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| 1 | 单程高增益1.9μm光纤气体拉曼激光器显示文摘报道了基于空心光子晶体光纤中氢气分子振动受激拉曼散射(SRS)的单程高增益1.9μm光纤气体激光器。用一个线偏振1064nm亚纳秒脉冲微芯激光器抽运一段长6.5m、充高压氢气的低损耗负曲率空心光纤,实现了到氢气分子一级振动斯托克斯波1907nm的有效转换。气压为2.3MPa时最大能量转换效率大于27%,相应的量子转换效率大于48%,激光平均功率约为10mW,峰值功率大于2000W。为实现高功率、窄线宽、大范围调谐的紧凑型中红外光纤激光器提供了一条潜在的有效途径。 | 王泽锋 于飞 William J Wadsworth Jonathan C Knight | 2014 | 光学学报2014，34，8： | 15 |
| 2 | A history of high-power laser research and development in the United Kingdom显示文摘The first demonstration of laser action in ruby was made in 1960 by T.H.Maiman of Hughes Research Laboratories,USA.Many laboratories worldwide began the search for lasers using different materials,operating at different wavelengths.In the UK,academia,industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications.This historical review looks at the contribution the UK has made to the advancement of the technology,the development of systems and components and their exploitation over the last 60 years. | Colin N.Danson Malcolm White John R.M.Barr Thomas Bett Peter Blyth David Bowley Ceri Brenner Robert J.Collins Neal Croxford A.E.Bucker Dangor Laurence Devereux Peter E.Dyer Anthony Dymoke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John M.Girkin Denis R.Hall David C.Hanna Wayne Harris David I.Hillier Christopher J.Hooker Simon M.Hooker Nicholas Hopps Janet Hull David Hunt Dino A.Jaroszynski Mark Kempenaars Helmut Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.Lewis Ken S.Lipton Abby Littlechild John Littlechild Peter Maggs Graeme P.A.Malcolm OBE Stuart P.D.Mangles William Martin Paul McKenna Richard O.Moore Clive Morrison Zulfikar Najmudin David Neely Geoff H.C.New Michael J.Norman Ted Paine Anthony W.Parker Rory R.Penman Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem H.Rizvi Nigel Seddon MBE Zheng-Ming Sheng David Slater Roland A.Smith Christopher Spindloe Roy Taylor Gary Thomas John W.G.Tisch Justin S.Wark Colin Webb S.Mark Wiggins Dave Willford Trevor Winstone | 2021 | High Power Laser Science and Engineering2021，9，2： | 5 |
| 3 | cytoplasmic domain of tissue factor promotes liver fibrosis in mice显示文摘AIM To evaluate the role of tissue factor(TF) and protease activated receptor(PAR)-2 in liver fibrosis.METHODS Using CCl4 administration for eight weeks, we induced hepatic fibrosis in wild-type C57BL/6 mice and in mice with deletion of the cytoplasmic signalling domain of TF(TF§CT/§CT), deletion of PAR-2(PAR-2-/-) and combined deletion of TF signalling domain and PAR-2(TF§CT/§CT/PAR-2-/-). Hepatic fibrosis area was assessed by quantitative imaging of picrosirius red staining. Hepatic collagen content was assessed by hydroxyproline levels. Hepatic stellate cells(αSMA positive) and hepatic macrophages(CD68 positive) were identified by immunohistochemistry. Hepatic gene expression was determined by PCR and liver TGFβ1 content by ELISA.RESULTS CCl4 treated mice with deletion of the PAR-2 gene(PAR-2-/-) and the cytoplasmic domain of TF(TF§CT/§CT) developed significantly less hepatic fibrosis, characterised by reduced liver fibrosis area and hydroxyproline content, compared to control wildtype mice treated with CCl4. The observed reduction in histological fibrosis was accompanied by a significant decrease in the hepatic content of TGFβ, the prototypic fibrogenic cytokine, as well as fewer activated hepatic stellate cells and hepatic macrophages. Deletion of the TF cytoplasmic signalling domain reduced hepatic fibrosis to levels similar to thoseobserved in mice lacking PAR-2 signalling but combined deletion provided no added protection against fibrosis indicating a lack of mutual modulating effects that have been observed in other contexts such as angiogenic responses.CONCLUSION Tissue factor cytoplasmic domain is involved in TF-PAR-2 signalling initiating hepatic fibrosis and is a potential therapeutic target, as its deletion would not impact coagulation. | Virginia Knight Dinushka Lourensz Jorge Tchongue Jeanne Correia Peter Tipping William Sievert | 2017 | World Journal of Gastroenterology2017，23，31： | 3 |
| 4 | Memory intensive statistical slgorithms for multibeam bathymetric data显示文摘 | Colin Ware William Knight David Well | 1991 | Computers & Geosciences1991，17，7： | 2 |
| 5 | Photonic Crystal Fibers显示文摘By offering greatly enhanced control of light compared to conventional step-index structures, photonic crystal fibres are radically improving the performance of linear and nonlinear fibre devices, including gas-Raman cells, super-continuum generators, soliton systems and cladding-pumped lasers. | William J. Wadsworth Jonathan C. Knight William H. Reeves Philip St.J. Russell | 2003 | 光学学报2003，23，S1： | 2 |
| 6 | Enteral vs total parenteral nutrition following major upper gastrointestinal surgery显示文摘 | George A.C. Wheble William R. Knight Omar A. Khan | 2012 | International Journal of Surgery2012，，4： | 2 |
| 7 | Petroleum geoscience in Norden - exploration, production and organization显示文摘 | Anthony M. Spencer Per Ivar Briskeby Lone Dyrmose Christensen Rune Foyn Marie KjФlleberg Erling Kvadsheim Ian Knight Morten Rye-Larsen John Williams | 2008 | Episodes2008，31，1： | 2 |
| 8 | Effect of carbon source on compost nitrogen and carbon losses显示文摘 | Suzelle Barrington Denis Choinière Maher Trigui William Knight | 2002 | Bioresource Technology2002，，3： | 2 |
| 9 | Choosing the optimal wall shear parameter for the prediction of plaque location—A patient-specific computational study in human left coronary arteries显示文摘 | Farhad Rikhtegar Joseph A. Knight Ufuk Olgac Stefan C. Saur Dimos Poulikakos William Marshall Philippe C. Cattin Hatem Alkadhi Vartan Kurtcuoglu | 2012 | Atherosclerosis2012，，2： | 1 |
| 10 | Preliminaryanalysis of a randomized trial comparing microemulsioncyclosporine and tacrolimus for recipients of renal transplantsfrom non-heart-beating donors显示文摘 | Williams ST Knight AL White SA | 2000 | Transplant Proc2000，32，3： | 1 |
| 11 | Biomimetic reliability strategies for self-healing vascular networks inengineering materials 显示文摘 | Williams H R Trask R S Knights A C | 2008 | Journal of the Royal Society Interface2008，5，： | 1 |
| 12 | Supercontinuum Generation in Photonic Crystal Fibers and Optical Fiber Tapers: a Novel Light Source 显示文摘 | WADSWORTH WILLIAM J ARTURO ORTIGOSA-BLANCH KNIGHT JONATHAN C | 2002 | J Opt Soc Am B2002，19，： | 1 |
| 13 | Choosing the optimal wall shear parameter for the prediction of plaque location—A patient-specific computational study in human right coronary arteries显示文摘 | Joseph Knight Ufuk Olgac Stefan C. Saur Dimos Poulikakos William Marshall Philippe C. Cattin Hatem Alkadhi Vartan Kurtcuoglu | 2010 | Atherosclerosis2010，，2： | 1 |
| 14 | Trends in postpartum hemorrhage in high resource countries; a review and recommendations from the International Postpartum Hemorrhage Collaborative Group 显示文摘 | Marian Knight William M Callaghan Cynthia Berg | 2009 | BMC Pregnancy and Childbirth2009，9，： | 1 |
| 15 | Prenatal screening for Down's syndrome with use of maternal serum markers显示文摘 | JE Haddow GE Palomaki GJ Knight J Williams A Pulkkinen JA Canick DN Saller and GB Bowers | 1992 | N Engl J Med1992，，： | 1 |
| 16 | Low loss silica hollow core fibers for 3-4 μm spectral region 显示文摘 | Fei Yu William J Wadsworth Jonathan C Knight | 2012 | Opt Express2012，20，11： | 1 |
| 17 | Brain-derived TNF-α mediates neuropathic pain显示文摘 | Tracey A Ignatowski William C Covey Paul R Knight | 1999 | Brain re- search1999，841，1： | 1 |
| 18 | Trends in postpartum hemor- rhage in high resource countries: a review and recommendations from the International Postpartum Hemorrhage Collaborative Group显示文摘 | Knight M William M Berg et C | 2009 | BMC Pregnancy Childbirth2009，9，55： | 1 |
| 19 | Strategies for effective mosquito control in constructed treatment wetlands显示文摘 | Robert L Knight William E Walton George F O’Meara William K Reisen Roland Wass | 2003 | Ecological Engineering2003，，4： | 1 |
| 20 | Meta-analyses of human gut microbes associated with obesity and IBD显示文摘 | William A. Walters Zech Xu Rob Knight | 2014 | FEBS Letters2014，，22： | 1 |
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