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| 1 | Copper-chelating therapeutic effect in Wilson disease with different clinical phenotypes and polymorphisms of ATP7B gene显示文摘CopperchelatingtherapeuticefectinWilsondiseasewithdiferentclinicalphenotypesandpolymorphismsofATP7BgeneRENMingShan1,HUWen?.. | REN MingShan1, HU WenBin1, ZHANG Zhi1, JU ShuangWu1, FAN YuXin2, WANG GongQiang1 and YANG RenMin1Keywords Wilson disease/therapy copper chelating agents ATP7B gene mutations | 1998 | World Journal of Gastroenterology1998，4，4： | 15 |
| 2 | Vacuolar invertase genes SbVIN1 and SbVIN2 are differently associated with stem and grain traits in sorghum (Sorghum bicolor)显示文摘In higher plants, vacuolar invertases play essential roles in sugar metabolism, organ development, and sink strength. In sorghum(Sorghum bicolor), two vacuolar invertase genes,Sb VIN1(Sobic. 004 G004800) and Sb VIN2(Sobic. 006 G160700) have been reported, but their enzymatic properties and functional differences are largely unknown. We combined molecular, biochemical and genomic approaches to investigate their roles in sorghum stem and grain traits. Sb VIN1 and Sb VIN2 showed different expression levels in internodes,leaves, and panicles, indicating that their importance in each organ was different. In an in vitro sucrose hydrolysis assay, proteins of both genes heterologously expressed in Pichia pastoris displayed similar enzyme properties including the same optimum reaction p H(5)and similar Kmfor sucroe(49 mmol L-1 and 45 mmol L-1 for Sb VIN1 and Sb VIN2,respectively). The optimum reaction temperatures of Sb VIN1 and Sb VIN2 were 45 °C and65 °C, respectively. Sb VIN2 showed higher tolerance to high temperature than Sb VIN1. We characterized the sequence variation of these two vacuolar invertase genes in a panel of 216 diverse inbred lines of sweet and grain sorghum and performed gene-based association analysis. Sb VIN1 showed significant associations with stem traits including stem length,stem diameter, internode number, stem fresh weight, and Brix, as well as grain traits including hundred-grain weight and grain width. Significantly associated variation sites were mainly in 5′ upstream and intron regions. Sb VIN2 only associated with grain width and stem water-soluble carbohydrates(WSCs) content. We conclude that the vacuolar invertase genes Sb VIN1 and Sb VIN2 are differently associated with stem and grain traits in sorghum. | Yunhua Chi Kimani Wilson Zhiquan Liu Xiaoyuan Wu Li Shang Limin Zhang Haichun Jing Huaiqing Hao | 2020 | The Crop Journal2020，8，2： | 2 |
| 3 | Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of bone mor- phogenetic protein IB receptor (ALK-6) that is expressed in both oocytes and granulosa cells显示文摘 | Wilson T Wu XY Juengel JL | 2001 | Biology of Reproduction2001，64，4： | 1 |
| 4 | Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of Bone morphogenetic protein IB receptor(ALK-6)that is expressed in Both oocytes and granulosa cells显示文摘 | WILSON T WU X Y JUENGEL J L | 2001 | Biol Reprod2001，64，4： | 1 |
| 5 | Social Functioning and Overall Mortality: Prospective Evidence from the Kuopio Ischemic Heart Disease Risk Factor Study显示文摘 | George A. Kaplan Thomas W. Wilson Richard D. Cohen Jussi Kauhanen Melien Wu Jukka T. Salonen | 1994 | Epidemiology1994，，5： | 1 |
| 6 | A common variant in methionine synthase reductase combined with low cobalamin ( vitamin B12 ) increases risk for spina bifida 显示文摘 | Wilson A Platt R Wu Q | 1999 | Mol Genet Metab1999，67，4： | 1 |
| 7 | Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of bone morphogenetic protein IB receptor (ALK26) that is expressed in both oocytes and granulosa ceils 显示文摘 | WILSON T WU X Y JUENGEL J L | 2001 | Biol Reprod2001，64，4： | 1 |
| 8 | Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of bone morphogenetic protein IB receptor (ALK26)that is expressed in Both oocytes and granulosa cells 显示文摘 | Wilson T Wu X Y Juenge I J | 2001 | Biol Reprod2001，64，： | 1 |
| 9 | Persistent donor cell gene expression among human induced pluripotent stem cells contributes to dif- ferences with human embryonic stem cells 显示文摘 | Ghosh Z Wilson KD Wu Y | 2010 | PLoS One2010，5，2： | 1 |
| 10 | A common variant in methionine synthase reductase combined with low cobalamin(vitamin B12) increases risk for spina bifida显示文摘 | Wilson A platt R Wu Q | 1999 | Mol Genet Metab1999，67，4： | 1 |
| 11 | Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of bone morphogenetic protein IB receptor (ALK-6) that is expressed in both oocytes and granulosa cells 显示文摘 | Wilson T Wu X Y Juengel J L | 2001 | Biology of Reproduction2001，64，： | 1 |
| 12 | A common variant in methionine synthase reductase combined with low cobalamin(vitamin B12)increases risk for spina bifida显示文摘 | Wilson A Platt R Wu Q | 1999 | Mol Genet Metab1999，67，4： | 1 |
| 13 | Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of bone morphogenetic protein IB receptor( ALK45 )that is expressed in both oocytes and granulosa cells 显示文摘 | WILSON T WU X Y JUENGEL J L | 2001 | Biol Reprod2001，64，4： | 1 |
| 14 | Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of bone morphogenetic protein IB receptor (ALK-6) that is expressed in both oocytes and granulosa cells显示文摘 | Wilson T Wu X Y Juengel J L | 2001 | Biol Reprod2001，64，4： | 1 |
| 15 | Highly prolific Boo- roola sheep have a mutation in the intracellular kinase do- main of bone morphogenetic protein IB receptor (ALK-6) that is expressed in both oocytes and granulosa cells显示文摘 | Wilson T Wu X Y Juengel J L | 2001 | Biology of Reproduction2001，64，4： | 1 |
| 16 | Are the psychological needs of adolescent survivors of pediatric cancer adequately identified and treated?显示文摘 | Lisa S. Kahalley Stephanie J. Wilson Vida L. Tyc Heather M. Conklin Melissa M. Hudson Shengjie Wu Xiaoping Xiong Heather H. Stancel Pamela S. Hinds | 2012 | Psycho‐Oncology2012，，2： | 1 |
| 17 | Modulation of notch signaling as a therapeutic approach for liver cancer显示文摘 | Wu G Wilson G George J Qiao L | 2015 | Curr Gene Ther2015，15，2： | 1 |
| 18 | Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of Bone morphogenetic protein IB receptor (ALK-6) that is expressed in Both ooeytes and granulosa cells显示文摘 | Wilson T Wu X Y Juenge I J | 2001 | Biolo Reprod2001，64，： | 1 |
| 19 | Highly prolific Booroola sheep have a mutation in the intraeellular kinase domain of bone morphogenetie protein IB receptor (ALK -6 ) that is expressed in both oecytes and granulose cells显示文摘 | WILSON T WU X Y JUENGEL J L | 2001 | Biol Reprod2001，64，： | 1 |
| 20 | Ascorbate inhibits iNOS expression and preserves vasoconstrictor responsiveness in skeletal muscle of septic mice显示文摘 | Wu F Wilson JX TymL K | 2003 | Am J Physiol Regul Integr Comp Physiol2003，285，1： | 1 |
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