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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Human ICE/CED-3 Protease Nomenclature显示文摘 | Emad S Alnemri David J Livingston Donald W Nicholson Guy Salvesen Nancy A Thornberry Winnie W Wong Junying Yuan | 1996 | Cell1996，，2： | 2 |
| 3 | 新的^(99m)Tc标记σ受体肿瘤显像剂显示文摘采用整体法设计合成了新的99mTc标记的配合物[N-[2-((2-oxo-2-(4-(3-phenylpropyl)piperazin-1-yl)ethyl)(2-mercaptoethyl)amino)acetyl]-2-aminoethanethiolato]technetium(Ⅴ)oxide(PPPE-MAMA′-99mTcO)([99mTc]-2)及其相应的铼配合物(PPPE-MAMA′-ReO)(Re-2).竞争结合实验表明Re-2对σ1和σ2受体有中等亲和力,Ki值分别为8.67±0.07和5.71±1.88μmol/L;荷MCF-7人乳癌裸鼠尾静脉注射[99mTc]-2后0.5h,4h,20h采集平面图像,20h时可以看到肿瘤部位有放射性浓集,共同注射[99mTc]-2和抑制剂氟哌啶醇(1mg/kg)后显像,20h时肿瘤部位无明显放射性浓集;体内生物分布结果显示,注射后24h肿瘤中的放射性摄取为0.14%±0.01%ID/g,肿瘤/肌肉比为6.02±0.87.上述结果表明:虽然用整体设计法对前体化合物的结构进行了较大修饰,但得到的99mTc-配合物([99mTc]-2)在肿瘤内仍有一定的浓集,与σ1和σ2受体仍保持一定的亲和力.在此配合物的基础上,对其进行进一步的结构修饰有可能得到对σ受体亲和力更高的肿瘤显像剂. | 樊彩云 贾红梅 Deuther-Conrad Winnie Brust Peter Steinbach Jrg 刘伯里 | 2005 | 中国科学(B辑)2005，35，6： | 1 |
| 4 | Development of novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles显示文摘 | Bruning JC Winny J Bonner WS | 1997 | Cell1997，，： | 1 |
| 5 | eSAGE: managing and analysis data Generated with serial analysis of gene expression (SAGE) 显示文摘 | Margulies E H WInnis J | 2000 | Bioinformatics2000，16，： | 1 |
| 6 | High connectivity among argali sheep from Afghanistan and adjacent countries: inferences from neutral and candidate gene microsatellites 显示文摘 | Luikart G~ Amish S J Winnie J | 2011 | Conservation Genetics2011，12，4： | 1 |
| 7 | Design, fabrication and testing of a novel MEMS resonator for mass sensing applications 显示文摘 | Davis Z J Winnie Svendsen Anja Boisen | 2007 | Microelectronic Engineering2007，，84： | 1 |
| 8 | Regula-tion of a multigenic invasion programme by the tran-scription factor,AP-1: re-expression of a down-regulated gene,TSC-36,inhibits invasion 显示文摘 | Johnston I M P Spence H J Winnie J N | 2000 | Oncogene2000，19，47： | 1 |
| 9 | Insulin dependence and pancreatic enzyme replacement therapy are independent prognostic factors for long-term survival after operation for chronic pancreatitis显示文摘 | Markus Winny Vagia Paroglou Hüseyin Bektas Alexander Kaltenborn Benedikt Reichert Lea Zachau Moritz Kleine Jürgen Klempnauer Harald Schrem | 2013 | Surgery2013，，： | 1 |
| 10 | Entering new territory: A study of internal crisis management and crisis communication in organizations 显示文摘 | Winni J | 2012 | Public Relations Review2012，38，2： | 1 |
| 11 | A survey of the effects of wolf predation risk on pregnancy rates and calf recruitment in elk显示文摘 | Creel S Christianson D A Winnie J A Jr | | 0，，08： | 1 |
| 12 | Invasion of v-Fos(FBR) -transformed cells is dependent upon histone deacetylaseactivity and suppression of histone deacetylase regulated genes显示文摘 | McGarry L C Winnie J N Ozanne B W | 2004 | Oncogene2004，23，31： | 1 |
| 13 | Glucocorticoid stress hormones and the effect of predation risk on elk reproduction显示文摘 | Creel S Winnie J A Jr Christianson D | | 0，，： | 1 |
| 14 | Elk alter habitat selection as an antipredator response to wolves显示文摘 | Creel S Winnie J Maxwell B | | 0，，10： | 1 |
| 15 | Population-based risk estimates of Wilms tumor in sporadic aniridia显示文摘 | Karen Gr?nskov J?rgen H. Olsen Annie Sand Winni Pedersen Niels Carlsen Anne Jylling Troels Lyngbye Karen Br?ndum-Nielsen Thomas Rosenberg | 2001 | Human Genetics2001，，1： | 1 |
| 16 | Impact of separating drug prescribing and dispensing on provider behavior:Taiwan's experience显示文摘 | Chou Y J Winnie C Y Lee C H | | 0，，03： | 1 |
| 17 | Regulation of a multigenic invasion programme by the transcription fac- tor, AP-I: re-expression of a down regulated gene, TSC- 36, inhibits invasion 显示文摘 | Johnston IM Spence H J Winnie JN | 2000 | Oncogene2000，19，47： | 1 |
| 18 | Special Relativity without One - way Velocity Assumptions : Part II 显示文摘 | Winnie J A | 1970 | Philosophy of Science1970，，2： | 1 |
| 19 | Design, fabrication and testing of a novel MEMS resonator for mass sensing applications显示文摘 | ZACHARY J WINNIES ANJA B | 2007 | Microelectronic Engineering2007，84，： | 1 |
| 20 | Video cystometry in youny infants with renal dilation with a history of urinary tract infeetion显示文摘 | Wen J G Yeung C K Winnie C W | 2001 | Uro Res2001，29，： | 1 |
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