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| 1 | Direct regulation of interleukin-6 expression by Notch signaling in macrophages显示文摘Interleukin-6 (IL-6 ) 是一多种,支持 inflammatory cytokine 由房间的各种各样的类型生产了,包括巨噬细胞。在 IL-6 基因倡导者区域以内, CBF1/Su (H)/Lag-1 (CSL ) 的签名绑定主题,在表明小径的槽口的关键 DNA 有约束力的蛋白质,被识别并且发现了与一致重叠原子因素(NF )-κB-binding 地点。槽口发信号高度被保存并且在有免疫力的房间涉及生物功能的规定。在这研究,我们调查了槽口在鼠科的巨噬细胞在 IL-6 抄本的规定发信号的角色。Notch1 蛋白质层次和劈开的 Notch1 (Val1744 ) 的外观的 upregulation 在鼠科的主要骨头与增加的 IL-6 mRNA 表示层次相关很好导出髓的巨噬细胞(BMMφ) 在由和 interferon-gamma 的 lipopolysaccharide (LPS ) 的激活以后(IFN-γ) 。BMMφ 的处理;与 γ压制槽口发信号的 transduction 的 -secretase 禁止者 IL-CHO 在 IL-6 mRNA 的水平和 IL-6 的数量导致了部分减少生产的蛋白质。相反,组成地激活的细胞内部的 Notch1 蛋白质的 overexpression (N 在 RAW264.7 像巨噬细胞的房间线的 IC ) 与空向量控制比在房间 transfected 导致了显著地更高的 IL-6 抄本表示层次。NF-κ B 禁止者完全废除了 mRNA 表示由 N IC 。用 anti-Notch1 抗体的染色质 immunoprecipitation (薄片) 证明 Notch1 在 LPS/IFN-γ 激活的 RAW264.7 房间与 IL-6 倡导者被联系;然而并非在 unstimulated 房间。一起拿,这些结果强烈建议 Notch1 断然经由 NF-κ 调整 IL-6 表示;在激活的巨噬细胞的 B。 | Wipawee Wongchana Tanapat Palaga | 2012 | Cellular & Molecular Immunology2012，9，2： | 15 |
| 2 | Anethum graveolens Linn.(dill) extract enhances the mounting frequency and level of testicular tyrosine protein phosphorylation in rats显示文摘Objective:To investigate the effect of Anethum graveolens(AG) extracts on the mounting frequency,histology of testis and epididymis,and sperm physiology.Methods:Male rats induced by cold immobilization before treating with vehicle or AG extracts [50,150,and 450 mg/kg body weight(BW)] via gastric tube for consecutive 1,7,and 14 d were examined for mounting frequency,testicular phosphorylation level by immunoblotting,sperm concentration,sperm acrosome reaction,and histological structures of testis and epididymis,respectively.Results:AG(50 mg/kg BW) significantly increased the mounting frequency on Days 1 and 7 compared to the control group.Additionally,rat testis treated with 50 mg/kg BW AG showed high levels of phosphorylated proteins as compared with the control group.In histological analyses,AG extract did not affect the sperm concentration,acrosome reaction,and histological structures of testis and epididymis.Conclusions:AG extract enhances the aphrodisiac activity and is not harmful to sperm and male reproductive organs. | Sitthichai IAMSAARD Thawatchai PRABSATTROO Wannisa SUKHORUM Supaporn MUCHIMAPURA Panee SRISAARD Nongnut UABUNDIT Wipawee THUKHAMMEE Jintanaporn WATTANATHORN | 2013 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2013，14，3： | 4 |
| 3 | Notch signaling regulates expression of Mcl-1 andapoptosis in PPD-treated macrophages显示文摘巨噬细胞是为由细菌和病毒的感染的细胞的目标。感染的巨噬细胞的命运在决定主人免疫者反应的结果起一个关键作用。巨噬细胞的 Apoptotic 房间死亡被认为是消除病原体的保护的主人防卫并且感染房间。在这研究,我们调查了槽口在在与结核菌素对待的巨噬细胞调整 apoptosis 发信号的参与净化的蛋白质衍生物(PPD ) 。导出髓的巨噬细胞(BMM ) 与 PPD 对待或与 Mycobacterium bovis 杆菌 Calmette-Gué 感染了的鼠科的骨头; rin (BCG ) 导致了 Notch1 的 upregulation。这 upregulation 在 transcriptional 和翻译层次两个都与 anti-apoptotic 基因 mcl-1 的 upregulation 相关很好。Notch1 和 Mcl-1 的减少的层次在当一个 gamma secretase 禁止者(GSI ) 禁止处理槽口受体,被使用时,与 PPD 对待的 BMM 被观察。而且,在像巨噬细胞的房间线 RAW264.7 的 silencing Notch1 减少了 Mcl-1 蛋白质表示,建议那 Notch1 为在巨噬细胞的 Mcl-1 表示是批评的。apoptotic 房间的重要增加与车辆控制相比面对 GSI 与 PPD 在 BMM 的处理之上被观察对待的房间。最后,在人和老鼠的 mcl-1 倡导者的分析揭示了保存潜在的 CSL/RBP-Jκ有约束力的地点。与 mcl-1 倡导者一起的 Notch1 的协会被染色质 immunoprecipitation 证实。一起拿,这些结果显示 Notch1 禁止直接控制 mcl-1 倡导者与 PPD 刺激的巨噬细胞的 apoptosis。 | Tanapat P alaga Siriluk Ratanabunyong Thitiporn Pattarakankul Naunpun Sangphech Wipawee Wongchana Yukihiro Hadae Patipark Kueanjinda | 2013 | Cellular & Molecular Immunology2013，10，5： | 4 |
| 4 | Prediction of Japanese green tea ranking by gas chromatography/mass spectrometry-based hydro- philic metabolite fingerprinting 显示文摘 | Wipawee P Eiichiro F Takeshi B | 2007 | Journal of Agriculture and Food Chemistry2007，55，： | 1 |
| 5 | Prediction of Japanese green tea ranking by gas chromatography/ massspectrometry-based hydrophilic metabolite fingerprinting显示文摘 | Wipawee P Eiichiro F Takeshi B | 2007 | Journal of Agricultural and Food Chemistry2007，55，2： | 1 |
| 6 | Secondary organic aerasol formation from aromatic precursors 显示文摘 | Wipawee D Alexandra E Yosuke K | 2003 | Environmental Science and Technology2003，37，16： | 1 |
| 7 | Worker assignment in cellular manufacturing considering technical and human skills显示文摘 | Bryan A. Norman Wipawee Tharmmaphornphilas Kim Lascola Needy Bopaya Bidanda Rona Colosimo Warner | 2002 | International Journal of Production Research2002，，6： | 1 |
| 8 | Prediction of Japanese Green Tea Ranking by Gas Chromatography/Mass Spectrometry-Based Hydrophilic Metabolite Fingerprinting显示文摘 | WIPAWEE PONGSUWAN EIICHIRO FUKUSAKI | 2007 | Agric Food Chem2007，55，： | 1 |
| 9 | Inhibition of gamma-secretase affects proliferation of leukemia and hepatoma cell lines through Notch signaling显示文摘 | Saipin Suwanjunee Wipawee Wongchana Tanapat Palaga | 2008 | Anti-Cancer Drugs2008，，5： | 1 |
| 10 | The Combined Extract of Purple Waxy Corn and Ginger Prevents Cataractogenesis and Retinopathy in Streptozotocin-Diabetic Rats显示文摘 | Paphaphat Thiraphatthanavong Jintanaporn Wattanathorn Supaporn Muchimapura Wipawee Thukham-mee Kamol Lertrat Bhalang Suriharn Jing Yi | 2014 | Oxidative Medicine and Cellular Longevity2014，，： | 1 |
| 11 | Involvement of Notch signaling pathway in regulating IL-12 expres-sion via c-Rel in activated macrophages显示文摘 | Natt Boonyatecha Naunpun Sangphech Wipawee Wongchana | 2012 | Mol Immunol2012，51，34： | 1 |
| 12 | Prediction of Japanese green tea ranking by gas chromatograph/mass spec- trometry-based hydrophilic metabolite fingerprinting 显示文摘 | WIPAWEE P EIICHIRO F TAKESHI B | 2007 | Journal of Agricultural and Food Chemistry2007，55，2： | 1 |
| 13 | Worker assignment in cellular manufacturing considering technical and human skills显示文摘 | Bryan Norman Wipawee Tharmmaphornphilas std | 2002 | International Journal of Production Research2002，40，6： | 1 |
| 14 | Prediction of Japanese green tea ranking by gas chromatography/mass spectrometry-based hydrophilic metabolite fingerprinting 显示文摘 | Wipawee P Eiichiro F Takeshi B | 2007 | Journal of Agricultural and Food Chemistry2007，55，2： | 1 |
| 15 | 辣木提取物对应激大鼠性能力具有增强作用(英文)显示文摘目的:探讨辣木叶提取物对改善应激条件下雄性性功能障碍的作用。创新点:根据氧化应激和多巴胺对雄性性功能的影响,推测具有抗氧化和单胺调节功能的辣木叶能改善应激条件下的雄性性功能障碍。方法:本文以雄性Wistar大鼠作为实验对象,通过对影响雄性性功能的各种因素进行测量及统计学分析,包括抗氧化性、B型单胺氧化酶(MAO-B)和5型磷酸二酯酶(PDE-5)活性、血清睾酮和皮质甾酮水平、睾丸内组织形态学变化。结论:研究结果表明,辣木叶提取物作为一种抗氧化剂具有抑制MAO-B和PDE-5活性的作用,同时能降低血清皮质酮水平,提高血清睾酮水平,增加睾丸间质细胞和精子的数量。睾丸间质细胞和精子的数量的增加可能是由于辣木叶提取物的抗氧化作用,插入阶段性功能增强可能是由于MAO-B和PDE-5活性的抑制和睾酮水平的增加。因此,辣木可以作为一种潜在的壮阳药。 | Thawatchai PRABSATTROO Jintanaporn WATTANATHORN Sitthichai IAMSAARD Pichet SOMSAPT Opass SRITRAGOOL Wipawee THUKHUMMEE Supaporn MUCHIMAPURA | 2015 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2015，16，3： | 1 |
| 16 | On the Performance Evaluation of TH and DS UWB MIMO Systems 显示文摘 | WIPAWEE S S MASOUD O | 2004 | IEEE Communications Society2004，，： | 1 |
| 17 | Human related issues in manufacturing cell design, implementation, and operation: a review and survey显示文摘 | Bopaya Bidanda Poonsiri Ariyawongrat Kim LaScola Needy Bryan A. Norman Wipawee Tharmmaphornphilas | 2004 | Computers & Industrial Engineering2004，，3： | 1 |
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