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| 1 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 2 | Sodium and potassium intake and risk of cardiovascular events and all-cause mortality: the Rotterdam study显示文摘 | GELEIJNSE J M WITTEMAN C M | 2007 | European Journal of Epidemiology2007，22，5： | 1 |
| 3 | Insulin metabolism and the risk of Alzheimer disease: the Rotter- dam Study显示文摘 | Schrijvers EM Witteman JC Sijbrands E J | 2010 | Neurology2010，75，22： | 1 |
| 4 | Insulin metabolism and the risk of Alzheimer disease: the Rotterdam Study 显示文摘 | Schrijvers E Witteman J Sijbrands E | 2010 | Neurology2010，75，22： | 1 |
| 5 | The relationship between RAST and skin test results in patients with asthma or rhinitis: a quantitative study with purihed major allergens 显示文摘 | Witteman A M Stapel S O Perdok G J | 1996 | J Allergy Clin Immunol1996，1，： | 1 |
| 6 | Decreased selenium levels in acute myocardial infraction显示文摘 | Kok F J Hofman A Witteman J C | 1989 | Journal of the American Medical Association1989，261，： | 1 |
| 7 | Insu- lin metabolism and the risk of Alzheimer disease: the Rot- terdam Study 显示文摘 | Schrjvers E M Witteman J C Sijbrands E J | 2010 | Neurology2010，75，22： | 1 |
| 8 | Reduction in blood pressure with a low sodium, high potassium, high magnesium salt in older subjects with mild to moderate hypertension显示文摘 | Geleijnse J M Witteman J C M Bak A A A | 1994 | BMJ1994，309，8： | 1 |
| 9 | Decreased selenium levels in acute myocardial infraction显示文摘 | KOK F J HOFMAN A WITTEMAN J C | 1989 | Journal of the American Medical Association1989，261，： | 1 |
| 10 | Dietary fatty acids and the risk of Parkinson disease:the rotterdam study显示文摘 | de Lau L M Bornebroek M Witteman J C | 2005 | Neurol- ogy2005，64，12： | 1 |
| 11 | A study of gene-environment interactiion on the gene for angiotensin converting enzyme:a combined functional and population based approach显示文摘 | Sayed-Tabatabaei FA Schut AF Hofman A Bertoli-Avella AM Vergeer J Witteman JC | 2004 | J Med Genet2004，22，： | 1 |
| 12 | Management of severe acute pancre- atitis :it S all - bouttiming 显示文摘 | Besselink MG van Santvoort HC Witteman B J | 2007 | Currpin Cfit Care2007，13，2： | 1 |
| 13 | Management of severe acute pancreatitis: it's all about timing 显示文摘 | Besselink MG van Santvoort HC Witteman B J | 2007 | Curr Opin Crit Care2007，13，2： | 1 |
| 14 | Low levels of endogenous androgens increase the risk of atherosclerosis in elderly men: the Rotterdam study显示文摘 | Hak A Witteman J de Jong F | 2002 | J Clin Endocrinol Metab2002，87，8： | 1 |
| 15 | Insulin metabolism and the risk of Alzheimer disease : the Rotterdam Study 显示文摘 | Schrijvers EM Witteman JC Sij brands E J | 2010 | Neurolo- gy2010，75，22： | 1 |
| 16 | Atrial fibrllation and the prothrombotic state in the elderly:the Rotterdamstudy显示文摘 | Heeringa J Van Der Kuip DA Chin BS Hofman A Witteman JC Lip Gy | 2003 | Stroke2003，34，2： | 1 |
| 17 | Variance he- terogeneity analysis for detection of potentially interacting ge- netic loci:Method and its limitations显示文摘 | Struchalin M V Dehghan A Witteman J C | 2010 | BMC Genet2010，13，11： | 1 |
| 18 | Single shot beam quality (M2)measurement using a spatial Fourier transform of the near field显示文摘 | OFFERHAUS H L EDWARDS C B WITTEMAN W J | 1998 | Opt Commun1998，151，13： | 1 |
| 19 | Reduction in blood pressure with a low sodium,high potassium,high magnesium salt in older subjects with mild to moderate hypertension显示文摘 | Geleijnse J M Witteman J C Bak A A | 1994 | British Medical Journal1994，309，： | 1 |
| 20 | Management of severe acute pancreatitis: it's all about timing显示文摘 | Besselink MG van Santvoart HC Witteman B J | 2007 | Curr Opin Crit Care2007，13，2： | 1 |
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