|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 美国国家卒中协会短暂性脑缺血发作处理指南显示文摘目的:短暂性脑缺血发作(TIA)是常见和重要的卒中先兆。其处理方法多样,大多数发表的指南在近年来均未被更新。我们试图制定一个全面的、无偏倚的、循证的TIA处理指南。方法:根据一种客观标准(可以预测在该研究领域中执业医师对专家提名的文献测量学方法)挑选出15名专家组成员。通过系统回顾检索到过去发表的指南,由专家对其中的推荐意见的质量进行独立评价。选择出质量最高的推荐意见,然后让专家组采用改良Delphi法通过多次问卷调查的方式进行修订,从而对新的修改达成共识。给专家们提供近期临床研究的系统评价,要求专家根据新的证据判断措辞修改的合理性并且根据证据等级和质量对最终的推荐意见进行评定。不允许专家在预期有可能存在任何利益冲突的专题方面提出推荐意见。结果:通过系统回顾检索到257个指南,其中有13篇文献包括的137条推荐意见符合所有纳入标准。需要6次重复的问卷调查对53条最终推荐意见的措辞达成共识。最终的推荐意见涉及TIA的初步处理、评价、内科治疗、外科治疗和危险因素控制。结论:对TIA患者医疗诊治的最终推荐意见强调了紧急评价和治疗的重要性。这种用于制定本指南的新方法是可行的,考虑到了快速更新并能减少偏倚。 | S. Claiborne Johnston Mai N. Nguyen-Huynh Miriam E. Schwarz Kate Fuller Christina Williams S. Andrew Josephsort Graeme J. Hankey Robert G. Hart Steven R. Levine Jose Biller Robert D. Brown Ralph L. Sacco L. Jaap Kappelle Peter J. Koudstaal Julien Bogousslavsky Louis R. Caplan Jan van Gijn Ale Algra Peter M. Rothwell Harold P. Adams Gregory W. Albers 李海峰(译) | 2007 | 国际脑血管病杂志2007，15，3： | 5 |
| 2 | Mechanical thrombectomy with the S olitaire AB device in large intracerebral artery occlusions显示文摘 | John J McCabe Timothy J Phillips Con Phatouros Tejinder Singh David Blacker Graeme J Hankey William McAuliffe | 2012 | Journal of Medical Imaging and Radiation Oncology2012，，2： | 2 |
| 3 | Alternative polyadenylation of mRNA and its role in cancer显示文摘Alternative polyadenylation(APA)is a molecular process that generates diversity at the 3′end of RNA polymeraseⅡtranscripts from over 60%of human genes.APA is derived from the existence of multiple polyadenylation signals(PAS)within the same transcript,and results in the differential inclusion of sequence information at the 3′end.While APA can occur between two PASs allowing for generation of transcripts with distinct coding potential from a single gene,most APA occurs within the untranslated region(3′UTR)and changes the length and content of these non-coding sequences.APA within the 3′UTR can have tremendous impact on its regulatory potential of the mRNA through a variety of mechanisms,and indeed this layer of gene expression regulation has profound impact on processes vital to cell growth and development.Recent studies have particularly highlighted the importance of APA dysregulation in cancer onset and progression.Here,we review the current knowledge of APA and its impacts on mRNA stability,translation,localization and protein localization.We also discuss the implications of APA dysregulation in cancer research and therapy. | Fuwen Yuan William Hankey Eric J.Wagner Wei Li Qianben Wang | 2021 | Genes & Diseases2021，8，1： | 2 |
| 4 | Patients With Prior Myocardial Infarction, Stroke, or Symptomatic Peripheral Arterial Disease in the CHARISMA Trial显示文摘 | Deepak L. Bhatt Marcus D. Flather Werner Hacke Peter B. Berger Henry R. Black William E. Boden Patrice Cacoub Eric A. Cohen Mark A. Creager J. Donald Easton Christian W. Hamm Graeme J. Hankey S. Claiborne Johnston Koon-Hou Mak Jean-Louis Mas Gilles Montal | 2007 | Journal of the American College of Cardiology2007，，19： | 1 |
| 5 | The oncogenomic function of androgen receptor in esophageal squamous cell carcinoma is directed by GATA3显示文摘Dear Editor,Esophageal carcinoma(EC)is the 6th leading cause of cancer death worldwide.In China,esophageal squamous cell carcinoma(ESCC)is the predominant histological subtype of EC and the 4th leading cause of death from cancer.1,2 While esophagectomy has been central to the standard of care for localized ESCC,relapse often occurs rapidly.For advanced ESCC,multimodality therapies incorporating systemic chemotherapies and/or radiotherapy have yielded limited clinical benefit.Despite extensive research efforts,no targeted therapies have yet been approved for the treatment of advanced ESCC.Interestingly,ESCC is strongly characterized by a male-predominant propensity,as both incidence and mortality rate are 2–3-fold higher in males than in females.1 Previous studies have revealed a possible association between androgen receptor(AR)signaling and male ESCC.3,4 AR is a ligand-dependent transcription factor that regulates target gene expression through binding to androgen-responsive elements(AREs)in the presence of androgens.Conversely,AR antagonists(e.g.,enzalutamide)compete with androgens to bind AR and inhibit its binding to AREs.5,6 To date,while the genomic function of AR has been extensively studied in prostate cancer,5,7,8 it remains unknown how AR exerts its oncogenic functions in ESCC at a genome-wide scale.Addressing this question is of high clinical relevance as it will establish a mechanistic basis for a promising therapeutic strategy targeting the AR transcription axis for ESCC patients. | Furong Huang Hongyan Chen Xiaolin Zhu Tongyang Gong Xukun Li William Hankey Hongyan Wang Zhong Chen Qianben Wang Zhihua Liu | 2021 | Cell Research2021，31，3： | 0 |
| 6 | 美国国家卒中协会短暂性脑缺血发作处理指南显示文摘目的:短暂性脑缺血发作(TIA)是常见和重要的卒中先兆。其处理方法多样,大多数发表的指南在近年来均未被更新。我们试图制定一个全面的、无偏倚的、循证的TIA处理指南。方法:根据一种客观标准(可以预测在该研究领域中执业医师对专家提名的文献测量学方法)挑选出15名专家组成员。通过系统回顾检索到过去发表的指南,由专家对其中的推荐意见的质量进行独立评价。选择出质量最高的推荐意见,然后让专家组采用改良Delphi法通过多次问卷调查的方式进行修订,从而对新的修改达成共识。给专家们提供近期临床研究的系统评价,要求专家根据新的证据判断措辞修改的合理性并且根据证据等级和质量对最终的推荐意见进行评定。不允许专家在预期有可能存在任何利益冲突的专题方面提出推荐意见。结果:通过系统回顾检索到257个指南,其中有13篇文献包括的137条推荐意见符合所有纳入标准。需要6次重复的问卷调查对53条最终推荐意见的措辞达成共识。最终的推荐意见涉及TIA的初步处理、评价、内科治疗、外科治疗和危险因素控制。结论:对TIA患者医疗诊治的最终推荐意见强调了紧急评价和治疗的重要性。这种用于制定本指南的新方法是可行的,考虑到了快速更新并能减少偏倚。 | S. Claibome Johnston Mai N. Nguyen-Huynh Miriam E. Schwarz Kate Fuller Christina Williams S. Andrew Josephson Graeme J. Hankey Robert G. Hart Steven R. Levine Jose Biller Robert D. Brown Ralph L. Sacco L. Jaap Kappelle Peter J. Koudstaal Julien Bogousslavsky Louis R. Caplan Jan van Gijn Ale Algra Peter M. Rothwell Harold P. Adams Gregory W. Albers 李海峰(译) | 2007 | 中华脑血管病杂志(电子版)2007，1，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员