|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Scientific design and preliminary results of three-dimensional variational data assimilation system of GRAPES显示文摘The scientific design and preliminary results of the data assimilation component of the Global-Regional Prediction and Assimilation System (GRAPES) recently developed in China Meteorological Administration (CMA) are presented in this paper. This is a three-dimensional variational (3DVar) assimilation system set up on global and regional grid meshes favorable for direct assimilation of the space-based remote sensing data and matching the frame work of the prediction model GRAPES. The state variables are assumed to decompose balanced and unbalanced components. By introducing a simple transformation from the state variables to the control variables with a recursive or spectral filter, the convergence rate of iteration for minimization of the cost function in 3DVar is greatly accelerated. The definition of dynamical balance depends on the characteristic scale of the circulation considered. The ratio of the balanced to the unbalanced parts is controlled by the prescribed statistics of background errors. Idealized trials produce the same results as the analytic solution. The results of real data case studies show the capability of the system to improve analysis compared to the traditional schemes. Finally, further development of the system is discussed. | XUE JiShan ZHUANG ShiYu ZHU GuoFu ZHANG Hua LIU ZhiQuan LIU Yan ZHUANG ZhaoRong | 2008 | Chinese Science Bulletin2008，53，22： | 33 |
| 2 | Direct assimilation of satellite radiance data in GRAPES variational assimilation system显示文摘Variational method is capable of dealing with observations that have a complicated nonlinear relation with model variables representative of the atmospheric state, and so make it possible to directly assimilate such measured variables as satellite radiance, which have a nonlinear relation with the model variables. Assimilation of any type of observations requires a corresponding observation operator, which establishes a specific mapping from the space of the model state to the space of observation. This paper presents in detail how the direct assimilation of real satellite radiance data is implemented in the GRAPES-3DVar analysis system. It focuses on all the components of the observation operator for direct assimilation of real satellite radiance data, including a spatial interpolation operator that transforms variables from model grid points to observation locations, a physical transformation from model variables to observed elements with different choices of model variables, and a data quality control. Assimilation experiments, using satellite radiances such as NOAA17 AMSU-A and AMSU-B (Advanced Microwave Sounding Unit), are carried out with two different schemes. The results from these experiments can be physically understood and clearly reflect a rational effect of direct assimilation of satellite radiance data in GRAPES-3DVar analysis system. | ZHU GuoFu XUE JiShan ZHANG Hua LIU ZhiQuan ZHUANG ShiYu HUANG LiPing DONG PeiMing | 2008 | Chinese Science Bulletin2008，53，22： | 11 |
| 3 | Rare earth oxides and their supported noble metals in application of environmental catalysis显示文摘Volatile organic compounds(VOCs),methane,carbon monoxide,soot,automotive exhaust,and nitrogen oxides are harmful to the atmosphere and human health.It is urgent to strictly control their emissions.Heterogeneous catalysis is an effective pathway for the removal of these pollutants,and the critical issue is the development of novel and high-performance catalysts.In this review,we briefly summarize the preparation methods,physicochemical properties,catalytic activities,and related reaction mechanisms for the above pollutants removal of the rare earth oxides,mixed rare earth oxide,rare earth oxidesupported noble metal,and mixed rare earth oxide-supported noble metal catalysts that have been investigated by our group and other researchers.It was found that catalytic performance was associated with the factors,such as specific surface area,pore structure,particle size and dispersion,adsorbed oxygen species concentration,reducibility,reactant activation ability or interaction between metal nanoparticles and support.Furthermore,we also envision the development trend of such a topic in future work. | Zhiquan Hou Wenbo Pei Xing Zhang Kunfeng Zhang Yuxi Liu Jiguang Deng Lin Jing Hongxing Dai | 2020 | Journal of Rare Earths2020，38，8： | 10 |
| 4 | Effect of filter-feeding fish silver carp on phytoplankton species and size distribution in surface water:A field study in water works显示文摘Silver carp were introduced into the pre-sedimentation pond to control excessive phytoplankton in raw water.The effectiveness of the filter-feeding silver carp on phytoplankton control and the effect of silver carp on phytoplankton community were investigated.The results showed that Microcystis could be effectively removed by silver carp stocked in the pre-sedimentation pond,and simultaneously,the concentration of single-cell phytoplankton increased obviously.The difference in phytoplankton species and singlecell phytoplankton size between in the water and in the gut of silver carp indicated that phytoplankton smaller than 5 μm,such as Chamydomonas and Platymonas,were almost not be filtered by silver carp,phytoplankton with the size between 5 and 20 μm could be partly filtered,and large size phytoplankton,mainly colony-forming Microcystis could be filtered almost completely.These filterfeeding characteristics directly caused the phytoplankton size distribution biased toward miniaturization.Therefore,this biological treatment using silver carp could be applied only to deal with groups of Microcystis-dominated eutrophic water,and was not appropriate in water bodies where single-cell micro phytoplankton were dominant.Especially when silver carp are used in water treatment,a cautious attitude should be taken based on the evaluation of phytoplankton biomass and species structure features in raw water. | Hua Ma Fuyi Cui Zhiquan Liu Zhenqiang Fan Wenjie He Peijun Yin | 2010 | Journal of Environmental Sciences2010，22，2： | 9 |
| 5 | Evaluation of drinking water treatment combined filter backwash water recycling technology based on comet and micronucleus assay显示文摘Based on the fact that recycling of combined filter backwash water(CFBW)directly to drinking water treatment plants(WTP)is considered to be a feasible method to enhance pollutant removal efficiency,we were motivated to evaluate the genotoxicity of water samples from two pilot-scale drinking water treatment systems,one with recycling of combined backwash water,the other one with a conventional process.An integrated approach of the comet and micronucleus(MN)assays was used with zebrafish(Danio rerio)to investigate the water genotoxicity in this study.The total organic carbon(TOC),dissolved organic carbon(DOC),and trihalomethane formation potential(THMFP),of the recycling process were lower than that of the conventional process.All the results showed that there was no statistically significant difference(P>0.05)between the conventional and recycling processes,and indicated that the genotoxicity of water samples from the recycling process did not accumulate in 15 day continuous recycling trial.It was worth noting that there was correlation between the concentrations of TOC,DOC,UV_(254),and THMFPs in water and the DNA damage score,with corresponding R^2 values of 0.68,0.63,0.28,and 0.64.Nevertheless,both DNA strand breaks and MN frequency of all water samples after disinfection were higher than that of water samples from the two treatment units,which meant that the disinfection by-products(DBPs)formed by disinfection could increase the DNA damage.Both the comet and MN tests suggest that the recycling process did not increase the genotoxicity risk,compared to the traditional process. | Ting Chen Yongpeng Xu Zhiquan Liu Shijun Zhu Wenxin Shi Fuyi Cui | 2016 | Journal of Environmental Sciences2016，28，4： | 8 |
| 6 | Integration, Quality Assurance, and Usage of Global Aircraft Observations in CRA显示文摘This paper presents a detailed description of integration, quality assurance procedure, and usage of global aircraft observations for China's first generation global atmospheric reanalysis(CRA) product(1979–2018). An integration method named 'classified integration' is developed. Aircraft observations from nine different sources are integrated into the Integrated Global Meteorological Observation Archive from Aircraft(IGMOAA), a new dataset from the National Meteorological Information Center(NMIC) of the China Meteorological Administration(CMA). IGMOAA consists of global aircraft temperature, wind, and humidity data from the surface to 100 h Pa, extending from 1973 to the present. Compared with observations assimilated in the Climate Forecast System Reanalysis(CFSR) of NCEP,the observation number of IGMOAA increased by 12.9% between 2010 and 2014, mainly as a result of adding more Chinese Aircraft Meteorological Data Relay(AMDAR) data. Complex quality control procedures for aircraft observations of NCEP are applied to detect data errors. Observations are compared with ERA-Interim reanalysis from 1979 to 2018 to investigate data quality of different types and aircraft, and subsequently to develop the blacklists for CRA. IGMOAA data have been assimilated in CRA in 2018 and are real-time updated at the CMA Data-as-a-Service(CMADaa S) platform. For CRA, the fits to observations improve over time. From 1994 to 2018, root-meansquare error(RMSE) of observations relative to CRA background decreases from 1.8 to 1.0℃ for temperature above 300 h Pa, and from 4.5 to 3 m s^(-1) for zonal wind. The RMSE for humidity appears to exhibit an apparent seasonal variation with larger errors in summer and smaller ones in winter. | Jie LIAO Huiying WANG Zijiang ZHOU Zhiquan LIU Lipeng JIANG Fang YUAN | 2021 | Journal of Meteorological Research2021，35，1： | 6 |
| 7 | Robust H_∞ guaranteed cost satisfactory fault-tolerant control for discrete-time systems with quadratic D stabilizability显示文摘The problem of robust H∞ guaranteed cost satisfactory fault-tolerant control with quadratic D stabilizability against actuator failures is investigated for a class of discrete-time systems with value-bounded uncertainties existing in both the state and control input matrices.Based on a more practical and general model of actuator continuous gain failures,taking the transient property,robust behaviour on H∞ performance and quadratic cost performance requirements into consideration,sufficient conditions for the existence of satisfactory fault-tolerant controller are given and the effective design steps with constraints of multiple performance indices are provided.Meanwhile,the consistency of the regional pole index,H∞ norm-bound constraint and cost performance indices is set up for fault-tolerant control.A simulation example shows the effectiveness of the proposed method. | Xiaodong Han Jiangong Liu Dexiao Xie Dengfeng Zhang Zhiquan Wang | 2010 | Journal of Systems Engineering and Electronics2010，21，3： | 5 |
| 8 | CRA-40/Atmosphere—The First-Generation Chinese Atmospheric Reanalysis(1979–2018):System Description and Performance Evaluation显示文摘Atmospheric reanalysis reproduces the past atmospheric conditions through assimilation of historical meteorological observations with fixed version of a numerical weather prediction(NWP)model and data assimilation(DA)system.It is widely used in weather,climate,and even business-related research and applications.This paper reports the development of CMA’s first-generation global atmospheric reanalysis(RA)covering 1979–2018(CRA-40;CRA refers to CMA-RA).CRA-40 is produced by using the Global Spectral Model(GSM)/Gridpoint Statistical Interpolation(GSI)at a 6-h time interval and a TL574 spectral(34-km)resolution with the model top at 0.27 hPa.A large number of reprocessed satellite data and widely collected conventional observations were assimilated during the reanalyzing process,including the reprocessed atmospheric motion vector(AMV)products from FY-2C/D/E/G satellites,dense conventional observations(at about 120 radiosonde and 2400 synoptic stations)over China,as well as MWHS-2 and GNSS-RO observations from FY-3C.The reanalysis fitting to observations is improved over time,especially for surface pressure with root-mean-square error reduced from 1.05 hPa in 1979 to 0.8 hPa,and for upper air temperature from 1.65 K in 1979 to 1.35 K,in 2018.The patterns of global analysis increments for temperature,specific humidity,and zonal wind are consistent with the changes in the observing system.Near surface temperature from the model’s 6-h forecast reflects the global warming trend reasonably.The CRA-40 precipitation pattern matches well with those of GPCP and other reanalyses.CRA-40 also successfully captures the QBO and its vertical and temporal development,hemispherical atmospheric circulation change,and moisture transport by the East Asian summer monsoon.CRA is now operationally running in near real time as a climate data assimilation system in CMA. | Zhiquan LIU Lipeng JIANG Chunxiang SHI Tao ZHANG Zijiang ZHOU Jie LIAO Shuang YAO Jingwei LIU Minyan WANG Huiying WANG Xiao LIANG Zhisen ZHANG Yan YAO Ting ZHU Zhe CHEN Wenhui XU Lijuan CAO Hui JIANG Kaixi HU | 2023 | Journal of Meteorological Research2023，37，1： | 4 |
| 9 | Influence of electric field on the quenched-in vacancy and solute clustering during early stage ageing of Al-Cu alloy显示文摘The effects of electric field on the evolution of excess quenched-in vacancy as well as solute clustering in Al-4wt%Cu alloy, and on the vacancy migration and formation enthalpy of pure aluminum were investigated, using positron annihilation lifetime spectroscopy, high-angle annular dark-field scanning transmission electron microscopy, transmission electron microscopy, hardness measurement and four-probe electrical resistivity measurement. The results showed that the electric field improved age hardening response obviously and postponed the decay of excess vacancies for 30 min during the early stage ageing of Al-4wt%Cu alloy. A large number of 2–4 nm GP zones with dense distribution were observed after 1 min ageing with an electric field applied. The electric field-assisted-aged sample owned a lower coarsening rate of GP zone, which was about three fifths of that in the aged sample without an electric field, from 1 min to 120 min ageing. The electric field contributed 8% increase of the vacancy migration enthalpy(0.663 ± 0.021 e V) of pure Al, comparing with that(0.611 ± 0.023 e V) of pure Al without an electric field. The increase of vacancy migration enthalpy, induced by the electric field, was responsible for the difference on evolution of quenched-in vacancy, rapid solute clustering and age hardening improvement during the early stage ageing of Al-4wt%Cu alloy. | Shang Fu Ying Zhang Huiqun Liu Danqing Yi Bin Wang Yong Jiang Zhiquan Chen Ning Qi | 2018 | Journal of Materials Science & Technology2018，34，2： | 3 |
| 10 | The Combined Effect of Plastic Particles Size and Concentration on Rotifers’ (Brachionus plicatilis) Performance显示文摘The presence of microplastics in aquatic ecosystems is of increasing global concern.Nano-sized plastics,in particular,can penetrate the cell membrane and cause biological death.Our study evaluated the combined impacts of several polystyrene mi-crospheres’sizes and nominal concentrations on the overall performance changes of Brachionus plicatilis.Experimental animals were exposed to three microplastic sizes(0.08,0.5 and 6μm)and five nominal concentrations(0,0.5,2,8,32μg mL−1)for 20 d.Our results showed that the toxicological effect of particle size on rotifers did not significantly depend on the nominal concentration.The interaction between the nominal concentration and size occurred only for body length and lorica width.Specifically,high nominal concentrations of microplastics that were close to nanometer size significantly impaired the overall vitality of rotifers,embodied in shortage of body type,delay in the arrival of maturity,reduction in the cumulative number of neonates,and the advance of the death process.In comparison,fair-sized size(0.5 and 6μm)displayed non-significant damage except for individual groups.Most notably,the net reproductive yield was only a third of what it was in the original environment,implying that there was not much fertility left.Besides,with the development of rotifers,the adverse effects of polystyrene microsphere drive had become more and more serious. | SUI Yanming WANG Senyang MOHSEN Mohamed ZHANG Longsheng SHEN Mengyan LIU Zhiquan NGUYEN Haidang ZHANG Shengmao LI Kaixing LV Linlan DONG Xuexing | 2022 | Journal of Ocean University of China2022，21，2： | 3 |
| 11 | UV illumination enhanced desorption of oxygen molecules from monolayer MoS2 surface显示文摘The oxygen adsorption can drastically alter the electronic properties of the two-dimensional(2D)materials,which is usually dificult to be removed.In this work,we report the ultraviolet(UV)ilumination induced desorption of the O2 molecules from the monolayer MoS2 surface by using the atmosphere dependent transport measurement,Kelvin probe microscopy,photoluminescence spectroscopy and X-ray photoelectron spectroscopy.Obvious increasing of the conductivity,rising of the Fermi level,and red shift of the photoluminescence peaks of the MoS2 were observed after the UV ilumination in vacuum,indicating the elimination of the depletion effect from the oxygen adsorption.Such parameter changes can be reversibly recovered by the subsequent O2 exposure.Furthermore,obvious decreasing of the oxygen concentration after the UV ilumination was also observed by X-ray photoelectron spectroscopy.Thus the UV induced O2 photodesorption effect is evidenced.The photo-excited charge transfer mechanism is proposed to account for the photodesorption effect.These results provide a nondestructive way to clean the MoS2 surface and manipulate the performance of the MoS2 based devices. | Yuhang Wang Zhiquan He Jinbing Zhang Hao Liu Xubo Lai Boyang Liu Yibao Chen Fengping Wang Liuwan Zhang | 2020 | Nano Research2020，13，2： | 3 |
| 12 | Corrosion Mechanism and Corrosion Model of Mg-Y Alloy in NaCl Solution显示文摘Corrosion of Mg–Y alloy was studied using electrochemical evaluations, immersion tests and SEM observations. Corrosion mechanisms of Mg-(0.25 and 2.5) Y alloy and Mg-(5, 8, and 15) Y alloy were uniform corrosion and pitting corrosion respectively, and the content of Mg_(24)Y_5 phases determined its effect acting as cathode to accelerate the corrosion or corrosion barrier to inhibit the corrosion. Corrosion resistance of Mg-(0.25, 2.5, 5, 8, and 15) Y alloys was as follows: Rt(Mg-0.25Y) < Rt(Mg-8Y) < Rt(Mg-15Y) < Rt(Mg-5Y) < Rt(Mg-2.5Y). Y could significantly improve the corrosion resistance of the Mg-Y alloy, but the excess of Y deteriorated the corrosion resistance of the Mg-Y alloy. The optimum content of Y in the studied alloys was 2.5%. | 徐宏 WU Zhiquan WANG Xiaoru 张新 REN Jiping SHI Yang WANG Zepu WANG Liwei LIU Changhua | 2016 | Journal of Wuhan University of Technology(Materials Science)2016，31，5： | 3 |
| 13 | The Impact of AIRS Atmospheric Temperature and Moisture Profiles on Hurricane Forecasts: Ike(2008) and Irene(2011)显示文摘Atmospheric Infra Red Sounder(AIRS) measurements are a valuable supplement to current observational data, especially over the oceans where conventional data are sparse. In this study, two types of AIRS-retrieved temperature and moisture profiles, the AIRS Science Team product(Sci Sup) and the single field-of-view(SFOV) research product, were evaluated with European Centre for Medium-Range Weather Forecasts(ECMWF) analysis data over the Atlantic Ocean during Hurricane Ike(2008) and Hurricane Irene(2011). The evaluation results showed that both types of AIRS profiles agreed well with the ECMWF analysis, especially between 200 h Pa and 700 h Pa. The average standard deviation of both temperature profiles was approximately 1 K under 200 h Pa, where the mean AIRS temperature profile from the AIRS Sci Sup retrievals was slightly colder than that from the AIRS SFOV retrievals. The mean Sci Sup moisture profile was slightly drier than that from the SFOV in the mid troposphere. A series of data assimilation and forecast experiments was then conducted with the Advanced Research version of the Weather Research and Forecasting(WRF) model and its three-dimensional variational(3DVAR) data assimilation system for hurricanes Ike and Irene. The results showed an improvement in the hurricane track due to the assimilation of AIRS clear-sky temperature profiles in the hurricane environment. In terms of total precipitable water and rainfall forecasts, the hurricane moisture environment was found to be affected by the AIRS sounding assimilation.Meanwhile, improving hurricane intensity forecasts through assimilating AIRS profiles remains a challenge for further study. | ZHENG Jing Jun LI Timothy J.SCHMIT Jinlong LI Zhiquan LIU | 2015 | Advances in Atmospheric Sciences2015，32，3： | 3 |
| 14 | FCT: a fully-distributed context-aware trust model for location based service recommendation显示文摘With the popularity of location based service(LBS), a vast number of trust models for LBS recommendation(LBSR) have been proposed. These trust models are centralized in essence, and the trusted third party may collude with malicious service providers or cause the single-point failure problem. This work improves the classic certified reputation(CR) model and proposes a novel fully-distributed context-aware trust(FCT)model for LBSR. Recommendation operations are conducted by service providers directly and the trusted third party is no longer required in our FCT model. Besides, our FCT model also supports the movements of service providers due to its self-certified characteristic. Moreover, for easing the collusion attack and value imbalance attack, we comprehensively consider four kinds of factor weights, namely number, time decay, preference and context weights. Finally, a fully-distributed service recommendation scenario is deployed, and comprehensive experiments and analysis are conducted. The results indicate that our FCT model significantly outperforms the CR model in terms of the robustness against the collusion attack and value imbalance attack, as well as the service recommendation performance in improving the successful trading rates of honest service providers and reducing the risks of trading with malicious service providers. | Zhiquan LIU Jianfeng MA Zhongyuan JIANG Yinbin MIAO | 2017 | Science China(Information Sciences)2017，60，8： | 2 |
| 15 | BnVIR:bridging the genotype-phenotype gap to accelerate mining of candidate variations underlying agronomic traits in Brassica napus显示文摘Dear Editor,Genetic variations,which range from single nucleotide polymor-phisms(SNPs)and short insertion/deletions(InDels)to large-scale structural variations(SVs),are the basis of phenotypic diversity.Understanding the effect of genetic variations on traits is critical for uncovering the genetic architecture of various phe-notypes. | Zhiquan Yang Congyuan Liang LuLu Wei Shengbo Wang Feifan Yin Dongxu Liu Liang Guo Yongming Zhou Qing-Yong Yang | 2022 | Molecular Plant2022，15，5： | 2 |
| 16 | An approach to quality assessment for web service selection based on the analytic hierarchy process for cases of incomplete information显示文摘Since web services intended for the same application environment tend to be functionally homogeneous, researchers have turned to their non-functional aspects in order to constructively compare web services and choose an appropriate one. In general, quality of service is very important to users. Many schemes that consider quality assessment have been proposed for web service selection. With the increasing number of qualityrelated attributes, an effective quality assessment method needs satisfactory scalability. Schemes based on the analytic hierarchy process(AHP) meet this requirement. However, prevalent methods in this vein overlook the fact that the traditional AHP needs a complete judgment matrix. In practice, all the information needed to construct a judgment matrix is often unavailable for a variety of reasons, due to which certain judgments cannot be made. In this paper, for an incomplete judgment matrix, we propose an improved AHP approach to consistency verification and the subsequent ordering. Our method can deal with situations where information is insufficient,and inherits all the merits of the traditional AHP approach. A case study establishes the effectiveness of our proposed method. | GAO Cong MA JianFeng LIU ZhiQuan MA XinDi | 2015 | Science China Chemistry2015，58，12： | 2 |
| 17 | Vacuolar invertase genes SbVIN1 and SbVIN2 are differently associated with stem and grain traits in sorghum (Sorghum bicolor)显示文摘In higher plants, vacuolar invertases play essential roles in sugar metabolism, organ development, and sink strength. In sorghum(Sorghum bicolor), two vacuolar invertase genes,Sb VIN1(Sobic. 004 G004800) and Sb VIN2(Sobic. 006 G160700) have been reported, but their enzymatic properties and functional differences are largely unknown. We combined molecular, biochemical and genomic approaches to investigate their roles in sorghum stem and grain traits. Sb VIN1 and Sb VIN2 showed different expression levels in internodes,leaves, and panicles, indicating that their importance in each organ was different. In an in vitro sucrose hydrolysis assay, proteins of both genes heterologously expressed in Pichia pastoris displayed similar enzyme properties including the same optimum reaction p H(5)and similar Kmfor sucroe(49 mmol L-1 and 45 mmol L-1 for Sb VIN1 and Sb VIN2,respectively). The optimum reaction temperatures of Sb VIN1 and Sb VIN2 were 45 °C and65 °C, respectively. Sb VIN2 showed higher tolerance to high temperature than Sb VIN1. We characterized the sequence variation of these two vacuolar invertase genes in a panel of 216 diverse inbred lines of sweet and grain sorghum and performed gene-based association analysis. Sb VIN1 showed significant associations with stem traits including stem length,stem diameter, internode number, stem fresh weight, and Brix, as well as grain traits including hundred-grain weight and grain width. Significantly associated variation sites were mainly in 5′ upstream and intron regions. Sb VIN2 only associated with grain width and stem water-soluble carbohydrates(WSCs) content. We conclude that the vacuolar invertase genes Sb VIN1 and Sb VIN2 are differently associated with stem and grain traits in sorghum. | Yunhua Chi Kimani Wilson Zhiquan Liu Xiaoyuan Wu Li Shang Limin Zhang Haichun Jing Huaiqing Hao | 2020 | The Crop Journal2020，8，2： | 2 |
| 18 | Efficient and high-fidelity base editor with expanded PAM compatibility for cytidine dinucleotide显示文摘Cytidine base editor(CBE),which is composed of a cytidine deaminase fused to Cas9 nickase,has been widely used to induce C-to-T conversions in a wide range of organisms.However,the targeting scope of current CBEs is largely restricted to protospacer adjacent motif(PAM)sequences containing G,T,or A bases.In this study,we developed a new base editor termed“nNme2-CBE”with excellent PAM compatibility for cytidine dinucleotide,significantly expanding the genome-targeting scope of CBEs.Using nNme2-CBE,targeted editing efficiencies of 29.0%-55.0%and 17.3%—52.5%were generated in human cells and rabbit embryos,respectively.In contrast to conventional nSp-CBE,the nNme2-CBE is a natural high-fidelity base editing platform with minimal DNA off-targeting detected in vivo.Significantly increased efficiency in GC context and precision were determined by combining nNme2Cas9 with rationally engineered cytidine deaminases.In addition,the Founder rabbits with accurate single-base substitutions at Fgf5 gene loci were successfully generated by using the nNme2-CBE system.These novel nNme2-CBEs with expanded PAM compatibility and high fidelity will expand the base editing toolset for efficient gene modification and therapeutic applications. | Zhiquan Liu Siyu Chen Yingqi Jia Huanhuan Shan Mao Chen Yuning Song Liangxue Lai Zhanjun Li | 2021 | Science China(Life Sciences)2021，64，8： | 2 |
| 19 | Satellite All-sky Infrared Radiance Assimilation:Recent Progress and Future Perspectives显示文摘Satellite infrared(IR)sounder and imager measurements have become one of the main sources of data used by data assimilation systems to generate initial conditions for numerical weather prediction(NWP)models and atmospheric analysis/reanalysis.This paper reviews the development of satellite IR data assimilation in NWP in recent years,especially the assimilation of all-sky satellite IR observations.The major challenges and future directions are outlined and discussed. | Jun LI Alan JGEER Kozo OKAMOTO Jason AOTKIN Zhiquan LIU Wei HAN Pei WANG | 2022 | Advances in Atmospheric Sciences2022，39，1： | 2 |
| 20 | Synthesis and properties of oligomers containing substituted bithiazole rings显示文摘 | Shuang Liu Weilin Sun Bingjing He Zhiquan Shen | 2004 | European Polymer Journal2004，，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员