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| 1 | 高危患者目标血压与心血管病预后显示文摘指南推荐血压目标值应〈140/90 mmHg(1mmHg=0.133kPa)以减少心血管事件的发生。但与其他心血管病预后(如冠状动脉事件)相比,包括脑卒中及心力衰竭在内的心血管病预后与收缩压下降关系更密切。一些心血管事件(如冠状动脉事件)风险在收缩压低时亦增高,风险-收缩压关系呈J形曲线,而脑卒中与血压不是J形曲线关系。 | B?hm M Schumacher H Teo KK Lonn EM Mahfoud F Mann JF Mancia G Redon J Schmieder RE Sliwa K Weber MA Williams BYusuf S 曲浥晨 叶鹏 | 2017 | 中华高血压杂志2017，25，6： | 14 |
| 2 | Archaea and the human gut:New beginning of an old story显示文摘Methanogenic archaea are known as human gut inhabitants since more than 30 years ago through the detection of methane in the breath and isolation of two methanogenic species belonging to the order Methanobacteriales,Methanobrevibacter smithii and Methanosphaera stadtmanae.During the last decade,diversity of archaea encountered in the human gastrointestinal tract(GIT)has been extended by sequence identification and culturing of new strains.Here we provide an updated census of the archaeal diversity associatedwith the human GIT and their possible role in the gut physiology and health.We particularly focus on the still poorly characterized 7th order of methanogens,the Methanomassiliicoccales,associated to aged population.While also largely distributed in non-GIT environments,our actual knowledge on this novel order of methanogens has been mainly revealed through GIT inhabitants.They enlarge the number of final electron acceptors of the gut metabolites to mono-di-and trimethylamine.Trimethylamine is exclusively a microbiota-derived product of nutrients(lecithin,choline,TMAO,L-carnitine)from normal diet,from which seems originate two diseases,trimethylaminuria(or Fish-Odor Syndrome)and cardiovascular disease through the proatherogenic property of its oxidized liver-derived form.This therefore supports interest on these methanogenic species and its use as archaebiotics,a term coined from the notion of archaea-derived probiotics. | Nadia Gaci Guillaume Borrel William Tottey Paul William O’Toole Jean-Fran?ois Brugère | 2014 | World Journal of Gastroenterology2014，20，43： | 5 |
| 3 | 消融的冰川:加拿大班夫国家公园亚高山带鲍湖中持久性有机氯的主要来源显示文摘有机氯杀虫剂和多氯联苯(PCB)是环境中普遍而稳固的化合物。现已查明,由于它们从温暖的地区逐渐蒸发出来,并在较冷的地区凝聚下来,因而它们富集在寒冷的环境中。在本研究中,我们的结果是,消融的冰川供给阿尔伯达亚高山带湖泊中的有机氯输入量为50%~97%,而提供的水量为73%。对氚的分析结果表明,在夏季的中、晚期,至少10%的冰川消融物是在1950~1970年期间沉积下来的,这期间它受到有机氯更多的污染。这一发现表明,气候变暖可能会使消融的冰川成为日益增多的淡水污染物来源。由于有机物贫乏的冰川粘土对多氯联苯这样的疏水化合物的吸附能力有限,因此冰川水流带来的有机氯大多呈溶解状态。 | Jules M. Blais David W. Schindler Derek C. G. Muir Martin Sharp David Donald MelissaLafrenière Eric Braekevelt William M. J. Strachan 周立志 | 2001 | AMBIO-人类环境杂志2001，30，7： | 4 |
| 4 | Effect of carbon source on compost nitrogen and carbon losses显示文摘 | Suzelle Barrington Denis Choinière Maher Trigui William Knight | 2002 | Bioresource Technology2002，，3： | 2 |
| 5 | Documenting the current definitions of chronic pelvic pain : implications for research 显示文摘 | Williams RE Hartmann KE Steege JF | 2004 | Obstet Gynecol2004，103，： | 1 |
| 6 | Postcoronary pain and the postmyocardial infarction syndrome显示文摘 | Williams RK Nagle RE Thompson RA | 1984 | Br Heart J1984，51，3： | 1 |
| 7 | Clinical findings and risk factors for Candida esophagitis in outpatients 显示文摘 | UNDENVOOD JA WILLIAMS JW KEATE RE | 2003 | Dis Esophagus2003，16，2： | 1 |
| 8 | Biochemical charaterization of recombinant fasions of lipopolysaccharide binding protein and bactericidal/permeability increasing protein显示文摘 | Wu HM Williams RE | 1997 | J Biol chem1997，，： | 1 |
| 9 | A protective role for HIF - 1 in response to redox manipulation and glucose deprivation: implications for tumorigenesis 显示文摘 | Williams KJ Teller BA Airley RE | 2002 | Oncogene2002，21，2： | 1 |
| 10 | Enhancement of SR-BI-mediated cholesteryl ester selective uptake from apoA -Ⅰ(-/-)HDL by apoA -Ⅰ requires HDL reorganization by LCAT显示文摘 | Temel RE Parks JS Williams DL | 2003 | Biol Chem2003，278，5： | 1 |
| 11 | A comprehensive process of reverse engineering from 3D meshes to CAD models显示文摘 | Roseline Bénière Gérard Subsol Gilles Gesquière Fran?ois Le Breton William Puech | 2013 | Computer-Aided Design2013，，11： | 1 |
| 12 | Review article: the pharmacology of rabeprazole显示文摘 | Williams MP Pounder RE | 1999 | Aliment Pharmacol Ther1999，1313，： | 1 |
| 13 | Estrogen receptor-immunoreactive neurons are present in the female rat lumbosacral spinal cord显示文摘 | Williams SJ Papka RE | 1996 | J Neurosci Res1996，46，4： | 1 |
| 14 | Noninvasive ventilation in ALS:indications and effect on quality of life显示文摘 | Bourke SC Bullock RE Williams TL | | Neurology0，，： | 1 |
| 15 | Treatment of Fibromyalgia with Formula Acupuncture: Investigation of Needle Placement, Needle Stimulation, and Treatment Frequency显示文摘 | Harris RE Tian X Williams DA | 2005 | J Altern Complement Med2005，11，4： | 1 |
| 16 | Prevalence and characteristics of irritable bowel syndrome among women with chromic pelvic pain显示文摘 | Williams RE Hartmann KE Sandier R | 2004 | Obset Gynecol2004，104，： | 1 |
| 17 | Review article∶ the pharmacology of rabeprazole显示文摘 | Williams MP Pounder RE | 1999 | Aliment PharmacolTher1999，13，3： | 1 |
| 18 | Micromide and guamarnide, eytotoxie alkaloids from a speeies of the marine eyanobaeterium Symploca显示文摘 | Williams PG Yoshida WY Moore RE | 2004 | J Nat Prod2004，67，1： | 1 |
| 19 | Warburg revisited: imaging tumor blood flow and metabolism显示文摘 | Miles KA Williams RE | 2008 | Cancer Imaging2008，，8： | 1 |
| 20 | Menopause-spe- cific questionnaire assessment in US population-based study shows negative impact on health-related quality of life 显示文摘 | Williams RE Levine KB Kalilani L | 2009 | Maturitas2009，62，2： | 1 |
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