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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Acomparison between BMI and conicity index on predicting coronary heart disease: the Framingham Heart Study显示文摘 | Kim KS Owen WL William D | 2000 | Ann Epidemiol2000，10，7： | 1 |
| 3 | Resistance ex- ercise in individuals with and without cardiovascular disease:2007 update:a scientific statement from the American Heart Association Council on Clinical Cardiology and Coun- cil on Nutrition,Physical Activity,and Metabolism显示文摘 | Williams MA Haskell WL Ades PA | 2007 | Circulation''2007，116，5： | 1 |
| 4 | A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding 显示文摘 | Braford MM McRorie RA Williams WL | 1976 | Anal Biochem1976，72，： | 1 |
| 5 | Surface expression of the netrin receptor UNC5HI is regulated through a protein kinase C-interacting protein/protein kinasedependent mechanism 显示文摘 | Williams ME Wu SC McKenna WL | 2003 | J Neurosci2003，23，11： | 1 |
| 6 | Captopril inhibits angiogenesis and slows the growth of experimental tumors in rats 显示文摘 | Olga VV William FW Mark WL | 1996 | J Clin Invest1996，98，： | 1 |
| 7 | A comparison between BMI and conicity index on predicting coronary heart disease:The Framingham Heart Study显示文摘 | Kim KS Owen WL Williams D | 2000 | Ann Epidemiol2000，10，7： | 1 |
| 8 | Smallest LDL particles are most strongly related to coronary disease progression in men显示文摘 | Williams PT Saperko HR Haskell WL | 2003 | Arterioscler Thromb Vasc Biol2003，23，： | 1 |
| 9 | Biochemistry of mammalian fertilization显示文摘 | McRorie RA Williams WL | | Annu- Rev Biochem0，43，0： | 1 |
| 10 | Acomparison between BMI and conicityindex on predicting coronary heart disease: the Framingham Heart Study 显示文摘 | Kim KS Owen WL William D | 2000 | Ann Epidemiol2000，10，7： | 1 |
| 11 | Expression of a functional human complement inhibitor in a transgenic pig as a model for prevention of xenogeneic hyperacute organ rejection显示文摘 | Williams BL Matis LA | 1994 | Proc Natl Acad Sci USA1994，91，11： | 1 |
| 12 | A comparison between BMI and Conicity index on predicting coronary heart disease: the Framingham Heart Study 显示文摘 | Kim KS Owen WL Williams D | 2000 | Ann Epidemiol2000，10，7： | 1 |
| 13 | A comparison between BMI and conicity index on predicting coronary heart disease:The Framingham heart study显示文摘 | Kim KS Owen WL Williams D | 2000 | Ann Epidemiol2000，10，7： | 1 |
| 14 | Micellar bile salt mobile phases for the liquid chromatographic separation of routine compounds and optical, geometrical, and structural isomer 显示文摘 | Fu ZS Hinze WL | 1990 | J Chromatogr Sci1990，28，6： | 1 |
| 15 | Determination and properties of an unidentified growth factor required by lactobacillus bulgaricus显示文摘 | Hoff E and Snell EE | 1949 | J Biol Chem1949，177，： | 1 |
| 16 | Iron uptake promotes hyperoxic injury to alveolar macrophages 显示文摘 | Wesselius LJ Williams WL Bailey K | 1999 | Am J Respir Crit Care Med1999，159，1： | 1 |
| 17 | A comparison be-tween BMI and Conicity index on predicting coronary heart disease:the Framingham Heart Study显示文摘 | Kim KS Owen WL Williams D | 2000 | Ann Epi-demiol2000，10，7： | 1 |
| 18 | Use of subvoxel registration and subtraction to improve demonstration of contrast enhancement in MRI of the brain显示文摘 | Williams EJ Oatridge A | 1996 | Neuroradiology1996，38，6： | 1 |
| 19 | Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischemia显示文摘 | Bao WL Williams AJ Faden AI | 2001 | Brain Res2001，922，2： | 1 |
| 20 | New insights into the protein C pathway potential implications for the biological activities of drotrecogin alfa (activated) 显示文摘 | Macias WL Yan SB Williams MD | 2005 | Crit Care2005，9，4： | 1 |
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