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| 1 | Critical size limit of biodegradable nanopartides for enhanced lymph node trafficking and paracortex penetration显示文摘Lymph node (LN) targeti ng through interstitial drain age of nan oparticles (NPs) is an attractive strategy to stimulate a pote nt immune respo nse, as LNs are the primary site for lymphocyte priming by antigen presenting cells (APCs) and triggering of an adaptive immune response. NP size has been shown to influence the efficiency of LN-targeting and retention after subcutaneous injection. For clinical translation, biodegradable NPs are preferred as carrier for vaccine delivery. However, the selective 'size gateM for effective LN-drainage, particularly the kinetics of LN trafficking, is less well defined. This is partly due to the challenge in generating size-controlled NPs from biodegradable polymers in the sub-100-nm range. Here, we report the preparation of three sets of poly(lactic-co-glycolic)-b-poly(ethylene-glycol)(PLGA-b-PEG) NPs with number average diameters of 20-, 40-, and 100-nm and narrow size distributions using flash nanoprecipitation. Using NPs labeled with a near-infrared dye, we showed that 20-nm NPs drain rapidly across proximal and distal LNs following subcutaneous inoculation in mice and are retai ned in LNs more effectively than NPs with a nu mber average diameter of 40-nm. The drain age of 100-nm NPs was n egligible. Furthermore, the 20-nm NPs showed the highest degree of penetration around the paracortex region and had enhanced access to dendritic cells in the LNs. Together, these data confirmed that small, size-controlled PLGA-b-PEG NPs at the lower threshold of about 30-nm are most effective for LN trafficking, retention, and APC uptake after s.c. administration. This report could inform the design of LN-targeted NP carrier for the delivery of therapeutic or prophylactic vaccines. | Gregory P. Howard Garima Verma Xiyu Ke Winter M. Thayer Timothy Hamerly Victoria K. Baxter John E. Lee Rhoel R. Dinglasan Hai-Quan Mao | 2019 | Nano Research2019，12，4： | 3 |
| 2 | cardiac contractility modulation in the treatment of heart failure:initial results and unanswered questions显示文摘 | Winter J Brack KE Ng GA | | 0，，： | 1 |
| 3 | Effects of soil mesofauna and farming management on decomposition of clover litter: a microcosm ex- periment显示文摘 | Ke X Winter K Filser J | 2005 | Soil Biology & Biochmistry2005，37，4： | 1 |
| 4 | Product market competition, corporate governance and firm performance: an empirical analysis for Germany显示文摘 | Januszewski S I K~ke J Winter J K | 2002 | Social Science Electronic Publishing2002，56，3： | 1 |
| 5 | Chs1 of Candida albicans is an essential chitin synthase required for synthesis of the septum and for cell integrity显示文摘 | Munro CA Winter KE | 2001 | Mol Microbiol2001，39，： | 1 |
| 6 | The GABAB receptor as a target for antidepressant drug action 显示文摘 | Ghose S Winter MK McCarson KE | 2011 | Br J Pharmacol2011，162，： | 1 |
| 7 | Soft tissue sarcomas:preoperative versus postoperative radiotherapy显示文摘 | Cheng EY Dusenbery KE Winters MR | 1996 | J Surg Oncol1996，61，2： | 1 |
| 8 | Effects of soil mesofauna and farming management on decomposition of clover litter: A micro- cosm experiment 显示文摘 | Ke X Winter K Filser J | 2005 | Soil Biology and Biochemistry2005，37，4： | 1 |
| 9 | Mechanisms underlying the autonomic modulation of ventricular fibrillation initia tion tentative prophylactic properties of vagus nerve stimulation on malignant arrhythmias in heart failure显示文摘 | Brack KE Winter J Ng GA | 2013 | Heart Fail Rev2013，18，4： | 1 |
| 10 | Soft tissue sarcomas:preoperative versus postoperative radiotherapy显示文摘 | Cheng EY Dussenbery KE Winters MR | 1996 | J Surg Oncol1996，61，： | 1 |
| 11 | Product market competition, corporate governance and firm performance: an empirical analysis for Germany 显示文摘 | Januszewski K? ke & Winter | 2002 | Research in Economics2002，56，： | 1 |
| 12 | Product market competition,corporate governance and firm performance:an empirical analysis for Germany显示文摘 | Januszewski Silke I K ke Jens Winter Joachim K | 2002 | Research in Economics2002，56，3： | 1 |
| 13 | Mechanisms underlying the autonomic modulation of ventricular fibrillation initiation tentative prophylactic properties of vagus nerve stimulation on malignant arrhythmias in heart failure显示文摘 | Brack KE Winter J Ng GA | 2013 | Heart Fail Rev2013，18，4： | 1 |
| 14 | The GABAa re- ceptor as a target for antidepressant drug action显示文摘 | Ghose S Winter MK McCarson KE | 2011 | Br J Pharmacol2011，162，1： | 1 |
| 15 | Calciumacetate versus calcium carbonate as oral phosphate binder in pediatric and adolescent hemodialysis patients显示文摘 | Wallot M Bonzel KE Winter A | 1996 | Pediatr Nephrol1996，10，5： | 1 |
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