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| 1 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 2 | Incidence and risk factors of the post- thrombotic syndrome 显示文摘 | DE WOLF MA WITTENS CH KAHN SR | 2012 | Phlebology2012，271，： | 1 |
| 3 | The intestinal transport of bovine milk exosomes is mediated by endocytosis in human colon carcinoma caco-2 cells and rat small intestinal IEC-6 cells显示文摘 | Wolf T Baier SR Zempleni J | 2015 | J Nutr2015，145，10： | 1 |
| 4 | Central circuits controlling locomotion in young frog tadpoles显示文摘 | Roberts A Soffe SR Wolf ES | 1998 | Ann New York Acad Sci1998，860，： | 1 |
| 5 | Enlarged middle fossa vesthular schwannoma surgery : experience with 735 cases 显示文摘 | Gjurie M Wigand ME Wolf SR | 2001 | Otology & Neurotology2001，22，： | 1 |
| 6 | Assessing hybridization in natural populations of Penstemon (Scrophulariaceae) using hypervariable inter-simple sequence repeat (ISSR) bands显示文摘 | XIANG QY KEPHART SR | 1998 | Mol Ecol1998，7，9： | 1 |
| 7 | Transcription factor RFX4 binding to the testis - specific histone H1t promoter in spermatocytes may be important for regulation of Hit gene transcription during spermatogenesis显示文摘 | Wolfe SA Vanwert JM Grimes SR | 2008 | J Cell Biochem2008，105，1： | 1 |
| 8 | Incidence and risk factors of the post-thrombotic syndrome显示文摘 | De Wolf MA Wittens CH Kahn SR | | 0，，1： | 1 |
| 9 | ' Sniffin ' sticks' : olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold 显示文摘 | Hummel T Sekinger B Wolf SR | 1997 | Chem Senses1997，92，： | 1 |
| 10 | An engineered human antibody to TNF (CDP571) for active Crohn's disease:a randomized double-blind placebo-controlled trial显示文摘 | Sandborn WJ Feagan BG Hanauer SB Present DH Sutherland LR Kamm MA Wolf DC Baker JP Hawkey C Archambault A Bernstein CN Novak C Heath PK Targan SR CDP571 Crohn's Disease Study Group | 2001 | Gastroenterology2001，120，6： | 1 |
| 11 | Testis-specific expression of the rat histone Hlt gene in transgenic mice显示文摘 | vanWert JM Wolfe SA Grimes SR | 1995 | Biochemistry1995，34，27： | 1 |
| 12 | Rodent model of reproductive tract leiomyomata:clinical and pathological features显示文摘 | Everitt JI Wolf DC Howe SR | 1995 | Am J Pathol1995，146，6： | 1 |
| 13 | Pineal tumors: analysis of treatment results in 20 patients 显示文摘 | Arnendola BE Wolf A Coy SR | 2005 | J Neurosurg2005，，： | 1 |
| 14 | Autorhythmometry in manic - depressives 显示文摘 | Atkinson M Kripke DF Wolf SR | 1975 | Chronobiologia1975，2，4： | 1 |
| 15 | Role of radiosurgery in craniopharyngiomas: Apreliminary report显示文摘 | Anendola Be Wolf A Coy SR | 2003 | Med Pediatronce2003，41，2： | 1 |
| 16 | TE2 and TEl subelements of the testis-speciflc histone Hlt promoter are functionally different显示文摘 | Wilkerson DC Wolfe SA Grimes SR | 2003 | J Cell Biochem2003，88，： | 1 |
| 17 | Transcriptional repression of the testisspecific histone Hlt gene mediated by an element upstream of the Hl/AC box显示文摘 | Wolfe SA Grimes SR | 2003 | Gene2003，308，： | 1 |
| 18 | Binding of nuclear proteins to an upstream element involved in transcriptional regulation of the testis-specific histone Hlt gene显示文摘 | Wolfe SA Grimes SR | 1999 | J Cell Biochem1999，75，4： | 1 |
| 19 | The economic effect of age-related hearing loss: national, state, and local estimates, 2002 and 2030 显示文摘 | Stucky SR Wolf KE Kuo T | 2010 | J Am Geriatr Soc2010，58，3： | 1 |
| 20 | Incidence and risk factors of the post-thrombotic syndrome显示文摘 | DE WOLF MA WITTENS CH KAHN SR | 2012 | Phlebology2012，27，1： | 1 |
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