- olet B have similar effects on mRNA accumulation of antioxidant genes in Nicotiana plumbaginifolia L显示文摘 | Willekens H Van Camp W Van Montagu M Inze D Langebartels C Sanderman H Jr | 1994 | Plant Physi- ology1994，106，3： | 1 |
| 14 | Catalase is a sink for H2O2 and is indispensable for stress defense in C3 plant显示文摘 | Willekens HS Chamnongpol MD Schraudner | 1997 | The European Molecular Biology Organization Journal1997，14，： | 1 |
| 15 | Catalases in plants 显示文摘 | Willekens H Ines D Van Montagu M | 1995 | Mol Breed1995，1，： | 1 |
| 16 | Ozone,sulfur dioxide,and ozone ultraviolet-B have similar effect on mRNA accumulation of antioxidant genes-in Nicotiana plumbaginifolia L显示文摘 | Willekens H Van Camp W Van Montagu M | 1994 | Plant Physiol1994，106，： | 1 |
| 17 | Catalase is a sink for H2O2 and is indispensable for stress defence in C3 plants 显示文摘 | Willekens H Chamnongpol S Davey M et a l | 1997 | The EMBO Journal1997，16，16： | 1 |
| 18 | Catalases in plants显示文摘 | Willekens H Inzé D Van Montagu M | 1995 | Molecular Breeding1995，1，3： | 1 |
| 19 | Obesity in adulthood and its consequences for life expectancy:a life-table analysis显示文摘 | Peeters A Barendreqt JJ Willekens F | 2003 | Ann Intern Med2003，138，1： | 1 |
| 20 | Defense activation and enhanced pathogen tolerance induced by H2O2 in transgenic tobacco 显示文摘 | Chamnongpol S Willekens H Moeder W | 1998 | Proceedings of the National Academy of Sciences of the United States of America1998，95，： | 1 |
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