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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Hepatitis B-specific T helper cell responses in uninfected infants born to HBsAg^(+)/HBeAg^(-) mothers显示文摘Vertically transmitted hepatitis B virus(HBV)usually causes chronic infection.While combined active–passive immunoprophylaxis in neonates of hepatitis B surface antigen-positive(HBsAg1)mothers at birth prevents vertical transmission,it is not yet clear whether neonates encounter the virus or its products in the absence of hepatitis B e antigen(HBeAg).This study was undertaken to investigate HBV antigen-specific T-cell responses in vaccinated neonates of HBsAg1/HBeAg2 mothers.Blood was collected from 46 HBsAg1 mothers and their neonates(subjects)as well as 24 age-matched controls.All neonates of HBsAg1 mothers received appropriate immunoprophylaxis,and HBsAg and hepatitis B surface antibody(anti-HBs)antibody titers were determined after completion of the vaccination course.Peripheral blood mononuclear cells(PBMCs)from infants at birth,1 and 6 months of age were stimulated with recombinant HBsAg,hepatitis B core antigen(HBcAg)and mitogen,and interferon(IFN)-c concentrations were determined by ELISA.HBsAg-induced production of IL-2,IL-5,IL-6 and IL-10 was assessed using a cytometric bead array kit on cells from 6-month-old neonates post-vaccination.All neonates were HBsAg2 and responded to vaccination.Increased IFN-c production following HBcAg stimulation was seen in 30.4%of neonates born to HBsAg1/HBeAg2 mothers.Subjects demonstrated significantly higher IL-2 production post-HBsAg stimulation,whereas IL-5,IL-6 and IL-10 cytokine responses were not significantly different.Almost one-third of uninfected neonates developed viral antigen-induced IFN-c production,suggesting that they had been exposed to virions or viral derivatives.This encounter,however,did not impair their T-cell responses to vaccination. | Lemonica Koumbi Antonio Bertoletti Vassiliki Anastasiadou Maria Machaira Winnie Goh Nikolaos G Papadopoulos Dimitris A Kafetzis Vassiliki Papaevangelou | 2010 | Cellular & Molecular Immunology2010，7，6： | 4 |
| 3 | Human ICE/CED-3 Protease Nomenclature显示文摘 | Emad S Alnemri David J Livingston Donald W Nicholson Guy Salvesen Nancy A Thornberry Winnie W Wong Junying Yuan | 1996 | Cell1996，，2： | 2 |
| 4 | Relationship between time of treatment of acute herpes petieneuralgia:clinical support for a new theory of the mechanismby which sympathetic blockade provides therapeutic benefit显示文摘 | Winnie A P Hartwell P W | 2013 | Regional Anaesthesia2013，，5： | 1 |
| 5 | Impact of gold mining on the environment and human health:a case study in the Migori gold belt,Kenya显示文摘 | Jason S O Winnie V M Monica A O | 2002 | Environmental Geochemistry and Health2002，24，： | 1 |
| 6 | Plexus blocks for lower extremity surgery:new answers to old problems显示文摘 | WINNIE A P RAMAMURTHY S DURANI Z | | 0，，： | 1 |
| 7 | Subarachnoid adrenal reed-ullar transplants for terminal cancer pain 显示文摘 | Winnie A Paggas GD Gupta TK | 1993 | Anesthesiology1993，79，4： | 1 |
| 8 | Relationship between time of treatment of acute herpes peticneuralgia: clinical support for a new theory of the mechanlsmby which sympathetic blockade provides therapeutic benefit 显示文摘 | WINNIE A P HARTWELL P W | 2013 | ResionalAnaesthesia2013，，5： | 1 |
| 9 | The ing- uinal paravascular technic of lumbar plexus anesthesia: the '3 in l'block显示文摘 | WINNIE A P RAMAMURTHY S DURRANI Z | 1973 | AnesthAnalg1973，52，6： | 1 |
| 10 | The Health Care Systems of China and India:Performance and Future Challenges显示文摘 | Winnie Y.W Mahal A | | 0，，04： | 1 |
| 11 | Anti-inflammatory pharmacotherapy for wheezing in preschool children 显示文摘 | KADITIS A G WINNIE G SYROGIANNOPOULOS G A | 2007 | Pediatric pulmonology2007，42，5： | 1 |
| 12 | Buprenorphine added to the local anesthetic for axillary brachial plexus block prolongs postoperative analgesia显示文摘 | CANDIDO K D WINNIE A P GHALEB A H | 2002 | Reg Anesth Pain Med2002，27，2： | 1 |
| 13 | A survey of the effects of wolf predation risk on pregnancy rates and calf recruitment in elk显示文摘 | Creel S Christianson D A Winnie J A Jr | | 0，，08： | 1 |
| 14 | Glucocorticoid stress hormones and the effect of predation risk on elk reproduction显示文摘 | Creel S Winnie J A Jr Christianson D | | 0，，： | 1 |
| 15 | Relationship between time of treat- ment of acute herpes peticneuralgia:clinical support for a new theory of the mechanismby which sympathetic blockade provides therapeutic ben- efit显示文摘 | WINNIE A P HARTWELL P W | 2013 | Regional Anaesthesia2013，，5： | 1 |
| 16 | Special Relativity without One - way Velocity Assumptions : Part II 显示文摘 | Winnie J A | 1970 | Philosophy of Science1970，，2： | 1 |
| 17 | Ultrasound Imaging of Placenta Accreta With MR Correlation显示文摘 | Winnie A Senta Berggruen | 2015 | Ultrasound Quarterly2015，31，： | 1 |
| 18 | Con- genital intrathoracic atomach: short esophagus or hiatal hernia? 显示文摘 | Alex WK Leung a Hugh S Lama Winnie CW | 2008 | Neonatology2008，93，： | 1 |
| 19 | Ultrasound imaging of placenta accreta with MRI correlation显示文摘 | Mar Winnie A Berggruen Senta Atueyi Ukamaka | 2015 | Ultrasound Quarterly2015，31，1： | 1 |
| 20 | Anti inflammatory treatment for recurrent wheezing in the first five years of life 显示文摘 | KADITIS A G GOURGOULIANIS K WINNIE G | 2003 | Pediatr Pulmonol2003，35，4： | 1 |
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