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| 1 | Role of surveillance imaging and endoscopy in colorectal cancer follow-up:Quality over quantity?显示文摘Colorectal cancer(CRC) is a prevalent disease and represents a major cause of morbidity and mortality in the developed world. Intensive post-treatment surveillance is routinely recommended by major expert groups for early stage(Ⅱ and Ⅲ) CRC survivors because previous meta-analyses showed a modest, but significant survival benefit. This practice has been recently challenged based on data emerging from several large phase Ⅲ randomized trials that demonstrated a lack of survival benefit from intensive surveillance strategies. In addition,findings from cost-effectiveness analyses of such an approach are inconsistent.Data on real-world practice, specifically adherence to these follow-up guidelines,are also limited. The debate is especially controversial in resected stage Ⅳ patients where there are currently no clear guidelines for follow-up. In an era of personalized medicine, there may be a shift towards a more risk-adapted approach to better define the optimal follow-up strategy. In this article, we review the evidence and highlight the role of surveillance in CRC survivors. | Shiru L Liu Winson Y Cheung | 2019 | World Journal of Gastroenterology2019，25，1： | 4 |
| 2 | Evolving treatment landscape for early and advanced pancreatic cancer显示文摘Pancreatic ductal adenocarcinoma is an infrequent cancer with a high disease related mortality rate, even in the context of early stage disease. Until recently, the rate of death from pancreatic cancer has remained largely similar whereby gemcitabine monotherapy was the mainstay of systemic treatment for most stages of disease. With the discovery of active multiagent chemotherapy regimens, namely FOLFIRINOX and gemcitabine plus nab-paclitaxel, the treatment landscape of pancreatic cancer is slowly evolving. FOLFIRINOX and gemcitabine plus nab-paclitaxel are now considered standard first line treatment options in metastatic pancreatic cancer. Studies are ongoing to investigate the utility of these same regimens in the adjuvant setting. The potential of these treatments to downstage disease is also being actively examined in the locally advanced context since neoadjuvant approaches may improve resection rates and surgical outcomes. As more emerging data become available, the management of pancreatic cancer is anticipated to change significantly in the coming years. | Sally C Lau Winson Y Cheung | 2017 | World Journal of Gastrointestinal Oncology2017，9，7： | 3 |
| 3 | Critical appraisal of laparoscopic vs open rectal cancer surgery显示文摘AIM:To evaluate the long-term clinical and oncological outcomes of laparoscopic rectal resection(LRR) and the impact of conversion in patients with rectal cancer.METHODS:An analysis was performed on a prospective database of 633 consecutive patients with rectal cancer who underwent surgical resection.Patients were compared in three groups:Open surgery(OP),laparoscopic surgery,and converted laparoscopic surgery.Short-term outcomes,long-term outcomes,and survival analysis were compared.RESULTS:Among 633 patients studied,200 patients had successful laparoscopic resections with a conversion rate of 11.1%(25 out of 225).Factors predictive of survival on univariate analysis include the laparoscopic approach(P = 0.016),together with factors such as age,ASA status,stage of disease,tumor grade,presence of perineural invasion and vascular emboli,circumferential resection margin < 2 mm,and postoperative adjuvant chemotherapy.The survival benefit of laparoscopic surgery was no longer significant on multivariateanalysis(P = 0.148).Neither 5-year overall survival(70.5% vs 61.8%,P = 0.217) nor 5-year cancer free survival(64.3% vs 66.6%,P = 0.854) were significantly different between the laparoscopic group and the converted group.CONCLUSION:LRR has equivalent long-term oncologic out c ome s w he n c ompare d t o OP.Laparos c opic conversion does not confer a worse prognosis. | Winson Jianhong Tan Min Hoe Chew Angela Renayanti Dharmawan Manraj Singh Sanchalika Acharyya Carol Tien Tau Loi Choong Leong Tang | 2016 | World Journal of Gastrointestinal Surgery2016，8，6： | 3 |
| 4 | Regional plantar foot pressure distributions on high-heeled shoes-shank curve effects显示文摘Forefoot pain is common in high-heeled shoe wearers due to the high pressure caused by the center of body mass moving forward and the increased arch height with heel elevation.Sufficient arch support could reduce the high pressure over forefoot.However,too much arch support could lead to abnormal foot alignment and pain over midfoot.Little information is reported on the relationship among plantar arch height,shank curve design and plantar pressure.This study aimed at quantifying the plantar arch height changes at different heel heights and investigating the effect of shank curve on plantar pressure distribution.The plantar arch height increased to(7.6±1.3) mm at heel height of 75 mm.The Chinese standard suggests the depth of last should be 8.5 mm for heel height of 75 mm.When a shank curve with higher depth of last(11 mm) was used,the peak pressure over forefoot further decreased in midstance phase,which might ease the forefoot problems,while the peak pressure over midfoot increased but not exceeded the discomfort pressure thresholds.To achieve a more ideal pressure distribution in high-heeled shoes,a higher than expected depth of last would be suggested that would not cause discomfort over midfoot. | Winson Lee | 2011 | Acta Mechanica Sinica2011，27，6： | 2 |
| 5 | 显示文摘 | OLIVER S G WINSON M K KELL D B | 1998 | Trends in Biotechnology1998，16，9： | 1 |
| 6 | Real-world evidence on adjuvant chemotherapy in older adults with stage II/III colon cancer显示文摘Colon cancer represents one of the most common cancers diagnosed in older adults worldwide.The standard of care in resected stage II and stage III colon cancer continues to evolve.While there is unequivocal evidence to suggest both disease free and overall survival benefits with the use of combination chemotherapy in patients with stage III colon cancer,data regarding its use in patients with stage II colon cancer are less clear.Further,although colon cancer is a disease that affects older adults,there is considerable debate on the value of adjuvant chemotherapy in the aging population.In particular,many older patients are undertreated when compared to their younger counterparts.In this review,we will describe the clinical trials that contributed to the current adjuvant chemotherapy approach in colon cancer,discuss representation of older adults in trials and the specific challenges associated with the management of this subpopulation,and highlight the role of comprehensive geriatric assessments.We will also review how real-world evidence complements the data gaps from clinical trials of early stage colon cancer. | Atul Batra Rodrigo Rigo Dropen Sheka Winson Y Cheung | 2020 | World Journal of Gastrointestinal Oncology2020，12，6： | 1 |
| 7 | Osteoehondral lesions of the talus: a revised classification 显示文摘 | Hepple S Winson IG Glew D | 1999 | Foot Ankle Int1999，20，12： | 1 |
| 8 | Hypertensive disorders during pregnancy in obstertrics and gynecology 显示文摘 | Winson JR | 1983 | Stlouis Mosby1983，23，4： | 1 |
| 9 | Multiple N-acyl-L-homoserine lactone signal molecules regulate production of virulence determinants and secondary metabolites in Pseudomonas aeruginosa显示文摘 | Winson M K Camara M Latifi A | 1995 | Proc National Acad Sci USA1995，92，20： | 1 |
| 10 | Quorum sensing and Chromobacterium violaceum:exploitation of violacein production and inhibition for the detection of N-acylhomoserine lactones显示文摘 | McClean K H Winson M K Fish L | 1997 | Microbiology1997，143，12： | 1 |
| 11 | Engineering the luxCDABE genes from photorhabdus iumineseens to provide a bioluminescent reporter for constitutive and promoter probe plasmids and mini-Tn5 eonstruets 显示文摘 | Winson K Swift S Hill J | 1998 | Ferns Microbiology Letters1998，163，2： | 1 |
| 12 | Multiple N-acyl-L-homoserine lactone signal molecules regulateproduction of virulence determinants and secondarymetabolites in Pseudomonas aeruginosa 显示文摘 | Winson M K Camara M Latifi A | 1995 | Proceed-ings of the National Academy of Sciences1995，92，20： | 1 |
| 13 | Quorum sensing and Chromobacterium violaceum: exploitation of violacein production and inhibition for the detection of N-acylhomoserine lactones显示文摘 | MCCLEAN K H WINSON M K FISH L | 1997 | Microbiology1997，143，： | 1 |
| 14 | Modified Joint Weibull approach to determine Load Enhancement Factors显示文摘 | James Giancaspro Winson Taam Raymond Wong | 2008 | International Journal of Fatigue2008，，4： | 1 |
| 15 | Metastatic lobular carcinoma of the breast:patterns of spread in the chest,abdomen,and pelvis on CT显示文摘 | Winson CB Hadar O Teitcher JB | 2000 | AJR Am I Roentgenol2000，175，9： | 1 |
| 16 | Vibration control of super tall buildings subjected to wind loads显示文摘 | WINSON CHAI MARIA Q FENG | 1997 | Int J Non - linear Mechanics1997，32，4： | 1 |
| 17 | Load transfer mechanics between trans-tibial prosthetic socket and residual limb-dynamic effects显示文摘 | Jia Xiaohong Zhang Ming Winson CCL | 2004 | J Biomechanics2004，37，： | 1 |
| 18 | Systematic function- al analysis of the yeast genome 显示文摘 | Oliver SG Winson MK Kell DB | 1998 | Trends in Biotechnolo- gy1998，16，9： | 1 |
| 19 | A survey of federated learning for edge computing:Research problems and solutions显示文摘Federated Learning is a machine learning scheme in which a shared prediction model can be collaboratively learned by a number of distributed nodes using their locally stored data.It can provide better data privacy be-cause training data are not transmitted to a central server.Federated learning is well suited for edge computing applications and can leverage the the computation power of edge servers and the data collected on widely dis-persed edge devices.To build such an edge federated learning system,we need to tackle a number of technical challenges.In this survey,we provide a new perspective on the applications,development tools,communication efficiency,security&privacy,migration and scheduling in edge federated learning. | Qi Xia Winson Ye Zeyi Tao Jindi Wu Qun Li | 2021 | High-Confidence Computing2021，1，1： | 1 |
| 20 | Systematic functional analysis of the yeast genome 显示文摘 | Oliver S G Winson M K Kell D B | 1998 | Trends Biotechnol1998，16，： | 1 |
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