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| 1 | Gut microbiome in primary sclerosing cholangitis:A review显示文摘Primary sclerosing cholangitis(PSC)is a chronic cholestatic liver disease characterized by biliary inflammation and stricturing.Exploration of the pathogenesis of PSC in light of its association with inflammatory bowel disease(IBD)and the“gut-liver”axis is an emerging area of interest.A growing number of studies have begun to elucidate the role of the gut microbiota,its metabolites and its influence on host immune responses in the development of PSC and PSCIBD.Studies of the fecal microbiota have highlighted enriched levels of certain species,including Veillonella,Streptococcus and Enterococcus,among others.A heightened immune response to enteric dysbiosis and bacterial translocation have also been implicated.For example,Klebsiella pneumoniae strains derived from gnotobiotic mice transplanted with PSC-IBD microbiota were found to induce pore formation in human intestinal epithelial cells and enhanced Th17 responses.Gut microbes have additionally been hypothesized to be implicated in PSC pathogenesis through their role in the synthesis of various metabolites,including bile acids(BAs),which function as signaling molecules with important gut and hepatic effects.An expanded knowledge of the gut microbiome as it relates to PSC offers critical insight into the development of microbe-altering therapeutic interventions,such as antibiotics,nutritional interventions and fecal microbial transplantation.Some of these have already shown some preliminary evidence of benefit.Despite exciting progress in the field,much work remains to be done;areas that are particularly lacking include functional characterization of the microbiome and examination of pediatric populations.In this review,we summarize studies that have investigated the microbiome in PSC and PSC-IBD as well as putative mechanisms,including the potential role of metabolites,such as BAs.We then briefly review the evidence for interventions with microbe-altering properties for treating PSC. | Rebecca Little Eytan Wine Binita M Kamath Anne M Griffiths Amanda Ricciuto | 2020 | World Journal of Gastroenterology2020，26，21： | 5 |
| 2 | CH3SH photolysis at 248nm,hydrogen atom yield and rate constant for the H+CH3SH reaction 显示文摘 | WINE P H NICOVICH J M HYNES A J | 1986 | J Phys Chem1986，90，17： | 2 |
| 3 | Augmened vasoconstrictor response to serotonin precede development of artherosclerosis in aorta of WHHL rabbit显示文摘 | WINES P A SCHMITZ J M PFISTER S L | 1989 | Atheriosclerosis1989，9，2： | 1 |
| 4 | The mechanism underlying defective Fcgamma receptor-mediated phagocytosis by HIV-1-infected human monocyte-derived macrophages显示文摘 | LEEANSYAH E WINES B D CROWE S M | | 0，，02： | 1 |
| 5 | Cone beam computed tomography evaluationof changes in the nasmaxillary complex associated with two types of maxil- lary expanders显示文摘 | Pangrazio-Kulbersh V Wine P Haughey M | 2012 | Angle Orthod2012，82，3： | 1 |
| 6 | Campylobacter jejuni mediated disruption of polarized epithelial monolayers is cell-type specific,time dependent,and correlates with bacterial invasion显示文摘 | WINE E CHAN V L SHERMAN P M | | 0，，06： | 1 |
| 7 | Antibodies to the collagen-like region of C1 q and type Ⅱ collagen are independent populations in systemic lupus erytbematosus and rheumatoid arthritis显示文摘 | Cook A D Rowley M J Wines B D | 1994 | J Autoimmun1994，，3： | 1 |
| 8 | Pancreatic trauma in children显示文摘 | Jacombs AS Wines M Holland AJ | 2004 | J Pediatr Surg2004，39，1： | 1 |
| 9 | Strain-specific probiotic ( Lactobacillus helveticus ) inhibition of Campylobacter jejuni invasion of human intestinal epithelial cells 显示文摘 | WINE E GAREAU M G JOHNSON-HENRY K | 2009 | FEMS Microbiology Let- ters2009，300，1： | 1 |
| 10 | Computed tomography measurement of the accuracy of component version in total hip arthroplasty显示文摘 | Andrew P Wines MB David M | 2006 | The Journal of Arthroptasty2006，21，5： | 1 |
| 11 | A temperature-dependent kinetics study of the important stratospheric reaction O(3P) + NO2 →NO + O2显示文摘 | Estupinan E G Nicovich J M Wine P H | 2001 | J Phys Chem2001，105，： | 1 |
| 12 | CFTR channels in immortalized human airway cells 显示文摘 | Haws C Krouse M E Xia Y Gruenert DC Wine J J | 1992 | Am J Physiol1992，263，： | 1 |
| 13 | Perfor- mance of a biaxial MEMS-based scanner for microdisplay applications 显示文摘 | WINE D W HELSEL M P JENKINS L | 2000 | Proceedings of SPIE2000，4178，： | 1 |
| 14 | CH3SH Photolysis at 24 8nm,Hydrogen Atom Yield and Rate Constant for the H+CH3SH Reaction显示文摘 | WINE P H NICOVICH J M HYNES A J | 1986 | J Phys Chem1986，90，17： | 1 |
| 15 | Branching ratios for BrO production from reactions of O(1D) with HBr, CF3Br, CH3Br, CF2 CIBr, and CF2HBr显示文摘 | Cronkhite J M Wine P H | 1998 | IntJ Chem Kinet1998，30，： | 1 |
| 16 | Acylation of anisole by acetic anhydride catalysed by BETA zeolite supported on pre-shaped silicon carbide显示文摘 | WINE G CUONG P H LEDOUX M J | 2006 | Catalysis Communications2006，7，10： | 1 |
| 17 | Acylation of anisole by acetic anhydride catalysed by BETA zeolite supported on preshaped silicon carbide显示文摘 | Wine G Pham-Huu C Ledoux M J | 2006 | Catalysis Communications2006，7，： | 1 |
| 18 | Widespread urpregulaon of N-methyl-D-aspartatc receptors after focal photothrombotic lesion in rat hrai显示文摘 | QUO M SCHME K WINE O W | 1999 | Neurosci Lett1999，273，2： | 1 |
| 19 | A prospective, randomized comparison of the use versus non-use of topical corticosteroids after laser in situ keratomileusis 显示文摘 | Price FW Wines L Price M Lyng A Ries J | 2001 | Ophthalmology2001，108，7： | 1 |
| 20 | The vrystal slruelure of staphylococcal superantigen-like protein 11 in complex witb sialyl Lewis X reveals the mechanism for cell binding and immune inhibition 显示文摘 | Chang M C Wines B D Baker H | 2007 | Mol Mierobiol2007，66，6： | 1 |
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