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| 1 | Lower baseline ALT cut-off values and HBV DNA levels better differentiate HBeAg(-) chronic hepatitis B patients from inactive chronic carriers显示文摘AIM:To determine whether new cut-off values for alanine aminotransferase(ALT)and baseline hepatitis B virus(HBV)DNA levels better differentiate HBeAg(-) chronic hepatitis B(CHB)patients from inactive chronic carriers. METHODS:Ninety-one patients[32 HBeAg(+)CHB, 19 inactive carriers and 40 HBeAg(-)CHB]were followed up for 2 years and were tested for HBV DNA levels by a PCR-based assay.ALT was tested twice during the last 6 mo using new cut-off values:ULN(upper limit of normal)30 IU/L for males,19 IU/L for females. Diagnostic accuracy,sensitivity,specificity,positive and negative predictive values were calculated by discriminant analysis. RESULTS:When using the revised ALT cut-off values, the lowest optimal HBV DNA level that differentiated HBeAg(-)CHB patients from inactive carriers was 50000 copies/mL.The diagnostic accuracy of HBV DNA to determine inactive carriers with a cut-off of 50000 copies/mL was similar to the previously recommended cut-off of 100 000 copies/mL(91%).HBV DNA levels were lower than the cut-off value in 95%of inactive carriers and in 28%of HBeAg(-)CHB patients.With ALT<30 IU/L in men and<19 IU/L in women and HBV DNA levels<100 000 copies/mL,the risk of CHB is 5%.On the other hand,if ALT values were>30 IU in men and>19 IU in women and baseline HBV DNA levels were>100000 copies/mL,the risk is 86%. CONCLUSION:New cut-off values for ALT together with HBV DNA levels proposed by AASLD(American Association for the Study of Liver Diseases)and NIH (National Institute of Health)consensus seem appropriate to characterize inactive carriers. | Nimer Assy Zaza Beniashvili Agness Djibre Gattas Nasser Maria Grosovski William Nseir | 2009 | World Journal of Gastroenterology2009，15，24： | 7 |
| 2 | Anticonvulsant activity of two metabotropic glutamate group I antagonists selective for the mGlu5 receptor:2 -methyl -6 -(phenylethynyl) -pyridine (MPEP),and (E)-6-methyl-2-styryl-pyridine (SIB 1893)显示文摘 | Chapman AG Nanan K Williams M | 2000 | Neuropharmacology2000，39，9： | 1 |
| 3 | Cytokine gene polymorphisms moderate illness severity in infants with respiratory syncytial virus infection显示文摘 | Deborah AG William JD Adriana Z | 2003 | Hum Immunol2003，64，3： | 1 |
| 4 | The ACE gene and muscle performance显示文摘 | Williams AG | 2000 | Nature2000，403，： | 1 |
| 5 | Regulatory T cell lineage specification by the fork head transcription factor foxp3显示文摘 | Fontenot JD Rasmussen JP Williams LM Dooley JL Farr AG Rudensky AY | 2005 | Immunity2005，22，3： | 1 |
| 6 | Abdominal lymphatic pump treatment increases leukocyte count flux in thoracic duct lymph显示文摘 | Hodge LM King HH? Williams AG | 2007 | Lymph Res Biol2007，5，2： | 1 |
| 7 | Mortality associated with congenital syphilis in the united states,1992 ~ 1998显示文摘 | DEBORAH AG WILLIAM CL MICHAEL E | 2002 | Pediatrics2002，109，： | 1 |
| 8 | Tooth contact in patients with temporomandibular disorders显示文摘 | Glaros AG Williams K Lausten L | 2005 | Cranio2005，23，3： | 1 |
| 9 | Rumen holotrich ciliate protozoa显示文摘 | Williams AG | 1986 | Microbiol Rev1986，50，1： | 1 |
| 10 | Genetic response to selection in cultivated plants:gene frequencies in Prunus avium显示文摘 | Williams W Brown AG | 1956 | Heredity1956，10，： | 1 |
| 11 | Relation be- tween folate status,a common mutation in methylenete- trahydrofolate reductase,and plasma homocysteine con- centrations显示文摘 | Jacques PF Bostom AG Williams RR | 1996 | Circulation1996，93，1： | 1 |
| 12 | Marfan's syndrome and the heart 显示文摘 | Stuart AG Williams A | 2007 | Arch Dis Child2007，92，4： | 1 |
| 13 | Association between schizophrenia and a microsatellite polymorphism at the dopamine D5 receptor gene 显示文摘 | Williams NM Cardno AG Murphy KC | 1997 | Psychiatr Genet1997，7，2： | 1 |
| 14 | Air pollution and child respiratory health: a case-crossover study in Australia and New Zealand显示文摘 | Barnett AG Williams GM Schwartz J | 2005 | Am J Respir Crit Care Med2005，171，11： | 1 |
| 15 | The ACE gene and muscle performance 显示文摘 | Williams AG | 2000 | Nature2000，403，： | 1 |
| 16 | Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations 显示文摘 | Jacques PF Bostom AG Williams RR | 1996 | Circulation1996，93，1： | 1 |
| 17 | Polysaccharide-degrading enzymes formed by three species of anaerobic rumen fungi grown on a range of carbohydrate substrates显示文摘 | Williams AG Orpin CG | 1987 | Can J Microbiol1987，33，5： | 1 |
| 18 | Air pollution and child respiratory health: a case-crossover study in Australia and New Zealand 显示文摘 | Barnett AG Williams GM Schwartz J Neller AH Best TL Petroeschevsky AL Simpson RW | 2005 | Am J Respir Crit Care Med2005，171，11： | 1 |
| 19 | Antibody positron emission tomography imaging in anticancer drugdevelopment显示文摘 | Lamberts LE Williams SP Terwisscha van Scheltinga AG | 2015 | J Clin Oncol2015，33，13： | 1 |
| 20 | X-ray structure of human stromelysin catalytic domain complexed with nonpeptide inhibitors: implications for inhibitor selectivity 显示文摘 | Williams MG Ye QZ | 1999 | Protein Sci1999，8，7： | 1 |
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