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| 1 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 2 | Design and application of decision support systems for integrated water management:lessons to be learnt显示文摘 | de Kok J L Wind H G | 2003 | Physics and Chemistry of the Earth2003，28，： | 1 |
| 3 | Overcoming environmental dose rate changes in luminescence dating of waterlain deposits 显示文摘 | Li B Li S H Winde A G | 2008 | Geochronometria2008，30，： | 1 |
| 4 | Surgical cure for early rectal carcinomas (T1)显示文摘 | Winde G Nottberg H Keller R | | 0，，09： | 1 |
| 5 | Surgical cure for early rectal carcinomas(T1):transanal endoscopic microsurgery vs anterior resection显示文摘 | Winde G Nottberg H Keller R | 1996 | Dis Colon Rectum1996，39，9： | 1 |
| 6 | Glutamine utilization by the small intestine显示文摘 | Wind mueller H G | 1982 | Ado enzymol1982，53，： | 1 |
| 7 | Numerical modeling of erosion and sedimentation around offshore pipelines 显示文摘 | Van Beek F A Wind H G | 1990 | Costal Engineering1990，14，2： | 1 |
| 8 | Identification of two genes in the unique short region ofpseudorabies virus; comparison with herpes simplex virus and varicella-zoster virus 显示文摘 | VAN ZIJL M VAN DER G H DE WIND N | 1990 | J Gen virol1990，71，： | 1 |
| 9 | Cross-shore mean flow in the surf zone显示文摘 | STIVE M J F WIND H G | 1986 | Coastal Engineering1986，10，： | 1 |
| 10 | Numerical modeling of erosion andSedimentation around offshore pipelines显示文摘 | F A Van Beek H G Wind | 1990 | Coastal Engineering1990，14，： | 1 |
| 11 | Molecular structure of coals:adebete显示文摘 | Derbyshire F Marzec A Schuhen H R Wilson M A Davis A Tekely P Delpuech J J Jurkiewicz A Bronnimann C E Wind R A Maciel G E Narayan R Bartle K Shape C | 1989 | Fuel1989，68，： | 1 |
| 12 | Interdisciplinary modeling:gaps and bridges显示文摘 | WIND H G DE KOK J L | 2002 | Marine Policy2002，26，4： | 1 |
| 13 | Cross shore mean flow in the surf zone显示文摘 | Stive M J F Wind H G | 1986 | Coastal Engineering1986，10，： | 1 |
| 14 | Comparison of the protective efficacy of recombinant pseudorabies viruses against pseudorabies and classical swine fever in pigs,influence of different promoters on gene expression and on protection显示文摘 | IDDEKINGE H V WIND N D WENSVOORT G | 1996 | Vaccine1996，14，1： | 1 |
| 15 | Cross - shore mean flow in the surf zone 显示文摘 | Stive M J F Wind H G | 1986 | Coastal Eng1986，，10： | 1 |
| 16 | A study of radiation stress and set up in the nearshore region显示文摘 | STIVE M J F WIND H G | 1982 | Coastal Eng1982，6，： | 1 |
| 17 | ComParison of the ProtectiVe effiecacy of recombinant Pseudorabies viruses agaist Pseudorabies and classical swine fever in Pigs; influence of different Promoters on gene exPression and on Protection显示文摘 | Iddekinge H V Wind N D Wensvoort G | 1996 | Vaccine1996，14，1： | 1 |
| 18 | Com parison of the protective effiecacy of recombinant Pseudorabies viruses agaist Pseudorabies and classical swine fever in pigs; influence of different Promoters on gene expression and on protection显示文摘 | Lddekinge H V Wind N D Wensvoort G | 1996 | Vaccine1996，14，1： | 1 |
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